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American Journal of Transplantation

Cover image for Vol. 8 Issue 5

May 2008

Volume 8, Issue 5

Pages 909–1081

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      Liver Transplantation for Hepatopulmonary Syndrome (HPS): What Is the MESSAGE? (pages 911–912)

      M. J. Krowka and M. B. Fallon

      Article first published online: 4 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02190.x

      Hepatopulmonary syndrome can receive MELD exception for liver transplantation, but additional syndrome specifics should be reported to the SRTR to further understand the waitlist and long-term impact of exception. See also article by Sulieman et al in this issue on page 954.

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      Prophylaxis versus Preemptive Protocols for CMV: Do They Impact Graft Survival? (pages 913–914)

      G. G. Miller and B. Kaplan

      Article first published online: 29 FEB 2008 | DOI: 10.1111/j.1600-6143.2008.02181.x

      Debate regarding prophylaxis versus preemptive therapy for CMV infection and disease remains contentious. In this issue, Kliem and colleagues report long term results of a large, randomized, control trial comparing these two approaches in kidney transplant recipients. See also article by Kliem et al in this issue on page 975.

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      A Closer Look at T Cells in the Artery Wall (pages 915–916)

      M. L. Rose

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02206.x

      A recent analysis of T cells in the arterial wall of cardiac transplant recipients with graft vasculopathy demonstrates effector memory CD4+ T cells, some of which bear the senescent CD28 null phenotype. This observation begs the question whether chronically activated CD4+ T cells may be directly damaging to the vessel wall. See also article by Hagemeijer et al in this issue on page 1040.

  3. Minireview

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      Machine Perfusion for ‘Marginal’ Liver Grafts (pages 917–924)

      P. Dutkowski, O. De Rougemont and P.-A. Clavien

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02165.x

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      Numerous new and promising data regarding both hypothermic and normothermic machine liver perfusion have emerged over the past decade. We summarize our understanding of the role of machine perfusion in preventing injury related to "extended criteria" donor livers and speculate on the “ideal” perfusion machine for clinical use.

  4. Ethics Corner

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      Organ Trafficking and Transplant Tourism: A Commentary on the Global Realities (pages 925–929)

      D. A. Budiani-Saberi and F. L. Delmonico

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02200.x

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      This report describes organ trafficking and transplant tourism and introduces alternative approaches that must be addressed by each country to combat organ trafficking.

  5. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      First Things First: Laying the Ethical and Factual Groundwork for Living Kidney Donor Selection Standards (pages 930–932)

      R. Steiner and A. J. Matas

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02201.x

      Our profession must agree on general ethical principles and factual risk data before attempting to standardize selection of living kidney donors. Or “We must agree……………..”

  6. Original Articles:

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
    1. Basic Science

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      Early Events in Kidney Donation: Progression of Endothelial Activation, Oxidative Stress and Tubular Injury After Brain Death (pages 933–941)

      Aurora M. Morariu, Theo A. Schuurs, Henri G. D. Leuvenink, Wim Van Oeveren, Gerhard Rakhorst and Rutger J. Ploeg

      Article first published online: 3 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02166.x

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      In brain dead rats, kidneys rapidly developed proinflammatory and procoagulant endothelial changes with tubular damage, but oxidative stress was only induced late, suggesting it plays only a secondary role in these injuries.

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      Transient Depletion of Dividing T Lymphocytes in Mice Induces the Emergence of Regulatory T Cells and Dominant Tolerance to Islet Allografts (pages 942–953)

      S. Giraud, B. Barrou, S. Sebillaud, P. Debré, D. Klatzmann and V. Thomas-Vaslin

      Article first published online: 12 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02195.x

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      The transient depletion of dividing T cells at the time of islets allograft - using either a conditional suicide transgene expressed in T cells or a hydroxyurea chemotherapy in diabetic mice- induces T cell homeostasis disturbance and the long-term increase in the proportion of CD4+CD25+Foxp3+ regulatory T cells.

    3. Clinical Science

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      OPTN Policy Regarding Prioritization of Patients with Hepatopulmonary Syndrome: Does It Provide Equitable Organ Allocation? (pages 954–964)

      B. M. Sulieman, L. G. Hunsicker, D. A. Katz and M. D. Voigt

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2007.02124.x

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      Patients listed with exception points for hepatopulmonary syndrome, using current UNOS criteria, have a substantial survival advantage over other listed patients, because of the exception points provided. See also editorial by Krowka and Fallon in this issue on page 911.

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      Deceased Organ Donor Characteristics and Clinical Interventions Associated with Organ Yield (pages 965–974)

      F. W. Selck, P. Deb and E. B. Grossman

      Article first published online: 12 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02205.x

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      An analysis of OPTN Deceased Donor Registry data reveals that intrinsic donor characteristics and donor management practices vary significantly across OPOs, and that risk-adjusted organ yield is more robust than the unadjusted method currently utilized and provides a method to both compare OPO performance and point to best practices.

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      Improvement in Long-Term Renal Graft Survival due to CMV Prophylaxis with Oral Ganciclovir: Results of a Randomized Clinical Trial (pages 975–983)

      V. Kliem, L. Fricke, T. Wollbrink, M. Burg, J. Radermacher and F. Rohde

      Article first published online: 5 FEB 2008 | DOI: 10.1111/j.1600-6143.2007.02133.x

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      Prophylaxis for CMV infection using oral ganciclovir improves long-term renal allograft survival. See also editorial by Miller and Kaplan in this issue on page 913.

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      Incidence of PTLD in Pediatric Renal Transplant Recipients Receiving Basiliximab, Calcineurin Inhibitor, Sirolimus and Steroids (pages 984–989)

      R. A. McDonald, J. M. Smith, M. Ho, R. Lindblad, D. Ikle, P. Grimm, R. Wyatt, M. Arar, D. Liereman, N. Bridges, W. Harmon and CCTPT Study Group

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02167.x

      Pediatric renal transplant recipients were enrolled in a multi-center, randomized, double-blind trial of steroid withdrawal using basiliximab, calcineurin inhibitor, and sirolimus which was terminated due to a high incidence of post-transplant lymphoproliferative disorder.

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      Functional Impairment of Cytomegalovirus Specific CD8 T Cells Predicts High-Level Replication After Renal Transplantation (pages 990–999)

      F. M. Mattes, A. Vargas, J. Kopycinski, E. G. Hainsworth, P. Sweny, G. Nebbia, A. Bazeos, M. Lowdell, P. Klenerman, R. E. Phillips, P. D. Griffiths and V. C. Emery

      Article first published online: 4 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02191.x

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      In 25 renal transplant recipients, functional impairment of HCMV-specific CD8 T cells in production of interferon-γ was associated with an increased risk of progression to high level replication of CMV in blood.

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      Risk Factors for Infection with Extended-Spectrum and AmpC β-Lactamase-Producing Gram-Negative Rods in Renal Transplantation (pages 1000–1005)

      L Linares, C. Cervera, F Cofán, D. Lizaso, F Marco, M. J Ricart, N Esforzado, F Oppenheimer, J. M Campistol and A Moreno

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02197.x

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      In 417 kidney and kidney-pancreas transplant recipients, the incidence of infection with ESBL-producing and AmpCβ-lactamase-producing gram-negative rods among gram-negative bacilli infections was 11.8%, associated with kidney-pancreas transplants, previous antibiotics, post-transplant dialysis, and post-transplant urinary obstruction.

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      Comparing Microarray Versus RT-PCR Assessment of Renal Allograft Biopsies: Similar Performance Despite Different Dynamic Ranges (pages 1006–1015)

      K. Allanach, M. Mengel, G. Einecke, B. Sis, L. G. Hidalgo, T. Mueller and P. F. Halloran

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02199.x

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      Comparison of RT-PCR and microarrays in assessing transcriptome changes in kidney transplant biopsies showed that both agreed strongly with each other and histopathology in assessing inflammation. Although the dynamic range PCR was greater, the dynamic range of both methods was sufficient to detect rejection.

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      EBV PCR in the Diagnosis and Monitoring of Posttransplant Lymphoproliferative Disorder: Results of a Two-Arm Prospective Trial (pages 1016–1024)

      D. E. Tsai, L. Douglas, C. Andreadis, D. T. Vogl, S. Arnoldi, R. Kotloff, J. Svoboda, R. D. Bloom, K. M. Olthoff, S. C. Brozena, S. J. Schuster, E. A. Stadtmauer, E. S. Robertson, M. A. Wasik and V. N. Ahya

      Article first published online: 29 FEB 2008 | DOI: 10.1111/j.1600-6143.2008.02183.x

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      This study determined that utilizing plasma as a specimen source and gene targets EBNA and EBER in EBV quantitative real-time PCR assays provided the highest sensitivity and specificity for diagnosing and monitoring PTLD. Therefore an assay that incorporates both gene targets would be the most successful in the management of PTLD patients.

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      Survival After Lung Transplantation of Cystic Fibrosis Patients Infected with Burkholderia cepacia Complex (pages 1025–1030)

      B. D. Alexander, E. W. Petzold, L. B. Reller, S. M. Palmer, R. D. Davis, C. W. Woods and J. J. LiPuma

      Article first published online: 3 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02186.x

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      Survival following lung transplantation was compared among cystic fibrosis patients infected with Burkholderia cepacia complex (Bcc) prior to transplant and infection with Bcc species other than B. cenocepacia did not significantly impact 5 year survival, whereas infection with B. cenocepacia was associated with decreased survival

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      Malignancy After Heart Transplantation: Incidence, Prognosis and Risk Factors (pages 1031–1039)

      M. G. Crespo-Leiro, L. Alonso-Pulpón, J. A. Vázquez de Prada, L. Almenar, J. M. Arizón, V. Brossa, J. F. Delgado, J. Fernandez-Yañez, N. Manito, G. Rábago, E. Lage, E. Roig, B. Diaz-Molina, D. Pascual and J. Muñiz

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02196.x

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      Analysis of follow-up data for 3393 Spanish heart transplant patients shows skin cancer to have a more favorable prognosis than other tumors, and suggests that prophylactic acyclovir counteracts the risk of neoplasia associated with certain induction treatments.

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      T cells in Cardiac Allograft Vasculopathy Are Skewed to Memory Th-1 Cells in the Presence of a Distinct Th-2 Population (pages 1040–1050)

      M. C. Hagemeijer, M. F. M. Van Oosterhout, D. F. Van Wichen, J. Van Kuik, E. Siera-de Koning, F. H. J. Gmelig Meyling, M. E. I. Schipper, N. De Jonge and R. A. De Weger

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02198.x

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      Neo-intima proliferation in cardiac allograft vasculopathy is induced by a population of T-helper cells that are in majority Th-1 cells producing only few cytokines and are low in CD-markers expression, but directly or indirectly result in high y-interferon and TGF-β production in the arterial wall. See also editorial by Rose in this issue on page 915.

  7. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      Regional and Racial Disparities in the Use of Live Non-Directed Kidney Donors (pages 1051–1055)

      D. L. Segev and R. A. Montgomery

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02192.x

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      The authors summarize allocation patterns resulting from current practice models of non-directed live donor kidney transplantation in the United States.

  8. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      Heart Transplantation for Homozygous Familial Transthyretin (TTR) V122I Cardiac Amyloidosis (pages 1056–1059)

      I. M. Hamour, H. J. Lachmann, H. J. B. Goodman, M. Petrou, M. M. Burke, P. N. Hawkins and N. R. Banner

      Article first published online: 3 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02162.x

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      The patient with heart failure due to cardiac amyloidosis caused by the familial transthyretin V122I variant received a successful heart transplant with no evidence of recurrence at 3 years.

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      Partial Bladder Transplantation with En Bloc Kidney Transplant—The First Case Report of a ‘Bladder Patch Technique’ in a Human (pages 1060–1063)

      T. Kato, G. Selvaggi, G. Burke, G. Ciancio, G. Zilleruelo, M. Hattori, R. Gosalbez and A. Tzakis

      Article first published online: 29 FEB 2008 | DOI: 10.1111/j.1600-6143.2008.02180.x

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      A child with severe congenital kidney and urinary tract abnormalities received a transplant of two kidneys en bloc with ureters connected to a patch of donor bladder, resulting in successful transplantation without reflux at 18 months follow-up.

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      Renal Transplantation to the Ovarian Vein: A Case Report (pages 1064–1066)

      V. K. H. Wong, R. Baker, J. Patel, K. Menon and N. Ahmad

      Article first published online: 29 FEB 2008 | DOI: 10.1111/j.1600-6143.2008.02185.x

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      A patient with a thrombosed inferior vena cava and iliac veins previously considered unsuitable for transplantation received a kidney transplanted to an ovarian vein, resulting in initial function, uncomplicated recovery, and excellent renal function at six months.

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      Successful Management of Eviscerated Renal Allograft with Preservation of Function (pages 1067–1070)

      H. Jeon, P. P. McHugh, D. Ranjan, T. D. Johnston, R. Gedaly and Lee L. Q. Pu

      Article first published online: 4 MAR 2008 | DOI: 10.1111/j.1600-6143.2008.02189.x

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      This case illustrates successful management of an eviscerated renal allograft secondary to a severe wound complication after transplantation, using muscle flaps and local tissue arrangement.

  9. Obituary

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      ERNST J. EICHWALD, MD (1913–2007) (pages 1071–1072)

      J. M. Cecka and H. M. Gebel

      Article first published online: 29 FEB 2008 | DOI: 10.1111/j.1600-6143.2008.02184.x

      Dr. Ernst J Eichwald discovered the male-specific H-Y minor histocompatibility antigen and was a founding editor of the “Transplantation Bulletin” which preceded the journal “Transplantation”.

  10. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      Heme Oxygenase-1 Polymorphisms and Renal Transplantation Outcomes: Balancing at the Detection Limit of Allelic Association Studies (pages 1077–1078)

      P. Hribova, P. Reinke, J. Petrasek, I. Brabcova, J.A. Hubacek and O. Viklicky

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02207.x

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      Heme Oxygenase-1 Gene Promoter Polymorphisms and Outcomes of Clinical Renal Transplantation (page 1079)

      A. E. Courtney, C. C. Patterson and A. P. Maxwell

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02218.x

  11. Erratum

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Ethics Corner
    6. Personal Viewpoint
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Obituary
    11. Letters to the Editor
    12. Erratum
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      Erratum (page 1080)

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02202.x

      This article corrects:
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      Erratum (page 1081)

      Article first published online: 14 APR 2008 | DOI: 10.1111/j.1600-6143.2008.02203.x

      This article corrects:

      HIV-Infected Liver and Kidney Transplant Recipients: 1- and 3-Year Outcomes

      Vol. 8, Issue 2, 355–365, Article first published online: 18 DEC 2007

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