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American Journal of Transplantation

Cover image for Vol. 8 Issue 9

September 2008

Volume 8, Issue 9

Pages 1763–1966

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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      Ethics Committee Oversight of Living Related Donor Kidney Transplantation in China (pages 1765–1766)

      D. W. Hanto

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02348.x

      With passage of the Regulation on Human Transplantation by the Council of the People's Republic of China, new guidelines for the oversight of living donor transplantation have been established. The international transplant community should recognize and support these steps. See also article by Lei et in this issue on page 1840.

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      Heart Transplanation: The End of the Beginning (pages 1767–1768)

      M. Yacoub

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02366.x

      The report on survival of heart transplants beyond 20 years raises important questions about changing our horizons and expectations for outcomes, particularly since only 12.5% of patients survived 20 years, and that many of these have debilitating diseases. See also special article by Deuse et al in this issue on page 1769.

  3. Special Article

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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      Twenty-Year Survivors of Heart Transplantation at Stanford University (pages 1769–1774)

      T. Deuse, F. Haddad, M. Pham, S. Hunt, H. Valantine, M. J. Bates, H. R. Mallidi, P. E. Oyer, R. C. Robbins and B. A. Reitz

      Version of Record online: 28 JUN 2008 | DOI: 10.1111/j.1600-6143.2008.02310.x

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      This study of 60 patients who survived more than 20 years after heart transplantation reveals a high incidence of hypertension, chronic renal failure, diabetes, malignancy, and allograft vasculopathy. See also editorial by Yacoub in this issue on page 1767.

  4. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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      Early Days of Liver Transplantation (pages 1775–1778)

      R. Y. Calne

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02315.x

      The story of the early days of liver transplantation illustrate how a strong idea, animal experimentation, and human experimentation can succeed in the face of prevailing skepticism and technical barriers.

  5. Minireview

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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      Design and Analysis of Clinical Trials in Transplantation: Principles and Pitfalls (pages 1779–1785)

      J. D. Schold and B. Kaplan

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02331.x

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      A critical appraisal of the difficulties in designing and interpreting randomized clinical trials in organ transplantation is presented.

  6. Original Articles:

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
    1. Basic Science

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      Effects of Mycophenolic Acid on Human Fibroblast Proliferation, Migration and Adhesion In Vitro and In Vivo (pages 1786–1797)

      C. Morath, H. Reuter, V. Simon, E. Krautkramer, W. Muranyi, V. Schwenger, P. Goulimari, R. Grosse, M. Hahn, P. Lichter and M. Zeier

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02322.x

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      Mycophenolic acid significantly impairs migrational capacity of fibroblasts in vitro as well as in vivo in the healing wound of renal allograft recipients, with reduced proliferation and fibrosis.

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      Activated Effector and Memory T Cells Contribute to Circulating sCD30: Potential Marker for Islet Allograft Rejection (pages 1798–1808)

      D. Saini, S. Ramachandran, A. Nataraju, N. Benshoff, W. Liu, N. Desai, W. Chapman and T. Mohanakumar

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02329.x

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      Circulating soluble CD30 (sCD30) levels increase following murine and human islet transplantation, perhaps due to sCD30 released in the circulation by both activated and memory CD4 T cells.

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      The Roles of CD8 Central and Effector Memory T-Cell Subsets in Allograft Rejection (pages 1809–1818)

      M. H. Oberbarnscheidt, Y-H. Ng and G. Chalasani

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02335.x

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      CD8 central memory T cells are dependent upon secondary lymphoid tissues for differentiation into effectors, and cause significantly slower allograft rejection than effector memory T cells in hosts that lack secondary lymphoid tissues.

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      C-Jun N-Terminal Kinase 2 Promotes Graft Injury via the Mitochondrial Permeability Transition After Mouse Liver Transplantation (pages 1819–1828)

      T. P. Theruvath, C. Czerny, V. K. Ramshesh, Z. Zhong, K. D. Chavin and J. J. Lemasters

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02336.x

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      Deficiency of c-Jun N-terminal kinase 2 (JNK2) improves mitochondrial function, mitigates storage/reperfusion injury and improves survival of mouse liver grafts.

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      The Anti-Non-Gal Xenoantibody Response to Xenoantigens on Gal Knockout Pig Cells Is Encoded by a Restricted Number of Germline Progenitors (pages 1829–1839)

      K. Kiernan, I. Harnden, M. Gunthart, C. Gregory, J. Meisner and M. Kearns-Jonker

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02337.x

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      Anti-non-gal xenoantibodies in monkeys immunized with GalTKO pig cells are encoded by the IGHV3-21 germline progenitor.

    6. Clinical Science

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      Ensuring the Safety of Living Kidney Donors and Recipients in China Through Ethics Committee Oversight: An Early Experience (pages 1840–1843)

      Z. Lei, M. Lulin, W. Guoliang and H. Xiaofei

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02311.x

      The new legal framework for living donor organ transplantation in China challenges individual centers to develop structures to ensure safety and ethical standards in the care of the donor and recipients. See also editorial by Hanto in this issue on page 1765.

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      Histological Assessment of Preimplantation Biopsies May Improve Selection of Kidneys from Old Donors After Cardiac Death (pages 1844–1851)

      M. G. J. Snoeijs, W. A. Buurman, M. H. L. Christiaans, J. P. Van Hooff, R. Goldschmeding, R. J. Van Suylen, C. J. Peutz-Kootstra and L. W. E. Van Heurn

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02318.x

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      In a cohort of 52 DCD kidney transplantations from donors of 60 years or over, histological score of pre-implantation biopsies but not donor age, kidney function or functional kidney weight was associated with graft function and premature graft loss.

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      Glycogen Synthase Kinase 3β: A Novel Marker and Modulator of Inflammatory Injury in Chronic Renal Allograft Disease (pages 1852–1863)

      R. Gong, Y. Ge, S. Chen, E. Liang, A. Esparza, E. Sabo, A. Yango, R. Gohh, A. Rifai and L. D. Dworkin

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02319.x

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      In patients with chronic renal allograft disease, glycogen synthase kinase 3b, is overexpressed in inflamed tubules and its inactivation by inhibitory phosphorylation correlated inversely with interstitial fibrosis and tubular atrophy.

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      Effect of Teriparatide on Early Bone Loss After Kidney Transplantation (pages 1864–1870)

      D. Cejka, T. Benesch, C. Krestan, P. Roschger, K. Klaushofer, P. Pietschmann and M. Haas

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02327.x

      Early bone loss after kidney transplantation is not influenced by recombinant PTH therapy.

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      Comparative Risk of Impaired Glucose Metabolism Associated with Cyclosporine Versus Tacrolimus in the Late Posttransplant Period (pages 1871–1877)

      F. L. Luan, H. Zhang, D. E. Schaubel, C. D. Miles, D. Cibrik, S. Norman and A. O. Ojo

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02328.x

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      The risk of diabetes following tacrolimus conversion in kidney transplant recipients was similar to the risk of patients continuing to receive cyclosporine.

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      Health Outcomes for Living Kidney Donors with Isolated Medical Abnormalities: A Systematic Review (pages 1878–1890)

      A. Young, L. Storsley, A. X. Garg, D. Treleaven, C. Y. Nguan, M. S. Cuerden and M. Karpinski

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02339.x

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      As transplant centers screen and counsel potential living kidney donors with isolated medical abnormalities (IMAs), uncertainties remain regarding long-term medical outcomes.

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      Melanoma in Organ Transplant Recipients: Clinicopathological Features and Outcome in 100 Cases (pages 1891–1900)

      R. N. Matin, D. Mesher, C. M. Proby, J. M. McGregor, J. N. Bouwes Bavinck, V. Del Marmol, S. Euvrard, C. Ferrandiz, A. Geusau, M. Hackethal, W. L. Ho, G. F. L. Hofbauer, B. Imko-Walczuk, J. Kanitakis, A. Lally, J. T. Lear, C. Lebbe, G. M. Murphy, S. Piaserico, D. Seckin, E. Stockfleth, C. Ulrich, F. T. Wojnarowska, H. Y. Lin, C. Balch, C. A. Harwood and on behalf of the Skin Care in Organ Transplant Patients, Europe (SCOPE) group

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02326.x

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      A multicentre retrospective analysis of 100 melanomas was undertaken demonstrating that outcome for post-transplant melanoma was similar to that of the general population for T1 and T2 tumours (2mm thickness); but significantly worse for T3 and T4 tumours (>2mm thickness).

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      Renal Histopathological Lesions After Lung Transplantation in Patients with Cystic Fibrosis (pages 1901–1910)

      C. Lefaucheur, D. Nochy, C. Amrein, P. Chevalier, R. Guillemain, M. Cherif, C. Jacquot, D. Glotz and G. S. Hill

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02342.x

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      In this study of renal histology in patients with lung transplantation for cystic fibrosis, the histologic lesions were surprisingly complex including oxalate deposition, toxicity from antimicrobial agents, and diabetic glomerulosclerosis, as well as calcineurin inhibitor effects.

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      The Role of the IL23/IL17 Axis in Bronchiolitis Obliterans Syndrome After Lung Transplantation (pages 1911–1920)

      B. M. Vanaudenaerde, S. I. De Vleeschauwer, R. Vos, I. Meyts, D. M. Bullens, V. Reynders, W. A. Wuyts, D. E. Van Raemdonck, L. J. Dupont and G. M. Verleden

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02321.x

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      This paper highlights the involvement of the IL23/IL17 pathway (indirectly TH 17 fate) in patients experiencing bronchiolitis obliterans syndrome (BOS) after lung transplantation and hence the crucial role of the balance between TH 17 effector cells and Treg cells in BOS.

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      Pulmonary Hypertension Associated with Lung Transplantation Obliterative Bronchiolitis and Vascular Remodeling of the Allograft (pages 1921–1930)

      R. Saggar, D. J. Ross, R. Saggar, D. A. Zisman, A. Gregson, J. P. Lynch III, M. P. Keane, S. Samuel Weigt, A. Ardehali, B. Kubak, C. Lai, D. Elashoff, M. C. Fishbein, W. D. Wallace and J. A. Belperio

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02338.x

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      Pulmonary hypertension is common in lung transplants with bronchiolitis obliterans, associated with vasculopathy in the pulmonary circulation.

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      Donor HLA-C Genotype Has a Profound Impact on the Clinical Outcome Following Liver Transplantation (pages 1931–1941)

      R. Hanvesakul, N. Spencer, M. Cook, B. Gunson, M. Hathaway, R. Brown, P. Nightingale, P. Cockwell, S. G. Hubscher, D. H. Adams, P. Moss and D. Briggs

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02341.x

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      This genetic study identifies the association of donor HLA-C2 genotype (ligands for killer immunoglobulin like receptor: 2DL1) with reduced incidence of chronic rejection, graft cirrhosis, graft loss and improved patient survival.

  7. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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      Increased Pancreatitis in Allografts Flushed with Histidine-Tryptophan-Ketoglutarate Solution: A Cautionary Tale (pages 1942–1945)

      D. Alonso, T. B. Dunn, T. Rigley, J. Y. Skorupa, M. E. Schriner, L. E. Wrenshall and R. B. Stevens

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02312.x

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      Suspicion of a causal relationship between histidine-tryptophan-ketoglutarate preservation solution use and pancreas transplantation outcomes prompted review of two transplant centers' experiences, suggesting that attention be directed to the HTK flush volume, rate, and pressure.

  8. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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      Successful Bilateral Lung Transplantation for Lymphangiomatosis (pages 1946–1950)

      C. V. Kinnier, J. P. C. Eu, R. D. Davis, D. N. Howell, J. Sheets and S. M. Palmer

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02340.x

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      In this first case of lung transplantation in a patient with lymphangiomatomis, the patient remains alive with stable lung function at four years, despite extensive extrapulmonary and bony lymphoproliferative disease.

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      Symptomatic Pulmonary Allograft Kaposi's Sarcoma in Two Lung Transplant Recipients (pages 1951–1956)

      S. J. Sathy, T. Martinu, K. Youens, C. M. Lawrence, D. N. Howell, S. M. Palmer and M. P. Steele

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02345.x

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      Kaposi's sarcoma affecting the pulmonary allograft, with or without a second concomitant malignancy, can be a complication of lung transplantation, and sirolimus may play a role in its treatment.

  9. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Special Article
    5. Personal Viewpoint
    6. Minireview
    7. Original Articles:
    8. Brief Communication
    9. Case Reports
    10. Letters to the Editor
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      Coagulation and Fractionated Plasma Separation and Adsorption (pages 1959–1960)

      Kiran Rifai, Peter Krisper, Andreas Kribben and Stefan Herget-Rosenthal

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02313.x

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      Different Preparations of Tacrolimus and Medication Errors (page 1962)

      A. Woywodt, M. Delargy and Z. Thain

      Version of Record online: 12 AUG 2008 | DOI: 10.1111/j.1600-6143.2008.02325.x

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      Uncertainty Does Not Preclude Rationality (page 1965)

      J. S. Taylor and A. Spital

      Version of Record online: 28 JUL 2008 | DOI: 10.1111/j.1600-6143.2008.02334.x

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