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American Journal of Transplantation

Cover image for Vol. 8 Issue 7

July 2008

Volume 8, Issue 7

Pages 1357–1569

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
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  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
    1. You have free access to this content
      T-Regulatory Cells in Human Transplantation (pages 1359–1360)

      L. C. Racusen

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02306.x

      Detection of FOXP3 transcripts in human organ transplants correlates with inflammation and rejection, and its significance remains to be established. See article by Bunnag et al on page 1423.

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      Who Cares? A Lesson from Pakistan on the Health of Living Donors (pages 1361–1362)

      G. M. Danovitch

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02290.x

      Understanding the health of paid and altruistic donors from Pakistan may be relevant to the debate over the commercialization of living kidney donation in the US. See article by Rizvi et al on page 1444.

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      Finding the Right Job for the Tool: Alemtuzumab and Its Role in Renal Transplantation (pages 1363–1364)

      K. A. Newell, L. C. Cendales and A. D. Kirk

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02291.x

      Clinical trial design in transplantation presents significant challenges that are highlighted by studies of new immunosuppressive agents such as alemtuzumab. See article by Margreiter et al on page 1480.

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      Tolerance Versus Immunosuppression: A Perspective (pages 1365–1366)

      P. F. Halloran, J. Bromberg, B. Kaplan and F. Vincenti

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02289.x

      Recent publicity around clinical tolerance should not distract patients or their doctors from the reality that there is no proven alternative to long term immunosuppression.

  3. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
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      The Spectrum of Antibody-Mediated Renal Allograft Injury: Implications for Treatment (pages 1367–1373)

      J. Gloor, F. Cosio, D. J. Lager and M. D. Stegall

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02262.x

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      Antibody mediated rejection exists as a spectrum of injury ranging from hyperacute rejection resulting in immediate graft loss, to early acute rejection occurring within the first weeks post transplant, and finally to chronic antibody-mediated rejection manifested as transplant glomerulopathy.

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      Pharmacogenetics of Immunosuppressants: Progress, Pitfalls and Promises (pages 1374–1383)

      D. Cattaneo, S. Baldelli and N. Perico

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02263.x

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      Genetics differences may play a key role in individual response to immunosuppressive agents, as summarized in this report on recent advances and limitations related to the pharmacogenetics of organ transplantation.

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      Mammalian Target of Rapamycin Inhibitor Dyslipidemia in Kidney Transplant Recipients (pages 1384–1392)

      B. L. Kasiske, A. de Mattos, S. M. Flechner, L. Gallon, H.-U. Meier-Kriesche, M. R. Weir and A. Wilkinson

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02272.x

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      This systematic review of randomized trials describes the dyslipidemia that occurs with mTOR inhibitors in kidney transplantation.

  4. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
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      Regulatory Face-Off: What Agency Should Oversee Face Transplants? (pages 1393–1395)

      A. K. Glazier

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02282.x

      Regulating face transplantation as an organ transplant under current federal regulatory structure would best address the significant clinical and ethical issues raised by face transplants while furthering the goal of NOTA.

  5. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
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      The Banff 2007 Working Classification of Skin-Containing Composite Tissue Allograft Pathology (pages 1396–1400)

      L. C Cendales, J. Kanitakis, S. Schneeberger, C. Burns, P. Ruiz, L. Landin, M. Remmelink, C. W. Hewitt, T. Landgren, B. Lyons, C. B. Drachenberg, K. Solez, A. D. Kirk, D. E. Kleiner and L. Racusen

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02243.x

      This report documents the conclusions of an international symposium on Composite Tissue Allograft (CTA) rejection held at the Ninth Banff Conference on Allograft Pathology in La-Coruna, Spain on June 26, 2007 and proposes a working classification, the Banff CTA-07, for the categorization of CTA rejection.

  6. Original Articles:

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
    1. Basic Science

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      THIS ARTICLE HAS BEEN RETRACTED Essential Role of Sphingosine-1-Phosphate Receptor 1-Bearing CD8+CD44+CCR7+ T Cells in Acute Skin Allograft Rejection (pages 1401–1412)

      H. Yuling, X. Ruijing, J. Xiang, X. Luokun, Y. Wenjun, C. Feng, H. Baojun, Y. Hui, Y. Guang, Y. Chunlei, Z. Jixin, C. Lang, Q. Li, A. Chang, B. Zhuan, J. Youxin, G. Feili and T. Jinquan

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02275.x

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      This work provides direct evidence that naturally-formed CD8+CD44+CCR7+S1P1+ memory T cells are major mediators of acute skin allograft rejection, and that S1P1 may serve as a functional marker of the subset of memory T cells.

      Corrected by:

      Retraction

      Vol. 11, Issue 6, 1343, Article first published online: 6 JUN 2011

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      Cidofovir Inhibits Polyomavirus BK Replication in Human Renal Tubular Cells Downstream of Viral Early Gene Expression (pages 1413–1422)

      E. Bernhoff, T. J. Gutteberg, K. Sandvik, H. H. Hirsch and C. H. Rinaldo

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02269.x

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      Cidofovir treatment of BK virus-infected human renal tubule epithelial cells resulted in inhibition of viral DNA replication and significant host cell toxicity.

    3. Clinical Science

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      FOXP3 Expression in Human Kidney Transplant Biopsies Is Associated with Rejection and Time Post Transplant but Not with Favorable Outcomes (pages 1423–1433)

      S. Bunnag, K. Allanach, G. S. Jhangri, B. Sis, G. Einecke, M. Mengel, T. F. Mueller and P. F. Halloran

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02268.x

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      FOXP3 mRNA expression analyzed by RT-PCR in human renal transplant biopsies for cause is associated with inflammation in the grafts, rejection, and time post-transplant but not with favorable graft outcomes. See editorial by Racusen in this issue on page 1359.

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      Expression of B Cell and Immunoglobulin Transcripts Is a Feature of Inflammation in Late Allografts (pages 1434–1443)

      G. Einecke, J. Reeve, M. Mengel, B. Sis, S. Bunnag, T. F. Mueller and P. F. Halloran

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02232.x

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      Microarray assessment of the burden of B cells and plasma cells in renal allograft biopsies for cause showed that B cell associated and immunoglobulin transcripts are associated with inflammation in biopsies >6 months post-transplant, but carry no independent prognostic information.

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      Health Status and Renal Function Evaluation of Kidney Vendors: A Report from Pakistan (pages 1444–1450)

      S. A. A. Naqvi, S. A. H. Rizvi, M. N. Zafar, E. Ahmed, B. Ali, K. Mehmood, M. J. Awan, B. Mubarak and F. Mazhar

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02265.x

      Kidney venders did not do as well as living intrafamilial donors in their health status and renal function evaluation.

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      The Association of State and National Legislation with Living Kidney Donation Rates in the United States: A National Study (pages 1451–1470)

      L. E. Boulware, M. U. Troll, L. C. Plantinga and N. R. Powe

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02266.x

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      In this national study of living kidney donation rates from 1988–2006, existing state and federal policies supporting donation were not associated with improvements in donation rates for living kidney donors who were related to transplant recipients but were associated with improvements in living-unrelated kidney donations.

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      Sirolimus May Reduce Fertility in Male Renal Transplant Recipients (pages 1471–1479)

      J. Zuber, D. Anglicheau, C. Elie, L. Bererhi, M-O. Timsit, M-F. Mamzer-Bruneel, M. Ciroldi, F. Martinez, R. Snanoudj, C. Hiesse, H. Kreis, F. Eustache, K. Laborde, E. Thervet and C. Legendre

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02267.x

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      This study provides evidence of sirolimus-induced male gonadal toxicity by showing frequent alterations in sperm parameters and a 15-fold decrease in fathered pregnancy rate in male renal transplant recipients receiving sirolimus.

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      Alemtuzumab (Campath-1H) and Tacrolimus Monotherapy After Renal Transplantation: Results of a Prospective Randomized Trial (pages 1480–1485)

      R. Margreiter, J. Klempnauer, P. Neuhaus, F. Muehlbacher, C. Boesmueller and R. Y. Calne

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02273.x

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      Alemtuzumab preconditioning followed by tacrolimus monotherapy in renal transplant recipients is safe and at least as efficient as a tacrolimus based triple-drug regimen.

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      PD-1 Expression and IL-2 Loss of Cytomegalovirus- Specific T Cells Correlates with Viremia and Reversible Functional Anergy (pages 1486–1497)

      U. Sester, D. Presser, J. Dirks, B. C. Gärtner, H. Köhler and M. Sester

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02279.x

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      This prospective study found that PD-1 and loss of IL-2 expression defines a reversible defect of CMV-specific CD4 T-cells that is associated with viremia after transplantation, and blocking PD-1 signaling may provide a potential target for enhancing the function of exhausted T-cells in chronic CMV-infection.

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      Baseline 6-Min Walk Distance Predicts Survival in Lung Transplant Candidates (pages 1498–1505)

      T. Martinu, M. A. Babyak, C. F. O'Connell, R. M. Carney, E. P. Trulock, R. D. Davis, J. A. Blumenthal, S. M. Palmer and For the INSPIRE Investigators

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02264.x

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      In this dual-site study of 376 lung transplant candidates, prospectively followed for up to 4 years, the six-minute walk distance obtained at time of transplant evaluation was significantly predictive of survival regardless of native disease and transplant status.

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      Pulmonary Hypertension in Patients with Bronchiolitis Obliterans Syndrome Listed for Retransplantation (pages 1506–1511)

      S. D. Nathan, O. A. Shlobin, S. Ahmad, S. D. Barnett, N. A. Burton, M. T. Gladwin and R. F. Machado

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02277.x

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      This retrospective review of patients re-listed for lung transplantation due to chronic allograft rejection reveals that about one third of patients have a component of pulmonary hypertension.

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      Altered Levels of CC Chemokines During Pulmonary CMV Predict BOS and Mortality Post-Lung Transplantation (pages 1512–1522)

      S. S. Weigt, R. M. Elashoff, M. P. Keane, R. M. Strieter, B. N. Gomperts, Y. Y. Xue, A. Ardehali, A. L. Gregson, B. Kubak, M. C. Fishbein, R. Saggar, D. J. Ross, J. P. Lynch III, D. A. Zisman and J. A. Belperio

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02280.x

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      Among lung transplant recipients, pulmonary CMV infection and disease cause altered levels of specific CC chemokines in bronchoalveolar lavage fluid, and these levels may be informative in predicting future clinical outcomes.

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      Predictive Value of Dobutamine Stress Echocardiography for Coronary Artery Disease Detection in Liver Transplant Candidates (pages 1523–1528)

      M. E. Harinstein, J. D. Flaherty, A. H. Ansari, J. Robin, C. J. Davidson, J. S. Rossi, S. L. Flamm, A. T. Blei, R. O. Bonow, M. Abecassis and M. Gheorghiade

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02276.x

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      This study of dobutamine stress echocardiography to detect obstructive coronary artery disease in patients awaiting liver transplantation found frequent chronotropic incompetence and low sensitivity in patients who achieve target heart rate, even in those with multiple cardiovascular disease risk factors, suggesting that alternative or additional methods or risk stratification are necessary.

  7. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
    1. You have free access to this content
      Calcineurin Inhibitor Withdrawal After Renal Transplantation with Alemtuzumab: Clinical Outcomes and Effect on T-Regulatory Cells (pages 1529–1536)

      J. Pascual, D. Bloom, J. Torrealba, R. Brahmbhatt, Z. Chang, H. W. Sollinger and S. J. Knechtle

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02260.x

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      Alemtuzumab induction was associated with increased Treg levels and following calcineurin inhibitor withdrawal, but with a trend toward increased rejection.

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      Aqueous Humor Alloreactive Cell Phenotypes, Cytokines and Chemokines in Corneal Allograft Rejection (pages 1537–1543)

      T. H. Flynn, N. A. Mitchison, S. J. Ono and D. F. P. Larkin

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02285.x

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      Aqueous humor samples offer an opportunity to study components of the allogeneic response during corneal rejection.

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      Airway Epithelial Cell Senescence in the Lung Allograft (pages 1544–1549)

      S. M. Parker, M. R. Goriwiec, L. A. Borthwick, G. Johnson, C. Ward, J. L. Lordan, P. A. Corris, G. C. Saretzki and A. J. Fisher

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02284.x

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      Cellular senescence occurs with increased frequency in the airway epithelium of lung transplants but is not associated with BOS.

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      Increase of Integrin-Linked Kinase Activity in Cultured Podocytes upon Stimulation with Plasma from Patients with Recurrent FSGS (pages 1550–1556)

      M. Hattori, Y. Akioka, H. Chikamoto, N. Kobayashi, K. Tsuchiya, M. Shimizu, S. Kagami and H. Tsukaguchi

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02287.x

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      This study of the effects of plasma from FSGS patients with post-transplant recurrence on cultured podocytes suggests the presence of circulating toxic factors in the plasma of some patients with recurrent FSGS, which induce an increase in podocyte integrin-linked kinase activity and detachment of podocytes from the glomerular basement membrane.

  8. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Personal Viewpoint
    6. Meeting Report
    7. Original Articles:
    8. Brief Communications
    9. Case Reports
    1. You have free access to this content
      Rescue of a Living Donor with Liver Transplantation (pages 1557–1561)

      B. Ringe, G. Xiao, D. A. Sass, J. Karam, S. Shang, T. P. Maroney, A. E. Trebelev, S. Levison, A. C. Fuchs, R. Petrucci, A. Ko, M. Gonzalez, J. C. Reynolds and W. C. Meyers

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02261.x

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      This living liver donor received a liver transplant eleven days following right hemihepatectomy and postoperative liver failure, and is alive after eight months.

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      Unexpected Postmortem Diagnosis of Acanthamoeba Meningoencephalitis Following Allogeneic Peripheral Blood Stem Cell Transplantation (pages 1562–1566)

      J. Pemán, I. Jarque, J. Frasquet, C. Alberola, M. Salavert, J. Sanz, B. Gomila and G. Esteban

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02270.x

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      This rare but fatal infectious complication of transplantation was diagnosed at autopsy.

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      Respiratory Failure Associated with Human Metapneumovirus Infection in an Infant Posthepatic Transplant (pages 1567–1569)

      K. M. A. Evashuk, S. E. Forgie, S. Gilmour, H. Huynh, B. E. Lee and J. L. Robinson

      Article first published online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02278.x

      Respiratory failure followed detection of human metapneumovirus from a 9-month-old child 8 days post-hepatic transplant.

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