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American Journal of Transplantation

Cover image for Vol. 9 Issue 1

January 2009

Volume 9, Issue 1

Pages 1–245

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      News and issues that affect organ and tissue transplantation (pages 1–2)

      SUE PONDROM

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02525.x

      This month The AJT Report examines the national donor programs recently launched in Australia, Canada and the U.K., and explores their potential for boosting donor rates in those countries.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have free access to this content
      Steroid Withdrawal: Moving on to the Next Questions (pages 3–4)

      J. J. Augustine and D. E. Hricik

      Article first published online: 4 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02465.x

      Recent uncontrolled trials and registry analyses, although flawed by selection bias, indicate that steroid-free immunosuppression is safe in many low-risk kidney transplant recipients. It is time to focus attention on the minority of patients who experience rejection after steroid withdrawal. See also article by Luan et al in this issue on page 160.

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      Transplantation Oversight—Finding the Right Balance Between the Layperson, the Transplant Professional and the Regulator (pages 5–6)

      G. B. G. Klintmalm and M. M. I. Abecassis

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02483.x

      Is UNOS the right body to make recommendations for standards for medical evaluation and care? The authors, who were involved in the development of the recent rule, suggest that it would be more appropriately done by the professional societies. See also article by Brown, Jr. et al in this issue on page 31.

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      Cardiac Allograft Hypertrophy: A New Target for Therapy, a Surrogate Marker for Survival? (pages 7–8)

      G. Torre-Amione

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02503.x

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      Long-term heart transplant survival may not simply be limited by allograft vasculopathy, but also by diffuse myocardial injury in form of left ventricular hypertrophy. See also article by Raichlin et al in this issue on page 132.

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      Allocation or Rationing—Word Choice Is Crucial (pages 9–10)

      A. J. Matas

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02484.x

      Changing use of the word “allocation” to “rationing” would be more realistic and could help move public policy decisions.

  3. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      Nine Things You Might Not Say or Hear in Transplantation (pages 11–13)

      J. S. Bromberg and P. F. Halloran

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02502.x

      It is time to stir up some debate on areas of organ transplantation that need sharper focus.

  4. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      Platelets Influence Vascularized Organ Transplants from Start to Finish (pages 14–22)

      A. D. Kirk, C. N. Morrell and W. M. Baldwin, III

      Article first published online: 4 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02473.x

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      Platelets have many potential effects on innate immune responses in the donor and recipient before transplantation as well as on adaptive immunity during antibody- and cell-mediated rejection.

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      Transplantation Risks and the Real World: What Does ‘High Risk’ Really Mean? (pages 23–30)

      R. B. Freeman and J. T. Cohen

      Article first published online: 4 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02476.x

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      The estimated risk of disease transmission from donor to recipient is thousands of times lower than most of the other mortality risks faced by transplant patients and is similar to everyday risks that most people willingly choose to take.

  5. Special Article

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      The Evolution and Direction of OPTN Oversight of Live Organ Donation and Transplantation in the United States (pages 31–34)

      R. S. Brown, Jr, R. Higgins and T. L Pruett

      Article first published online: 6 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02433.x

      Over the past 20 years the Organ Procurement and Transplantation Network (OPTN) developed policies and bylaws concerning allocation of deceased donor organs, and since the OPTN final rule in 2000 has a growing mandate in living donation. See also editorial by Klintmalm and Abecassis in this issue on page 5.

  6. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      Nonadherence Consensus Conference Summary Report (pages 35–41)

      R. N. Fine, Y. Becker, S. De Geest, H. Eisen, R. Ettenger, R. Evans, D. Lapointe Rudow, D. McKay, A. Neu, T. Nevins, J. Reyes, J. Wray and F. Dobbels

      Article first published online: 15 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02495.x

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      A Consensus Conference was held in January 2008 to detail the impact of non-adherence (NA) on the outcome of solid organ transplantation (SOT).

  7. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. Basic Science

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      Disruption of Murine Cardiac Allograft Acceptance by Latent Cytomegalovirus (pages 42–53)

      C. H. Cook, A. A. Bickerstaff, J-J. Wang, P. D. Zimmerman, M. R. Forster, T. Nadasdy, R. B. Colvin, G. A. Hadley and C. G. Orosz

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02457.x

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      In mice, heart allograft recipients latently infected with murine CMV had 80% graft loss at 100 days after transplantation compared to 8% graft loss in naïve recipients, suggesting that in this model responses to MCMV disrupt allograft acceptance.

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      Aging Augments IL-17 T-Cell Alloimmune Responses (pages 54–63)

      B. M. Tesar, W. Du, A. C. Shirali, W. E. Walker, H. Shen and D. R. Goldstein

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02458.x

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      Aged mice exhibit elevated CD4+ memory alloimmune responses as compared to young mice, which contributes to the tempo of acute allograft rejection.

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      Effector Functions of Donor-Reactive CD8 Memory T Cells Are Dependent on ICOS Induced During Division in Cardiac Grafts (pages 64–73)

      A. D. Schenk, V. Gorbacheva, M. Rabant, R. L. Fairchild and A. Valujskikh

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02460.x

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      The induction of ICOS expression is an important feature of CD8 memory T-cell activation within allograft tissue, and ICOS is a specific target for neutralizing the functions of endogenous CD8 memory T cells.

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      Nox-2 Is a Modulator of Fibrogenesis in Kidney Allografts (pages 74–82)

      A. Djamali, A. Vidyasagar, M. Adulla, D. Hullett and S. Reese

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02463.x

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      Classical phagocytic Nox-2 is involved in the pathogenesis of allograft tubulointerstitial fibrosis via transcription factor Smad2, EMT and myofibroblasts.

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      Anticarbohydrate Antibody Repertoires in Patients Transplanted with Fetal Pig Islets Revealed by Glycan Arrays (pages 83–90)

      O. Blixt, M. Kumagai-Braesch, A. Tibell, C. G. Groth and J. Holgersson

      Article first published online: 22 JAN 2009 | DOI: 10.1111/j.1600-6143.2008.02471.x

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      The carbohydrate specificities of antibodies in serum samples taken before and after transplantation from seven patients transplanted with fetal pig islet-like cell clusters were analyzed using a glycan array with 200 structurally defined glycans.

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      Long-Term Survival of Nonhuman Primate Islets Implanted in an Omental Pouch on a Biodegradable Scaffold (pages 91–104)

      D. M. Berman, J. J. O'Neil, L. C. K. Coffey, P. C. J. Chaffanjon, N. M. Kenyon, P. Ruiz Jr, A. Pileggi, C. Ricordi and Norma S. Kenyon

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02489.x

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      Auto and allogeneic islets seeded on a synthetic biodegradable scaffold and transplanted in an omental pouch in nonhuman primates engrafted and survived for long periods of time, with sustained improvement in metabolic control.

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      The Indirect Alloresponse Impairs the Induction but Not Maintenance of Tolerance to MHC Class I-Disparate Allografts (pages 105–113)

      M. J. Weiss, D. A. Guenther, J. D. Mezrich, H. Sahara, C. Y. Ng, A. J. Meltzer, J. K. Sayre, M. E. Cochrane, A. C. Pujara, S. L. Houser, D. H. Sachs, B. R. Rosengard, J. S. Allan, G. Benichou and J. C. Madsen

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02494.x

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      Donor class I peptide administration before transplantation prevents immune tolerance induction in mice receiving heart or kidney transplants mismatched for class I.

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      Effects of Donor Age and Cell Senescence on Kidney Allograft Survival (pages 114–123)

      A. Melk, B. M. W. Schmidt, H. Braun, A. Vongwiwatana, J. Urmson, L.-F. Zhu, D. Rayner and P. F. Halloran

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02500.x

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      Old donor kidneys display abnormal parenchymal susceptibility to transplant stresses and enhanced induction of senescence marker p16INK4a, but are not more immunogenic.

  8. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. Basic Science

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      Portal Venous Donor-Specific Transfusion in Conjunction with Sirolimus Prolongs Renal Allograft Survival in Nonhuman Primates (pages 124–131)

      K. K. Dhanireddy, D. A. Bruno, T. A. Weaver, H. Xu, X. Zhang, F. V. Leopardi, D. A. Hale and A. D. Kirk

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02448.x

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      A preoperative donor specific blood transfusion administered via the portal vein significantly delays the onset of acute renal allograft rejection in rhesus monkeys when delivered in combination with sirolimus but not tacrolimus.

  9. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. Clinical Science

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      Cardiac Allograft Remodeling After Heart Transplantation Is Associated with Increased Graft Vasculopathy and Mortality (pages 132–139)

      E. Raichlin, H. R. Villarraga, K. Chandrasekaran, A. L. Clavell, R. P. Frantz, S. S. Kushwaha, R. J. Rodeheffer, C. G. McGregor, R. C. Daly, S. J. Park, W. K. Kremers, B. S. Edwards and N. L. Pereira

      Article first published online: 4 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02474.x

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      Abnormal left ventricular geometric patterns assessed by serial echocardiography occurs early and is common after heart transplantation. A concentric hypertrophy pattern at one year is associated with increased subsequent graft vasculopathy and mortality. See also editorial by Torre-Amione in this issue on page 7.

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      Outcomes Following De Novo CNI-Free Immunosuppression After Heart Transplantation: A Single-Center Experience (pages 140–148)

      A. S. Leet, P. J. Bergin, M. Richardson, A. J. Taylor, D. Esmore and D. M. Kaye

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02456.x

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      Using sirolimus and mycophenolate to avoid calcineurin inhibitors in heart transplants was associated with more rejection, infection, and pleural effusions.

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      Serum Matrix Metalloprotease-1 and Vascular Endothelial Growth Factor–A Predict Cardiac Allograft Rejection (pages 149–159)

      S. Aharinejad, K. Krenn, A. Zuckermann, R. Schäfer, M. Gmeiner, A. Thomas, A. Aliabadi, B. Schneider and M. Grimm

      Article first published online: 4 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02470.x

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      Serum MMP-1 and VEGF-A concentrations predict cardiac allograft rejection, and can be useful for choice of surveillance and immunosuppression protocols.

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      Graft and Patient Survival in Kidney Transplant Recipients Selected for de novo Steroid-Free Maintenance Immunosuppression (pages 160–168)

      F. L. Luan, D. E. Steffick, C. Gadegbeku, S. P. Norman, R. Wolfe and A. O. Ojo

      Article first published online: 27 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02442.x

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      De novo steroid-free immunosuppression in selected kidney transplant patients carries no increased risk for graft loss and patient death 4 years after transplantation. See also editorial by Augustine and Hricik in this issue on page 3.

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      Molecular Correlates of Scarring in Kidney Transplants: The Emergence of Mast Cell Transcripts (pages 169–178)

      M. Mengel, J. Reeve, S. Bunnag, G. Einecke, B. Sis, T. Mueller, B. Kaplan and P. F. Halloran

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02462.x

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      Correlating microarray gene expression data with histopathology revealed mast cell associated transcripts as a robust molecular marker of scarring and prognosis in renal allografts.

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      Allospecific CD154+ T Cells Associate with Rejection Risk After Pediatric Liver Transplantation (pages 179–191)

      C. Ashokkumar, A. Talukdar, Q. Sun, B. W. Higgs, J. Janosky, P. Wilson, G. Mazariegos, R. Jaffe, A. Demetris, J. Dobberstein, K. Soltys, G. Bond, A. W. Thomson, A. Zeevi and R. Sindhi

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02459.x

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      In children receiving liver transplants, CD154 positive circulating memory cytotoxic T cells are associated with increased risk of rejection.

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      Impact of Tips Preliver Transplantation for the Outcome Posttransplantation (pages 192–200)

      G. P. Guerrini, M. Pleguezuelo, S. Maimone, V. Calvaruso, E. Xirouchakis, D. Patch, N. Rolando, B. Davidson, K. Rolles and A. Burroughs

      Article first published online: 4 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02472.x

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      The use of TIPS in liver transplant candidates improves risk-adjusted graft and patient survival at 1 year.

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      Proteasome Inhibition Causes Apoptosis of Normal Human Plasma Cells Preventing Alloantibody Production (pages 201–209)

      D. K. Perry, J. M. Burns, H. S. Pollinger, B. P. Amiot, J. M. Gloor, G. J. Gores and M. D. Stegall

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02461.x

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      Bortezomib induces plasma cell apoptosis in vitro, and decreased bone marrow plasma cells and alloantibody levels in vivo in two patients.

  10. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. Clinical Science

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      Recovery Factors Affecting Utilization of Small Pediatric Donor Kidneys (pages 210–216)

      L. K. Kayler, J. Magliocca, S. Fujita, R. D. Kim, I. Zendejas, A. W. Hemming, R. Howard and J. D. Schold

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02447.x

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      Concurrent intestine recovery from pediatric donors < 21 kg is associated with higher kidney non-recovery and lower transplantation rates of recovered kidneys, but kidney graft outcomes are not appreciably affected by concurrent intestine or liver procurement.

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      Histidine-Tryptophan-Ketoglutarate (HTK) Is Associated with Reduced Graft Survival in Pancreas Transplantation (pages 217–221)

      Z. A. Stewart, A. M. Cameron, A. L. Singer, N. N. Dagher, R. A. Montgomery and D. L. Segev

      Article first published online: 4 NOV 2008 | DOI: 10.1111/j.1600-6143.2008.02449.x

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      By analyzing four years of national data on preservation solution and pancreas transplant outcomes, the authors found that HTK use was associated with worse survival when compared with UW solution.

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      Donor-Derived Mesenchymal Stem Cells Remain Present and Functional in the Transplanted Human Heart (pages 222–230)

      M. J. Hoogduijn, M. J. Crop, A. M. A. Peeters, S. S. Korevaar, M. Eijken, J. J. Drabbels, D. L. Roelen, A. P. M. M. Maat, A. H. M. M. Balk, W. Weimar and C. C. Baan

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02450.x

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      Functional mesenchymal stem cells of donor origin are present in the human heart six years after transplantation, whereas they found no evidence for the presence of mesenchymal stem cells of recipient origin.

  11. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      The Use of Antibody to Complement Protein C5 for Salvage Treatment of Severe Antibody-Mediated Rejection (pages 231–235)

      J. E. Locke, C. M. Magro, A. L. Singer, D. L. Segev, M. Haas, A. T. Hillel, K. E. King, E. Kraus, L. M. Lees, J. K. Melancon, Z. A. Stewart, D. S. Warren, A. A. Zachary and R. A. Montgomery

      Article first published online: 31 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02451.x

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      Eculizumab, a complement C5 inhibitor, was used in a kidney transplant patient undergoing severe antibody mediated rejection, demonstrating effective blockade the membrane attack complex (MAC) and associated with subsequent complete recovery of renal function.

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      Successful Long-Term Outcome of the First Combined Heart and Kidney Transplant in a Patient with Systemic AL Amyloidosis (pages 236–240)

      V. Audard, M. Matignon, L. Weiss, P. Remy, A. Pardon, C. Haioun, K. Belhadj, L. Salomon, M. L. Hillon, D. Sahali, E. Vermes, P. Lang and P. Grimbert

      Article first published online: 4 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02469.x

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      Combined heart and kidney transplantation without stem cell transplantation was used in this patient with ALamyloidosis with severe cardiac and renal involvement.

  12. Book Review

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have full text access to this OnlineOpen article
  13. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoint
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communication
    10. Original Articles
    11. Brief Communications
    12. Case Reports
    13. Book Review
    14. Letters to the Editor
    1. You have free access to this content
      Coagulation and Fractionated Plasma Separation and Adsorption (pages 242–243)

      B.K.I. Meijers, M.F. Hoylaerts and P. Evenepoel

      Article first published online: 19 DEC 2008 | DOI: 10.1111/j.1600-6143.2008.02485.x

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