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American Journal of Transplantation

Cover image for Vol. 10 Issue 12

December 2010

Volume 10, Issue 12

Pages 2563–2730, E1–E1

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 2563–2564)

      SUE PONDROM

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03344.x

      This month, “The AJT Report” explores the state of transplantation in Europe, takes a look at two recent live liver donor deaths, and highlights some hot topics covered at the first joint meeting of the European Society for Organ Transplantation and the American Society of Transplantation.

  2. Letter from AST and ASTS

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      Letter from AST and ASTS (page 2565)

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03345.x

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      Therapeutic Potential for CD39 in Renal Transplantation: There is Hope (pages 2567–2568)

      V. E. Laubach

      Version of Record online: 25 OCT 2010 | DOI: 10.1111/j.1600-6143.2010.03300.x

      Delivery of soluble CD39, or CD39-like molecules, may offer a clinical therapeutic strategy for combating ischemia reperfusion injury. See article by Crikis et al on page 2586.

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      Sirolimus and Kidney Transplantation: Unraveling an Inflammatory Affair (pages 2569–2570)

      T. Weichhart and M. D. Säemann

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03306.x

      The authors consider the effects of sirolimus on the innate immune system in renal transplant patients. See article by Brouard et al on page 2604.

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      The Noninferiority Trial: Don't Don't Do It (pages 2571–2573)

      T. R. Srinivas, B. Kaplan and H.-U. Meier-Kriesche

      Version of Record online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03323.x

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      The authors point out the complexities in the design and interpretation of the noninferiority trial. See article by Krämer et al on page 2632.

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      Living Donor Nephrectomy: Understanding Long-Term Risk in Minority Populations (pages 2574–2576)

      R. S. Gaston and C. J. Young

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03324.x

      An important study by Lentine and colleagues (NEJM 363: 724, 2010) informs the ongoing debate regarding evaluation and follow-up of living kidney donors.

  4. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      When Disaster Strikes: Death of a Living Organ Donor (pages 2577–2581)

      L. E. Ratner and P. R. Sandoval

      Version of Record online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03341.x

      The authors opine that risks for living donors have not been absolutely minimized, in particular due to insufficient review, analysis and dissemination of new insights to the transplant community when a donor death or adverse event occurs.

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      Enhancing the Expanded Criteria Donor Policy as an Intervention to Improve Kidney Allocation: Is It Actually a ’Net-Zero’ Model? (pages 2582–2585)

      J. D. Schold and Y. N. Hall

      Version of Record online: 10 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03320.x

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      It is the authors' view that more uniform implementation of ECD policy could improve efficiency and effectiveness of deceased donor kidney allocation without deleteriously impacting equity.

  5. Original Articles

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. Laboratory Science

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      Transgenic Overexpression of CD39 Protects Against Renal Ischemia-Reperfusion and Transplant Vascular Injury (pages 2586–2595)

      S. Crikis, B. Lu, L. M. Murray-Segal, C. Selan, S. C. Robson, A. J. F. D’Apice, H. H. Nandurkar, P. J. Cowan and K. M. Dwyer

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03257.x

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      The authors find that transgenic overexpression of hCD39 confers protection in two mouse models of ischemia reperfusion injury. See editorial by Laubach on page 2567.

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      L-Selectin Is Dispensable for T Regulatory Cell Function Postallogeneic Bone Marrow Transplantation (pages 2596–2603)

      M. J. Carlson, L. M. Fulton, J. M. Coghill, M. L. West, J. E. Burgents, Y. Wan, A. Panoskaltsis-Mortari, T. F. Tedder, B. R. Blazar and J. S. Serody

      Version of Record online: 10 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03319.x

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      The authors demonstrate that regulatory T cells do not need to express CD62L to prevent GVHD.

    3. Clinical Science

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      Comparative Transcriptional and Phenotypic Peripheral Blood Analysis of Kidney Recipients Under Cyclosporin A or Sirolimus Monotherapy (pages 2604–2614)

      S. Brouard, I. Puig-Pey, J.-J. Lozano, A. Pallier, C. Braud, M. Giral, M. Guillet, M. C. Londoño, F. Oppenheimer, J. M. Campistol, J.-P. Soulillou and A. Sanchez-Fueyo

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03302.x

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      The authors report molecular profiling of patients under isolated cyclosporin A and sirolimus treatment. See editorial by Weichhart and Säemann on page 2569.

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      Reducing Immunosuppression Preserves Allograft Function in Presumptive and Definitive Polyomavirus-Associated Nephropathy (pages 2615–2623)

      S. Schaub, H. H. Hirsch, M. Dickenmann, J. Steiger, M. J. Mihatsch, H. Hopfer and M. Mayr

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03310.x

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      This study indicates that the strategy of early detection of BK-viremia and reduction of immunosuppression preserves allograft function even in patients developing definitive polyomavirus-associated nephropathy.

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      Association Of Marital Status With Access To Renal Transplantation (pages 2624–2631)

      M. W. Khattak, G. S. Sandhu, R. Woodward, J. S. Stoff and A. S. Goldfarb-Rumyantzev

      Version of Record online: 10 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03318.x

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      The authors evaluate the association of marital status with access to renal transplantation and demonstrate that being married is associated with better access to renal transplantation compared to never being married or being widowed.

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      Tacrolimus Once Daily (ADVAGRAF) Versus Twice Daily (PROGRAF) in De Novo Renal Transplantation: A Randomized Phase III Study (pages 2632–2643)

      B. K. Krämer, B. Charpentier, L. Bäckman, H. Tedesco Silva Jr, G. Mondragon-Ramirez, E. Cassuto-Viguier, G. Mourad, R. Sola, P. Rigotti, J. Ortuno Mirete and for the Tacrolimus Prolonged Release Renal Study Group

      Version of Record online: 14 SEP 2010 | DOI: 10.1111/j.1600-6143.2010.03256.x

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      This international, multicenter, randomized, double-blind, double-dummy, phase III study finds that once-daily, prolonged-release tacrolimus has therapeutic equivalence and a comparable safety profile to twice-daily tacrolimus in renal transplant recipients. See editorial by Srinivas et al on page 2571.

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      Body Mass Index, Waist Circumference and Mortality in Kidney Transplant Recipients (pages 2644–2651)

      C. P. Kovesdy, M. E. Czira, A. Rudas, A. Ujszaszi, L. Rosivall, M. Novak, K. Kalantar-Zadeh, M. Z. Molnar and I. Mucsi

      Version of Record online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03330.x

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      The authors examine the association of waist circumference and of body mass index (BMI) with all-cause mortality in a large prospective cohort of kidney transplant recipients, and find that higher waist circumference is associated with higher mortality, while higher BMI is associated with lower mortality.

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      Impact of MELD on Waitlist Outcome of Retransplant Candidates (pages 2652–2657)

      H. J. Kim, J. J. Larson, Y. S. Lim, W. R. Kim, R. A. Pedersen, T. M. Therneau and C. B. Rosen

      Version of Record online: 10 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03315.x

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      In this evaluation of the MELD score in patients awaiting repeat liver transplantation, the authors find that primary and repeat liver transplant candidates fare equitably under the current MELD-based allocation system.

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      Height Contributes to the Gender Difference in Wait-List Mortality Under the MELD-Based Liver Allocation System (pages 2658–2664)

      J. C. Lai, N. A. Terrault, E. Vittinghoff and S. W. Biggins

      Version of Record online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03326.x

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      This analysis of the current liver allocation system demonstrates that women have a 19% increased risk of wait-list mortality compared to men with the same MELD scores, and that height contributes to this gender disparity.

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      Use of Tissue Plasminogen Activator in Liver Transplantation from Donation After Cardiac Death Donors (pages 2665–2672)

      K. Hashimoto, B. Eghtesad, G. Gunasekaran, M. Fujiki, T. D. Uso, C. Quintini, F. N. Aucejo, D. M. Kelly, C. G. Winans, D. P. Vogt, B. M. Parker, S. A. Irefin, C. M. Miller and J. J. Fung

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03337.x

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      The authors report on the use of donor intra-arterial recombinant tissue plasminogen activator to lower the risk of ischemic-type biliary strictures following liver transplantation from donation after cardiac death donors.

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      Glomerular Filtration Rate Following Pediatric Liver Transplantation—The SPLIT Experience (pages 2673–2682)

      K. Campbell, V. Ng, S. Martin, J. Magee, J. Goebel, R. Anand, K. Martz, J. Bucuvalas and the SPLIT Renal Function Working Group

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03316.x

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      This multicenter study from the SPLIT (Studies in Pediatric Liver Transplantation) group uses measured glomerular filtration rate to define the prevalence of decreased kidney function in 397 pediatric liver transplant patients and identifies risk factors associated with decreased kidney function in this population.

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      Rotavirus Infection in Adult Small Intestine Allografts: A Clinicopathological Study of a Cohort of 23 Patients (pages 2683–2689)

      O. A. Adeyi, G. Costa, K. M. Abu-Elmagd and T. Wu

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03311.x

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      The authors report on rotavirus enteritis presenting in 23 small bowel allograft recipients, its association with acute cellular rejection, and its sequelae once controlled.

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      Improved Function of Circulating Angiogenic Cells Is Evident in Type 1 Diabetic Islet-Transplanted Patients (pages 2690–2700)

      A. Petrelli, A. Maestroni, G. P. Fadini, D. Belloni, M. Venturini, M. Albiero, S. Kleffel, B. G. Mfarrej, A. Del Maschio, P. Maffi, A. Avogaro, E. Ferrero, G. Zerbini, A. Secchi and P. Fiorina

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03309.x

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      The authors demonstrate that circulating angiogenic cells have increased in vitro apoptosis, altered IL-8 production and defective angiogenic ability in type-1 diabetics, and that these defects are normalized following islet transplantation.

  6. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      Transplant Center Provision of Education and Culturally and Linguistically Competent Care: A National Study (pages 2701–2707)

      E. J. Gordon, J. C. Caicedo, D. P. Ladner, E. Reddy and M. M. Abecassis

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03304.x

      The authors survey US transplant administrators about education provided concerning kidney transplantation and living donation, and find that most administrators report formal pre-evaluation education sessions but only half report sessions promoting living donation as the best treatment option.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      Robotic-Assisted Laparoscopic Donor Nephrectomy with Transvaginal Extraction of the Kidney (pages 2708–2711)

      A. Pietrabissa, M. Abelli, A. Spinillo, M. Alessiani, S. Zonta, E. Ticozzelli, A. Peri, A. Dal Canton and P. Dionigi

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03305.x

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      The authors report the first case of transvaginal extraction of a kidney in a donor with an intact uterus.

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      Liver and Vascularized Posterior Rectus Sheath Fascia Composite Tissue Allotransplantation (pages 2712–2716)

      S. Agarwal, A. H. Dorafshar, R. C. Harland, J. M. Millis and L. J. Gottlieb

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03331.x

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      The authors describe an approach toward abdominal wall closure of a pediatric kidney and liver transplant recipient that involves transferring donor vascularized posterior rectus sheath fascia in continuity with the donor liver.

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      Preserved Endocrine Function in a Pancreas Transplant Recipient with Pancreatic Panniculitis and Antibody-Mediated Rejection (pages 2717–2722)

      M. Prikis, D. Norman, S. Rayhill, A. Olyaei, M. Troxell and A. Mittalhenkle

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03332.x

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      The authors describe a case of preserved endocrine function in a pancreas transplant recipient with pancreatic panniculitis and antibody-mediated rejection.

  8. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      Rituximab May Not Lead to Increased Infection Rates in Transplant Recipients (pages 2723–2724)

      M. Drage, V. Hadjianastassiou, A. Dorling and N. Mamode

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03195.x

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      First Case of Toxocara Eosinophilic Ascites After Combined Pancreas and Kidney Transplantation (page 2727)

      S. Schaffellner, D. Wagner, M. Sereinigg, E. Jakoby, D. Kniepeiss, P. Stiegler, T. Valentin, F. Iberer and K.H. Tscheliessnigg

      Version of Record online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03325.x

    4. Online only

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  9. Errata

    1. Top of page
    2. The AJT Report
    3. Letter from AST and ASTS
    4. Editorials
    5. Personal Viewpoints
    6. Original Articles
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Errata
    1. You have free access to this content
      Erratum (page 2728)

      Version of Record online: 9 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03343.x

      This article corrects:

      Erratum

      Vol. 10, Issue 10, 2381–2382, Version of Record online: 17 SEP 2010

      This article corrects:

      Immune Reconstitution Following Rabbit Antithymocyte Globulin

      Vol. 10, Issue 9, 2132–2141, Version of Record online: 27 AUG 2010

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      Erratum (page 2729)

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03346.x

      This article corrects:

      Hypothermia – a Limiting Factor in Using Warm Ischemically Damaged Kidneys

      Vol. 1, Issue 4, 316–320, Version of Record online: 5 APR 2002

      This article corrects:
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      Erratum (page 2730)

      Version of Record online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03347.x

      This article corrects:

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