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American Journal of Transplantation

Cover image for Vol. 10 Issue 9

September 2010

Volume 10, Issue 9

Pages 1953–2186

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communications
    6. Case Reports
    7. Letters to the Editor
    8. Erratum
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1953–1954)

      SUE PONDROM

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03273.x

      The FDA proposes granting vascularized composite allografts the definition of “organs,” giving them regulation under the Final Rule. This month, “The AJT Report” explores the implications of this potential change, takes a look at a way to track transplant program profitability, and highlights some hot topics from the American Transplant Congress.

  2. Editorials

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communications
    6. Case Reports
    7. Letters to the Editor
    8. Erratum
    1. You have free access to this content
      Cold Machine Perfusion or Static Cold Storage of Kidneys: Why the Debate Continues (pages 1955–1956)

      W. D. Irish and E. Katz

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03217.x

      The debate regarding the efficacy of cold machine perfusion versus static cold storage for prevention of delayed graft function in organs from deceased donors continues, despite the results of two well-designed clinical trials. See article by Watson et al on page 1991.

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      The Molecular Phenotype of Heart Transplant Biopsies (pages 1957–1958)

      C. C. Marboe

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03238.x

      Molecular phenotyping of heart transplant biopsies could provide a better understanding of biopsy histology and cardiac dysfunction in allograft rejection. See article by Mengel et al on page 2105.

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      The ‘Two, One, Zero’ Decision: What to Do with Suboptimal Deceased Donor Kidneys (pages 1959–1960)

      R. Shapiro, P. F. Halloran, F. L. Delmonico and J. S. Bromberg

      Version of Record online: 20 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03204.x

      While it is feasible to transplant two ECD kidneys into a single recipient, we need better data to help us decide with confidence whether a given set of kidneys should be transplanted into two patients, one patient, or not at all. See article by Esker et al on page 2000.

  3. Original Articles

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communications
    6. Case Reports
    7. Letters to the Editor
    8. Erratum
    1. Laboratory Science

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      Beneficial Effects of Desferrioxamine on Encapsulated Human Islets—In Vitro and In Vivo Study (pages 1961–1969)

      V. Vaithilingam, J. Oberholzer, G. J. Guillemin and B. E. Tuch

      Version of Record online: 20 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03209.x

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      Desferrioxamine treatment enhanced hypoxia inducible factor-1α and vascular endothelial growth factor expression in encapsulated human islets and improved their ability to function when transplanted into diabetic recipients.

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      B Cells Help Alloreactive T Cells Differentiate Into Memory T Cells (pages 1970–1980)

      Y.-H. Ng, M. H. Oberbarnscheidt, H. C. K. Chandramoorthy, R. Hoffman and G. Chalasani

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03223.x

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      B cell help for alloreactive T cells promotes their proliferation and survival to generate optimal numbers of functional memory T cells.

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      Rapamycin and MPA, But Not CsA, Impair Human NK Cell Cytotoxicity Due to Differential Effects on NK Cell Phenotype (pages 1981–1990)

      D. N. Eissens, A. Van Der Meer, B. Van Cranenbroek, F. W. M. B. Preijers and I. Joosten

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03242.x

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      CsA, MPA and Rapa each have distinct effects on NK-cell phenotype and function in vitro, which may have important implications for NK-cell function in vivo after transplantation and for their use in GVHD prophylaxis.

    4. Clinical Science

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      Cold Machine Perfusion Versus Static Cold Storage of Kidneys Donated After Cardiac Death: A UK Multicenter Randomized Controlled Trial (pages 1991–1999)

      C. J. E. Watson, A. C. Wells, R. J. Roberts, J. A. Akoh, P. J. Friend, M. Akyol, F. R. Calder, J. E. Allen, M. N. Jones, D. Collett and J. A. Bradley

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03165.x

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      Machine perfusion and simple cold storage of DCD kidneys produce equivalent transplant outcome in a UK multicentre randomised controlled trial. See editorial by Irish & Katz on page 1955.

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      Technical Aspects of Unilateral Dual Kidney Transplantation from Expanded Criteria Donors: Experience of 100 Patients (pages 2000–2007)

      B. Ekser, L. Furian, A. Broggiato, C. Silvestre, E.S. Pierobon, N. Baldan and P. Rigotti

      Version of Record online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03188.x

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      This report presents the results of a large series of dual kidney transplantation from ECD, with a detailed description of an advantageous surgical technique of unilateral placement. See editorial by Shapiro et al on page 1959.

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      Marked Variation of the Association of ESRD Duration Before and After Wait Listing on Kidney Transplant Outcomes (pages 2008–2016)

      J. D. Schold, A. R. Sehgal, T. R. Srinivas, E. D. Poggio, S. D. Navaneethan and B. Kaplan

      Version of Record online: 20 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03213.x

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      The previously documented association between waiting time on dialysis and reduced kidney transplant outcomes is predominantly explained by time to placement on the waiting list.

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      Biopsy-Diagnosed Renal Disease in Patients After Transplantation of Other Organs and Tissues (pages 2017–2025)

      A. Schwarz, H. Haller, R. Schmitt, M. Schiffer, C. Koenecke, C. Strassburg, F. Lehner, J. Gottlieb, C. Bara, J. U. Becker and V. Broecker

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03224.x

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      This study of 105 renal biopsies after liver, lung, heart and bone marrow transplantation addresses whether or not calcineurin-inhibitor toxicity is the only cause of renal insufficiency after non-renal transplantation.

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      Primary CMV Infections Are Common in Kidney Transplant Recipients After 6 Months Valganciclovir Prophylaxis (pages 2026–2032)

      I. Helanterä, L. Kyllönen, I. Lautenschlager, K. Salmela and P. Koskinen

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03225.x

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      In a retrospective analysis of 127 Finnish CMV D+/R kidney transplant recipients who received 6 months valganciclovir prophylaxis, 37% developed late-onset CMV infection after the end of prophylaxis and 43/47 of these infections were symptomatic.

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      Peritransplant Immunoadsorption for Positive Crossmatch Deceased Donor Kidney Transplantation (pages 2033–2042)

      G. Bartel, M. Wahrmann, H. Regele, Ž. Kikić, G. Fischer, W. Druml, F. Mühlbacher and G. A. Böhmig

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03226.x

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      This study demonstrates successful transplantation of crossmatch-positive deceased donor kidney allograft recipients using a protocol of peri-transplant immunoadsorption for rapid alloantibody depletion immediately before transplant surgery.

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      Increased Incidence of Colorectal Malignancies in Renal Transplant Recipients: A Case Control Study (pages 2043–2050)

      J. M. Park, M.-G. Choi, S. W. Kim, I.-S. Chung, C. W. Yang, Y. S. Kim, C. K. Jung, K. Y. Lee and J.-H. Kang

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03231.x

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      Comparing the frequency of colorectal neoplasia among renal transplant with that of the healthy subjects, this work could found that the renal transplant cohort had an apparent increase in their risk of advanced colorectal neoplasia.

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      Severe Vascular Lesions and Poor Functional Outcome in Kidney Transplant Recipients with Lupus Anticoagulant Antibodies (pages 2051–2060)

      G. Canaud, F. Bienaimé, L.-H. Noël, V. Royal, M.-A. Alyanakian, M.-D. Dautzenberg, M. Rabant, J. Posson, E. Thervet, D. Anglicheau, H. Kreis, F. Martinez, C. Legendre and J. Zuber

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03233.x

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      In a retrospective study, the presence of lupus anticoagulant at the time of transplantation was associated with a high rate of thrombosis, the hallmark lesions of antiphospholipid syndrome associated nephropathy, an increase in chronic vascular scores and a faster decline in mGFR.

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      Allotransplantation of Cryopreserved Parathyroid Tissue for Severe Hypocalcemia in a Renal Transplant Recipient (pages 2061–2065)

      S. M. Flechner, E. Berber, M. Askar, B. Stephany, A. Agarwal and Mira Milas

      Version of Record online: 25 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03234.x

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      A renal transplant recipient with life threatening post parathyroidectomy hypocalcemia was successfully treated with an allotransplant using cryopreserved parathyroid tissue from a third party.

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      Inflammation in Areas of Tubular Atrophy in Kidney Allograft Biopsies: A Potent Predictor of Allograft Failure (pages 2066–2073)

      R. B. Mannon, A. J. Matas, J. Grande, R. Leduc, J. Connett, B. Kasiske, J. M. Cecka, R. S. Gaston, F. Cosio, S. Gourishankar, P. F. Halloran, L. Hunsicker, D. Rush and for the DeKAF Investigators

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03240.x

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      A more global assessment of inflammation in kidney allograft biopsies to include inflammation in atrophic areas may provide critical insight into the prognosis of late graft injury.

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      Influence of Recipient Race on the Outcome of Simultaneous Pancreas and Kidney Transplantation (pages 2074–2081)

      F. L. Luan*, M. Kommareddi, D. M. Cibrik, M. Samaniego and A. O. Ojo

      Version of Record online: 20 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03211.x

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      Inferior pancreas and kidney graft survival in African American SPK patients

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      Experience with a Novel Efalizumab-Based Immunosuppressive Regimen to Facilitate Single Donor Islet Cell Transplantation (pages 2082–2091)

      N. A. Turgeon, J. G. Avila, J. A. Cano, J. J. Hutchinson, I. R. Badell, A. J. Page, A. B. Adams, M. H. Sears, P. H. Bowen, A. D. Kirk, T. C. Pearson and C. P. Larsen

      Version of Record online: 25 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03212.x

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      Carefully selected patients with T1DM can be rendered insulin independent after a single islet infusion with a novel efalizumab-based immunosuppressive regimen.

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      An Early Regional Experience with Expansion of Milan Criteria for Liver Transplant Recipients (pages 2092–2098)

      J. J. Guiteau, R. T. Cotton, W. K. Washburn, A. Harper, C. A. O’Mahony, A. Sebastian, S. Cheng, G. Klintmalm, M. Ghobrial, G. Halff, L. Mieles and J. Goss

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03222.x

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      This multicenter, prospective study showed benefit of orthotopic liver transplantation in patients exceeding Milan Criteria based on preoperative imaging.

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      Anonymous Living Liver Donation: Donor Profiles and Outcomes (pages 2099–2104)

      T. W. Reichman, A. Fox, L. Adcock, L. Wright, S. E. Abbey, G. Levy and D. R. Grant

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03244.x

      In a center experienced in live liver donation, anonymous donors are altruistic individuals who can successfully enhance the donor pool with acceptable morbidity similar to that of living-related liver donors.

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      The Molecular Phenotype of Heart Transplant Biopsies: Relationship to Histopathological and Clinical Variables (pages 2105–2115)

      M. Mengel, B. Sis, D. Kim, J. Chang, K. S. Famulski, L. G. Hidalgo, G. Einecke, D. G. De Freitas, W. Tymchak, J. Burton and P. F. Halloran

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03182.x

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      Assessing 105 endomyocardial allograft biopsies by Affymetrix microarrays revealed that the current ISHLT system for diagnosing rejection does not reflect the molecular phenotype and lacks clinical relevance; and that the interpretation of Quilty lesions are more strongly associated with the molecular phenotype than current ISHLT rejection grades. See editorial by Marboe on page 1957.

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      Association of Race and Socioeconomic Position with Outcomes in Pediatric Heart Transplant Recipients (pages 2116–2123)

      T. P. Singh, D. C. Naftel, L. Addonizio, W. Mahle, M. T. Foushee, S. Zangwill, E. D. Blume, J. K. Kirklin, R. Singh, J. K. Johnston and R. Chinnock

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03241.x

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      This multi-center study of pediatric heart transplant recipients suggests a complex relationship between recipient socioeconomic position and graft loss

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      Solid Organ Transplantation in AL Amyloidosis (pages 2124–2131)

      P. T. Sattianayagam, S. D. J. Gibbs, J. H. Pinney, A. D. Wechalekar, H. J. Lachmann, C. J. Whelan, J. A. Gilbertson, P. N. Hawkins and J. D. Gillmore

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03227.x

      Solid organ transplantation has historically been contentious in systemic AL amyloidosis because of the multisystem nature of the condition as well as the theoretical risk of graft amyloid recurrence, but this series highlights the outcomes and feasibility of transplantation in selected individuals.

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      Immune Reconstitution Following Rabbit Antithymocyte Globulin (pages 2132–2141)

      S. Gurkan, Y. Luan, N. Dhillon, S. R. Allam, T. Montague, J. S. Bromberg, S. Ames, S. Lerner, Z. Ebcioglu, V. Nair, R. Dinavahi, V. Sehgal, P. Heeger, B. Schroppel and B. Murphy

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03210.x

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      This prospective study examines the contribution of thymopoiesis versus homeostatic proliferation to immune reconstitution following rATG and the influence of rATG on the emergence of Treg in renal transplant recipients.

  4. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communications
    6. Case Reports
    7. Letters to the Editor
    8. Erratum
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      Successful Isolated Liver Transplantation in a Child with Atypical Hemolytic Uremic Syndrome and a Mutation in Complement Factor H (pages 2142–2147)

      W. Haller, D. V. Milford, T. H. J. Goodship, K. Sharif, D. F. Mirza and P. J. McKiernan

      Version of Record online: 25 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03228.x

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      Pre-emptive liver transplantation prior to the development of endstage renal disease is a valuable option in the management of atypical haemolytic uraemic syndrome associated with complement factor H mutations.

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      No-Touch Hepatic Hilum Technique to Treat Early Portal Vein Thrombosis After Pediatric Liver Transplantation (pages 2148–2153)

      J. Bueno, M. Perez-Lafuente, C. Venturi, A. Segarra, I. Barber, J. A. Molino, A. Romero, J. Ortega, I. Bilbao, V. Martinez-Ibañez and R. Charco

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03236.x

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      The authors describe an effective novel technique for treating early portal vein complications post-liver transplantation in five infants, with a combination of minimal surgery without liver hilum manipulation and endovascular treatment.

  5. Case Reports

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communications
    6. Case Reports
    7. Letters to the Editor
    8. Erratum
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      Eculizumab, Bortezomib and Kidney Paired Donation Facilitate Transplantation of a Highly Sensitized Patient Without Vascular Access (pages 2154–2160)

      B. E. Lonze, N. N. Dagher, C. E. Simpkins, J. E. Locke, A. L. Singer, D. L. Segev, A. A. Zachary and R. A. Montgomery

      Version of Record online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03191.x

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      For a young patient with 100% PRA and loss of vascular access, several non-traditional therapies (bortezomib, domino paired kidney donation, splanchnic venous drainage of the graft, and eculizumab) were combined to achieve successful renal transplantation.

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      Fatal Apophysomyces elegans Infection Transmitted by Deceased Donor Renal Allografts (pages 2161–2167)

      B. D. Alexander, W. A. Schell, A. M. Siston, C. Y. Rao, W. A. Bower, S. A. Balajee, D. N. Howell, Z. S. Moore, J. Noble-Wang, J. A. Rhyne, A. T. Fleischauer, J. M. Maillard, M. Kuehnert, D. Vikraman, B. H. Collins, C. E. Marroquin and B. J. Park

      Version of Record online: 25 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03216.x

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      This study examines the source of renal mucormycosis transmitted to two recipients by donated organs recovered from a near-drowning victim.

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      Combined Pancreas and En Bloc Kidney Transplantation Using a Bladder Patch Technique From Very Small Pediatric Donors (pages 2168–2172)

      J. Sageshima, G. Ciancio, L. Chen, G. Selvaggi, S. Nishida, E. Akpinar, E. Nesher, A. Romano, R. Misawa and G. W. Burke, III

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03229.x

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      Pancreas, kidney, and bladder patch grafts from two donors younger than two years old were successfully transplanted into adult recipients.

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      Extracorporeal Membrane Oxygenation in Nonintubated Patients as Bridge to Lung Transplantation (pages 2173–2178)

      K. M. Olsson, A. Simon, M. Strueber, J. Hadem, O. Wiesner, J. Gottlieb, T. Fuehner, S. Fischer, G. Warnecke, C. Kühn, A. Haverich, T. Welte and M. M. Hoeper

      Version of Record online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03192.x

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      The use of ECMO in fully awake patients is a promising bridging strategy for patients with terminal cardiopulmonary failure.

  6. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communications
    6. Case Reports
    7. Letters to the Editor
    8. Erratum
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      Single Kidney Transplantation from Young Pediatric Donors in the United States (page 2179)

      D. Tittelbach-Helmrich, O. Drognitz, P. Pisarski, G. Seifert and O. Thomusch

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03135.x

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      Single Kidney Transplantation from Young Pediatric Donors in the United States (page 2180)

      Liise K. Kayler, Joseph Magliocca, Robin D. Kim, Richard Howard and Jesse D. Schold

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03219.x

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      Intraoperative No Go Donor Hepatectomy in Living Donor Liver Transplantation (pages 2181–2182)

      V. Vij, V. K. Ramaswamy, S. Goja, P. Dargan, A. Mallya, N. Goyal and S. Gupta

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03155.x

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      Not All Donor No-Goes Should Go (page 2183)

      M. Guba and I. D. McGilvray

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03220.x

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      Preventing CMV Viremia and Disease 3–6 Months After Renal Transplantation (page 2184)

      Sherif Beniameen Mossad

      Version of Record online: 15 JUL 2010 | DOI: 10.1111/j.1600-6143.2010.03176.x

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  7. Erratum

    1. Top of page
    2. The AJT Report
    3. Editorials
    4. Original Articles
    5. Brief Communications
    6. Case Reports
    7. Letters to the Editor
    8. Erratum
    1. You have free access to this content
      Erratum (page 2186)

      Version of Record online: 27 AUG 2010 | DOI: 10.1111/j.1600-6143.2010.03249.x

      This article corrects:

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