You have free access to this content

American Journal of Transplantation

Cover image for Vol. 9 Issue 11

November 2009

Volume 9, Issue 11

Pages 2445–2647

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 2445–2446)

      SUE PONDROM

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02866.x

      • image

      The AJT Report takes a closer look at this potentially transformative drug. Also this month, we examine the rising interest in Th17, and explore what it means to search for a kidney on Craigslist.

  2. Minireviews

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. You have free access to this content
      Mycophenolate Mofetil and Calcineurin-Inhibitor Reduction: Recent Progress (pages 2447–2452)

      Josep M. Grinyó and Josep M. Cruzado

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02812.x

      The authors review recent progress about this immunosuppression strategy in renal transplantation and its association with renal function and risk for acute rejection.

    2. You have free access to this content
      The ‘Indirect’ Effects of Cytomegalovirus Infection (pages 2453–2458)

      R. B. Freeman, Jr.

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02824.x

      Emerging descriptions of the mechanisms CMV employs to maintain persistence and replication in the host may shed light on the so-called indirect effects of CMV infection in the immunocompromized host.

    3. You have free access to this content
      Effect of Antibodies on Endothelium (pages 2459–2465)

      X. Zhang and E. F. Reed

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02819.x

      • image
      • image

      Antibodies binding to antigens in endothelial cells can contribute to the process of transplant rejection by stimulating pro-inflammatory, pro-survival, and proliferation signal transduction events.

  3. Special Article

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. You have free access to this content
      The Declaration of Istanbul: Review and Commentary by the American Society of Transplant Surgeons Ethics Committee and Executive Committee (pages 2466–2469)

      A. I. Reed, R. M. Merion, J. P. Roberts, G. B. Klintmalm, M. M. Abecassis, K. M. Olthoff and A. N. Langnas

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02827.x

      While the ASTS Ethics and Executive Committees agree with the principles stated in the Declaration of Istanbul, there are certain policy proposals that need clarification and some that cannot be reasonably accomplished in the United States today.

  4. Laboratory Science

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. Original Articles

      You have free access to this content
      Localization, Etiology and Impact of Calcium Phosphate Deposits in Renal Allografts (pages 2470–2478)

      P. Evenepoel, E. Lerut, M. Naesens, B. Bammens, K. Claes, D. Kuypers, P. Vermeersch, B. Meijers, B. Van Damme and Y. Vanrenterghem

      Article first published online: 14 AUG 2009 | DOI: 10.1111/j.1600-6143.2009.02792.x

      • image
      • image
      • image
      • image

      Calcium-phosphate deposition in the renal allograft is highly prevalent in the early posttransplant period, implicating disordered mineral metabolism.

    2. You have free access to this content
      Viral Infection Induces De Novo Lesions of Coronary Allograft Vasculopathy Through a Natural Killer Cell-Dependent Pathway (pages 2479–2484)

      J. A. Graham, R. A. Wilkinson, T. Hirohashi, C. M. Chase, R. B. Colvin, J. C. Madsen, J. A. Fishman and P. S. Russell

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02801.x

      • image
      • image
      • image

      In mice lacking both T- and B-lymphocytes, accelerated cardiac allograft vasculopathy developed in the setting of lymphocytic choriomeningitis virus infection via an NK-cell dependent pathway.

    3. You have free access to this content
      Endoscopic Gastric Submucosal Transplantation of Islets (ENDO-STI): Technique and Initial Results in Diabetic Pigs (pages 2485–2496)

      G. J. Echeverri, K. McGrath, R. Bottino, H. Hara, E. M. Dons, D. J. Van Der Windt, B. Ekser, A. Casu, S. Houser, M. Ezzelarab, R. Wagner, M. Trucco, F. G. Lakkis and D. K. C. Cooper

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02815.x

      • image
      • imageimage
      • image
      • image
      • imageimageimage

      Allotransplantation of adult islets in pigs into the gastric submucosal space by endoscopy was followed by better engraftment and function than after transplantation into the portal vein

  5. Clinical Science

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. Original Articles

      You have free access to this content
      Immunosuppressant Therapy Adherence and Graft Failure Among Pediatric Renal Transplant Recipients (pages 2497–2504)

      M. A. Chisholm-Burns, C. A. Spivey, R. Rehfeld, M. Zawaideh, D. J. Roe and R. Gruessner

      Article first published online: 14 AUG 2009 | DOI: 10.1111/j.1600-6143.2009.02793.x

      • image
      • image

      This study of the United States Renal Data System and Medicare prescription claims data indicates that graft failure is associated with non-adherence, and adherent pediatric recipients experienced longer graft survival compared to non-adherent recipients

    2. You have free access to this content
      Pharmacokinetics for Once- Versus Twice-Daily Tacrolimus Formulations in De Novo Kidney Transplantation: A Randomized, Open-Label Trial (pages 2505–2513)

      Z. Wlodarczyk, J.-P. Squifflet, M. Ostrowski, P. Rigotti, S. Stefoni, F. Citterio, Y. Vanrenterghem, B. K. Krämer, D. Abramowicz, F. Oppenheimer, F. Pietruck, G. Russ, C. Karpf and N. Undre

      Article first published online: 14 AUG 2009 | DOI: 10.1111/j.1600-6143.2009.02794.x

      • image
      • image
      • image
      • image
      • image
      • image

      This prospective, randomized, PK study in de novo kidney transplant patients showed comparable systemic steady-state tacrolimus exposure, and a good correlation between trough tacrolimus levels and AUC, for once- and twice-daily tacrolimus formulations.

    3. You have free access to this content
      How Do Living Kidney Donors Develop End-Stage Renal Disease? (pages 2514–2519)

      R. Kido, Y. Shibagaki, K. Iwadoh, I. Nakajima, S. Fuchinoue, T. Fujita and S. Teraoka

      Article first published online: 14 AUG 2009 | DOI: 10.1111/j.1600-6143.2009.02795.x

      • image

      We observed that in living kidney donors who developed ESRD, renal functions were stable for a long time (about a decade or more) after heminephrectomy but suddenly started to decline following the development of co-morbidities known as progression or accelerating factors of CKD.

    4. You have free access to this content
      Antibody-Mediated Microcirculation Injury Is the Major Cause of Late Kidney Transplant Failure (pages 2520–2531)

      G. Einecke, B. Sis, J. Reeve, M. Mengel, P. M. Campbell, L. G. Hidalgo, B. Kaplan and P. F. Halloran

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02799.x

      • imageimageimageimage
      • imageimageimage
      • image

      In patients presenting with indications for kidney transplant biopsy, antibody mediated rejection accounts for the majority of progression to late graft loss, but in many cases the diagnosis is missed by current criteria.

    5. You have free access to this content
      De Novo Donor-Specific Antibody at the Time of Kidney Transplant Biopsy Associates with Microvascular Pathology and Late Graft Failure (pages 2532–2541)

      L. G. Hidalgo, P. M. Campbell, B. Sis, G. Einecke, M. Mengel, J. Chang, J. Sellares, J. Reeve and P. F. Halloran

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02800.x

      • image
      • image
      • image
      • image
      • image
      • image

      De novo DSA associates with lesions of microcirculation inflammation and damage, C4d in renal transplant biopsies for clinical indication, and with decreased subsequent graft survival.

    6. You have free access to this content
      Donor-Estimated GFR as an Appropriate Criterion for Allocation of ECD Kidneys into Single or Dual Kidney Transplantation (pages 2542–2551)

      R. Snanoudj, M. Rabant, M. O. Timsit, A. Karras, E. Savoye, L. Tricot, A. Loupy, C. Hiesse, J. Zuber, H. Kreis, F. Martinez, E. Thervet, A. Méjean, T. Lebret, C. Legendre and M. Delahousse

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02797.x

      • image
      • image
      • imageimageimage
      • image

      Allocation of ECD kidneys from donors aged over 65 years into single or dual kidney transplantation according to donor estimated GFR with a cut-off value of 60 mL/min results in similar and satisfactory outcome.

    7. You have free access to this content
      Interstitial Fibrosis Quantification in Renal Transplant Recipients Randomized to Continue Cyclosporine or Convert to Sirolimus (pages 2552–2560)

      A. Servais, V. Meas-Yedid, O. Toupance, Y. Lebranchu, A. Thierry, B. Moulin, I. Etienne, C. Presne, De Ligny B. Hurault, P. Le Pogamp, Y. Le Meur, D. Glotz, C. Hayem, J. C. Olivo Marin and E. Thervet

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02803.x

      • imageimageimage
      • image

      In this multicenter, randomized, prospective trial, kidney transplant patients converted from cyclosporine to sirolimus had improvemed renal function at one year, but biopsy results showed no between-group difference in interstitial fibrosis quantified automatically by a program of color segmentation.

    8. You have free access to this content
      Outcome of Subclinical Antibody-Mediated Rejection in Kidney Transplant Recipients with Preformed Donor-Specific Antibodies (pages 2561–2570)

      A. Loupy, C. Suberbielle-Boissel, G. S. Hill, C. Lefaucheur, D. Anglicheau, J. Zuber, F. Martinez, E. Thervet, A. Méjean, D. Charron, J. P. Duong van Huyen, P. Bruneval, C. Legendre and D. Nochy

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02813.x

      • image
      • image
      • image
      • image
      • imageimageimage

      In a cohort of kidney transplant recipients with preformed donor specific antibodies, this study of protocol biopsies documents the course of subclinical antibody mediated rejection and the emergence of a chronic antibody mediated rejection phenotype at 1 year.

    9. You have free access to this content
      Evolution of Coronary Artery Calcifications Following Kidney Transplantation: Relationship with Osteoprotegerin Levels (pages 2571–2579)

      A.-S. Bargnoux, A.-M. Dupuy, V. Garrigue, I. Jaussent, G. Gahide, S. Badiou, I. Szwarc, S. Deleuze, H. Vernhet, J.-P. Cristol and G. Mourad

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02814.x

      After kidney transplantation; baseline osteoprotegerin (OPG) levels were associated with baseline coronary artery calcification (CAC) but no significant association was observed between baseline or one-year OPG levels and CAC progression.

    10. You have free access to this content
      The Impact of Preexisting or Acquired Kaposi Sarcoma Herpesvirus Infection in Kidney Transplant Recipients on Morbidity and Survival (pages 2580–2586)

      C. Francès, A. G. Marcelin, Ch. Legendre, S. Chevret, E. Dussaix, J. Lejeune, S. Euvrard, A Bigorie, T. F. Schulz, F. Agbalika, C. Lebbé and the skin and organ transplantation group of the French Society of Dermatology

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02816.x

      • image
      • image

      In this prospective French national study, 3 years after transplantation, 13% of kidney recipients with KSHV infection acquired before transplantation developed Kaposi's sarcoma, and 4.7% of KSHV negative recipients who received a kidney from a positive donor had KSHV related clinical manifestations without difference in terms of survival and graft loss.

    11. You have free access to this content
      Strain-Encoded Cardiac Magnetic Resonance for the Evaluation of Chronic Allograft Vasculopathy in Transplant Recipients (pages 2587–2596)

      G. Korosoglou, N. F. Osman, T. J. Dengler, N. Riedle, H. Steen, S. Lehrke, E. Giannitsis and H. A. Katus

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02769.x

      • image
      • image
      • image
      • image
      • image
      • image

      The quantification of myocardial perfusion and diastolic strain rate are useful parameters for the assessment of cardiac allograft vasculopathy, and may prove to be effective for routine surveillance.

    12. You have free access to this content
      Transplant Outcomes and Economic Costs Associated with Patient Noncompliance to Immunosuppression (pages 2597–2606)

      B. W. Pinsky, S. K. Takemoto, K. L. Lentine, T. E. Burroughs, M. A. Schnitzler and P. R. Salvalaggio

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02798.x

      • image
      • image
      • image
      • image

      In this study of US Medicare claims, patient non-compliance with immunosuppresion medications not only increased the risk of graft failure and death, but was also associated with an average increase in health care costs of almost $13,000.

  6. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. You have free access to this content
      HLA Class I Antibodies Provoke Graft Arteriosclerosis in Human Arteries Transplanted into SCID/Beige Mice (pages 2607–2614)

      S. Galvani, N. Augé, D. Calise, J. C. Thiers, C. Canivet, N. Kamar, L. Rostaing, M. Abbal, F. Sallusto, R. Salvayre, T. Böhler, Y. Zou, P. Stastny, A. Nègre-Salvayre and M. Thomsen

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02804.x

      • image
      • image
      • image
      • image

      In original model of human mesenteric arteries grafted into immunodeficient mice, passive transfer of antibodies towards HLA class I provokes graft arteriosclerosis in the absence of cellular immunity.

    2. You have free access to this content
      Memory T-Cell Predominance Following T-Cell Depletional Therapy Derives from Homeostatic Expansion of Naive T Cells (pages 2615–2623)

      A. Sener, A. L. Tang and D. L. Farber

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02820.x

      • image
      • image
      • image
      • image
      • image
      • image
      • image

      In a mouse model thymoglobulin treatment results in depletion of naive as well as alloantigen-specific memory T cells and the post-depletional T cell compartment is repopulated to a significant extent by homeostatic expansion of naive T cells which convert to memory phenotypes.

    3. You have free access to this content
      Regulatory Allospecific NK Cell Function Is Differentially Associated with HLA C Allotypes (pages 2624–2630)

      G. Zenhaeusern, O. Gasser, G. Hönger, B. Durovic, M. Stern and C. Hess

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02808.x

      • image
      • image
      • image
      • image

      A distinct subset of human NK cells that are activated – rather than inhibited – upon cell-cell interaction and secrete anti-inflammatory cytokines are identified.

    4. You have free access to this content
      Recurrence-Free Long-Term Survival After Liver Transplantation in Patients with 18F-FDG Non-Avid Hilar Cholangiocarcinoma on PET (pages 2631–2636)

      A. Kornberg, B. Küpper, K. Thrum, J. Wilberg, A. Sappler and D. Gottschild

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02821.x

      • image
      • image

      Patients with 18F-FDG non-avid hilar cholangiocarcinoma on PET may achieve recurrence-free long-term survival after liver transplantation, while liver transplant candididates with 18F-FDG avid hilar cholangiocarcinoma have a very high risk of posttransplant tumor recurrence.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. You have free access to this content
      Strongyloides Stercoralis Hyperinfection Transmitted by Liver Allograft in a Transplant Recipient (pages 2637–2640)

      M. J. Rodriguez-Hernandez, M. Ruiz-Perez-Pipaon, E. Cañas, C. Bernal and F. Gavilan

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02828.x

      A 67 year-old man with fever and vomiting two months post-liver transplantation was biopsied and showed massive infiltration by strongyloides stercoralis larvae and adult worms.

    2. You have free access to this content
      Reduced Size Liver Transplantation from a Donor Supported by a Berlin Heart (pages 2641–2643)

      M. V. Misra, C. J. Smithers, L. E. Krawczuk, R. L. Jenkins, B. C. Linden, C. B. Weldon and H. B. Kim

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02818.x

      • image

      A successful case of a reduced-size liver transplant performed using the left lateral segment of a pediatric donor whose cardiac function was supported by a Berlin Heart.

  8. Letter to the Editor

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. You have free access to this content
      Safety and Long-Term Efficacy of Eculizumab in a Renal Transplant Patient with Recurrent Atypical Hemolytic–Uremic Syndrome (pages 2644–2645)

      V. Chatelet, V. Frémeaux-Bacchi, T. Lobbedez, M. Ficheux and B. Hurault de Ligny

      Article first published online: 22 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02817.x

      • image
  9. Erratum

    1. Top of page
    2. The AJT Report
    3. Minireviews
    4. Special Article
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communications
    8. Case Reports
    9. Letter to the Editor
    10. Erratum
    1. You have free access to this content
      Erratum (page 2646)

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02833.x

      This article corrects:

      Effect of Comorbidity Adjustment on CMS Criteria for Kidney Transplant Center Performance

      Vol. 9, Issue 3, 506–516, Article first published online: 3 FEB 2009

    2. You have free access to this content
      Erratum (page 2647)

      Article first published online: 15 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02865.x

      This article corrects:
      This article corrects:

      Erratum

      Vol. 9, Issue 9, 2205, Article first published online: 20 AUG 2009

SEARCH

SEARCH BY CITATION