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American Journal of Transplantation

Cover image for Vol. 10 Issue 1

January 2010

Volume 10, Issue 1

Pages 2–193

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 2–4)

      SUE PONDROM

      Article first published online: 17 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02978.x

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      This month, in a special expanded section, “The AJT Report” examines some of the newer—and in some cases, controversial—desensitization therapies available. We also explore whether transplant centers and procurement organizations are prepared to care for patients with H1N1 influenza.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
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      Introducing Volume 10 of AJT (page 5)

      P. F. Halloran

      Article first published online: 17 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02976.x

      As we begin volume 10 of AJT, the editors would like to call your attention to some new and enhanced features.

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      Steroids in Pediatric Kidney Transplantation: A Balancing Act in Progress (pages 6–7)

      John C. Magee

      Article first published online: 17 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02923.x

      The issue of steroid withdrawal in pediatric kidney transplantation involves risks as well as benefits, and poses analytical challenges in interpreting studies halted and unblinded prior to enrollment. See article by Benfield et al on page 81.

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      Is Rituximab Safe to Use in Kidney Transplant Patients? (pages 8–9)

      S. C. Jordan and D. Glotz

      Article first published online: 17 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02925.x

      Rituximab is an emerging therapeutic agent in transplantation, but concerns remain over proof of efficacy, safety and dosing. See article by Kamar et al on page 89.

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      Biologic Markers as Predictors for Liver Transplant Outcome (pages 10–11)

      R. B. Freeman

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02878.x

      The rate of change of AFP levels before transplantation is another, maybe more biologically relevant, way to assess liver transplant prognosis for hepatocellular cancer. See article by Vibert et al on page 129.

  3. Minireview

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
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      Metabolic Syndrome and Solid-Organ Transplantation (pages 12–17)

      A. Sharif

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02882.x

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      Metabolic syndrome is common among patients with organ transplants, and requires clinicians to be familiar with pathophysiology, diagnosis, patient/graft outcomes and ongoing controvers

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      Erratum

      Vol. 12, Issue 5, 1358, Article first published online: 26 APR 2012

  4. Special Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
    1. You have free access to this content
      Guidance on Novel Influenza A/H1N1 in Solid Organ Transplant Recipients (pages 18–25)

      D. Kumar, M. I. Morris, C. N. Kotton, S. A. Fischer, M. G. Michaels, U. Allen, E. A. Blumberg, M. Green, A. Humar, M. G. Ison and on Behalf of the AST Infectious Diseases Community of Practice and Transplant Infectious Diseases Section of TTS

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02960.x

      This report outlines the clinical response to the H1N1 challenge in transplantation.

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      Calculated PRA (CPRA): The New Measure of Sensitization for Transplant Candidates (pages 26–29)

      J. M. Cecka

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02927.x

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      The calculated PRA (CPRA) replaced PRA in the UNOS allocation algorithm October 1, 2009 to provide a more uniform measure of sensitization and better access for sensitized renal transplant candidates.

  5. Laboratory Science

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
    1. Original Articles

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      Anti-thrombin Therapy During Warm Ischemia and Cold Preservation Prevents Chronic Kidney Graft Fibrosis in a DCD Model (pages 30–39)

      F. Favreau, R. Thuillier, J. Cau, S. Milin, E. Manguy, G. Mauco, X. Zhu, L. O. Lerman and T. Hauet

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02924.x

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      Thrombin inhibition during kidney preservation prevents fibrosis in a pig autotransplant model.

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      PD-1/B7-H1 Interaction Contribute to the Spontaneous Acceptance of Mouse Liver Allograft (pages 40–46)

      M. Morita, M. Fujino, G. Jiang, Y. Kitazawa, L. Xie, M. Azuma, H. Yagita, S. Nagao, A. Sugioka, Y. Kurosawa, S. Takahara, J. Fung, S. Qian, L. Lu and X.-K. Li

      Article first published online: 4 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02859.x

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      B7-H1 upregulation on tissue cells of liver allografts plays a critical role of the induction of the spontaneous tolerance after hepatic transplantation in mice.

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      Therapy with Nonglycosaminoglycan-Binding Mutant CCL7: A Novel Strategy to Limit Allograft Inflammation (pages 47–58)

      S. Ali, G. O’Boyle, P. Hepplewhite, J. R. Tyler, H. Robertson and J. A. Kirby

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02868.x

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      A non-GAG-binding mutant CCL7 limits allograft inflammation by reducing T cell priming as well as leukocyte infiltration.

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      Role of TNFα in Early Chemokine Production and Leukocyte Infiltration into Heart Allografts (pages 59–68)

      D. Ishii, A. D. Schenk, S. Baba and R. L. Fairchild

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02921.x

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      Administration of anti-TNFα mAb attenuates early allograft inflammation and priming of donor-reactive CD4 and CD8 T cells in murine recipients of MHC-mismatched cardiac allografts.

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      IFN-γ Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells (pages 69–80)

      B. Wei, S. Baker, J. Wieckiewicz and K. J. Wood

      Article first published online: 4 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02858.x

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      IFN-γ, produced rapidly and transiently by alloantigen reactive regulatory T cells (Tregs) when they reencounter antigen, can be utilized by Tregs and is essential for their function in vivo resulting in enhanced STAT1 activation but decreased AKT activation.

  6. Clinical Science

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
    1. Original Articles

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      A Randomized Double-Blind, Placebo Controlled Trial of Steroid Withdrawal after Pediatric Renal Transplantation (pages 81–88)

      M. R. Benfield, S. Bartosh, D. Ikle, B. Warshaw, N. Bridges, Y. Morrison and W. Harmon

      Article first published online: 6 AUG 2009 | DOI: 10.1111/j.1600-6143.2009.02767.x

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      Although steroid withdrawal is possible after pediatric renal transplantation, the immunosuppressive protocol used in this study was associated with excessive risks. See Editorial by Magee on page 6.

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      Incidence and Predictive Factors for Infectious Disease after Rituximab Therapy in Kidney-Transplant Patients (pages 89–98)

      N. Kamar, O. Milioto, B. Puissant-Lubrano, L. Esposito, M. C. Pierre, A. Ould Mohamed, L. Lavayssière, O. Cointault, D. Ribes, I. Cardeau, M. B. Nogier, D. Durand, M. Abbal, A. Blancher and L. Rostaing

      Article first published online: 28 JUL 2009 | DOI: 10.1111/j.1600-6143.2009.02785.x

      After kidney transplantation, rituximab therapy was associated with a high risk of infectious episodes. See Editorial by Jordan and Glotz on page 8.

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      Thrombophilic Factors Do Not Predict Outcomes in Renal Transplant Recipients Under Prophylactic Acetylsalicylic Acid (pages 99–105)

      L. Ghisdal, N. Broeders, K.-M. Wissing, A. Saidi, T. Bensalem, J. Mbaba Mena, A. Lemy, W. Wijns, O. Pradier, A.-D. Hoang, D. Mikhalski, V. Donckier, P. Cochaux, H. El Housni, M. Abramowicz, P. Vereerstraeten and D. Abramowicz

      Article first published online: 21 OCT 2009 | DOI: 10.1111/j.1600-6143.2009.02855.x

      The presence of thrombophilic factors dosed at the day of renal transplantation does not influence thrombo-embolic events, acute rejection, graft or patient survival in patients transplanted after 2000 and receiving prophylactic acetylsalicylic acid.

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      Markers of the Hepatic Component of the Metabolic Syndrome as Predictors of Mortality in Renal Transplant Recipients (pages 106–114)

      D. M. Zelle, E. Corpeleijn, R. M. van Ree, R. P. Stolk, E. van der Veer, R. O. B. Gans, J. J. Homan van der Heide, G. Navis and S. J. L. Bakker

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02876.x

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      In a cohort of 602 renal transplant recipients, liver enzymes were measured as markers of the hepatic component of the metabolic syndrome and found to be independently predictive of cardiovascular and all-cause mortality.

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      Successful DCD Kidney Transplantation Using Early Corticosteroid Withdrawal (pages 115–123)

      R. E. Chudzinski, K. Khwaja, P. Teune, J. Miller, H. Tang, M. Pavlakis, C. Rogers, S. Johnson, S. Karp, D. Hanto and D. Mandelbrot

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02922.x

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      DCD kidney transplant recipients can successfully undergo early corticosteroid withdrawal, with no apparent compromise of graft function and patient survival.

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      Chylous Ascites Requiring Surgical Intervention after Donor Nephrectomy: Case Series and Single Center Experience (pages 124–128)

      J. Aerts, A. Matas, D. Sutherland and R. Kandaswamy

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02883.x

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      A case of chylous ascites refractory to conservative management is presented and the literature is reviewed.

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      Progression of Alphafetoprotein Before Liver Transplantation for Hepatocellular Carcinoma in Cirrhotic Patients: A Critical Factor (pages 129–137)

      E. Vibert, D. Azoulay, E. Hoti, S. Iacopinelli, D. Samuel, C. Salloum, A. Lemoine, H. Bismuth, D. Castaing and R. Adam

      Article first published online: 17 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02750.x

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      Liver Transplantation for Alcoholic Liver Disease in Europe: A Study from the ELTR (European Liver Transplant Registry) (pages 138–148)

      P. Burra, M. Senzolo, R. Adam, V. Delvart, V. Karam, G. Germani, J. Neuberger and for ELITA and of behalf of ELTR Liver Transplant Centers

      Article first published online: 1 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02869.x

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      In Europe, patients transplanted for alcoholic liver disease have significantly better outcomes than patients with viral and cryptogenic cirrhosis, but de novo tumors, cardiovascular events and social factors were more frequent as causes of death.

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      Absence of Donor-Specific Anti-HLA Antibodies After ABO-Incompatible Heart Transplantation in Infancy: Altered Immunity or Age? (pages 149–156)

      S. Urschel, P. M. Campbell, S. R. Meyer, I. M. Larsen, J. Nuebel, J. Birnbaum, H. Netz, K. Tinckam, T. Kauke, K. Derkatz, J. Y. Coe, J. L. Platt and L. J. West

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02877.x

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      Cardiac transplantation in childhood is associated with less frequent de novo development of anti-HLA antibodies than reported in older individuals, and in this experience, recipients of ABO-incompatible transplants produced class II antibodies donor-specific HLA antibodies less frequently.

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      Clinical Predictors of Relapse after Treatment of Primary Gastrointestinal Cytomegalovirus Disease in Solid Organ Transplant Recipients (pages 157–161)

      A. J. Eid, S. K. Arthurs, P. J. Deziel, M. P. Wilhelm and R. R. Razonable

      Article first published online: 4 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02861.x

      Assessment of the clinical outcomes of primary gastrointestinal CMV disease in solid organ transplant recipients identified the extent of tissue involvement as a significant predictor of relapse after treatment with intravenous ganciclovir or valganciclovir.

  7. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
    1. You have free access to this content
      Type I Interferons Are Not Critical for Skin Allograft Rejection or the Generation of Donor-Specific CD8+ Memory T Cells (pages 162–167)

      M. H. Oberbarnscheidt, J. S. Obhrai, A. L. Williams, D. M. Rothstein, W. D. Shlomchik, G. Chalasani and F. G. Lakkis

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02871.x

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      In a mouse model of skin transplantation, the absence of type I interferon receptor in both the donor and recipient or the recipient alone did not alter allograft rejection or the generation of donor-specific CD8 memory T cells.

  8. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
    1. You have free access to this content
      Successful Renal Transplantation in Factor H Autoantibody Associated HUS with CFHR1 and 3 Deficiency and CFH Variant G2850T (pages 168–172)

      A. M. Waters, I. Pappworth, K. Marchbank, D. Bockenhauer, K. Tullus, M. C. Pickering, L. Strain, N. Sebire, R. Shroff, S. D. Marks, T. H. J. Goodship and L. Rees

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02870.x

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      Successful isolated renal transplantation is described in a case of CFH-autoantibody associated HUS with CFHR1 and 3 deficiency and CFH variant G2850T.

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      Successful Immunotherapy of HCMV Disease Using Virus-Specific T Cells Expanded from an Allogeneic Stem Cell Transplant Recipient (pages 173–179)

      G. R. Hill, S.-K. Tey, L. Beagley, T. Crough, J. A. Morton, A. D. Clouston, P. Whiting and R. Khanna

      Article first published online: 16 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02872.x

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      Virus-specific T cells from a stem cell transplant patient were used successfully to treat CMV disease.

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      De Novo HLA Sensitization and Antibody Mediated Rejection Following Pregnancy in a Heart Transplant Recipient (pages 180–183)

      P. J. O’Boyle, J. D. Smith, A. J. Danskine, H. S. Lyster, M. M. Burke and N. R. Banner

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02875.x

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      This study describes the onset of cardiac failure due to antibody-mediated rejection following a miscarriage six years post transplantation.

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      Extreme Subcutaneous, Intramuscular and Inhaled Insulin Resistance Treated by Pancreas Transplantation Alone (pages 184–188)

      J. R. Sa, M. A. Alvarenga, E. B. Rangel, C. S. Melaragno, A. M. Gonzalez, M. M. Linhares, A. Salzedas, A. K. Carmona, V. Tonetto-Fernandes, M. A. Gabbay, J. O. Medina Pestana and S. A. Dib

      Article first published online: 2 DEC 2009 | DOI: 10.1111/j.1600-6143.2009.02881.x

      This report describes pancreas transplantation alone in patients with extreme subcutaneous, intramuscular and inhaled insulin resistance.

  9. Book Review

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
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      Liver Transplantation—Challenging Controversies and Topics edited by Everson GT and Trotter JF (page 189)

      John O’Grady

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02873.x

      This book is a series of chapters that deal with controversial or fast-moving areas in liver transplantation, always providing insight if not necessarily answers.

  10. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireview
    5. Special Articles
    6. Laboratory Science
    7. Clinical Science
    8. Brief Communication
    9. Case Reports
    10. Book Review
    11. Letters to the Editor
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      Hepatitis C Virus Infection in a Living-Related Liver Donor (page 191)

      S. Gruttadauria, D. Pagano, I. Petridis, G. Vizzini, R. Volpes, P. A. Grossi and B. Gridelli

      Article first published online: 24 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02874.x

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      No Evidence for Microsatellite Instability in Immunodeficiency-Related Skin Cancers (pages 192–193)

      C. Borie, S. Euvrard, O. Vérola, O. Buhard, S. Barete, J. M. Molina, J. Kanitakis, D. Kérob, C. Lebbé and A. Duval

      Article first published online: 4 NOV 2009 | DOI: 10.1111/j.1600-6143.2009.02862.x

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