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American Journal of Transplantation

Cover image for Vol. 9 Issue 4

April 2009

Volume 9, Issue 4

Pages 653–865

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
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      News and issues that affect organ and tissue transplantation (pages 653–654)

      SUE PONDROM

      Article first published online: 26 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02630_1.x

      This month, The AJT Report takes a look at developments in islet cell transplantation, and examines the disappointing results of the HALT-C trial.

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      HALT-C Is Huge Disappointment (page 654)

      Article first published online: 26 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02630_2.x

      This month, The AJT Report takes a look at developments in islet cell transplantation, and examines the disappointing results of the HALT-C trial.

  2. Editorial

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
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      Direct versus Indirect Allorecognition Pathways: On the Right Track (pages 655–656)

      G. Benichou and A. W. Thomson

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02572.x

      Optimal control of the T cell response may rely primarily on therapeutic control of the indirect allorecognition pathway. See article by Kang et al on page 709.

  3. Personal View Points

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
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      Primum Non Nocere: Is Chronic Kidney Disease Staging Appropriate in Living Kidney Transplant Donors? (pages 657–660)

      Y. Barri, T. Parker III, B Kaplan and R. Glassock

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02562.x

      A study of measured and estimated glomerular filtration rate in renal transplant living donors before and 3 months after uni-nephrectomy labeled many of them as having “Stage 3 Chronic Kidney Disease” post-donation, particularly in older donors, a label that could have adverse implications in these healthy people.

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      Maternal and Fetal Outcomes After Living Kidney Donation (pages 661–668)

      I. F. Nevis, A. X. Garg and for the Donor Nephrectomy Outcomes Research (DONOR) Network

      Article first published online: 26 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02623.x

      The information from two new studies is put into the context of past literature to guide what women should now be told about the effects of living kidney donation on future pregnancy. See article by Reisæter et al on page 820 & article by Ibrahim et al on page 825.

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      Framing Disparities Along the Continuum of Care from Chronic Kidney Disease to Transplantation: Barriers and Interventions (pages 669–674)

      K. Ladin, J. R. Rodrigue and D. W. Hanto

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02561.x

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      This paper explores the case of racial disparities, illustrating key factors predicting and perpetuating disparities and presenting opportunities for intervention.

  4. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
    1. Laboratory Science

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      Upregulation of TNF Receptor Type 2 in Human and Experimental Renal Allograft Rejection (pages 675–686)

      U. Hoffmann, T. Bergler, M. Rihm, C. Pace, B. Krüger, P. Rümmele, B. Stoelcker, B. Banas, D. N. Männel and B. K. Krämer

      Article first published online: 3 MAR 2009 | DOI: 10.1111/j.1600-6143.2008.02536.x

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      This study of TNFR2 in renal allograft biopsies and in an experimental transplantation model in rats demonstrated an increase in TNFR2 during allograft rejection and an association with renal function.

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      Blockade of KATP Channels Reduces Endothelial Hyperpolarization and Leukocyte Recruitment upon Reperfusion After Hypoxia (pages 687–696)

      M. Figura, L. Chilton, A. Liacini, M. Maric Viskovic, V. Phan, D. Knight, T. M. Millar, K. Patel, P. Kubes, W. R. Giles and L. A. Tibbles

      Article first published online: 9 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02553.x

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      Hypoxia induces a profound hyperpolarization of endothelial cells via KATP channels that triggers SAPK/JNK activation and leukocyte recruitment in vitro and in vivo.

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      Indirect CD4+ TH1 Response, Antidonor Antibodies and Diffuse C4d Graft Deposits in Long-Term Recipients Conditioned by Donor Antigens Priming (pages 697–708)

      C. Ballet, K. Renaudin, N. Degauque, H. L. Mai, F. Boëffard, D. Lair, L. Berthelot, C. Feng, H. Smit, C. Usal, M. Heslan, R. Josien, S. Brouard and J.-P. Soulillou

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02556.x

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      In a model of MHC mismatched allotransplantation, the cellular and humoral responses recapitulate the characteristics linked to active chronic antibody-mediated rejection.

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      Preferential Priming of Alloreactive T Cells with Indirect Reactivity (pages 709–718)

      T. V. Brennan, A. Jaigirdar, V. Hoang, T. Hayden, F.-C. Liu, H. Zaid, C. K. Chang, R. P. Bucy, Q. Tang and S.-M. Kang

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02578.x

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      The indirect pathway is disproportionately activated relative to the direct pathway of T cell allorecognition, allowing the less frequent indirect pathway to play a major role in acute rejection. See editorial by Benichou and Thomson page 655.

    5. Clinical Science

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      Lung Transplantation in Infants and Toddlers from 1990 to 2004 at St. Louis Children's Hospital (pages 719–726)

      A. Elizur, A. Faro, C. B. Huddleston, S. K. Gandhi, D. White, C. A. Kuklinski and S. C. Sweet

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02552.x

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      This article compares the outcomes of infants and toddlers undergoing lung transplantation to outcomes in older children transplanted for similar pathophysiologies.

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      Posttransplant Bronchiolitis Obliterans Syndrome Is Associated with Bronchial Epithelial to Mesenchymal Transition (pages 727–733)

      S. Hodge, M. Holmes, B Banerjee, M. Musk, A. Kicic, G. Waterer, P. N. Reynolds, G. Hodge and D. C. Chambers

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02558.x

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      Expression of EMT markers of 9SMA, S100A4, and ED-A was increased in airway cells from patients with BOS.

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      Exercise Training Improves Aerobic Capacity and Skeletal Muscle Function in Heart Transplant Recipients (pages 734–739)

      M. Haykowsky, D. Taylor, D. Kim and W. Tymchak

      Article first published online: 26 MAR 2009 | DOI: 10.1111/j.1600-6143.2008.02531.x

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      Twelve weeks of exercise training was effective in improving VO2peak, lean tissue mass and muscle strength in heart transplant recipients.

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      Immediate Retransplantation for Pancreas Allograft Thrombosis (pages 740–745)

      E. F. Hollinger, J. A. Powelson, R. S. Mangus, M. M. Kazimi, T. E. Taber, M. L. Goble and J. A. Fridell

      Article first published online: 3 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02517.x

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      Immediate retransplantation following pancreatic graft thrombosis restores durable allograft function with outcomes comparable to first-time pancreas transplantation.

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      Early Hepatic Artery Thrombosis after Liver Transplantation: A Systematic Review of the Incidence, Outcome and Risk Factors (pages 746–757)

      J. Bekker, S. Ploem and K. P. De Jong

      Article first published online: 3 MAR 2009 | DOI: 10.1111/j.1600-6143.2008.02541.x

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      The incidence of early hepatic artery thrombosis after liver transplantation is rather low while the clinical consequences are devastating in terms of graft loss and patient mortality.

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      Unique Early Gene Expression Patterns in Human Adult-to-Adult Living Donor Liver Grafts Compared to Deceased Donor Grafts (pages 758–772)

      J. De Jonge, S. Kurian, A. Shaked, K. R. Reddy, W. Hancock, D. R. Salomon and K. M. Olthoff

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02557.x

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      There are significant differences between living donor and deceased donor liver grafts in immediate early gene expression patterns, with distinct immune/inflammatory profiles and downregulation of metabolic pathways in living donor grafts.

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      Liver Transplantation Using Donation After Cardiac Death Donors: Long-Term Follow-Up from a Single Center (pages 773–781)

      M. E. De Vera, R. Lopez-Solis, I. Dvorchik, S. Campos, W. Morris, A. J. Demetris, P. Fontes and J. W. Marsh

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02560.x

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      Patients with MELD > 30 or on mechanical ventilation/hemodialysis may have a greater benefit from DCD liver transplants than non-critically ill patients.

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      Outcome After Liver Transplantation for NASH Cirrhosis (pages 782–793)

      S. M. Malik, M. E. DeVera, P. Fontes, O. Shaikh and J. Ahmad

      Article first published online: 26 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02590.x

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      Liver transplantation for NASH cirrhosis has acceptable outcomes although patients with NASH cirrhosis and the combination of older age, higher BMI, diabetes and hypertension have a poor outcome.

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      Treatment-dependent Loss of Polyfunctional CD8+ T-cell Responses in HIV-infected Kidney Transplant Recipients Is Associated with Herpesvirus Reactivation (pages 794–803)

      O. Gasser, F. Bihl, S. Sanghavi, C. Rinaldo, D. Rowe, C. Hess, D. Stablein, M. Roland, P. Stock and C. Brander

      Article first published online: 3 MAR 2009 | DOI: 10.1111/j.1600-6143.2008.02539.x

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      This study of 27 HIV-infected kidney transplant recipients revealed depletion of polyfunctional virus-specific CTL after thymoglobulin treatment.

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      Impact of Immunosuppressive Medication on the Risk of Renal Allograft Failure due to Recurrent Glomerulonephritis (pages 804–811)

      A. V. Mulay, C. Van Walraven and G. A. Knoll

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02554.x

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      USRDS data showed that none of the commonly prescribed immunosuppressive medications had any effect on preventing renal allograft failure due to recurrent glomerulonephritis.

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      Focal C4d+ in Renal Allografts Is Associated with the Presence of Donor-Specific Antibodies and Decreased Allograft Survival (pages 812–819)

      R. L. Kedainis, M. J. Koch, D. C. Brennan and H. Liapis

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02555.x

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      Both focal and diffuse C4d+ was correlated with the presence of DSA.

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      Pregnancy and Birth After Kidney Donation: The Norwegian Experience (pages 820–824)

      A. V. Reisæter, J. Røislien, T. Henriksen, L. M. Irgens and A. Hartmann

      Article first published online: 6 OCT 2008 | DOI: 10.1111/j.1600-6143.2008.02427.x

      This registry study from 1967 through 2002 reporting on 106 pregnancies after kidney donation shows that pregnancy generally is safe in these women, slightly increased preeclampsia in the secondary analysis must be interpreted with caution due to a low number of cases and events. See article by Ibrahim et al on page 825 & viewpoint by Nevis and Garg on page 661

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      Pregnancy Outcomes After Kidney Donation (pages 825–834)

      H. N. Ibrahim, S. K. Akkina, E. Leister, K. Gillingham, G. Cordner, H. Guo, R. Bailey, T. Rogers and A. J. Matas

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02548.x

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      The prevalence of gestational hypertension and preeclampsia was similar between women who had donated a kidney and the general population, but increased in these women relative to their pre-donation pregnancies. See article by Reisæter et al on page 820 & viewpoint by Nevis and Garg on page 661.

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      Incidence Rate and Outcome of Gram-Negative Bloodstream Infection in Solid Organ Transplant Recipients (pages 835–843)

      M. N. Al-Hasan, R. R. Razonable, J. E. Eckel-Passow and L. M. Baddour

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02559.x

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      The incidence of Gram-Negative bacteremia following solid organ transplantation is almost twenty-fold greater than is seen in the general population, potentially necessitating a reevaluation of the optimal empiric treatment regimen.

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      Outcomes of Simultaneous Heart–Kidney Transplant in the US: A Retrospective Analysis Using OPTN/UNOS Data (pages 844–852)

      J. Gill, T. Shah, I. Hristea, D. Chavalitdhamrong, B. Anastasi, S. K. Takemoto and S. Bunnapradist

      Article first published online: 26 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02588.x

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      Simultaneous heart kidney transplant was associated with superior patient survival compared to heart transplant only, but with similar overall renal allograft survival and superior functional renal graft survival compared deceased donor kidney only transplant.

  5. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
    1. Clinical Science

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      Bridge to Thoracic Organ Transplantation in Patients with Pulmonary Arterial Hypertension Using a Pumpless Lung Assist Device (pages 853–857)

      M. Strueber, M. M. Hoeper, S. Fischer, M. Cypel, G. Warnecke, J. Gottlieb, A. Pierre, T. Welte, A. Haverich, A. R. Simon and S. Keshavjee

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02549.x

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      Four patients with right heart failure due to pulmonary arterial hypertension were bridged to thoracic organ transplantation using a pumpless lung assist device.

  6. Case Report

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
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      Successful Anti-TNFα Treatment in a Child with Posttransplant Recurrent Focal Segmental Glomerulosclerosis (pages 858–861)

      S. Leroy, V. Guigonis, D. Bruckner, V. Emal-Aglae, G. Deschênes, A. Bensman and T. Ulinski

      Article first published online: 6 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02550.x

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      A child with a post-transplantation recurrence of FSGS was successfully treated by anti-TNFα agents despite a constant high activity of disease as demonstrated by relapse after discontinuation of anti-TNFα agents.

  7. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
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      Prognosis of Pretransplant Melanoma (page 862)

      O. R. Colegio, C. M. Proby, J. S. Bordeaux, J. M. McGregor and for the Melanoma Working Group of the International Transplant Skin Cancer Collaborative (ITSCC) & Skin Care in Organ Transplant Patients, Europe (SCOPE)

      Article first published online: 26 MAR 2009 | DOI: 10.1111/j.1600-6143.2008.02510.x

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  8. Errata

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Personal View Points
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Errata
    1. You have free access to this content
      Erratum (page 865)

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02584.x

      This article corrects:

      Chronic Kidney Disease After Hematopoietic Cell Transplantation: A Systematic Review

      Vol. 8, Issue 11, 2378–2390, Article first published online: 25 SEP 2008

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