Sirolimus May Reduce Fertility in Male Renal Transplant Recipients (pages 1471–1479)
J. Zuber, D. Anglicheau, C. Elie, L. Bererhi, M-O. Timsit, M-F. Mamzer-Bruneel, M. Ciroldi, F. Martinez, R. Snanoudj, C. Hiesse, H. Kreis, F. Eustache, K. Laborde, E. Thervet and C. Legendre
Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02267.x
This study provides evidence of sirolimus-induced male gonadal toxicity by showing frequent alterations in sperm parameters and a 15-fold decrease in fathered pregnancy rate in male renal transplant recipients receiving sirolimus.