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American Journal of Transplantation

Cover image for Vol. 11 Issue 1

January 2011

Volume 11, Issue 1

Pages 1–186

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1–2)

      SUE PONDROM

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03394.x

      This month, “The AJT Report” takes a look at some of the popular and reliable online resources available to transplant patients and donors, and features a study reporting high survival rates in heart transplant patients with hypertrophic cardiomyopathy.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      LITERATURE Watch (page 3)

      JONATHAN S. BROMBERG

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03393.x

      AJT initiates a new feature this month, Literature Watch, as a means of bringing important recent basic science discoveries to the attention of the transplant community.

  3. New in AJT

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      New in AJT (page 5)

      Allan D. Kirk

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03392.x

  4. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      Putting the IMPACT Study into Perspective: Should CMV Prophylaxis Be Extended to 6 Months for High Risk Transplants? (pages 6–7)

      D. R. Snydman

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03353.x

      The author critically assesses the debate over the proper interpretation of the IMPACT trial regarding CMV prophylaxis in high risk recipients, and whether one should extend prophylaxis for 6 months. See viewpoint by Kalil et al on page 18 and letter by Humar on page 177.

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      Identification and Targeting of Costimulation-Resistant T cells in Renal Transplantation (pages 8–9)

      Donna L. Farber

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03361.x

      A study in this issue by Kirk and colleagues identifying a memory T cell population resistant to CD28 costimulation blockade has implications for using costimulation-based immunosuppression therapies to prevent rejection while maintaining protective immunity. See article by Lo et al on page 22.

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      Native Renal Cysts and Dialysis Duration Are Risk Factors for Renal Cell Carcinoma in Renal Transplant Recipients (page 10)

      R. Shapiro and B. Kaplan

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03376.x

      Native kidney ultrasounds can be important in screening renal transplant patients pre- and post-transplantation. See article by Goh and Vathsala on page 86.

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      The Grading of Donor Complications: GPAs or Pass/Fail? (pages 11–12)

      K. M. Olthoff

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03377.x

      The authors explore grading of complications in living liver donors and discuss how much risk is “acceptable” for this procedure. See article by Azoulay et al on page 101.

  5. Special Article

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      Implementation of Vascularized Composite Allografts in the United States: Recommendations From the ASTS VCA Ad Hoc Committee and the Executive Committee (pages 13–17)

      L. Cendales, D. Granger, M. Henry, J. Jones, A. Langnas, D. Levi, J. Magee, R. Merion, K. Olthoff, T. Pruett, J. Roberts and M. Abecassis

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03374.x

      The authors propose a structured framework for the development of a prospective, thoughtful realization of Vascularized Composite Allografts in the US from the ASTS perspective.

  6. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      IMPACT Trial Results Should Not Change Current Standard of Care of 100 Days for Cytomegalovirus Prophylaxis (pages 18–21)

      A. C. Kalil, J. Sun and D. F. Florescu

      Article first published online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03342.x

      The authors evaluate the results of the IMPACT trial and opine that it does not have the strength of evidence to change current clinical practice of 100-day cytomegalovirus prophylaxis. See editorial by Snydman on page 6 and letter by Humar on page 177.

  7. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
    1. Laboratory Science

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      Selective Targeting of Human Alloresponsive CD8+ Effector Memory T Cells Based on CD2 Expression (pages 22–33)

      D. J. Lo, T. A. Weaver, L. Stempora, A. K. Mehta, M. L. Ford, C. P. Larsen and A. D. Kirk

      Article first published online: 10 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03317.x

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      The authors show that alloresponsive memory T cells, particularly those resistant to costimulation blockade, can be selectively inhibited in vitro by targeting CD2, a molecule enriched on the surface of effector and memory T cells. See editorial by Farber on page 8.

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      Prolongation of Cardiac Allograft Survival by a Novel Population of Autologous CD117+ Bone Marrow-Derived Progenitor Cells (pages 34–44)

      T. J. Grazia, R. J. Plenter, H. M. Lepper, F. Victorino, S. D. Miyamoto, J. T. Crossno Jr., B. A. Pietra, R. G. Gill and M. R. Zamora

      Article first published online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03335.x

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      In this study, the authors enriched autologous CD117+ cells from bone marrow and used them therapeutically in fully allo-mismatched murine heart transplant recipients, leading to significant dose-dependent/CD117-dependent prolongation of cardiac allograft survival.

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      Cytomegalovirus Latency Promotes Cardiac Lymphoid Neogenesis and Accelerated Allograft Rejection in CMV Naïve Recipients (pages 45–55)

      S. L. Orloff, Y.-K. Hwee, C. Kreklywich, T. F. Andoh, E. Hart, P. A. Smith, I. Messaoudi and D. N. Streblow

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03365.x

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      Intra-cardiac lymphoid structures develop during rat cytomegalovirus (RCMV) latency, and transplantation of these latently infected hearts into RCMV naïve rats enhances recipient immune activation and significantly accelerates the rate of rejection.

    4. Clinical Science

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      Significance of C4d Banff Scores in Early Protocol Biopsies of Kidney Transplant Recipients with Preformed Donor-Specific Antibodies (DSA) (pages 56–65)

      A. Loupy, G. S. Hill, C. Suberbielle, D. Charron, D. Anglicheau, J. Zuber, M. O. Timsit, J. P. Duong, P. Bruneval, Dewi Vernerey, J. P. Empana, X. Jouven, D. Nochy and C. H. Legendre

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03364.x

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      By stratifying the risk of chronic antibody mediated rejection according to the triangular association of microvascular inflammation, donor specific antibody (DSA) and C4d staining, the authors find that microcirculation inflammation and class II DSA are more robust predictors for subsequent humoral graft injury than C4d staining.

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      Immunosuppression with Belatacept-Based, Corticosteroid-Avoiding Regimens in De Novo Kidney Transplant Recipients (pages 66–76)

      R. Ferguson, J. Grinyó, F. Vincenti, D. B. Kaufman, E. S. Woodle, B. A. Marder, F. Citterio, W. H. Marks, M. Agarwal, D. Wu, Y. Dong and P. Garg

      Article first published online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03338.x

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      Results from this pilot trial suggest that immunosuppression using either of two belatacept-based regimens that avoid both calcineurin inhibitors and steroids results in acceptable rates of acute rejection and improved renal function relative to a tacrolimus-based regimen in kidney transplant recipients.

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      Import Kidney Transplants from Nonmandatory Share Deceased Donors: Characteristics, Distribution and Outcomes (pages 77–85)

      L. K. Kayler, J. Sokolich, J. Magliocca and J. D. Schold

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03359.x

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      Import kidney transplants from non-mandatory share deceased donors are associated with increased risks of graft failure, patient death, and delayed graft function compared to non-mandatory share local transplants.

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      Native Renal Cysts and Dialysis Duration Are Risk Factors for Renal Cell Carcinoma in Renal Transplant Recipients (pages 86–92)

      A. Goh and A. Vathsala

      Article first published online: 25 OCT 2010 | DOI: 10.1111/j.1600-6143.2010.03303.x

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      This study confirms the impact of uremia on the development of native renal cysts, and demonstrates that native renal cysts can be a surrogate marker for the future development of renal cell carcinoma in renal transplant patients who have already been exposed to prolonged periods of uremia. See editorial by Shapiro and Kaplan on page 10.

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      Efficacy and Safety of Continuous Local Infusion of Ropivacaine after Retroperitoneoscopic Live Donor Nephrectomy (pages 93–100)

      A.-R. Biglarnia, G. Tufveson, T. Lorant, F. Lennmyr and J. Wadström

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03358.x

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      Continuous local infusion of ropivacaine provides sufficient analgesia and opioid-sparing effect as well as reduces the incidence of nausea and vomiting after hand-assisted retroperitoneoscopic live donor nephrectomy.

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      Short- and Long-term Donor Morbidity in Right Lobe Living Donor Liver Transplantation: 91 Consecutive Cases in a European Center (pages 101–110)

      D. Azoulay, P. Bhangui, P. Andreani, C. Salloum, V. Karam, E. Hoti, G. Pascal, R. Adam, D. Samuel, Ph. Ichai, F. Saliba and D. Castaing

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03284.x

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      A systematic study of the short and long-term outcomes in 91 consecutive right liver donors from a high volume hepatobiliary center in Europe shows that, though the severity of donor complications reduced with time, there was a consistently high overall morbidity rate requiring persistent vigilance should the operation become routine. See editorial by Olthoff on page 11.

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      Coccidioidomycosis in Liver Transplant Recipients in an Endemic Area (pages 111–119)

      D. Vucicevic, E. J. Carey and J. E. Blair

      Article first published online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03328.x

      Among 391 liver transplant recipients residing in a Coccidioides-endemic area, 15 had active coccidioidomycosis, the majority of which occurred in the first post-transplantation year, with high attendant morbidity and mortality; as such, the authors recommend a revised antifungal strategy of universal prophylaxis for 6-12 months for liver transplant recipients residing in areas of high endemicity.

      Corrected by:

      Erratum

      Vol. 11, Issue 3, 639, Article first published online: 22 FEB 2011

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      Improved Survival in Pediatric Heart Transplant Recipients: Have White, Black and Hispanic Children Benefited Equally? (pages 120–128)

      T. P. Singh, C. S. Almond and K. Gauvreau

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03357.x

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      In this study, the authors analyze trends in post-transplant survival among pediatric heart transplant recipients in the US during the last 20 years to assess whether the improvement in post-transplant survival has benefited the major racial groups equally.

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      Usefulness of Exhaled Nitric Oxide to Guide Risk Stratification for Bronchiolitis Obliterans Syndrome After Lung Transplantation (pages 129–137)

      C. Neurohr, P. Huppmann, S. Leuschner, W. von Wulffen, T. Meis, H. Leuchte, F. Ihle, G. Zimmermann, C. Baezner, R. Hatz, H. Winter, L. Frey, P. Ueberfuhr, I. Bittmann, J. Behr and for the Munich Lung Transplant Group

      Article first published online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03327.x

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      Serial measurements of fractional exhaled nitric oxide reveal a significantly lower mean individual variation in stable recipients as compared to patients switching to unstable course; in particular, exceeding a threshold of 20 ppb is associated with development of future bronchiolitis obliterans syndrome.

  8. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      Interaction of Antithymocyte Globulins with Dendritic Cell Antigens (pages 138–145)

      J. Leitner, K. Grabmeier-Pfistershammer, O. Majdic, G. Zlabinger and P. Steinberger

      Article first published online: 18 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03322.x

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      The authors perform a comprehensive analysis of dendritic cell antigens that are recognized by anti-thymocyte globulins (ATGs) and identify several novel ATG specificities, including CD81, CD82, CD98, CD99 and CD147.

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      Pediatric Organ Transplantation and Risk of Premalignant and Malignant Tumors in Sweden (pages 146–151)

      J. F. Simard, E. Baecklund, A. Kinch, C. Brattström, Å. Ingvar, D. Molin, J. Adami, P. Fernberg, H. Wilczek, A. Ekbom and K. E. Smedby

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03367.x

      In a cohort of 536 pediatric organ transplant recipients with up to 36 years of follow-up in Sweden, the authors find that solid organ transplantation before age 18 years is associated with an increased risk of any cancer, as well as specific types such as NHL and non-melanoma skin cancers.

  9. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      Recurrence of Complement Factor H-Related Protein 5 Nephropathy in a Renal Transplant (pages 152–155)

      K. A. Vernon, D. P. Gale, E. Goicoechea de Jorge, A. G. McLean, J. Galliford, A. Pierides, P. H. Maxwell, D. Taube, M. C. Pickering and H. T. Cook

      Article first published online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03333.x

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      The authors report the first case of graft recurrence of CFHR5 nephropathy 46 days after transplantation.

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      Kidney Transplant from the Same Donor without Maintenance Immunosuppression after Previous Hematopoietic Stem Cell Transplant (pages 156–162)

      J. Fangmann, H. Kathrin Al-Ali, U. Sack, M. Kamprad, H. M. Tautenhahn, S Faber, J. Hauss, D. Niederwieser, T. Lindner and A. Bachmann

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03352.x

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      The authors present a case in which haploidentical hematopoietic stem cell transplant for acute myeloid leukemia allowed for kidney transplantation from the same donor without maintenance immunosuppression.

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      Three Cases of Alopecia Following Clinical Islet Transplantation (pages 163–168)

      D. M. Zuk, A. Koh, S. Imes, A. M. J. Shapiro and P. A. Senior

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03348.x

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      The authors describe the late development of alopecia in three female islet transplant recipients and its relationship to maintenance immunosuppression and lymphodepleting induction.

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      Post-Liver Transplantation Multicentric Castleman Disease Treated with Valganciclovir and Weaning of Immunosuppression (pages 169–172)

      E. J. Lim, P. Crowley, C. A. Mitchell and P. W. Angus

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03366.x

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      The authors describe the case of an HIV-negative man who developed human herpes virus 8-associated multicentric Castleman disease 11 years post-liver transplantation and who was successfully treated with valganciclovir and weaning of immunosuppression.

  10. Reports from the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      Balamuthia mandrillaris Transmitted Through Organ Transplantation — Mississippi, 2009 (pages 173–176)

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03395_1.x

      Two reports from the MMWR highlight the development of donor-derived severe and fatal Balamuthia meningoencephalitis in multiple recipients of organs from donors with unrecognized central nervous system infections.

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  11. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      Optimizing Allocation of Kidneys from Older Donors (page 182)

      P. Ruggenenti, P. Cravedi and G. Remuzzi

      Article first published online: 29 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03334.x

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  12. Erratum

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. New in AJT
    5. Editorials
    6. Special Article
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Erratum
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      Erratum (page 186)

      Article first published online: 30 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03396.x

      This article corrects:

      Vascular Stents in the Management of Portal Venous Complications in Living Donor Liver Transplantation

      Vol. 10, Issue 5, 1276–1283, Article first published online: 26 MAR 2010

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