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American Journal of Transplantation

Cover image for Vol. 10 Issue 10

October 2010

Volume 10, Issue 10

Pages 2187–2382

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 2187–2188)

      SUE PONDROM

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03286.x

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      This month, “The AJT Report” explores the high cost of pancreas acquisition, and how it hampers islet transplantation in the U.S. Additionally, we review efforts by Yale University researchers to take a first step toward the goal of generating fully functional lungs.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      Does Early (CNI) Conversion Lead to Eternal (Renal) Salvation? (pages 2189–2190)

      G. McKenna and J. F. Trotter

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03269.x

      Early conversion from calcineurin inhibitors to m-TOR inhibitors may lead to improved renal function in liver transplant recipients, but further confirmation of the safety and efficacy is needed. See article by Masetti et al on page 2252.

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      Prediction Model for Delayed Kidney Transplant Function: No Need for New Regulation (pages 2191–2192)

      Stephen T. Bartlett, Eugene J. Schweitzer and Matthew Cooper

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03253.x

      The proposed model to better predict the occurrence of DGF may miss the mark and further complicate the process of informed consent. See article by Irish et al on page 2279.

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      Operational Tolerance After Liver Transplantation: Raising the Bar or Tripping Up? (pages 2193–2194)

      James F. Trotter and John O’Grady

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03252.x

      The randomized trial evaluating the occurrence of tolerance in liver transplant recipients reported in this issue represents an opportunity to learn lessons for future studies. See article by Benítez et al on page 2296.

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      Liver Transplantation for Alcoholic Liver Disease: Knowing the Future Informs the Present (pages 2195–2196)

      J. Neuberger and K. Webb

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03285.x

      Knowing the likelihood, timing and pattern of alcohol consumption after liver transplantation allows a targeted therapeutic and behavioral approach to reducing the impact of recidivism. See article by DiMartini et al on page 2305.

  3. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
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      US Health Care Reform and Transplantation. Part I: Overview and Impact on Access and Reimbursement in the Private Sector (pages 2197–2202)

      D. A. Axelrod, D. Millman and M. M. Abecassis

      Version of Record online: 3 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03246.x

      The changes in the American private health insurance market as a result of the health care reform legislation can have both positive and negative consequences for transplant centers.

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      US Health Care Reform and Transplantation, Part II: Impact on the Public Sector and Novel Health Care Delivery Systems (pages 2203–2207)

      D. A. Axelrod, D. Millman and M. M. Abecassis

      Version of Record online: 3 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03247.x

      The changes in public sector health care financing represent opportunities for transplant leaders to guide these developments.

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      The Quality of Health Insurance Service Delivery for Kidney Transplant Recipients: A Patient Perspective (pages 2208–2214)

      E. J. Gordon and D. Conti

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03248.x

      Semi-structured interviews with kidney transplant recipients (n = 87) about their interactions with insurance agencies found that 37% reported negative, and 79% reported neutral or positive interactions with their insurer.

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      The Molecular Phenotype of Kidney Transplants (pages 2215–2222)

      P. F. Halloran, D. G. De Freitas, G. Einecke, K. S. Famulski, L. G. Hidalgo, M. Mengel, J. Reeve, J. Sellares and B. Sis

      Version of Record online: 10 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03267.x

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      The molecular features of transplant biopsies are best summarized in terms of three elements: specific diseases; the active injury-repair response; and the cumulative burden of injury.

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      An Integrated View of Molecular Changes, Histopathology and Outcomes in Kidney Transplants (pages 2223–2230)

      P. F. Halloran, D. G. De Freitas, G. Einecke, K. S. Famulski, L. G. Hidalgo, M. Mengel, J. Reeve, J. Sellares and B. Sis

      Version of Record online: 10 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03268.x

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      Integration of molecular and histologic biopsy features with HLA antibody measurements is creating a new understanding of the determinants of kidney transplant function and outcomes.

  4. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. Laboratory Science

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      Donor Pretreatment with Tetrahydrobiopterin Saves Pancreatic Isografts from Ischemia Reperfusion Injury in a Mouse Model (pages 2231–2240)

      M. Maglione, R. Oberhuber, B. Cardini, K. Watschinger, M. Hermann, P. Obrist, P. Hengster, W. Mark, S. Schneeberger, G. Werner-Felmayer, J. Pratschke, R. Margreiter, E. R. Werner and G. Brandacher

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03262.x

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      Among three different clinically applicable treatment regimens with tetrahydrobiopterin tested to prevent ischemia reperfusion injury in pancreatic isografts, donor pre-treatment turned out to be the most promising approach.

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      Loss of Solute Carriers in T Cell-Mediated Rejection in Mouse and Human Kidneys: An Active Epithelial Injury–Repair Response (pages 2241–2251)

      G. Einecke, D. Kayser, J. M. Vanslambrouck, B. Sis, J. Reeve, M. Mengel, K. S. Famulski, C. G. Bailey, J. E. J. Rasko and P. F. Halloran

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03263.x

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      Molecular changes in the epithelium observed during rejection, such as loss of solute carrier transcripts, are not a unique consequence of rejection but occur also in other types of injury and thus represent an active injury-repair response of the epithelium that is stereotyped across disease states.

    3. Clinical Science

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      Early Withdrawal of Calcineurin Inhibitors and Everolimus Monotherapy in de novo Liver Transplant Recipients Preserves Renal Function (pages 2252–2262)

      M. Masetti, R. Montalti, G. Rompianesi, M. Codeluppi, R. Gerring, A. Romano, B. Begliomini, F. Di Benedetto and G. E. Gerunda

      Version of Record online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03128.x

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      Efficacy outcomes were based on per protocol (PP), in other words the estimated GFRs were calculated from the patients who stayed on EVR. See editorial by McKenna & Trotter on page 2189.

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      Renal Transplantation in HIV-Infected Patients: The Paris Experience (pages 2263–2269)

      M. Touzot, E. Pillebout, M. Matignon, L. Tricot, J. P. Viard, E. Rondeau, C. Legendre, D. Glotz, M. Delahousse, P. Lang and M. N. Peraldi

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03258.x

      Systematic protocol biopsies performed in a cohort of 27 HIV-infected recipients reveal a low incidence of acute rejection.

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      Loss of Nephrin Expression in Glomeruli of Kidney-Transplanted Patients Under m-TOR Inhibitor Therapy (pages 2270–2278)

      L. Biancone, B. Bussolati, G. Mazzucco, A. Barreca, E. Gallo, M. Rossetti, M Messina, B. Nuschak, F. Fop, D. Medica, V. Cantaluppi, G. Camussi and G. P. Segoloni

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03259.x

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      Nephrin expression within glomeruli is reduced in kidney transplants of patients treated with MTOR inhibitors.

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      A Risk Prediction Model for Delayed Graft Function in the Current Era of Deceased Donor Renal Transplantation (pages 2279–2286)

      W. D. Irish, J. N. Ilsley, M. A. Schnitzler, S. Feng and D. C. Brennan

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03179.x

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      This model for predicting DGF after deceased donor renal transplantation serves as a nomogram depicting the relative contribution of risk factors and a DGF risk calculator. See editorial by Bartlett et al on page 2191.

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      25-OH-Vitamin D Deficiency and Cellular Alloimmunity as Measured by Panel of Reactive T Cell Testing in Dialysis Patients (pages 2287–2295)

      D. Sawinski, J. Uribarri, D. Peace, T. Yao, P. Wauhop, P. Trzcinka, K. Ostrow, E. D. Poggio and P. S. Heeger

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03264.x

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      A study of the relationship between serum 25-OH vitamin D and T cell alloimmunity in transplant candidates on hemodialysis found that the strength of the alloimmune response was stronger in vitamin D-deficient transplant candidates, independent of other factors associated with sensitization.

      Corrected by:

      Erratum

      Vol. 11, Issue 4, 873, Version of Record online: 29 MAR 2011

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      ATG-Fresenius Treatment and Low-Dose Tacrolimus: Results of a Randomized Controlled Trial in Liver Transplantation (pages 2296–2304)

      C. E. Benítez, I. Puig-Pey, M. López, M. Martínez-Llordella, J. J. Lozano, F. Bohne, M. C. Londoño, J. C. García-Valdecasas, M. Bruguera, M. Navasa, A. Rimola and A. Sánchez-Fueyo

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03164.x

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      In liver transplant recipients, drastic minimization of immunosuppressive drug usage following peri-transplant polyclonal T cell depleting antibodies plus low dose tacrolimus monotherapy is associated with high rates of acute rejection and no obvious clinical benefits. See editorial by Trotter & O'Grady on page 2193.

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      Trajectories of Alcohol Consumption Following Liver Transplantation (pages 2305–2312)

      A. DiMartini, M. A. Dew, N. Day, M. G. Fitzgerald, B. L. Jones, M. E. DeVera and P. Fontes

      Version of Record online: 19 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03232.x

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      This study reveals four distinct patterns of alcohol use following liver transplantation in alcoholic liver disease. See editorial by Neuberger & Webb on page 2195.

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      Once-Daily Prolonged-Release Tacrolimus (ADVAGRAF) Versus Twice-Daily Tacrolimus (PROGRAF) in Liver Transplantation (pages 2313–2323)

      P. Trunečka, O. Boillot, D. Seehofer, A. D. Pinna, L. Fischer, B.-G. Ericzon, R. I. Troisi, U. Baccarani, J. Ortiz de Urbina, W. Wall and for the Tacrolimus Prolonged Release Liver Study Group

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03255.x

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      Once-daily, prolonged-release tacrolimus demonstrates therapeutic equivalence and comparable safety profile to established twice-daily tacrolimus in liver transplant recipients in this randomized, double-blind, double-dummy study.

      Corrected by:

      Erratum

      Vol. 10, Issue 12, 2730, Version of Record online: 29 NOV 2010

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      Renal Failure Five Years After Lung Transplantation Due to Polyomavirus BK-Associated Nephropathy (pages 2324–2330)

      A. Egli, D. S. Helmersen, K. Taub, H. H. Hirsch and A. Johnson

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03265.x

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      A 67-year old female presented with hypertension and progressive renal failure due to polyomavirus-associated nephropathy 5 years after lung transplantation.

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      Skeletal Integrity and Visceral Transplantation (pages 2331–2340)

      J. Resnick, N. Gupta, J. Wagner, G. Costa, R. J. Cruz Jr., L. Martin, D. A. Koritsky, S. Perera, L. Matarese, K. Eid, B. Schuster, M. Roberts, S. Greenspan and K. Abu-Elmagd

      Version of Record online: 3 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03245.x

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      Intestinal transplant recipients are at risk of osteoporosis secondary to bone loss before and after transplantation, and require comprehensive preventive measures and prompt therapeutic intervention utilizing intravenous bisphosphonates or subcutaneous human PTH1-34.

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      Process of Care Events in Transplantation: Effects on the Cost of Hospitalization (pages 2341–2348)

      N. N. Egorova, A. C. Gelijns, A. J. Moskowitz, J. C. Emond, R. Krapf, E. J. Lazar, S. Guillerme, H. S. Kaplan and G. Greco

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03260.x

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      Process of care events are a significant component of the cost of health care in transplantation, even though the majority does not harm patients.

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      De novo Therapy with Everolimus, Low-Dose Ciclosporine A, Basiliximab and Steroid Elimination in Pediatric Kidney Transplantation (pages 2349–2354)

      L. Pape, G. Offner, M. Kreuzer, K. Froede, J. Drube, N. Kanzelmeyer, J. H. H. Ehrich and T. Ahlenstiel

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03266.x

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      De novo immunosuppressive therapy with Everolimus, low-dose Ciclosporine A, Basiliximab and steroid elimination in pediatric kidney transplantation leads to 100% one year graft and patient survival, good graft function, no acute rejections and a low number of infectious complications.

  5. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      In Vivo Function of Immune Inhibitory Molecule B7-H4 in Alloimmune Responses (pages 2355–2362)

      K. Yamaura, T. Watanabe, O. Boenisch, M. Yeung, S. Yang, C. N. Magee, R. Padera, S. Datta, T. Schatton, Y. Kamimura, M. Azuma and N. Najafian

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03250.x

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      The recipient but not donor B7-H4 molecule can participate in negative regulation of alloimmune responses in a murine model of solid organ transplantation.

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      Embolization of Polycystic Kidneys as an Alternative to Nephrectomy Before Renal Transplantation: A Pilot Study (pages 2363–2369)

      F. Cornelis, L. Couzi, Y. Le Bras, R. Hubrecht, E. Dodré, M. Geneviève, V. Pérot, H. Wallerand, J. M. Ferrière, P. Merville and N. Grenier

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03251.x

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      Embolization of enlarged polycystic kidneys in 25 patients was effective in obtaining sufficient volume reduction for graft implantation and appears to be an advantageous alternative to nephrectomy before renal transplantation.

  6. Case Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      Negative Pressure Wound Therapy Used to Heal Complex Urinary Fistula Wounds Following Renal Transplantation into an Ileal Conduit (pages 2370–2373)

      Sarah Heap, Sanjay Mehra, Afshin Tavakoli, Titus Augustine, Hany Riad and Ravi Pararajasingam

      Version of Record online: 25 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03237.x

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      Two cases underwent successful negative wound pressure therapy to eradicate the local sepsis and help the healing of a recurrent urinary fistula following kidney transplantation into an ileal conduit.

  7. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
    2. You have free access to this content
    3. You have free access to this content
      Response: DonorNet and the Potential Effects on Organ Utilization (page 2376)

      L. K. Kayler, J. D. Schold and J. F. Magliocca

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03197.x

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      Response: DonorNet and the Potential Effects on Organ Utilization (page 2377)

      D. A. Gerber, C. J. Arrington, S. E. Taranto, T. Baker and R. S. Sung

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03230.x

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      Mycophenolate Mofetil: A Possible Cause of Hemophagocytic Syndrome Following Renal Transplantation? (pages 2378–2379)

      L. Raffray, L. Couzi, J. F. Viallard, J. L. Pellegrin, V. Augis, J. P. Vernant and P. Merville

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03254.x

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  8. Erratum

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Personal Viewpoints
    5. Original Articles
    6. Brief Communications
    7. Case Report
    8. Letters to the Editor
    9. Erratum
    1. You have free access to this content
      Erratum (page 2380)

      Version of Record online: 27 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03214.x

      This article corrects:
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      Erratum (pages 2381–2382)

      Version of Record online: 17 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03296.x

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      This article corrects:

      Immune Reconstitution Following Rabbit Antithymocyte Globulin

      Vol. 10, Issue 9, 2132–2141, Version of Record online: 27 AUG 2010

      Corrected by:

      Erratum

      Vol. 10, Issue 12, 2728, Version of Record online: 9 NOV 2010

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