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American Journal of Transplantation

Cover image for Vol. 10 Issue 6

June 2010

Volume 10, Issue 6

Pages 1339–1496

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1339–1340)

      SUE PONDROM

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03158.x

      This month “The AJT Report” takes a look at a new policy in the works for the U.S. organ allocation system, and reviews a lawsuit that challenges the constitutionality of NOTA's ban on compensation for bone marrow donors, which could influence solid organ donation policy.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
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      Is Extracorporeal Support Becoming the New Standard for the Preservation of DCD Grafts? (pages 1341–1342)

      C. Fondevila

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03134.x

      While normothermic extracorporeal support is a promising alternative to reduce ischemic injury in DCD grafts, further clinical studies are needed to evaluate its true impact on outcomes. See article by Rojas-Pena et al on page 1365.

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      The Importance of Skin Cancer Prevention in Organ Transplant Patients An Editorial to Paper by Salgo: ‘Switch to Sirolimus in Long-Term Renal Transplant Recipients: Reduced Premalignancies and Nonmelanoma Skin Cancer in a Controlled, Prospective, Randomized, Blinded Study’ (pages 1343–1344)

      C. Mitchell

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03133.x

      Renal transplant patients should be managed by dermatologists to prevent and manage skin cancer, a common cause of morbidity and mortality in organ transplant patients. See article by Salgo et al on page 1385.

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      Living Donor Kidney Donation in the United States: Quo Vadis? (pages 1345–1346)

      G. Danovitch, J. Veale and B. Hippen

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03097.x

      Editorial comment on the ethical concerns raised by Woodle, et al regarding a policy of preferentially allocating kidneys from non-directed living donors to facilitate paired-exchange and chain transplantation. See article by Woodle et al on page 1460.

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      Giving Birth to an Operation: Laparoscopic Live Donor Nephrectomy with Vaginal Extraction. Is This Misconceived? (pages 1347–1348)

      L. E. Ratner and M. D. Pescovitz

      Article first published online: 26 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03084.x

      Vaginal extraction of the kidney: the start of something new or only a case report? See article by Allaf et al on page 1473.

  3. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
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      The International Normalized Ratio (INR) in the MELD Score: Problems and Solutions (pages 1349–1353)

      R. J. Porte, T. Lisman, A. Tripodi, S. H. Caldwell, J. F. Trotter and the Coagulation in Liver Disease Study Group

      Article first published online: 19 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03064.x

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      Possible solutions to reduce the intralaboratory variation of the INR measured to calculate the MELD score of liver transplant candidates are discussed.

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      Natural Killer Cells and the Immune Response in Solid Organ Transplantation (pages 1354–1358)

      W. Van Der Touw and J. S. Bromberg

      Article first published online: 26 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03086.x

      Knowledge demonstrating the inflammatory as well as regulatory roles of natural killer cells in solid organ transplantation is discussed, drawing from other immune models to provide mechanistic insight.

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      Valganciclovir: Recent Progress (pages 1359–1364)

      M. D. Pescovitz

      Article first published online: 28 APR 2010 | DOI: 10.1111/j.1600-6143.2010.03112.x

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      Valganciclovir is now widely used for prevention of cytomegalovirus infection after transplantation. This paper reviews the recent data on efficacy for treatment, extended prophylaxis in high-risk patients and use in children.

  4. Laboratory Science

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
    1. Original Articles

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      Extracorporeal Support: Improves Donor Renal Graft Function After Cardiac Death (pages 1365–1374)

      A. Rojas-Pena, J. L. Reoma, E. Krause, E. L. Boothman, N. P. Padiyar, K. E. Cook, R. H. Bartlett and J. D. Punch

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03063.x

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      Extracorporeal support during organ procurement from donors after cardiac arrest is able to resuscitate kidneys to transplantable status with immediate graft function after 30 minutes of warm ischemia/cardiac arrest. See editorial by Fondevila on page 1341.

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      Phenotype, Distribution and Alloreactive Properties of Memory T Cells from Cynomolgus Monkeys (pages 1375–1384)

      Ognjenka Nadazdin, Svjetlan Boskovic, Toru Murakami, D. H. O’Connor, Roger W. Wiseman, J. A. Karl, J. J. Tuscher, D. H. Sachs, J. C. Madsen, Georges Tocco, Tatsuo Kawai, A. B. Cosimi and Gilles Benichou

      Article first published online: 14 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03119.x

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      This study analyzes the frequencies and functional properties of alloreactive memory T cells in non-human primates.

  5. Clinical Science

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
    1. Original Articles

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      Switch to a Sirolimus-Based Immunosuppression in Long-Term Renal Transplant Recipients: Reduced Rate of (Pre-)Malignancies and Nonmelanoma Skin Cancer in a Prospective, Randomized, Assessor-Blinded, Controlled Clinical Trial (pages 1385–1393)

      R. Salgo, J. Gossmann, H. Schöfer, H. G. Kachel, J. Kuck, H. Geiger, R. Kaufmann and E. H. Scheuermann

      Article first published online: 1 FEB 2010 | DOI: 10.1111/j.1600-6143.2009.02997.x

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      This single-center trial found that switching long-term renal transplant recipients to sirolimus inhibits the progression of premalignancies of the skin and reduces the occurance of new NMSC compared to continuation of the original immunosuppressive therapy. See editorial by Mitchell 1343.

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      Patient Willingness to Pay for a Kidney for Transplantation (pages 1394–1400)

      D. K. Herold

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03113.x

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      ESRD patients were surveyed on their willingness to pay for a kidney for transplantation with 78.5% being willing to pay and men, patients with poor/fair health status, and those with household incomes ≥$50,000 most willing to pay.

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      Everolimus Plus Reduced-Exposure CsA versus Mycophenolic Acid Plus Standard-Exposure CsA in Renal-Transplant Recipients (pages 1401–1413)

      H. Tedesco Silva Jr., D. Cibrik, T. Johnston, E. Lackova, K. Mange, C. Panis, R. Walker, Z. Wang, G. Zibari and Y. S. Kim

      Article first published online: 28 APR 2010 | DOI: 10.1111/j.1600-6143.2010.03129.x

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      Everolimus plus progressively reduced CsA exposure yields similar efficacy and renal function compared with standard-exposure CsA plus MPA in de-novo renal-transplant recipients at 1 year.

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      Successful Salvage of Kidney Allografts Threatened by Ureteral Stricture Using Pyelovesical Bypass (pages 1414–1419)

      R. A. Azhar, M. Hassanain, M. AlJiffry, S. Aldousari, T. Cabrera, S. Andonian, P. Metrakos, M. Anidjar and S. Paraskevas

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03137.x

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      In 7 of 8 kidney transplants with refractory ureteral strictures, subcutaneous pyelovesical bypass graft using an artificial ureter resulted in good long-term function without evidence of obstruction or infection.

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      Evolution of Causes and Risk Factors for Mortality Post-Liver Transplant: Results of the NIDDK Long-Term Follow-Up Study (pages 1420–1427)

      K. D. S. Watt, R. A. Pedersen, W. K. Kremers, J. K. Heimbach and M. R. Charlton

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03126.x

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      A multicentered prospectively obtained transplant cohort analyzed for long-term outcomes with an in-depth analysis of risk factors showed diabetes and renal failure both pre- and post-transplant are strongly associated with increased mortality.

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      Systemic Markers of Inflammation Are Associated with Cardiac Allograft Vasculopathy and an Increased Intimal Inflammatory Component (pages 1428–1436)

      S. Arora, A. Gunther, B. Wennerblom, T. Ueland, A. K. Andreassen, E. Gude, K. Endresen, O. Geiran, N. Wilhelmsen, R. Andersen, P. Aukrust and L. Gullestad

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03118.x

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      Advanced cardiac allograft vasculopathy determined by intravascular ultrasound/virtual histology analysis is associated with an inflammatory signature comprising of elevated C-reactive protein, vascular cell adhesion molecule-1 and neopterin.

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      How Safe Is It to Transplant Organs from Deceased Donors with Primary Intracranial Malignancy? An Analysis of UK Registry Data (pages 1437–1444)

      C. J. E. Watson, R. Roberts, K. A. Wright, D. C. Greenberg, B. A. Rous, C. H. Brown, C. Counter, D. Collett and J. A. Bradley

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03130.x

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      In a review of 179 donors with a history of intracranial malignancy in the UK, there was no transmission to the 448 recipients of 495 organs.

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      Encouraging Psychological Outcomes After Altruistic Donation to a Stranger (pages 1445–1452)

      E. K. Massey, L. W. Kranenburg, W. C. Zuidema, G. Hak, R. A. M. Erdman, M. Hilhorst, J. N. M. IJzermans, J. J. Busschbach and W. Weimar

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03115.x

      Interviews with 24 altruistic donors revealed genuine motives, high satisfaction and stable psychological well-being after donation to a stranger.

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      Outcome Evaluation of ‘Sharing the Gift of Life’: An Organ and Tissue Donation Educational Program for American Indians (pages 1453–1459)

      N. L. Fahrenwald, C. Belitz and A. Keckler

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03120.x

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      This test of a culturally-derived deceased organ donor educational program for American Indians resulted in significant changes in intention to serve as a deceased donor.

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      Ethical Considerations for Participation of Nondirected Living Donors in Kidney Exchange Programs (pages 1460–1467)

      E. S. Woodle, J. A. Daller, M. Aeder, R. Shapiro, T. Sandholm, V. Casingal, D. Goldfarb, R. M. Lewis, J. Goebel, M. Siegler and for the Paired Donation Network

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03136.x

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      A detailed ethical analysis regarding participation of non-directed donors in kidney exchange programs, including chain exchanges, found that multiple unique ethical challenges are raised that require specific protections to prevent undue harm. See editorial by Danovitch et al on page 1345.

  6. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
    1. You have free access to this content
      Foreigners Traveling to the U.S. for Transplantation May Adversely Affect Organ Donation: A National Survey (pages 1468–1472)

      M. L. Volk, G. J. W. Warren, R. R. Anspach, M. P. Couper, R. M. Merion and P. A. Ubel

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03111.x

      In this national survey of the general public, 38% of participants indicated that the practice of foreigners traveling to the U.S. to receive a deceased donor transplant might affect their decision to become an organ donor.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
    1. You have free access to this content
      Laparoscopic Live Donor Nephrectomy with Vaginal Extraction: Initial Report (pages 1473–1477)

      M. E. Allaf, A. Singer, W. Shen, I. Green, K. Womer, D. L. Segev and R. A. Montgomery

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03131.x

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      Following vaginal extraction of a right laparoscopic live donor kidney, with warm ischemia time of 3 minutes, the donor did not receive any postoperative parenteral narcotic analgesia and was discharged home within 24 hours. See editorial by Ratner and Pescovitz on page 1347.

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      Robotic Transabdominal Kidney Transplantation in a Morbidly Obese Patient (pages 1478–1482)

      P. Giulianotti, V. Gorodner, F. Sbrana, I. Tzvetanov, H. Jeon, F. Bianco, K. Kinzer, J. Oberholzer and E. Benedetti

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03116.x

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      Robotic assisted, minimally invasive kidney transplantation may avoid wound-related complications in morbidly obese kidney transplant recipients.

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      Successful Living Donor Liver Transplantation in Portomesenteric Thrombosis (pages 1483–1485)

      S. G. Iyer, C. L. C. Lau, K. Y. S. Chang, S. W. K. Mak and K. K. Madhavan

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03124.x

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      The inferior mesenteric vein was used as an inflow source to perform living donor liver transplantation.

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      Visceral Leishmaniasis in a Kidney Transplant Recipient: Parasitic Interstitial Nephritis, a Cause of Renal Dysfunction (pages 1486–1489)

      S. Dettwiler, T. McKee, K. Hadaya, F. Chappuis, C. Van Delden and S. Moll

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03125.x

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      Parasitic nephritis due to visceral leishmaniasis can present in patients with kidney allografts who have returned from endemic areas and complain of intermittent fever, weight loss, and severe asthenia.

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      Successful Organ Transplantation from Donors Poisoned with a Carbamate Insecticide (pages 1490–1492)

      J. H. Garcia, G. R. Coelho, G. A. Marques, J. B. Gadelha, J. B. Vasconcelos, J. T. Valença Jr., R. M. Esmeraldo, J. A. Meija, C. A. Leite and E. R. Almeida

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03132.x

      Kidney, heart, and liver grafts from donors poisoned by carbamate were successfully transplanted.

  8. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
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      Proinsulin Processing and Transplanted Islets (page 1495)

      M. R. Rickels and A. Naji

      Article first published online: 19 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03069.x

  9. Erratum

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Laboratory Science
    6. Clinical Science
    7. Brief Communication
    8. Case Reports
    9. Letters to the Editor
    10. Erratum
    1. You have free access to this content
      Erratum (page 1496)

      Article first published online: 1 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03139.x

      This article corrects:

      Commemorating the 10th anniversary of the launch of the AJT project

      Vol. 10, Issue 5, 1111, Article first published online: 20 APR 2010

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