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American Journal of Transplantation

Cover image for Vol. 10 Issue 4

April 2010

Volume 10, Issue 4

Pages 708–957

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 708–710)

      SUE PONDROM

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2009.03058.x

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      “The AJT Report” explores possible safety concerns over generic immunosuppressants. We also examine new 2009 UNOS data and revisit Australia's organ donation program.

  2. Editorial

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
    1. You have free access to this content
      Educating Kidney Transplant Professionals and Candidates May Improve Utilization, Allocation Efficiency and Lifetime Survival (pages 711–712)

      K. A. Andreoni

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03048.x

      Is the answer to more appropriate use of ECD Kidney Grafts as reviewed by Grams et al in this publication better education of transplant professionals and patients? See article by Grams et al on page 802.

  3. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
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      MicroRNAs as Immune Regulators: Implications for Transplantation (pages 713–719)

      A. Harris, S. M. Krams and O. M. Martinez

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03032.x

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      The biogenesis, function, and analysis of microRNA will become increasingly relevant to transplantation.

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      Recurrent Primary Biliary Cirrhosis After Liver Transplantation (pages 720–726)

      M. G. Silveira, J. A. Talwalkar, K. D. Lindor and R. H. Wiesner

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03038.x

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      Recurrent primary biliary cirrhosis is a frequent clinical outcome after liver transplantation in selected patients, though only a few individuals to date have developed end-stage liver disease leading to death or requiring hepatic re-transplantation.

  4. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
    1. You have free access to this content
      Transplantation and Mental Retardation: What Is the Meaning of a Discrimination? (pages 727–730)

      N. Panocchia, M. Bossola and G. Vivanti

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03052.x

      Patients with mental retardation should not be excluded a priori from solid organ transplantation: every patient deserves an individual evaluation.

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      What the Medical Excuse Teaches Us About the Potential Living Donor as Patient (pages 731–736)

      L. F. Ross

      Article first published online: 3 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.03010.x

      Although a false medical excuse is morally unjustifiable, a medical excuse understood as a “general statement of lack of suitability” is morally permissible because it promotes donor autonomy, and protects and preserves the donor's rights to privacy and confidentiality.

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      ‘Normal for Now’ or ‘At Future Risk’: A Double Standard for Selecting Young and Older Living Kidney Donors (pages 737–741)

      R. W. Steiner

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03023.x

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      Young, normal, “acceptable” kidney donor candidates may be at higher pre-donation lifetime risk for ESRD than are middle-aged donors with mild hypertension, whose lifetime risk for ESRD is judged “unacceptable.”

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      Good Ethics Requires Good Science: Why Transplant Programs Should NOT Disclose Misattributed Parentage (pages 742–746)

      L. F. Ross

      Article first published online: 3 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.03011.x

      Transplant professionals should not disclose misattributed parentage because the tests used to establish living donor-recipient compatibility are inadequate to accurately determine misattributed paternity, and it is not the responsibility of the transplant professionals to undertake such serious forensic evaluations.

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      The System of Health Insurance for Living Donors Is a Disincentive for Live Donation (pages 747–750)

      E. S. Ommen and J. S. Gill

      Article first published online: 29 JAN 2010 | DOI: 10.1111/j.1600-6143.2009.02994.x

      As Americans debate the issue of universal health insurance, this opinion piece argues that provision of basic medical insurance is a necessity for living donation and that the system of attributing donor costs to the recipient's insurance is inefficient, has the potential to undermine the care of living donors, and is a disincentive to the expansion of living donation.

  5. Laboratory Science

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
    1. Original Articles

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      Treg-Therapy Allows Mixed Chimerism and Transplantation Tolerance Without Cytoreductive Conditioning (pages 751–762)

      N. Pilat, U. Baranyi, C. Klaus, E. Jaeckel, N. Mpofu, F. Wrba, D. Golshayan, F. Muehlbacher and T. Wekerle

      Article first published online: 10 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03018.x

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      In mice, administration of polyclonal recipient Tregs together with rapamycin obviates the need for irradiation in costimulation blockade-based fully allogeneic bone marrow transplantation.

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      Ex vivo Application of Carbon Monoxide in UW Solution Prevents Transplant-Induced Renal Ischemia/Reperfusion Injury in Pigs (pages 763–772)

      J. Yoshida, K. S. Ozaki, M. A. Nalesnik, S. Ueki, M. Castillo-Rama, G. Faleo, M. Ezzelarab, A. Nakao, B. Ekser, G. J. Echeverri, M. A. Ross, D. B. Stolz and N. Murase

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03040.x

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      Porcine kidney grafts preserved in CO-containing UW solution are protected from ischemia/reperfusion injury and have improved function after transplantation compared to those with untreated UW solution.

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      Investigation of Lymphocyte Depletion and Repopulation Using Alemtuzumab (Campath-1H) in Cynomolgus Monkeys (pages 773–783)

      D. J. Van Der Windt, C. Smetanka, C. Macedo, J. He, R. Lakomy, R. Bottino, B. Ekser, G. J. Echeverri, D. Metes, J. N. M. Ijzermans, M. Trucco, D. K. C. Cooper and F. G. Lakkis

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03050.x

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      Alemtuzumab administered to nonhuman primates that are negative for CD52 on erythrocytes achieves excellent lymphocyte depletion while avoiding hemolysis.

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      Inhibition of Matrix Metalloproteinase-9 Attenuates Acute Small-for-Size Liver Graft Injury in Rats (pages 784–795)

      Z. Y. Ma, J. M. Qian, X. H. Rui, F. R. Wang, Q. W. Wang, Y. Y. Cui and Z. H. Peng

      Article first published online: 29 JAN 2010 | DOI: 10.1111/j.1600-6143.2009.02993.x

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      Inhibition of matrix metalloproteinase-9 with CTT-peptide attenuates acute small-for-size liver graft injury.

    5. Brief Communication

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      An Unexpected Counter-Regulatory Role of IL-10 in B-Lymphocyte-Mediated Transplantation Tolerance (pages 796–801)

      G. Zhao, D. J. Moore, K. M. Lee, J. I. Kim, P. E. Duff, M. R. O’Connor, T. Hirohashi, J. Lei, M. Yang, J. F. Markmann and S. Deng

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03027.x

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      Although regulatory B cells are thought to prevent autoimmunity by production of IL-10, neutralization of IL-10 by antibody blockade or gene disruption unexpectedly enhanced induction of B cell-dependent tolerance to cardiac allografts by anti-CD45RB and improved chronic allograft vasculopathy.

  6. Clinical Science

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
    1. Original Articles

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      Listing for Expanded Criteria Donor Kidneys in Older Adults and Those with Predicted Benefit (pages 802–809)

      M. E. Grams, K. L. Womer, R. M. Ugarte, N. M. Desai, R. A. Montgomery and D. L. Segev

      Article first published online: 10 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03020.x

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      This national study of UNOS kidney transplant registrants finds wide variations in ECD listing practices that are not necessarily consistent with published recommendations of subgroups likely to benefit from these organs. See editorial by Andreoni on page 711.

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      Defining the Canonical Form of T-Cell-Mediated Rejection in Human Kidney Transplants (pages 810–820)

      K. S. Famulski, G. Einecke, B. Sis, M. Mengel, L. G. Hidalgo, B. Kaplan and P. F. Halloran

      Article first published online: 3 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.03007.x

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      IFN-gamma effects and alternative macrophage activation are features of severe T cell mediated rejection in human kidney transplant biopsies providing a method for identifying T cell mediated rejection independent of histopathology.

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      Altruistic Donor Triggered Domino-Paired Kidney Donation for Unsuccessful Couples from the Kidney-Exchange Program (pages 821–827)

      J. I. Roodnat, W. Zuidema, J. Van De Wetering, M. De Klerk, R. A. M. Erdman, E. K. Massey, M. T. Hilhorst, J. N. M. IJzermans and W. Weimar

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03034.x

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      In our Domino-paired donation program, the availability of 51 altruistic donors and 35 difficult to match incompatible couples, eventually led to 86 transplants, including 51 donations to patients on the waiting list.

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      A Randomized Trial to Assess the Impact of Early Steroid Withdrawal on Growth in Pediatric Renal Transplantation: The TWIST Study (pages 828–836)

      R. Grenda, A. Watson, R. Trompeter, B. Tönshoff, J. Jaray, M. Fitzpatrick, L. Murer, K. Vondrak, H. Maxwell, R. Van Damme-Lombaerts, C. Loirat, E. Mor, P. Cochat, D. V. Milford, M. Brown and N. J. A. Webb

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03047.x

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      TWIST trial provides evidence that early steroid withdrawal following abbreviated daclizumab induction and TAC/MMF maintenance immunosuppression improves growth rate in children as early as 6 months after renal transplantation.

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      Systematic Evaluation of Pancreas Allograft Quality, Outcomes and Geographic Variation in Utilization (pages 837–845)

      D. A. Axelrod, R. S. Sung, K. H. Meyer, R. A. Wolfe and D. B. Kaufman

      Article first published online: 1 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.02996.x

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      The Pancreas Donor Risk Index identifies factors associated with graft loss following transplantation which appear to differentially affect pancreas allograft survival in isolated transplants compared with simultaneous kidney-pancreas transplant.

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      Pancreatic Graft Survival Despite Partial Vascular Graft Thrombosis due to Splenocephalic Anastomoses (pages 846–851)

      C. Margreiter, W. Mark, D. Wiedemann, R. Sucher, R. Öllinger, C. Bösmüller, M. Freund, H. T. Maier, A. Greiner, H. Fritsch, J. Pratschke, R. Margreiter and F. Aigner

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03060.x

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      With data from both anatomical and clinical observational studies, the authors highlight the relevance of intraparenchymal anastomoses of the pancreas for graft survival despite partial Y-graft thrombosis after pancreas transplantation.

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      Cyclosporine A Protects Against Primary Biliary Cirrhosis Recurrence After Liver Transplantation (pages 852–858)

      A. J. Montano-Loza, S. Wasilenko, J. Bintner and A. L. Mason

      Article first published online: 3 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.03006.x

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      Liver transplant recipients receiving cyclosporine have a lower risk of recurrence of primary biliary cirrhosis, but recurrence did not impact long-term patient survival.

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      Alleviating the Burden of Small-for-Size Graft in Right Liver Living Donor Liver Transplantation Through Accumulation of Experience (pages 859–867)

      S. C. Chan, C. M. Lo, K. K. C. Ng and S. T. Fan

      Article first published online: 10 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03017.x

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      Through accumulation of experience in living donor liver transplantation, graft survival is excellent even when grafts are small-for-size.

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      Risk of Colorectal Carcinoma in Post-Liver Transplant Patients: A Systematic Review and Meta-analysis (pages 868–876)

      J. Sint Nicolaas, V. De Jonge, E. W. Steyerberg, E. J. Kuipers, M. E. Van Leerdam and S. J. O. Veldhuyzen-van Zanten

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03049.x

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      This meta-analysis of the risk of colorectal cancer (CRC) in liver transplant patients found an increased relative risk for CRC for the overall as well as the non-PSC transplant patients compared to the weighted age-matched general population.

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      Low Central Venous Pressure with Milrinone During Living Donor Hepatectomy (pages 877–882)

      H.-G. Ryu, F. S. Nahm, H.-M. Sohn, E.-J. Jeong and C.-W. Jung

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03051.x

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      Milrinone-induced low CVP improves the surgical field during living donor hepatectomy.

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      Once Daily Calcineurin Inhibitor Monotherapy in Pediatric Liver Transplantation (pages 883–888)

      U. D. Ekong, H. Bhagat and E. M. Alonso

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03061.x

      Successful initiation of once-daily calcineurin inhibitor monotherapy in pediatric liver transplant recipients results in significant improvement in calculated creatinine clearance at 1 and 2 years following dose change.

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      Nucleic Acid Testing (NAT) of Organ Donors: Is the ‘Best’ Test the Right Test? A Consensus Conference Report (pages 889–899)

      A. Humar, M. Morris, E. Blumberg, R. Freeman, J. Preiksaitis, B. Kiberd, E. Schweitzer, S. Ganz, A. Caliendo, J. P. Orlowski, B. Wilson, C. Kotton, M. Michaels, S. Kleinman, S. Geier, B. Murphy, M. Green, M. Levi, G. Knoll, D. Segev, S. Brubaker, R. Hasz, D. J. Lebovitz, D. Mulligan, K. O’Connor, T. Pruett, M. Mozes, I. Lee, F. Delmonico and S. Fischer

      Article first published online: 29 JAN 2010 | DOI: 10.1111/j.1600-6143.2009.02992.x

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      This consensus report outlines several issues surrounding optimal testing of potential donors for HIV, HCV and HBV and includes suggestions regarding the use of Nucleic Acid Testing, its advantages and disadvantages, and areas for further research.

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      Receptor for Advanced Glycation End Products in Donor Lungs Is Associated with Primary Graft Dysfunction After Lung Transplantation (pages 900–907)

      A. Pelaez, S. D. Force, A. A. Gal, D. C. Neujahr, A. M. Ramirez, P. M. Naik, D.A. Quintero, A. V. Pileggi, K. A. Easley, R. Echeverry, E. C. Lawrence, D. M. Guidot and P. O. Mitchell

      Article first published online: 1 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.02995.x

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      Lung transplant recipients may be at higher risk for developing primary graft dysfunction if their corresponding donor lungs have higher levels of soluble receptor for advanced glycation end products (sRAGE).

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      Neurological Complications Following Adult Lung Transplantation (pages 908–914)

      F. J. Mateen, R. A. Dierkhising, A. A. Rabinstein, D. Van De Beek and E. F. M. Wijdicks

      Article first published online: 1 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.02998.x

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      Neurological complications affect 92% of lung-transplant recipients within 10 years, with perioperative stroke and encephalopathy being the most common severe complications.

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      Increasing Lung Allocation Scores Predict Worsened Survival Among Lung Transplant Recipients (pages 915–920)

      V. Liu, M. R. Zamora, G. S. Dhillon and D. Weill

      Article first published online: 1 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.03003.x

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      This retrospective study of patients receiving lung transplantation after the implementation of the Lung Allocation Score reveals that only those with scores of 60 or greater are at an increased risk of death; the risk of death differed based on underlying diagnosis.

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      The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts (pages 921–930)

      K. A. Williams, T-L. Kelly, M. T. Lowe, D. J. Coster and on behalf of all contributors to the Australian Corneal Graft Registry

      Article first published online: 1 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.03002.x

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      Analyses of outcomes in 1,476 recipients of bilateral corneal transplants followed in a national register indicate that a patient who suffers a rejection episode in either graft is then at significantly greater odds of suffering a rejection episode in the corneal graft in the other eye.

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      How Different Conceptions of Risk Are Used in the Organ Market Debate (pages 931–937)

      A. Aronsohn, J. R. Thistlethwaite, Jr., D. L. Segev and L. F. Ross

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03035.x

      Renal and hepatic transplant physicians and surgeons, overwhelmingly reject the legalization of living donor organ markets (80% for kidneys and 90% for liver lobes) with risk to the donor listed among the most important factors both by supporters and opponents of a market approach.

    18. Brief Communication

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      Elevated Incidence of Posttransplant Erythrocytosis After Simultaneous Pancreas Kidney Transplantation (pages 938–942)

      G. Guerra, R. Indahyung, C. M. Bucci, J. D. Schold, J. F. Magliocca and H.-U. Meier-Kriesche

      Article first published online: 10 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03012.x

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      Combined Kidney Pancreas transplantation is associated with an increased incidence of polycythemia.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
    1. You have free access to this content
      Immediate Posttransplantation Cotrimoxazole-Induced Immune Thrombocytopenia (pages 943–946)

      R. Caluwé, S. Van Laecke, M.-P. Emonds, P. Peeters and R. Vanholder

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03028.x

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      Drug-induced immune thrombocytopenia should be considered when confronted with thrombocytopenia early after transplantation, with cotrimoxazole as one of the most likely causative agents due to its intensive use in the field of transplantation.

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      EBV-Associated Leukoencephalopathy with Late Onset of Central Nervous System Lymphoma in a Kidney Transplant Recipient (pages 947–951)

      A. Vaglio, L. Manenti, C. Mancini, E. Chierici, R. Cobelli, F. Bacci, A. Palmisano, C. Buzio, L. Bignardi and U. Maggiore

      Article first published online: 20 MAR 2010 | DOI: 10.1111/j.1600-6143.2009.02999.x

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      EBV-associated leukoencephalopathy, a rare post-transplant neurological complication, may precede the development of CNS lymphoma.

  8. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorial
    4. Minireviews
    5. Personal Viewpoints
    6. Laboratory Science
    7. Clinical Science
    8. Case Reports
    9. Letters to the Editor
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      Response to O’Connell and Colleagues (page 955)

      M. Hornum, M. Iversen and B. Feldt-Rasmussen

      Article first published online: 10 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03014.x

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      Proinflammatory Events and HLA Antibodies (page 956)

      A. A. Zachary, R. A. Montgomery, J. E. Locke and M. S. Leffell

      Article first published online: 10 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03013.x

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      Response to Proinflammatory Events and HLA Antibodies (page 957)

      K. E. Kokko, R. A. Bray, P. W. Nickerson and H. M. Gebel

      Article first published online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03031.x

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