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American Journal of Transplantation

Cover image for Vol. 10 Issue 7

July 2010

Volume 10, Issue 7

Pages 1497–1716

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1497–1498)

      SUE PONDROM

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03203.x

      This month, transplant professionals weigh in on health-care reform, and what the new law might mean for the field. Also “The AJT Report” takes a close look at what happened to the expanded immunosuppressant coverage provision.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    1. You have free access to this content
      Just How Stable Is Allograft Tolerance? (pages 1499–1500)

      R. G. Gill

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03171.x

      In some cases, an infection may trigger allograft rejection even after putative regulatory tolerance has been established, raising the question: is allograft tolerance ever really stable? See article by Wang et al on page 1524.

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      Does Hematuria Contraindicate Kidney Donation? (pages 1501–1502)

      B. J. Nankivell

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03169.x

      Whether to use kidneys from donors with asymptomatic microscopic hematuria necessitates a thoughtful nephrological approach. See article by Kido et al on page 1597.

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      Transplant Data Collection: You Get What You Pay for (pages 1503–1504)

      R. B. Freeman

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03144.x

      Not surprisingly, separately funded, supported and incentivized transplant data collection systems are not completely concordant, as illustrated by comparing the SRTR to the A2ALL data. Please see article by Gillespie et al on page 1630.

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      Evaluating Liver Transplantation in Childhood: Is Life-Style Attainment in Adulthood the Ultimate Measure of Transplant Success? (pages 1505–1506)

      M. A. Heneghan

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03170.x

      Overall well-being and social integration should receive more attention then they currently receive. See article by Dommergues et al on page 1643.

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      Unfair Priority for HCC: A Problem Whose Ideal Solution Remains Unsolved (pages 1507–1508)

      M. L. Volk

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03154.x

      The ideal solution to priority for HCC will require better tools to predict survival benefit from liver transplantation. See article by Washburn et al on page 1652.

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      Dimensions of Antibody-Mediated Rejection (pages 1509–1510)

      R. B. Colvin

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03172.x

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      Alloantibody is widely accepted as a major cause of acute and chronic rejection in the kidney. Development of consensus criteria in other organ transplants, such as the pancreas and heart will accelerate progress. See article by de Kort et al on page 1669.

  3. Minireviews

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Reports
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      Retroviral Restriction Factors and Infectious Risk in Xenotransplantation (pages 1511–1516)

      Y. Meije, R. R. Tönjes and J. A. Fishman

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03146.x

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      Humans and other animal species have developed a system of intracellular proteins called “restriction factors” that protect against retroviral infection. These innate antiviral mechanisms are reviewed in the context of the potential infectious risks of xenotransplantation in humans.

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      Thrombotic Microangiopathy After Kidney Transplantation (pages 1517–1523)

      M. Noris and G. Remuzzi

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03156.x

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      Recent insights on the causes of post-transplant thrombotic microangiopathy, and on prophylactic and therapeutic options, including plasma therapy, combined kidney and liver transplantation and targeted complement inhibitors are discussed in this review.

  4. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    1. Laboratory Science

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      Infection with the Intracellular Bacterium, Listeria monocytogenes, Overrides Established Tolerance in a Mouse Cardiac Allograft Model (pages 1524–1533)

      T. Wang, E. B. Ahmed, L. Chen, J. Xu, J. Tao, C.-R. Wang, M.-L. Alegre and A. S. Chong

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03066.x

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      The cytokines, IL-6 and IFN-beta, produced in response to infection with Listeria monocytogenes, precipitate the loss of tolerance and the rejection of accepted cardiac allografts in mice. See editorial by Gill on page 1499.

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      Genome-Wide Transcription Profile of Endothelial Cells After Cardiac Transplantation in the Rat (pages 1534–1544)

      B. Mikalsen, B. Fosby, J. Wang, C. Hammarström, H. Bjærke, M. Lundström, M. Kasprzycka, H. Scott, P.-D. Line and G. Haraldsen

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03157.x

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      Microarray analyses of endothelial cells enriched from cardiac grafts revealed that the majority of differentially expressed genes were affected by the transplantation procedure rather than allograft rejection.

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      Influence of Immunosuppression on Alloresponse, Inflammation and Contractile Function of Graft After Intestinal Transplantation (pages 1545–1555)

      J. Fujishiro, T. C. Pech, T. F. Finger, M. Praktinjo, B. Stoffels, J. Standop, K. Abu-Elmagd, A. Tuerler, A. Hirner, J. C. Kalff and N. Schaefer

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03117.x

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      Perioperative immunosuppression with tacrolimus and sirolimus attenuates the cellular and molecular inflammatory alloresponse in the intestinal muscularis propria and subsequent dysmotility of the graft after small bowel transplantation.

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      Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig-to-Primate Kidney Xenotransplantation (pages 1556–1568)

      C. C. Lin, M. Ezzelarab, R. Shapiro, B. Ekser, C. Long, H. Hara, G. Echeverri, C. Torres, H. Watanabe, D. Ayares, A. Dorling and D. K. C. Cooper

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03147.x

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      In a genetically-modified pig-to-baboon kidney transplantation model, activation of platelets to express tissue factor is associated with initiation of the development of consumptive coagulopathy, and subsequent expression of tissue factor on peripheral blood mononuclear cells is associated with the onset of features of consumptive coagulopathy, often in the relative absence of features of acute humoral xenograft rejection.

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      Sensitization to Minor Antigens Is a Significant Barrier in Bone Marrow Transplantation and Is Prevented by CD154:CD40 Blockade (pages 1569–1579)

      H. Xu, Y. Huang, L. R. Hussain, Z. Zhu, L. D. Bozulic, C. Ding, J. Yan and S. T. Ildstad

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03148.x

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      This study shows that antibody plays a dominant role in rejection of bone marrow cells in recipients sensitized to minor antigens.

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      Deceleration of Regenerative Response Improves the Outcome of Rat with Massive Hepatectomy (pages 1580–1587)

      M. Ninomiya, K. Shirabe, T. Terashi, H. Ijichi, Y. Yonemura, N. Harada, Y. Soejima, A. Taketomi, M. Shimada and Y. Maehara

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03150.x

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      The suppression of MEK/ERK signaling pathway during the early phase after hepatectomy makes the regenerative response linear, alleviating the lobular derangement and improves the prognosis for animals bearing a small remnant liver.

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      TLR4 Mediates Early Graft Failure After Intraportal Islet Transplantation (pages 1588–1596)

      Q. Gao, L. L. Ma, X. Gao, W. Yan, P. Williams and D. P. Yin

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03151.x

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      Elimination of TLR4 in donor or inhibition of TLR4 activation in recipient with anti-HMGB1 antibody prevents early graft failure following intraportal islet transplantation.

    8. Clinical Science

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      Persistent Glomerular Hematuria in Living Kidney Donors Confers a Risk of Progressive Kidney Disease in Donors After Heminephrectomy (pages 1597–1604)

      R. Kido, Y. Shibagaki, K. Iwadoh, I. Nakajima, S. Fuchinoue, T. Fujita and S. Teraoka

      Version of Record online: 26 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03077.x

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      Living kidney donors with persistent glomerular hematuria both pre- and post-donation had higher risk of developing persistent proteinuria or progressive decline in kidney function, suggesting the need for more discretion in selecting and following these donors. See editorial by Nankivell on page 1501.

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      The Influence of Socioeconomic Deprivation on Outcomes Following Renal Transplantation in the United Kingdom (pages 1605–1612)

      M. R. Stephens, M. Evans, M. A. Ilham, A. Marsden and A. Asderakis

      Version of Record online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03041.x

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      This study investigates the relationship between deprivation (social and economic) and outcomes following renal transplantation in the United Kingdom and demonstrates adverse results for patients from the most socio-economically disadvantaged areas.

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      Improving Distribution Efficiency of Hard-to-Place Deceased Donor Kidneys: Predicting Probability of Discard or Delay (pages 1613–1620)

      A. B. Massie, N. M. Desai, R. A. Montgomery, A. L. Singer and D. L. Segev

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03163.x

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      The PODD (Probability Of Delay or Discard) prediction model identifies deceased donor kidneys at highest risk of delayed transplantation beyond 36 hours or discard, and could be used in attempts to expedite allocation and reduce discard rates of these hard-to-place kidneys.

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      Database Comparison of the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) and the SRTR U.S. Transplant Registry (pages 1621–1633)

      B. W. Gillespie, R. M. Merion, E. Ortiz-Rios, L. Tong, A. Shaked, R. S. Brown, A. O. Ojo, P. H. Hayashi, C. L. Berg, M. M. Abecassis, A. S. Ashworth, C. E. Friese, J. C. Hong, J. F. Trotter, J. E. Everhart and the A2ALL Study Group

      Version of Record online: 25 FEB 2010 | DOI: 10.1111/j.1600-6143.2010.03039.x

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      While this study found the quality of data submitted to the Organ Procurement and Transplantation Network (OPTN) to be generally good, greater attention to data quality, particularly missing data, would improve the usefulness of the data for research. Please see editorial by Freeman on page 1503.

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      Current Lifestyle of Young Adults After Liver Transplantation During Childhood (pages 1634–1642)

      J. P. Dommergues, A. Letierce, L. Gravereau, F. Plainguet, O. Bernard and D. Debray

      Version of Record online: 23 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03054.x

      Investigation of the current life-style of 116 young adults aged 17 years or more who had undergone LT in childhood, showed that most appeared at particular risk for delays in autonomy, and exhibited psychological disturbances that might partly account for lower performances at school than healthy peers. See editorial by Heneghan on page 1505.

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      Hepatocellular Carcinoma Patients Are Advantaged in the Current Liver Transplant Allocation System (pages 1643–1648)

      K. Washburn, E. Edwards, A. Harper and R. Freeman

      Version of Record online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03127.x

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      Candidates for liver transplantation with HCC MELD exception scores drop off the waiting list at lower rates than non-HCC candidates indicating that these patients continue to maintain too much priority in the current allocation system for cadaveric liver allografts. See editorial by Volk on page 1507.

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      High Viremia, Prolonged Lamivudine Therapy and Recurrent Hepatocellular Carcinoma Predict Posttransplant Hepatitis B Recurrence (pages 1649–1659)

      J. Chun, W. Kim, B. G. Kim, K. L. Lee, K.-S. Suh, N.-J. Yi, K. U. Park, Y. J. Kim, J.-H. Yoon and H. S. Lee

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03162.x

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      In a retrospective study of 209 HBsAg-positive patients who underwent orthotopic liver transplantation (OLT) for liver failure and HCC, independent predictors of posttransplant hpeatitis B recurrence are high viremia at OLT, prolonged lamivudine therapy and recurrent hepatocellular carcinoma after OLT.

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      Pancreas Allograft Biopsies with Positive C4d Staining and Anti-Donor Antibodies Related to Worse Outcome for Patients (pages 1660–1667)

      H. De Kort, R. B. Munivenkatappa, S. P. Berger, M. Eikmans, A. Van Der Wal, E. J. De Koning, C. Van Kooten, E. De Heer, R. N. Barth, J. A. Bruijn, B. Philosophe, C. B. Drachenberg and I. M. Bajema

      Version of Record online: 23 APR 2010 | DOI: 10.1111/j.1600-6143.2010.03079.x

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      This is the first pancreas transplant biopsy study in which antibody-mediated rejection as defined by positive C4d staining and donor specific antibodies was shown to correlate with worse long term graft survival, and with the pathological features of active septal and acinar inflammation and acinar cell injury/necrosis. See editorial by Colvin on page 1509.

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      Coronary Flow Reserve by Transthoracic Echocardiography Predicts Epicardial Intimal Thickening in Cardiac Allograft Vasculopathy (pages 1668–1676)

      F. Tona, E. Osto, G. Tarantini, A. Gambino, F. Cavallin, G. Feltrin, R. Montisci, A. L. P. Caforio, G. Gerosa and S. Iliceto

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03160.x

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      This study demonstrates that coronary flow reserve assessment by transthoracic echocardiography may be a novel noninvasive diagnostic tool in the detection of cardiac allograft vasculopathy defined as coronary maximal intimal thickness ≥0.5 mm.

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      Pediatric Health-Related Quality of Life: Feasibility, Reliability and Validity of the PedsQL™ Transplant Module (pages 1677–1685)

      J. Weissberg-Benchell, T. E. Zielinski, S. Rodgers, R. N. Greenley, D. Askenazi, S. L. Goldstein, E. M. Fredericks, S. McDiarmid, L. Williams, C. A. Limbers, K. Tuzinkiewicz, S. Lerret, E. M. Alonso and J. W. Varni

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03149.x

      A report on a new measure of healt-related quality of life for pediatric solid organ transplant recipients, which demonstrated excellent initial feasibility, reliability and construct validity.

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      Recommendations for the Assessment and Reporting of Multivariable Logistic Regression in Transplantation Literature (pages 1686–1694)

      A. C. Kalil, J. Mattei, D. F. Florescu, J. Sun and R. S. Kalil

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03141.x

      An assessment of the quality of multivariable logistic regression in six major transplantation journals found that the report of this method is unsatisfactory; a practical solution for the use and reporting of logistic regression in transplantation journals is suggested.

  5. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Reports
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      High Dose Epoetin Beta in the First Weeks Following Renal Transplantation and Delayed Graft Function: Results of the Neo-PDGF Study (pages 1695–1700)

      F. Martinez, N. Kamar, N. Pallet, P. Lang, A. Durrbach, Y. Lebranchu, A. Adem, S. Barbier, E. Cassuto-Viguier, F. Glowaki, Y. Le Meur, L. Rostaing, C. Legendre, O. Hermine, G. Choukroun and for the NeoPDGF Study Investigators

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03142.x

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      High-dose epoietin-β has no beneficial effect with regard to renal function at one and three months after renal transplantation in patients at risk for delayed graft function.

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      Therapeutic mTOR Inhibition in Autosomal Dominant Polycystic Kidney Disease: What Is the Appropriate Serum Level? (pages 1701–1706)

      G. Canaud, B. Knebelmann, P. C. Harris, F. Vrtovsnik, J.-M. Correas, N. Pallet, C. M. Heyer, E. Letavernier, F. Bienaimé, E. Thervet, F. Martinez, F. Terzi and C. Legendre

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03152.x

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      Low dose of sirolimus fails to prevent a mild form of polycystic kidney donor, and the dose of sirolimus required to inhibit mTOR varies according to the tissue.

  6. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Minireviews
    5. Original Articles
    6. Brief Communications
    7. Case Reports
    1. You have free access to this content
      Combined Pancreatic Islet–Lung Transplantation: A Novel Approach to the Treatment of End-Stage Cystic Fibrosis (pages 1707–1712)

      L. Kessler, S. Bakopoulou, R. Kessler, G. Massard, N. Santelmo, M. Greget, F. Moreau, O. Helms, D. Bosco, P. Gasche-Soccal, P. Morel, P. Wolf, T. Berney and on behalf of the GRAGIL group

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03143.x

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      Virus-specific memory CD8 T cells recognize and proliferate in response to allogeneic transplants.

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      Nevirapine-Induced Stevens Johnson–Syndrome and Fulminant Hepatic Failure Requiring Liver Transplantation (pages 1713–1716)

      J. Jao, M. Sturdevant, J. Del Rio Martin, T. Schiano, M. I. Fiel and S. Huprikar

      Version of Record online: 25 JUN 2010 | DOI: 10.1111/j.1600-6143.2010.03153.x

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      This report describes a case of nevirapine-induced Stevens-Johnson syndrome and fulminant hepatic failure requiring liver transplantation.

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