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American Journal of Transplantation

Cover image for Vol. 9 Issue 7

July 2009

Volume 9, Issue 7

Pages 1487–1698

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1487–1488)

      SUE PONDROM

      Version of Record online: 29 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02753.x

      This month The AJT Report looks at the LYFT kidney-allocation concept, and where it may have gone wrong, as well as research that shows how television news stories about transplants often leave out important information for donors.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
    1. You have free access to this content
      Heavy LYFTing: KASting Pearls Before Swine (pages 1489–1490)

      J. Bromberg and J. Gill

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02688.x

      The use of “Life Years from Transplant” (LYFT) to allocate kidneys is controversial. Several articles in this issue of AJT present critiques and analysis of KAS and LYFT and provide a road map for future progress. See Special Feature on pages 1500–1532.

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      HLA-C and Liver Transplant Outcomes: Interpreting the Facts (pages 1491–1492)

      J. B. Mendel, K. D. Chavin, C. Bratton and S. J. Knechtle

      Version of Record online: 29 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02718.x

      The current issue contains a report contradicting an earlier report published in this journal casting doubt on the association of HLA-C genotype with liver transplant outcomes. See Brief Communication by Tran et al on page 1674–1678.

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      Lung Transplantation Outcomes: The Importance and Inadequacies of Assessing Survival (pages 1493–1494)

      R. D. Yusen

      Version of Record online: 29 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02698.x

      In addition to assessing survival, comprehensive studies of donor allocation system outcomes should assess issues such as morbidity and quality of life. See Article by Titman et al on page 1640–1649.

  3. Minireview

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
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      Mycophenolate Blood Level Monitoring: Recent Progress (pages 1495–1499)

      T. Van Gelder

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02678.x

      Therapeutic drug monitoring for mycophenolic acid is under debate, and in this mini-review recently published clinical trials on this topic are discussed.

  4. Special Feature

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
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      The AST's Perspective on the Proposed Kidney Allocation System (page 1500)

      B. Murphy, F. Vincenti and H.-U. Meier-Kriesche

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02674.x

      In the present format the proposed new allocation system does not achieve an acceptable balance between justice and equity.

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      Moving Kidney Allocation Forward: The ASTS Perspective (pages 1501–1506)

      R. B. Freeman, A. T. Matas, M. Henry, D. L. Segev, D. B. Kaufman and J. P. Roberts

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02697.x

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      The American Society of Transplantation had major concerns regarding the proposed changes in kidney allocation policy and proposes some alternative approaches.

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      The Kidney Allocation Score: Methodological Problems, Moral Concerns and Unintended Consequences (pages 1507–1512)

      B. Hippen

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02594.x

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      In this viewpoint, several methodological and moral concerns with the KAS proposal are reviewed, concluding that any iteration of the KAS is unlikely to surmount these concerns.

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      Evaluating Options for Utility-Based Kidney Allocation (pages 1513–1518)

      D. L. Segev

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02667.x

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      This viewpoint explores various kidney allocation systems, and proposes a framework for quantifying the goals of the transplant community and evaluating options for utility-based allocation.

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      Balancing Multiple and Conflicting Allocation Goals: A Logical Path Forward (pages 1519–1522)

      P. G. Stock

      Version of Record online: 29 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02715.x

      A potential strategy for a new allocation system for kidney allocation should match predicted longevity of the donor kidney with predicted survival of the transplant recipient, while balancing the disparate goals of the multiple stakeholders.

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      Predictability of Survival Models for Waiting List and Transplant Patients: Calculating LYFT (pages 1523–1527)

      R. A. Wolfe, K. P. McCullough and A. B. Leichtman

      Version of Record online: 29 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02708.x

      The predictive value of graft and patient survival models for patients on the kidney transplant wait list are comparable to or better than other predictive models used for organ allocation.

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      Developing a New Kidney Allocation Policy: The Rationale for Including Life Years from Transplant (pages 1528–1532)

      M. D. Stegall

      Version of Record online: 29 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02712.x

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      The viewpoint outlines the rationale for using LYFT as the major utility metric in kidney allocation and describes a compromise proposal in which recent public feedback is incorporated into the OPTN draft proposal.

  5. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
    1. Laboratory Science

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      Tirofiban and Activated Protein C Synergistically Inhibit the Instant Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human Blood (pages 1533–1540)

      S. Akima, W. J. Hawthorne, E. Favaloro, A. Patel, K. Blyth, Y. Mudaliar, J. R. Chapman and P. J. O’Connell

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02673.x

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      Targeting the platelet and coagulation pathways with tirofiban and rhAPC was found to be more effective at preserving human islets than either agent used alone in an in vitro assay simulating clinical IBMIR.

    2. Clinical Science

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      The Pregnancy Rate and Live Birth Rate in Kidney Transplant Recipients (pages 1541–1549)

      J. S. Gill, N. Zalunardo, C. Rose and M. Tonelli

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02662.x

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      In this analysis of female kidney transplant recipients aged 15-45 years in the United States between 1990–2003, the pregnancy rate was markedly lower and declined more rapidly than that in the general American population, while the live birth rate was far lower than that reported in previous studies.

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      The Effects of DonorNet 2007 on Kidney Distribution Equity and Efficiency (pages 1550–1557)

      A. B. Massie, S. L. Zeger, R. A. Montgomery and D. L. Segev

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02670.x

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      By analyzing UNOS kidney transplant data before and after implementation of DonorNet 2007, the authors show no change in distribution equity yet more refusals, longer cold times for those with already prolonged cold times, and a higher discard rate associated with this policy change.

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      Recipient Outcomes for Expanded Criteria Living Kidney Donors: The Disconnect Between Current Evidence and Practice (pages 1558–1573)

      Y. Iordanous, N. Seymour, A. Young, J. Johnson, A. V. Iansavichus, M. S. Cuerden, J. S. Gill, E. Poggio, A. X. Garg and for the Donor Nephrectomy Outcomes Research (DONOR) Network

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02671.x

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      This systematic review examined the impact of selecting Expanded Criteria Living Kidney Donors on recipient outcomes, and found that recipients of kidneys from older living donors had significantly poorer outcomes compared to younger donors.

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      Early Renal Ischemia-Reperfusion Injury in Humans Is Dominated by IL-6 Release from the Allograft (pages 1574–1584)

      D. K. De Vries, J. H. N. Lindeman, D. Tsikas, E. De Heer, A. Roos, J. W. De Fijter, A. G. Baranski, J. Van Pelt and A. F. M. Schaapherder

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02675.x

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      Reperfusion of the donor kidney is associated with an inflammatory response that is dominated by IL-6 release.

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      Life Insurance for Living Kidney Donors: A Canadian Undercover Investigation (pages 1585–1590)

      R. C. Yang, A. Young, I. F. P. Nevis, D. Lee, A. K. Jain, A. Dominic, E. Pullenayegum, S. Klarenbach, A. X. Garg and for the Donor Nephrectomy Outcomes Research (DONOR) Network

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02679.x

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      Kidney donors were not disadvantaged in the first step of applying for life insurance.

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      Hepatitis C Virus Compartmentalization and Infection Recurrence after Liver Transplantation (pages 1591–1601)

      S. Ramirez, S. Perez-del-Pulgar, J. A. Carrion, J. Costa, P. Gonzalez, A. Massaguer, C. Fondevila, J. C. Garcia-Valdecasas, M. Navasa and X. Forns

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02666.x

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      Our results show that HCV compartmentalization is frequent in HCV-infected liver transplant patients, but do not support a contribution of extrahepatic compartments to HCV infection recurrence after liver transplantation.

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      Orthotopic, but Reversed Implantation of the Liver Allograft in Situs Inversus Totalis—A Simple New Approach to a Difficult Problem (pages 1602–1606)

      S. C. Rayhill, D. Scott, S. Orloff, J.-L. Horn, J. Schwartz, A. Zaman, A. Sasaki, W. S. Naugler, M. Chang, J. Gaumond, Y. Wu and J. Ham

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02676.x

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      A right-to-left flip of the liver into a left sided hepatic fossa and a reversed cavaplasty comprise the principal components of a simple new technique for liver transplantation in patients with situs inversus totalis.

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      Fixed- or Controlled-Dose Mycophenolate Mofetil with Standard- or Reduced-Dose Calcineurin Inhibitors: The Opticept Trial (pages 1607–1619)

      R. S. Gaston, B. Kaplan, T. Shah, D. Cibrik, L. M. Shaw, M. Angelis, S. Mulgaonkar, H.-U. Meier-Kriesche, D. Patel and R. D. Bloom

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02668.x

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      In this randomized trial, concentration-controlled dosing of mycophenolate mofetil with reduced doses of calcineurin inhibitors was not inferior to standard dosing.

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      Rejection Reversibly Alters Enteroendocrine Cell Renewal in the Transplanted Small Intestine (pages 1620–1628)

      T. M. Fishbein, G. Novitskiy, D. M. Lough, C. Matsumoto, S. S. Kaufman, K. Shetty and M. Zasloff

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02681.x

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      Acute intestinal rejection is associated with a loss of certain subtypes of enteroendocrine cells, most profoundly those expressing PYY, occurring via a mechanism that depletes NEUROG3 progenitors.

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      Ischemic Preconditioning (IP) of the Liver as a Safe and Protective Technique against Ischemia/Reperfusion Injury (IRI) (pages 1629–1639)

      A. Franchello, N. Gilbo, E. David, A. Ricchiuti, R. Romagnoli, E. Cerutti and M. Salizzoni

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02680.x

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      This prospective randomized study showed the safety and efficacy of ischemic preconditioning in liver transplantation, evaluating its correlation to clinical and histological improvement of both optimal and marginal preconditioned grafts.

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      Disease-Specific Survival Benefit of Lung Transplantation in Adults: A National Cohort Study (pages 1640–1649)

      A. Titman, C. A. Rogers, R. S. Bonser, N. R. Banner and L. D. Sharples

      Version of Record online: 29 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02613.x

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      Adult lung transplantation results in survival benefit for all patient groups in the UK national transplantation program. See Editorial by Yusen on page 1493–1494.

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      Proton Pump Inhibitors Reduce Mycophenolate Exposure in Heart Transplant Recipients—A Prospective Case-Controlled Study (pages 1650–1656)

      S. Kofler, N. Shvets, A. K. Bigdeli, M. A. König, P. Kaczmarek, M.-A. Deutsch, M. Vogeser, G. Steinbeck, B. Reichart and I. Kaczmarek

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02682.x

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      Mycophenolic acid drug exposure is markedly reduced by proton pump inhibitor comedication in MMF treated transplant recipients.

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      Delay of Adequate Empiric Antibiotic Therapy Is Associated with Increased Mortality among Solid-Organ Transplant Patients (pages 1657–1665)

      B. Hamandi, A. M. Holbrook, A. Humar, J. Brunton, E. A. Papadimitropoulos, G. G. Wong and L. Thabane

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02664.x

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      A retrospective cohort study revealed that more than half of solid-organ transplant recipients received delayed adequate empiric antibiotic therapy, which was found to be associated with increased hospital mortality compared to patients receiving timely adequate therapy.

  6. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
    1. Clinical Science

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      Deceased Donor Kidney Transplantation from Donors with Acute Renal Failure due to Rhabdomyolysis (pages 1666–1670)

      K. L. Mekeel, A. A. Moss, D. C. Mulligan, H. A. Chakkera, K. Hamawi, M. J. Mazur, R. L. Heilman and K. S. Reddy

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02663.x

      Rhabdomyolysis with acute renal failure should not be a contra-indication for donation: although recipients may experience slow or delayed graft function, kidneys from these donors recover normal graft function within one month after transplantation.

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      Secondary Listing for Deceased-Donor Kidney Transplantation Does Not Increase Likelihood of Engraftment at a Large Transplant Center (pages 1671–1673)

      V. Kumar, B. A. Julian, M. H. Deierhoi and J. J. Curtis

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02677.x

      Secondary listing for renal transplantation at a center with a large waiting list conferred no benefit to the patient and was expensive for Medicare.

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      Reassessing the Impact of Donor HLA-C Genotype on Long-Term Liver Transplant Survival (pages 1674–1678)

      T. H. Tran, D. Middleton, B. Döhler, S. Scherer, A. Meenagh, C. Sleator and G. Opelz

      Version of Record online: 10 APR 2009 | DOI: 10.1111/j.1600-6143.2009.02609.x

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      In contrast to a previous report, genotyping of 913 deceased liver donors for the relevant KIR epitopes of HLA-C did not confirm a significant impact of donor HLA-C2 genotype on allograft or patient survival. See Editorial by Mendel et al on page 1491–1492.

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      Adoptive T-Cell Therapy of a Lung Transplanted Patient with Severe CMV Disease and Resistance to Antiviral Therapy (pages 1679–1684)

      G. Brestrich, S. Zwinger, A. Fischer, M. Schmück, A. Röhmhild, M. H. Hammer, A. Kurtz, L. Uharek, C. Knosalla, H. Lehmkuhl, H.-D. Volk and P. Reinke

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02672.x

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      The adoptive transfer of specific T-cell lines was examined as a new treatment strategy for SOT recipients suffering from severe CMV infections with resistance to antiviral.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
    1. You have free access to this content
      Unrecognized Acute Phosphate Nephropathy in a Kidney Donor with Consequent Poor Allograft Outcome (pages 1685–1689)

      N. Agrawal, R. Nair, L. P. McChesney, S. Tuteja, M. Suneja and C. P. Thomas

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02686.x

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      Kidneys transplanted from one deceased donor with acute phosphate nephropathy fared poorly in both kidney recipients.

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      Prevalence of Human Herpesvirus-6 Chromosomal Integration (CIHHV-6) in Italian Solid Organ and Allogeneic Stem Cell Transplant Patients (pages 1690–1697)

      L. Potenza, P. Barozzi, M. Masetti, M. Pecorari, P. Bresciani, A. Gautheret-Dejean, G. Riva, D. Vallerini, S. Tagliazucchi, M. Codeluppi, F. Di Benedetto, G. E. Gerunda, F. Narni, G. Torelli and M. Luppi

      Version of Record online: 10 JUN 2009 | DOI: 10.1111/j.1600-6143.2009.02685.x

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      Human Herpesvirus 6 chromosomal integration (CIHHV-6) showed a prevalence of 0.9% in Italian AlloSCT and SOT patients, and might represent a diagnostic pitfall unless HHV-6 viral loads on different specimens are compared.

  8. Erratum

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Feature
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Erratum
    1. You have free access to this content
      Erratum (page 1698)

      Version of Record online: 20 MAY 2009 | DOI: 10.1111/j.1600-6143.2009.02654.x

      This article corrects:

      Perceptions of Transitional Care Needs and Experiences in Pediatric Heart Transplant Recipients

      Vol. 9, Issue 3, 614–619, Version of Record online: 19 FEB 2009

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