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American Journal of Transplantation

Cover image for Vol. 9 Issue 12

December 2009

Volume 9, Issue 12

Pages 2649–2858

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 2649–2650)

      SUE PONDROM

      Version of Record online: 23 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02947.x

      This month, “The AJT Report” takes a look at ways to improve quality of life for pediatric transplant patients, and also reviews China's new organ donation policy.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
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      Breaking Down Donor-Reactive T-Cell Activation to Two Steps (pages 2651–2652)

      E. D. Poggio and R. L. Fairchild

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02842.x

      In mouse cardiac allograft recipients, donor-reactive CD8 T cells proliferate without development to efffector function in the absence of CD154 costimulation. See article by Shah et al on page 2697.

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      Detailed Outcomes Analyses Are Essential for Optimizing Kidney Utilization Strategies (pages 2653–2654)

      R. P. Pelletier

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02841.x

      The optimal surgical approach for transplanting pediatric donor kidneys must pit the need to obtain the greatest number of recipients against that of obtaining the best possible outcomes. See article by Kayler et al on page 2745.

  3. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
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      The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity (pages 2655–2661)

      M. D. Säemann, M. Haidinger, M. Hecking, W. H. Hörl and T. Weichhart

      Version of Record online: 25 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02832.x

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      Recent findings on the role of mTOR in the immune system indicate that rapamycin, in contrast to its immunosuppressive properties in helper T cells, has the potential to foster inflammation via activating innate immune cells.

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      Race and Ethnicity in Access to and Outcomes of Liver Transplantation: A Critical Literature Review (pages 2662–2668)

      A. K. Mathur, C. J. Sonnenday and R. M. Merion

      Version of Record online: 23 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02857.x

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      Racial and ethnic disparities in access to and outcomes from liver transplantation should be studied by more robust data collection, providing a better understanding of the nature of these disparities from the time of diagnosis with liver disease to registration on a transplant waiting list, and eventually to post-transplant outcomes.

  4. Laboratory Science

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
    1. Original Articles

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      Results of Gal-Knockout Porcine Thymokidney Xenografts (pages 2669–2678)

      A. D. Griesemer, A. Hirakata, A. Shimizu, S. Moran, A. Tena, H. Iwaki, Y. Ishikawa, P. Schule, J. S. Arn, S. C. Robson, J. A. Fishman, M. Sykes, D. H. Sachs and K. Yamada

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02849.x

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      There was greater than 50 days average survival of life-supporting xenogeneic renal grafts in baboons using a modified immunosuppressive regimen designed to facilitate the induction of tolerance to GalT-KO thymokidneys.

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      TNF Receptors Differentially Signal and Are Differentially Expressed and Regulated in the Human Heart (pages 2679–2696)

      R. S. Al-Lamki, A. P. Brookes, J. Wang, M. J. Reid, J. Parameshwar, M. J. Goddard, G. Tellides, T. Wan, W. Min, J. S. Pober and J. R. Bradley

      Version of Record online: 25 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02831.x

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      TNF receptors 1 and 2 are differentially expressed on various cardiac cell types (myocytes, endothelial cells, fibroblasts), and are differentially altered by allograft rejection, showing decreased TNFR1 and increased TNFR2 expression.

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      CD154 Deficiency Uncouples Allograft CD8+ T-Cell Effector Function from Proliferation and Inhibits Murine Airway Obliteration (pages 2697–2706)

      P. D. Shah, E. E. West, A. B. Whitlock, J. B. Orens and J. F. McDyer

      Version of Record online: 23 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02805.x

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      CD8+ T cells from CD154-deficient mice had significantly impaired effector cytokine responses uncoupled from proliferation that was associated with diminished airway obliteration compared to controls. See editorial by Poggio and Fairchild on page 2651.

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      Nitric Oxide Ventilation of Rat Lungs from Non-Heart-Beating Donors Improves Posttransplant Function (pages 2707–2715)

      B. M. Dong, J. B. Abano and T. M. Egan

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02840.x

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      Ventilation of lungs with nitric oxide in non-heart-beating donors, in the ex-vivo circuit, and after lung transplant, resulted in improved lung function and gas exchange, with reduced up-regulation of TNF-α, but had no effect on activation of NF-κB or MAPK signaling pathways.

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      Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets (pages 2716–2726)

      D. J. Van Der Windt, R. Bottino, A. Casu, N. Campanile, C. Smetanka, J. He, N. Murase, H. Hara, S. Ball, B. E Loveland, D. Ayares, F. G. Lakkis, D. K. C. Cooper and M. Trucco

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02850.x

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      This study demonstrated survival and functional performance of pig islets expressing hCD46 following transplantation in diabetic non-human primates for three months in four of five recipients.

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      Disengaging the IL-2 Receptor with Daclizumab Enhances IL-7–Mediated Proliferation of CD4+ and CD8+ T Cells (pages 2727–2735)

      P. Monti, C. Brigatti, A. K. Heninger, M. Scirpoli and E. Bonifacio

      Version of Record online: 25 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02825.x

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      The anti CD25 monoclonal antibody Daclizumab increases the T cell response to the homeostatic cytokine IL-7.

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      Regulatory T-Cell Counter-Regulation by Innate Immunity Is a Barrier to Transplantation Tolerance (pages 2736–2744)

      J. I. Kim, M. K. Lee IV, D. J. Moore, S. B. Sonawane, P. E. Duff, M. R. O’Connor, H. Yeh, M. M. Lian, S. Deng, A. J. Caton and J. F. Markmann

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02847.x

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      Injury and inflammation resulting from the transplant procedure inactivate T-reg-mediated graft prolongation, in part, by downregulating Foxp3 levels in T-regs.

  5. Clinical Science

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
    1. Original Articles

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      Single Kidney Transplantation from Young Pediatric Donors in the United States (pages 2745–2751)

      L. K. Kayler, J. Magliocca, R. D. Kim, R. Howard and J. D. Schold

      Version of Record online: 23 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02809.x

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      Evaluation of deceased-donor kidney transplant graft survival from SRTR data revealed that single kidneys from pediatric donors >35 kg are similar to ideal standard criteria donors (SCDs), and single kidneys from pediatric donors 10–35 kg are similar to non-ideal SCDs. See editorial by Pelletier on page 2653.

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      Influence of Cyclooxygenase-2 (COX-2) Gene Promoter Polymorphism −765 on Graft Loss After Renal Transplantation (pages 2752–2757)

      C. Courivaud, J. Bamoulid, A. Loupy, M. Deschamps, C. Ferrand, D. Le Corre, P. Tiberghien, J.-M. Chalopin, C. Legendre, E. Thervet, P. Saas and D. Ducloux

      Version of Record online: 25 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02830.x

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      COX-2 gene promoter polymorphism at position -765 (G to C) is associated with a higher rate of graft loss in renal transplant recipients.

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      The Impact of C4d Pattern and Donor-Specific Antibody on Graft Survival in Recipients Requiring Indication Renal Allograft Biopsy (pages 2758–2767)

      A. Haririan, B. Kiangkitiwan, D. Kukuruga, M. Cooper, H. Hurley, C. Drachenberg and D. Klassen

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02836.x

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      In 297 kidney recipients with indication biopsies, focal C4d had similar impact on graft survival as diffuse pattern, and in patients biopsied in the first year, DSA was predictive of worse outcome regardless of C4d.

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      The Success of Continued Steroid Avoidance After Kidney Transplantation in the US (pages 2768–2776)

      J. D. Schold, A. Santos, S. Rehman, J. Magliocca and H.-U. Meier-Kriesche

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02838.x

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      Even though rapid steroid withdrawal strategies are becoming more popular after kidney transplantation, a significant number of patients do not succeed in staying off steroids.

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      Impaired Insulin Sensitivity as an Underlying Mechanism Linking Hepatitis C and Posttransplant Diabetes Mellitus in Kidney Recipients (pages 2777–2784)

      S. Baid-Agrawal, U. Frei, P. Reinke, R. Schindler, M. A. Kopp, P. Martus, T. Berg, J. S. Juergensen, S. D. Anker and W. Doehner

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02843.x

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      Analysis of glucose metabolism in kidney transplant recipients in this cross-sectional study identifies impaired peripheral insulin sensitivity as the most likely pathogenic mechanism involved in the development of post transplant diabetes mellitus associated with hepatitis C infection.

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      Impact of Medicare Coverage on Disparities in Access to Simultaneous Pancreas and Kidney Transplantation (pages 2785–2791)

      J. K. Melancon, L. M. Kucirka, L. E. Boulware, N. R. Powe, J. E. Locke, R. A. Montgomery and D. L. Segev

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02845.x

      In this study of UNOS waiting list data, a change in Medicare coverage for simultaneous pancreas and kidney transplantation was associated with improved access to this procedure for Medicare patients, but did not impact the significant racial disparities that motivated this coverage change.

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      Predictors of Having a Potential Live Donor: A Prospective Cohort Study of Kidney Transplant Candidates (pages 2792–2799)

      P. P. Reese, J. A. Shea, R. D. Bloom, J. S. Berns, R. Grossman, M. Joffe, A. Huverserian and H. I. Feldman

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02848.x

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      This prospective cohort study of kidney transplant candidates at a single center revealed that low income and older age were associated with a lower odds of attracting a potential live donor, while knowledge about transplantation, gender and race were not associated with the outcome.

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      Recurrent Idiopathic Membranous Nephropathy: Early Diagnosis by Protocol Biopsies and Treatment with Anti-CD20 Monoclonal Antibodies (pages 2800–2807)

      Ziad M. El-Zoghby, Joseph P. Grande, M. G Fraile, S. M. Norby, F. C. Fervenza and F. G. Cosio

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02851.x

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      Treatment with anti-CD20 antibodies was associated with resolution of histologic manifestations of the disease and favorable clinical outcomes in six of eight cases by 12 months post treatment.

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      Racial and Ethnic Differences in Mortality in Children Awaiting Heart Transplant in the United States (pages 2808–2815)

      T. P. Singh, K. Gauvreau, R. Thiagarajan, E. D. Blume, G. Piercey and C. S. Almond

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02852.x

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      In the US during 1999–2006, minority children had a significantly higher wait-list mortality compared to white children after adjusting for clinical risk factors.

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      Positron Emission Tomography in Clinical Islet Transplantation (pages 2816–2824)

      O. Eriksson, T. Eich, A. Sundin, A. Tibell, G. Tufveson, H. Andersson, M. Felldin, A. Foss, L. Kyllönen, B. Langstrom, B. Nilsson, O. Korsgren and T. Lundgren

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02844.x

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      PET imaging of the peritransplant period of clinical intraportal islet transplantation showed both a heterogenous distribution of islets in the liver and an immediate loss of islets at transplantation.

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      Reimbursing Live Organ Donors for Incurred Non-Medical Expenses: A Global Perspective on Policies and Programs (pages 2825–2836)

      M. Sickand, M. S. Cuerden, S. W. Klarenbach, A. O. Ojo, C. R. Parikh, N. Boudville, A. X. Garg and for the Donor Nephrectomy Outcomes Research Network

      Version of Record online: 25 SEP 2009 | DOI: 10.1111/j.1600-6143.2009.02829.x

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      Legislation and programs to facilitate living organ donor reimbursement were examined in 40 countries that practice living organ donation: reimbursement is expressly legal in 16 countries, reimbursement programs exist in 21 countries, and these programs differ in operation and scope.

  6. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
    1. You have free access to this content
      Paradoxical Functions of B7: CD28 Costimulation in a MHC Class II-Mismatched Cardiac Transplant Model (pages 2837–2844)

      J. Yang, L.V. Riella, O. Boenisch, J. Popoola, S. Robles, T. Watanabe, V. Vanguri, X. Yuan, I. Guleria, L. A. Turka, M. H. Sayegh and A. Chandraker

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02839.x

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      B7:CD28 deficiency paradoxically accelerates allograft rejection in a MHC class II-mismatched model by interfering with Treg generation.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
    1. You have free access to this content
      Periostitis Secondary to Prolonged Voriconazole Therapy in Lung Transplant Recipients (pages 2845–2850)

      T. F. Wang, T. Wang, R. Altman, P. Eshaghian, J. P. Lynch III, D. J. Ross, J. A. Belperio, S. S. Weigt, R. Saggar, A. Gregson, B. Kubak and R. Saggar

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02837.x

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      This case series outlines a novel syndrome of bone pain, elevated serum alkaline phosphatase, and abnormal bone scan, suggesting periostitis related to prolonged voriconazole therapy in lung transplant recipients.

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      Apparent Remission of a Solitary Metastatic Pulmonary Lesion in a Liver Transplant Recipient Treated with Sorafenib (pages 2851–2854)

      M. Yeganeh, R. S. Finn and S. Saab

      Version of Record online: 23 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02860.x

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      Sorafenib may be effective against recurrent hepatocellular carcinoma in a liver transplant recipient.

  8. Book Review

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
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      ‘When Altruism Isn't Enough: The Case for Compensating Kidney Donors’ (page 2855)

      D. W. Hanto

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02846.x

      An expert group of physicians, lawyers, ethicists, and economists argue for a government regulated system of compensation for living donors in a series of eight articles in this book.

  9. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Book Review
    10. Letters to the Editor
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      Mycophenolate Mofetil Versus Azathioprine in Organ Transplantation (pages 2856–2857)

      P. Cravedi, A. Perna, P. Ruggenenti and G. Remuzzi

      Version of Record online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02853.x

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