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American Journal of Transplantation

Cover image for Vol. 9 Issue 5

May 2009

Volume 9, Issue 5

Pages 983–1255

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 983–984)

      SUE PONDROM

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02669.x

      This month, The AJT Report investigates the risks associated with using donation after cardiac death livers and explores whether the benefits outweigh the drawbacks. Also this month, we look at two novel methods for donor kidney removal.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
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      The Cost and Quality Paradox (pages 985–986)

      D. A. Axelrod, K. L. Lentine, P. R. Salvalaggio and M. A. Schnitzler

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02600.x

      Examination of the relationship between cost and quality of transplant care reveals a complex interaction of patient, donor, and process factors. See article by Englesbe et al on page 1108.

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      Clinical Utility of Measuring T-Cell Immunity to CMV in Transplant Recipients (pages 987–988)

      L. Danziger-Isakov and P. S. Heeger

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02599.x

      A testing strategy capable of detecting anti-CMV T cell immunity posttransplantation could be used to guide decisions about the need for continuing anti-viral prophylaxis. See article by Kumar et al on page 1214.

  3. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
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      Signal Transduction Pathways Involved in Brain Death-Induced Renal Injury (pages 989–997)

      H. R. Bouma, R. J. Ploeg and T. A. Schuurs

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02587.x

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      MAP-kinases could provide very promising drug targets as key players in mediating the inflammatory response seen after brain death.

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      Mechanisms of Alloantibody Production in Sensitized Renal Allograft Recipients (pages 998–1005)

      M. D. Stegall, P. G. Dean and J Gloor

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02612.x

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      This overview of antibody production mechanisms in sensitized transplant patients includes the role of long-lived plasma cells and the possible role of memory B cells.

  4. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. Laboratory Science

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      Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation (pages 1006–1016)

      C. Knosalla, K. Yazawa, A. Behdad, N. Bodyak, H. Shang, L. Bühler, S. Houser, B. Gollackner, A. Griesemer, I. Schmitt-Knosalla, H.-J. Schuurman, M. Awwad, D. H. Sachs, D. K. C. Cooper, K. Yamada, A. Usheva and S. C. Robson

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02602.x

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      Microarray-based gene expression profiling detects renal and cardiac endothelial heterogeneity in pig-to-baboon xenotransplantation.

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      Allergic Airway Hyperreactivity Increases the Risk for Corneal Allograft Rejection (pages 1017–1026)

      J. Y. Niederkorn, P. W. Chen, J. Mellon, C. Stevens and E. Mayhew

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02603.x

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      Allergic asthma in mice is associated with an increased incidence and tempo of corneal allograft rejection.

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      MMP-Dependent Migration of Extrapulmonary Myofibroblast Progenitors Contributing to Posttransplant Airway Fibrosis in the Lung (pages 1027–1036)

      M. Sato, S. Hirayama, H. Lara-Guerra, M. Anraku, T. K. Waddell, M. Liu and S. Keshavjee

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02605.x

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      MMP-dependent migration of extrapulmonary myofibroblast progenitors is an important contributing mechanism in the development of allograft airway fibrosis in the lung.

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      Immunomodulatory Effects of Mixed Hematopoietic Chimerism: Immune Tolerance in Canine Model of Lung Transplantation (pages 1037–1047)

      R. A. Nash, M. Yunosov, K. Abrams, B. Hwang, C. Castilla-Llorente, P. Chen, A. S. Farivar, G. E. Georges, R. C. Hackman, W. J. E. Lamm, M. Lesnikova, H. D. Ochs, J. Randolph-Habecker, S. F. Ziegler, R. Storb, B. Storer, D. K. Madtes, R. Glenny and M. S. Mulligan

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02619.x

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      In a canine model, establishing mixed hematopoietic chimerism prevented clinical rejection of lung grafts and activation of both effector and regulatory immune responses.

    5. Clinical Science

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      Histidine-Tryptophan-Ketoglutarate (HTK) Is Associated with Reduced Graft Survival of Deceased Donor Kidney Transplants (pages 1048–1054)

      Z. A. Stewart, B. E. Lonze, D. S. Warren, N. N. Dagher, A. L. Singer, R. A. Montgomery and D. L. Segev

      Article first published online: 3 MAR 2009 | DOI: 10.1111/j.1600-6143.2008.02545.x

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      Compared to UW, HTK preservation was associated with a 20% increase in graft loss and a 43% increase in graft loss for allografts surviving beyond 12 months. See article by Stevens et al on page 1055.

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      Increased Primary Non-Function in Transplanted Deceased-Donor Kidneys Flushed with Histidine-Tryptophan-Ketoglutarate Solution (pages 1055–1062)

      R. B. Stevens, J. Y. Skorupa, T. H. Rigley, G. R. Yannam, K. J. Nielsen, M. E. Schriner, A. J. Skorupa, A. Murante, E. Holdaway and L. E. Wrenshall

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02624.x

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      Deceased-donor kidneys appear to be at an increased risk of primary non-function after preservation with histidine-tryptophan-ketoglutarate solution. See article by Stewart et al on page 1048.

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      Reducing De Novo Donor-Specific Antibody Levels during Acute Rejection Diminishes Renal Allograft Loss (pages 1063–1071)

      M. J. Everly, J. J. Everly, L. J. Arend, P. Brailey, B. Susskind, A. Govil, A. Rike, P. Roy-Chaudhury, G. Mogilishetty, R. R. Alloway, A. Tevar and E. S. Woodle

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02577.x

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      De novo DSA detected at rejection is associated with reduced allograft survival, but prompt DSA reduction is associated with improved allograft survival.

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      Changes of Circulating Antibody Levels Induced by ABO Antibody Adsorption for ABO-Incompatible Kidney Transplantation (pages 1072–1080)

      P. V. Valli, G. Puga Yung, T. Fehr, C. Schulz-Huotari, N. Kaup, T. Güngör, P. Ambühl, M. Weber, U. Schanz, J. D. Seebach and G. Stussi

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02579.x

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      ABO immunoadsorption columns in ABO incompatible kidney transplantation are not antigen-specific, but remove additional antibodies against carbohydrate antigens.

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      Intensive and Prolonged Treatment of Focal and Segmental Glomerulosclerosis Recurrence in Adult Kidney Transplant Recipients: A Pilot Study (pages 1081–1086)

      G. Canaud, J. Zuber, R. Sberro, V. Royale, D. Anglicheau, R. Snanoudj, K. Gaha, E. Thervet, F. Lefrère, M. Cavazzana-Calvo, L.-H. Noël, A. Méjean, Ch. Legendre and F. Martinez

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02580.x

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      An open-label, nonrandomized pilot trial showed that 90% of patients achieved complete and sustained proteinuria remission with a program of steroids, intravenous cyclosporine, and intensive plasmapherisis.

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      Early and Limited Use of Tacrolimus to Avoid Rejection in an Alemtuzumab and Sirolimus Regimen for Kidney Transplantation: Clinical Results and Immune Monitoring (pages 1087–1098)

      S. J. Knechtle, J. Pascual, D D. Bloom, J. R. Torrealba, E. Jankowska-Gan, W. J. Burlingham, J. Kwun, R. B. Colvin, V. Seyfert-Margolis, K. Bourcier and H. W. Sollinger

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02581.x

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      Depletional therapy with alemtuzumab in combination with limited tacrolimus and long-term sirolimus was associated with good renal allograft survival and sirolimus monotherapy in 4 of 10 patients, but half the patients had alloantibody or C4d posisitve biopsies at one year.

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      Comparison of Combination Plasmapheresis/IVIg/Anti-CD20 Versus High-Dose IVIg in the Treatment of Antibody-Mediated Rejection (pages 1099–1107)

      C. Lefaucheur, D. Nochy, J. Andrade, J. Verine, C. Gautreau, D. Charron, G. S. Hill, D. Glotz and C. Suberbielle-Boissel

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02591.x

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      The combination PP/IVIg/Anti-CD20 is associated with better removal of anti-HLA donor specific antibodies and better graft outcomes.

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      Case Mix, Quality and High-Cost Kidney Transplant Patients (pages 1108–1114)

      M. J. Englesbe, J. B. Dimick, Z. Fan, O. Baser and J. D. Birkmeyer

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02592.x

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      Medicare payments for kidney transplant patients are greater for high risk patients and patients treated at poor quality centers. See editorial by Axelrod et al on page 985.

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      Efficacy on Renal Function of Early Conversion from Cyclosporine to Sirolimus 3 Months After Renal Transplantation: Concept Study (pages 1115–1123)

      Y. Lebranchu, A. Thierry, O. Toupance, P. F. Westeel, I. Etienne, E. Thervet, B. Moulin, T. Frouget, Y. Le Meur, D. Glotz, A-E. Heng, C. Onno, M. Buchler, S. Girardot-Seguin and B. Hurault De Ligny

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02615.x

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      Early conversion from cyclosporine to sirolimus was associated with improvement in renal function at 12 months, despite a numerical increase in rejection in the sirolimus group.

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      Disparities in the Utilization of Live Donor Renal Transplantation (pages 1124–1133)

      J. L. Gore, G. M. Danovitch, M. S. Litwin, P-T. T. Pham and J. S. Singer

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02620.x

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      Analysis of US transplant data revealed pronounced disparities in receipt of live donor renal transplantation by race/ethnicity and socioeconomic status, with lower rates in patients who were older, African-American, or of lower socioeconomic status.

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      A Multicenter Study of Valganciclovir Prophylaxis up to Day 120 in CMV-Seropositive Lung Transplant Recipients (pages 1134–1141)

      V. Monforte, C. Lopez, F. Santos, F. Zurbano, M. De La Torre, A. Sole, J. Gavalda, P. Ussetti, R. Lama, J. Cifrian, J. M. Borro, A. Pastor, O. Len, C. Bravo and A. Roman

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02574.x

      Valganciclovir prophylaxis results in a low incidence of CMV disease and appears more effective than oral ganciclovir.

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      Preemptive Therapy for Systemic and Pulmonary Human Cytomegalovirus Infection in Lung Transplant Recipients (pages 1142–1150)

      G. Gerna, D. Lilleri, V. Rognoni, M. Agozzino, F. Meloni, T. Oggionni, C. Pellegrini, E. Arbustini and A. M. D'Armini

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02616.x

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      Monitoring of HCMV infection (in both blood and lung) and HCMV-specific T-cell response may improve the control of HCMV infection in lung transplant recipients.

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      Clinical Burden of Screening Asymptomatic Patients for Coronary Artery Disease Prior to Liver Transplantation (pages 1151–1157)

      D. Filì, G. Vizzini, D. Biondo, G. Pietrosi, R. Volpes, U. Palazzo, A. D'Antoni, I. Petridis, A. Luca and B. Gridelli

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02589.x

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      Given the low prevalence of silent coronary artery disease, there is no need for a protocol of strict CAD screening in liver transplant candidates.

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      Transarterial Chemoinfusion for Hepatocellular Carcinoma as Downstaging Therapy and a Bridge toward Liver Transplantation (pages 1158–1168)

      W. De Luna, D. Y. Sze, A. Ahmed, B. Y. Ha, W. Ayoub, E. B. Keeffe, A. Cooper, C. Esquivel and M. H. Nguyen

      Article first published online: 16 MAR 2009 | DOI: 10.1111/j.1600-6143.2009.02576.x

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      Transarterial chemoinfusion can be an effective treatment both as a bridge to liver transplant and as a downstaging modality for patients with tumor burden that was initially beyond the Milan criteria.

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      Adult Right-Lobe Living Liver Donors: Quality of Life, Attitudes and Predictors of Donor Outcomes (pages 1169–1178)

      D. A. DuBay, S. Holtzman, L. Adcock, S. Abbey, S. Greenwood, C. Macleod, A. Kashfi, M. Jacob, E. L. Renner, D. R. Grant, G. A. Levy and G. Therapondos

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02614.x

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      Health related quality of life post-donation was at least as good as population norms in adult right lobe living liver donors; however, factors such as pre-donation concerns, the possession of a graduate degree, and a psychiatric diagnosis were associated with lower mental health scores.

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      Study of the Factors Affecting Health-Related Quality of Life in Adolescents After Liver Transplantation (pages 1179–1188)

      R. M. Taylor, L. S. Franck, F. Gibson, N. Donaldson and A. Dhawan

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02604.x

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      Health related quality of life is lower in adolescents after liver transplantation than in controls, related to effects of immunosuppression and psychosocial factors.

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      Development of a Severe von Willebrand Factor/ADAMTS13 Dysbalance During Orthotopic Liver Transplantation (pages 1189–1196)

      I. T. A. Pereboom, J. Adelmeijer, Y. Van Leeuwen, H. G. D. Hendriks, R. J. Porte and T. Lisman

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02621.x

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      Persistently high levels of von Willebrand factor combined with a temporary deficiency ADAMTS13 results in a hyperreactive hemostatic system during liver transplantation in humans.

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      Provider Utilization of High-Risk Donor Organs and Nucleic Acid Testing: Results of Two National Surveys (pages 1197–1204)

      L. M. Kucirka, R. Namuyinga, C. Hanrahan, R. A. Montgomery and D. L. Segev

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02593.x

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      Practicing in an OPO that performs NAT for HIV and/or HCV is associated with significantly higher odds of using organs from CDC high infectious risk donors.

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      Long-Term Outcomes of CMV Disease Treatment with Valganciclovir Versus IV Ganciclovir in Solid Organ Transplant Recipients (pages 1205–1213)

      A. Åsberg, A. Humar, A. G. Jardine, H. Rollag, M. D. Pescovitz, H. Mouas, A. Bignamini, H. Töz, I. Dittmer, M. Montejo, A. Hartmann and on behalf of the VICTOR Study Group

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02617.x

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      In transplanted patients treated for CMV disease with GCV/VGCV, there was no difference in long-term outcomes while persistent DNAemi at Day 21, CMV IGG serostatus at start of treatment, and development of resistance are relevant factors for individualization of treatment.

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      Cell-Mediated Immunity to Predict Cytomegalovirus Disease in High-Risk Solid Organ Transplant Recipients (pages 1214–1222)

      D. Kumar, S. Chernenko, G. Moussa, I. Cobos, O. Manuel, J. Preiksaitis, S. Venkataraman and A. Humar

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02618.x

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      The measurement of CMV-specific cell mediated immunity may be useful for predicting CMV disease occurring after prophylaxis. See editorial by Danziger-Isakov and Heeger on page 987.

  5. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
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      Anti-Factor H Autoantibodies in a Fifth Renal Transplant Recipient with Atypical Hemolytic and Uremic Syndrome (pages 1223–1229)

      M. Le Quintrec, J. Zuber, L.-H. Noel, E. Thervet, V. Frémeaux-Bacchi, W.-H. Fridman, C. Legendre and M.-A. Dragon-Durey

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02586.x

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      The detection and monitoring of anti Factor-H auto-antibodies in an atypical HUS case prevented a relapse in a fifth transplantation.

      Corrected by:

      Erratum

      Vol. 9, Issue 9, 2205, Article first published online: 20 AUG 2009

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      Predominant Th1 and Cytotoxic Phenotype in Biopsies from Renal Transplant Recipients with Transplant Glomerulopathy (pages 1230–1236)

      S. Homs, H. Mansour, D. Desvaux, C. Diet, M. Hazan, M. Buchler, Y. Lebranchu, D. Buob, C. Badoual, M. Matignon, V. Audard, P. Lang and P. Grimbert

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02596.x

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      Markers for Th1 and granzyme B were expressed more strongly in renal transplant recipients with transplant glomerulopathy.

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      Changes in Pediatric Renal Transplantation After Implementation of the Revised Deceased Donor Kidney Allocation Policy (pages 1237–1242)

      S. Agarwal, N. Oak, J. Siddique, R. C. Harland and E. D. Abbo

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02608.x

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      The number of pediatric renal transplants with allografts from deceased donors less than 35 years old has increased since 2005, while HLA-mismatched allografts have increased and living donors have decreased.

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      Isolated Central Nervous System Posttransplant Lymphoproliferative Disorder Treated with High-Dose Intravenous Methotrexate (pages 1243–1248)

      L. B. Nabors, C. A. Palmer, B. A. Julian, A. M. Przekwas and C. E. Kew

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02598.x

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      Intravenous methotrexate is an effective treatment option that is tolerated in patients with renal transplants and central nervous system PTLD.

  6. Case Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      Acute Cytomegalovirus Cholecystitis Following Renal Transplantation (pages 1249–1252)

      M. Drage, A. Reid, C. J. Callaghan, Y. Baber, S. Freeman, E. Huguet and C. J. Watson

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02607.x

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      Two patients presented with severe hemorrhagic CMV cholecystitis following renal transplantation and required immediate resuscitation and emergency cholecystectomy.

  7. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      Death from Metastatic Donor-Derived Ovarian Cancer in a Male Kidney Transplant Recipient (page 1253)

      F. Bellati, C. Napoletano, M. Nuti and P. Benedetti Panici

      Article first published online: 16 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02601.x

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  8. Erratum

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      Erratum (page 1255)

      Article first published online: 24 FEB 2009 | DOI: 10.1111/j.1600-6143.2009.02595.x

      This article corrects:

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