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American Journal of Transplantation

Cover image for Vol. 10 Issue 8

August 2010

Volume 10, Issue 8

Pages 1717–1952

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1717–1718)

      SUE PONDROM

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03235.x

      This month, The AJT Report explores new efforts to assess cancer risk in transplant patients, including a multinational study underway to better understand skin cancer in the post-transplant population.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Immunotherapy for Invasive Fungal Infections in Transplant Patients: Back to the Future? (pages 1719–1720)

      Hans H. Hirsch and Anders Hartmann

      Article first published online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03189.x

      For kidney transplant patients with life-threatening disseminated fungal infections and failure of modern antifungal therapies, exogenous interferon-gamma might represent an adjunct salvage therapy, but the risk-benefit ratio is not yet established. See Article by Armstrong-James et al on page 1796.

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      Posttransplant Prophylaxis Strategies for Hepatitis B (pages 1721–1722)

      E. Gane

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03193.x

      Oral antivirals combined with low-dose hepatitis B immunoglobulin provide highly effective prophylaxis against recurrent hepatitis B following liver transplantation for chronic hepatitis B. See Article by Degertekin et al on page 1823.

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      The Sleeping Giant Awakens—Liver Transplantation in China (pages 1723–1724)

      J. Fung

      Article first published online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03185.x

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      The number of liver transplants in China continues to rise, but the challenge of increasing the use of donation after brain death remains daunting. See Article by Allam et al on page 1834.

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      The Anti-LFA-1 Trial in Islet Transplantation (pages 1725–1726)

      J. Oberholzer, K. Kinzer and P. Fiorina

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03184.x

      The results of this small efalizumab study in islet transplantation are interesting but by no means definitive. See Article by Posselt et al on page 1870.

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      Immunosuppressive Agents and CMV Risk in the VICTOR Study (pages 1727–1728)

      R. K. Avery and B. Kaplan

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03194.x

      Post-hoc analysis of the VICTOR trial data concerning immunosuppressive agents yields some anticipated and some unexpected results. See Article by Åsberg et al on page 1881.

  3. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
    1. Laboratory Science

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      Alloimmune Activation Enhances Innate Tissue Inflammation/Injury in a Mouse Model of Liver Ischemia/Reperfusion Injury (pages 1729–1737)

      X. Shen, F. Reng, F. Gao, Y. Uchida, R. W. Busuttil, J. W. Kupiec-Weglinski and Y. Zhai

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03205.x

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      Alloreactive CD4 T cells are capable of enhancing innate tissue inflammation via an antigen independent and CD15 4-dependant mechanism.

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      Allografts Stimulate Cross-Reactive Virus-Specific Memory CD8 T Cells with Private Specificity (pages 1738–1748)

      M. A. Brehm, K. A. Daniels, B. Priyadharshini, T. B. Thornley, D. L. Greiner, A. A. Rossini and R. M. Welsh

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03161.x

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      Virus-specific memory CD8 T cells recognize and proliferate in response to allogeneic transplants.

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      Differential Role of Naïve and Memory CD4+ T-Cell Subsets in Primary Alloresponses (pages 1749–1759)

      D. Golshayan, J.-C. Wyss, M. Buckland, M. Hernandez-Fuentes and R. I. Lechler

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03180.x

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      In an adoptive transfer and skin transplantation, naïve CD4+ T cells represent the major threat to the allograft (direct and indirect pathway allorecognition), while memory cells contribute only at the early stages when the direct pathway prevails.

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      Regulatory T Cells Are Critical to Tolerance Induction in Presensitized Mouse Transplant Recipients Through Targeting Memory T Cells (pages 1760–1773)

      W. Ge, J. Jiang, W. Liu, D. Lian, A. Saito, B. Garcia, X. C. Li and H. Wang

      Article first published online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03186.x

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      Inhibition of memory T-cell expansion by anti-OX40L treatment proves to be a prerequisite for the expansion of Tregs in donor antigen presensitized recipients.

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      Rapamycin-Conditioned Donor Dendritic Cells Differentiate CD4+CD25+Foxp3+ T Cells In Vitro with TGF-β1 for Islet Transplantation (pages 1774–1784)

      K. L. Pothoven, T. Kheradmand, Q. Yang, J. L. Houlihan, H. Zhang, M. DeGutes, S. D. Miller and X. Luo

      Article first published online: 12 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03199.x

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      Donor dendritic cells pre-conditioned with rapamycin and TGF-beta 1 induce donor-specific regulatory T cells in vitro, which suppress islet allograft rejection in vivo.

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      The Jak Inhibitor CP-690,550 Preserves the Function of CD4+CD25brightFoxP3+ Regulatory T Cells and Inhibits Effector T Cells (pages 1785–1795)

      V. D. K. D. Sewgobind, M. E. Quaedackers, L. J. W. Van Der Laan, R. Kraaijeveld, S. S. Korevaar, G. Chan, W. Weimar and C. C. Baan

      Article first published online: 12 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03200.x

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      Phosphospecific flow cytometry showed that although CP-690,550 partially inhibited IL-2-mediated Jak/STAT5 phosphorylation in Tregs, their capacities in suppression assays were preserved, while Teff function was almost fully inhibited.

    7. Clinical Science

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      Exogenous Interferon-γ Immunotherapy for Invasive Fungal Infections in Kidney Transplant Patients (pages 1796–1803)

      D. Armstrong-James, I. A. Teo, S. Shrivastava, M. A. Petrou, D. Taube, A. Dorling and S. Shaunak

      Article first published online: 26 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03094.x

      Interferon-γ immuno-therapy to rapidly cured disseminated invasive fungal infections refractory to conventional anti-fungal drug therapy without any impairment of kidney allograft function. See Editorial by Hirsch and Hartmann on page 1719.

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      De novo Thrombotic Microangiopathy in Renal Allograft Biopsies—Role of Antibody-Mediated Rejection (pages 1804–1811)

      A. A. Satoskar, R. Pelletier, P. Adams, G. M. Nadasdy, S. Brodsky, T. Pesavento, M. Henry and T. Nadasdy

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03178.x

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      Antibody-mediated rejection appears to be the most common and important cause of thrombotic microangiopathy in renal allografts.

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      NK Cell Transcripts and NK Cells in Kidney Biopsies from Patients with Donor-Specific Antibodies: Evidence for NK Cell Involvement in Antibody-Mediated Rejection (pages 1812–1822)

      L. G. Hidalgo, B. Sis, J. Sellares, P. M. Campbell, M. Mengel, G. Einecke, J. Chang and P. F. Halloran

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03201.x

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      Using microarray analysis of kidney biopsies along with HLA antibody information at the time of biopsy, NK cell transcripts and CD56+ NK cells in peritubular capillaries are selectively identified in biopsies from DSA-positive patients, indicating a role for NK cells in antibody-mediated rejection.

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      Impact of Virologic Breakthrough and HBIG Regimen on Hepatitis B Recurrence After Liver Transplantation (pages 1823–1833)

      B. Degertekin, Steven-Huy B. Han, E. B. Keeffe, E. R. Schiff, V. A. Luketic, R. S. Brown, Jr., S. Emre, C. Soldevila-Pico, K. R. Reddy, M. B. Ishitani, T. T. Tran, T. L. Pruett, A. S. F. Lok and the NIH HBV-OLT Study Group

      Article first published online: 23 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03046.x

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      In 183 liver transplants for hepatitis B, low dose or finite duration of HBIG when combined with antiviral therapy resulted in low rates of HBV recurrence after liver transplantation, including patients with breakthrough pretransplant, as long as rescue therapy is administered pre- and post-transplant. See Editorial by Gane on page 1721.

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      Clinical Outcomes for Saudi and Egyptian Patients Receiving Deceased Donor Liver Transplantation in China (pages 1834–1841)

      N. Allam, M. Al Saghier, Y. El Sheikh, M. Al Sofayan, H. Khalaf, M. Al Sebayel, A. Helmy, Y. Kamel, A. AlJedai, H. Abdel-Dayem, N. M. Kenetman, A. Al Saghier, W. Al Hamoudi and A. A. Abdo

      Article first published online: 26 MAR 2010 | DOI: 10.1111/j.1600-6143.2010.03088.x

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      Patient and graft survival rates are low in Saudi and Egyptian patients receiving liver transplantation compared to those transplanted locally. See Editorial by Fung on page 1723.

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      Operative Start Times and Complications After Liver Transplantation (pages 1842–1849)

      B. E. Lonze, A. Parsikia, E. L. Feyssa, K. Khanmoradi, V. R. Araya, R. F. Zaki, D. L. Segev and J. A. Ortiz

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03177.x

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      In this retrospective analysis of 578 liver transplants performed at a single center, multivariate analyses of post-operative complications revealed that nighttime operations were associated with a greater risk of early death compared to daytime operation.

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      Prospective Evaluation of Intraoperative Hemodynamics in Liver Transplantation with Whole, Partial and DCD Grafts (pages 1850–1860)

      M. Sainz-Barriga, K. Reyntjens, M. G. Costa, L. Scudeller, X. Rogiers, P. Wouters, B. De Hemptinne and R. I. Troisi

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03207.x

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      Hepatic graft inflow and perfusion varied according to the type and quality of the organ, and according to systemic hemodynamics and cardiac output.

      Corrected by:

      Erratum

      Vol. 10, Issue 9, 2186, Article first published online: 27 AUG 2010

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      Prophylaxis Against Hepatitis B Recurrence Posttransplantation Using Lamivudine and Individualized Low-Dose Hepatitis B Immunoglobulin (pages 1861–1869)

      L. Jiang, L. Yan, B. Li, T. Wen, J. Zhao, L. Jiang, N. Cheng, Y. Wei, J. Yang, M. Xu and W. Wang

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03208.x

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      This retrospective study demonstrated that lamivudine combined with individualized low-dose intramuscular hepatitis B immunoglobulin provides a safe and effective prophylaxis against HBV recurrence after liver transplantation at about 5% of the cost of conventional high-dose intravenous hepatitis B immunoglobulin regimens.

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      Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti-LFA-1 Antibody Efalizumab (pages 1870–1880)

      A. M. Posselt, M. D. Bellin, M. Tavakol, G. L. Szot, L. A. Frassetto, U. Masharani, R. K. Kerlan, L. Fong, F. G. Vincenti, B. J. Hering, J. A. Bluestone and P. G. Stock

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03073.x

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      An immunosuppressive regimen based on the anti-LFA-1 antibody efalizumab showed some promising results in eight islet transplant recipients. See Editorial by Oberholzer et al 1725.

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      Effects of the Intensity of Immunosuppressive Therapy on Outcome of Treatment for CMV Disease in Organ Transplant Recipients (pages 1881–1888)

      A. Åsberg, A. G. Jardine, A. A. Bignamini, H. Rollag, M. D. Pescovitz, C. C. Gahlemann, A. Humar, A. Hartmann and on behalf of the VICTOR Study Group

      Article first published online: 10 MAY 2010 | DOI: 10.1111/j.1600-6143.2010.03114.x

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      Lower total intensity of immunosuppressive therapy is associated with more effective early, but not overall, CMV DNAemia eradication by valganciclovir/ganciclovir therapy in organ transplant recipients with CMV disease. See Editorial by Avery and Kaplan on page 1727.

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      Comparison of the Incidence of Malignancy in Recipients of Different Types of Organ: A UK Registry Audit (pages 1889–1896)

      D. Collett, L. Mumford, N. R. Banner, J. Neuberger and C. Watson

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03181.x

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      Trends in malignancy incidence over time in transplant recipients varied according to whether a kidney, liver, heart or lung was transplanted and the type of cancer.

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      Solid Organ Transplantation After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective, Multicenter Study of the EBMT (pages 1897–1906)

      C. Koenecke, B. Hertenstein, J. Schetelig, A. Van Biezen, E. Dammann, A. Gratwohl, A. Ganser, M. Schleuning, M. Bornhäuser, N. Jacobsen, N. Kröger, D. Niederwieser, T. De Witte and T. Ruutu

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03187.x

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      Selected patients receiving organ transplants after hematopoietic stem cell transplantation have good patient and organ survival.

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      Expanding the Criteria of Organ Procurement from Donors with Prostate Cancer: The Application of the New Italian Guidelines (pages 1907–1911)

      A. D’Errico-Grigioni, M. Fiorentino, F. Vasuri, B. Corti, L. Ridolfi, W. F. Grigioni and the Pathology Unit for organ safety of the ‘F. Addarii’ Institute, Bologna: Alberto Bagni, Maria Giulia Pirini, Deborah Malvi, Benedetta Fabbrizio, Giacomo Caprara, Nicola Alvaro

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03198.x

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      Extension of donor pool to elderly subjects with prostate cancer results in significant gain in organ harvesting.

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      Neighborhood Poverty, Racial Composition and Renal Transplant Waitlist (pages 1912–1917)

      M. R. Saunders, K. A. Cagney, L. F. Ross and G. C. Alexander

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03206.x

      In the USRDS linked to US Census data, there was a combined negative effect of neighborhood poverty and neighborhood minority composition on individuals' time to renal transplant waitlist.

  4. Brief Communication

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Induction of Indoleamine 2,3-Dioxygenase by Gene Delivery in Allogeneic Islets Prolongs Allograft Survival (pages 1918–1924)

      H. Dellê and I. L. Noronha

      Article first published online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03190.x

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      Induction of IDO expression in islet cells following transfection with Lipofectamine in rates with allogeneic islet transplants improves metabolic control and prolongs islet graft survival.

  5. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Fumagillin for Treatment of Intestinal Microsporidiosis in Renal Transplant Recipients (pages 1925–1930)

      L. Champion, A. Durrbach, P. Lang, M. Delahousse, C. Chauvet, C. Sarfati, D. Glotz and J.-M. Molina

      Article first published online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03166.x

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      Fumagillin was effective in treatment of ten cases of intestinal microsporidiosis, but monitoring of tacrolimus levels was necessary.

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      Recombinant Tissue-Type Plasminogen Activator in the Treatment of Acute Renal Artery Thrombosis After Kidney Transplantation (pages 1931–1933)

      A. Garcia, G. Vedula, R. Nowygrod, L. E. Ratner and M. J. Goldstein

      Article first published online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03183.x

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      Operative thrombectomy and intra-arterial infusion of plasminogen activator were used to salvage a living related kidney transplant after acute renal artery thrombosis.

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      Long-Term Outcomes of Liver Transplantation in Type 1 Gaucher Disease (pages 1934–1939)

      R. M. Ayto, D. A. Hughes, P. Jeevaratnam, K. Rolles, A. K. Burroughs, P. K. Mistry, A. B. Mehta and G. M. Pastores

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03168.x

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      Liver transplantation in patients with Gaucher disease is a successful treatment modality for those with end-stage hepatic failure.

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      An Innovative Sphincter Preserving Pull-Through Technique with En Bloc Colon and Small Bowel Transplantation (pages 1940–1946)

      K. R. Eid, G. Costa, G. J. Bond, R. J. Cruz, E. Rubin, K. Bielefeldt, D. Koritsky and K. M. Abu-Elmagd

      Article first published online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03167.x

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      Achievement of full anal continence after a new innovative intersphincteric pull-through technique of hindgut reconstruction with en bloc small bowel and colon transplantation in a Crohn's disease patient with irreversible intestinal failure.

  6. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communication
    6. Case Reports
    7. Letters to the Editor
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      Is Rituximab Safe to Use in Kidney Transplant Patients? (page 1949)

      G. Tydén, L. Mjornstedt, H. Ekberg and G. Tufveson

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03145.x

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      Long-Term Outcomes After Living-Donor Liver Transplantation for Alagille Syndrome: A Single Center 20-Year Experience in Japan (pages 1951–1952)

      T. Hori, H. Egawa, Y. Takada, F. Oike, M. Kasahara, Y. Ogura, S. Sakamoto, K. Ogawa, Y. Yonekawa, J. H. Nguyen, H. Doi, M. Ueno and S. Uemoto

      Article first published online: 23 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03196.x

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