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American Journal of Transplantation

Cover image for Vol. 11 Issue 2

February 2011

Volume 11, Issue 2

Pages 187–414

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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      The AJT Report: News and issues that affect organ and tissue transplantation (pages 187–188)

      SUE PONDROM

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03426.x

      Is individualized organ repair in our future? This month, “The AJT Report” explores warm ex vivo lung perfusion, and what it might mean for the future of organ transplantation.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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      LITERATURE Watch (page 189)

      JONATHAN S. BROMBERG

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03427.x

      Literature Watch highlights several recent articles that underscore innate immunity's role in regulating adaptive immune responses, including perhaps those involved in transplant immunity.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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      Surgeons and Research: Talent, Training, Time, Teachers and Teams (pages 191–193)

      A. D. Kirk and S. Feng

      Version of Record online: 12 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03399.x

      The authors reflect on the challenges facing surgeons, particularly young transplant surgeons, pursuing a rigorous scientific career. See article by Englesbe et al on page 245.

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      Paired Kidney Donation: A (Virtual) Balancing Act (pages 194–195)

      A. W. Bingaman, R. A Bray, H. M. Gebel and K. A. Newell

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03398.x

      The authors point out that the utility of paired kidney donation programs needs to increasingly be evaluated by real data and real crossmatch results rather than assumptions and simulations. See article by Ferrari et al on page 272.

  4. Minireview

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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      Clinical Aspects of Intravenous Immunoglobulin Use in Solid Organ Transplant Recipients (pages 196–202)

      S. C. Jordan, M. Toyoda, J. Kahwaji and A. A. Vo

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03400.x

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      This minireview examines the peer-reviewed data regarding the clinical applications and complications of intravenous immunoglobulin use in solid organ transplant recipients.

  5. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
    1. Laboratory Science

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      Distinct Inflammatory Signals Have Physiologically Divergent Effects on Epigenetic Regulation of Foxp3 Expression and Treg Function (pages 203–214)

      G. Lal, N. Yin, J. Xu, M. Lin, S. Schroppel, Y. Ding, I. Marie, D. E. Levy and J. S. Bromberg

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03389.x

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      The authors show that various inflammatory signals differentially modulate Foxp3 epigenetically, affecting its stability and expression, and modulating the suppressive function of regulatory T cells in transplantation.

      Corrected by:

      Erratum

      Vol. 11, Issue 3, 638, Version of Record online: 22 FEB 2011

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      Improved Intraportal Islet Transplantation Outcome by Systemic IKK-beta Inhibition: NF-κB Activity in Pancreatic Islets Depends on Oxygen Availability (pages 215–224)

      C. Chen, R. Moreno, B. Samikannu, R. G. Bretzel, M. L. Schmitz and T. Linn

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03390.x

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      While NF-κB typically has an anti-apoptotic role in pancreatic islets under normoxia, it has a predominantly pro-apoptotic role under the hypoxic conditions present following islet transplantation, and its blockage improves islet xenograft survival and function in mice.

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      SPECT/CT Lymphoscintigraphy of Heterotopic Cardiac Grafts Reveals Novel Sites of Lymphatic Drainage and T Cell Priming (pages 225–234)

      K. Brown, A. Badar, K. Sunassee, M. A. Fernandes, H. Shariff, S. Jurcevic, P. J. Blower, S. H. Sacks, G. E. D. Mullen and W. Wong

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03388.x

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      Mediastinal lymph nodes are identified as the draining lymph nodes of mouse heterotopic cardiac allografts and, as such, they should be used for ex vivo and adoptive transfer studies in addition to the spleen.

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      Noninvasive Detection of Graft Rejection by In Vivo19F MRI in the Early Stage (pages 235–244)

      U. Flögel, S. Su, I. Kreideweiß, Z. Ding, L. Galbarz, J. Fu, C. Jacoby, O. Witzke and J. Schrader

      Version of Record online: 7 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03372.x

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      This study describes a novel noninvasive approach for detection of organ rejection via visualization of the host's innate immune response making use of emulsified perfluorocarbons, which are preferentially phagocytized by monocytes/macrophages and specifically detected by in vivo19F MRI.

    5. Clinical Science

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      Young Transplant Surgeons and NIH Funding (pages 245–252)

      M. J. Englesbe, R. S Sung and D. L. Segev

      Version of Record online: 10 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03314.x

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      This study shows that few young transplant surgeons achieve NIH funding although many express an interest in more protected time for research. See editorial by Kirk and Feng on page 191.

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      Transplant Surgery Fellow Perceptions About Training and the Ensuing Job Market—Are the Right Number of Surgeons Being Trained? (pages 253–260)

      D. J. Reich, J. C. Magee, K. Gifford, R. M. Merion, J. P. Roberts, G. B. G. Klintmalm, P. G. Stock and the ASTS Fellowship Training Committee

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03308.x

      A survey of recent graduates from ASTS-approved transplant surgery fellowships reveals strengths and weaknesses of the training, highlights a tight post-fellowship job market, and reviews recent ASTS initiatives to enhance the quality and ascertain the proper number of transplant surgery fellowships.

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      Academic Careers and Lifestyle Characteristics of 171 Transplant Surgeons in the ASTS (pages 261–271)

      L. S. Florence, S. Feng, C. E. Foster III, J. P. Fryer, K. M. Olthoff, E. Pomfret, P. A. Sheiner, H. Sanfey and G. L. Bumgardner

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03381.x

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      Survey responses from 154 male and 17 female abdominal transplant surgeons in the ASTS characterize their education and academic career path, clinical practice workload, academic productivity and lifestyle characteristics.

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      Virtual Crossmatch Approach to Maximize Matching in Paired Kidney Donation (pages 272–278)

      P. Ferrari, S. Fidler, J. Wright, C. Woodroffe, P. Slater, A. Van Althuis-Jones, R. Holdsworth and F. T. Christiansen

      Version of Record online: 10 NOV 2010 | DOI: 10.1111/j.1600-6143.2010.03313.x

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      This study reports on the development and validation of a new computer program designed to optimally match incompatible live donor/recipient pairs and reduce the probability of matched pairs having a positive crossmatch. See editorial by Bingaman et al on page 194.

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      Experience of Laparoscopic Incisional Hernia Repair in Kidney and/or Pancreas Transplant Recipients (pages 279–286)

      G. R. Yannam, T. L. Gutti, R. High, R. B. Stevens, J. S. Thompson and M. C. Morris

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03351.x

      Laparoscopic incisional hernia repair can be performed safely and effectively in kidney and/or pancreas transplant recipients compared to non-transplant patients.

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      Infectious Complications More Than 1 Year after Liver Transplantation: A 3-Decade Nationwide Experience (pages 287–295)

      F. Åberg, H. Mäkisalo, K. Höckerstedt and H. Isoniemi

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03384.x

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      In the long term after liver transplantation, 1 in 15 recipients is estimated to develop at least one severe infection each year, most commonly cholangitis, pneumonia or sepsis.

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      Gender Differences in Liver Donor Quality Are Predictive of Graft Loss (pages 296–302)

      J. C. Lai, S. Feng, J. P. Roberts and N. A. Terrault

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03385.x

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      Female donors are older, shorter, and more frequently the victims of stroke, and these aspects of donor quality, not gender mismatch, drive the graft loss associated with female donors.

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      Cognitive and Academic Outcomes after Pediatric Liver Transplantation: Functional Outcomes Group (FOG) Results (pages 303–311)

      L.G. Sorensen, K. Neighbors, K. Martz, F. Zelko, J. C. Bucuvalas, E. M. Alonso and Studies of Pediatric Liver Transplantation (SPLIT) and Functional Outcomes Group (FOG)

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03363.x

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      Results of this multicenter study of pediatric liver transplant recipients during the early primary grades suggest a higher prevalence of cognitive and academic delays, executive function deficits and learning disabilities as compared to a normal population.

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      De Novo Donor HLA-Specific Antibodies after Heart Transplantation Are an Independent Predictor of Poor Patient Survival (pages 312–319)

      J. D. Smith, N. R. Banner, I. M. Hamour, M. Ozawa, A. Goh, D. Robinson, P. I. Terasaki and M. L. Rose

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03383.x

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      A retrospective study of 243 cardiac transplant patients, followed annually for up to 13 years, shows that production of de novo donor-specific HLA antibodies portends worse patient survival and is an independent risk factor for poor patient survival.

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      Pathologic Interpretation of Transbronchial Biopsy for Acute Rejection of Lung Allograft Is Highly Variable (pages 320–328)

      S. M. Arcasoy, G. Berry, C. C. Marboe, H. D. Tazelaar, M. R. Zamora, H. J. Wolters, K. C. Fang and S. Keshavjee

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03382.x

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      This study shows that the histopathologic diagnosis of acute lung allograft rejection is highly variable in a large, international and multicenter cohort.

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      Bile Acids Aspiration Reduces Survival in Lung Transplant Recipients with BOS Despite Azithromycin (pages 329–335)

      V. Mertens, K. Blondeau, L. Van Oudenhove, B. Vanaudenaerde, R. Vos, R. Farre, A. Pauwels, G. Verleden, D. Van Raemdonck, D. Sifrim and L. J. Dupont

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03380.x

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      Long-term survival and freedom from progression of bronchiolitis obliterans are significantly reduced in lung transplant patients with bile acid aspiration despite continuous azithromycin therapy.

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      Reduction of Immunosuppression as Initial Therapy for Posttransplantation Lymphoproliferative Disorder (pages 336–347)

      R. Reshef, S. Vardhanabhuti, M. R. Luskin, D. F. Heitjan, D. Hadjiliadis, S. Goral, K. L. Krok, L. R. Goldberg, D. L. Porter, E. A. Stadtmauer and D. E. Tsai

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03387.x

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      The authors describe the response of post-transplant lymphoproliferative disease to reduction of immunosuppression and analyze predictors of response and survival in a large single-center cohort.

  6. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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      Donor Antioxidant Strategy Prolongs Cardiac Allograft Survival by Attenuating Tissue Dendritic Cell Immunogenicity (pages 348–355)

      M. Jurewicz, T. Ueno, J. Azzi, K. Tanaka, T. Murayama, S. Yang, M. H. Sayegh, M. Niimi and R. Abdi

      Version of Record online: 23 DEC 2010 | DOI: 10.1111/j.1600-6143.2010.03360.x

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      The authors demonstrate prolongation of cardiac allograft survival as well as attenuation of chronic allograft rejection via a novel donor anti-ischemic regimen, the effect of which is linked to decreased donor-derived dendritic cell immunogenicity.

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      Transporting Live Donor Kidneys for Kidney Paired Donation: Initial National Results (pages 356–360)

      D. L. Segev, J. L. Veale, J. C. Berger, J. M. Hiller, R. L. Hanto, D. B. Leeser, S. R. Geffner, S. Shenoy, W. I. Bry, S. Katznelson, M. L. Melcher, M. A. Rees, E. N. S. Samara, A. K. Israni, M. Cooper, R. J. Montgomery, L. Malinzak, J. Whiting, D. Baran, J. I. Tchervenkov, J. P. Roberts, J. Rogers, D. A. Axelrod, C. E. Simpkins and R. A. Montgomery

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03386.x

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      In this study of live donor kidney transplants that required transportation of the organ and resultant cold ischemia, the authors report that excellent early function was seen, supporting the safety and feasibility of this practice.

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      Antifungal Prophylaxis in Lung Transplantation—A World-wide Survey (pages 361–366)

      C. F. Neoh, G. I. Snell, T. Kotsimbos, B. Levvey, C. O. Morrissey, M. A. Slavin, K. Stewart and D. C. M. Kong

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03375.x

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      A web-based survey among lung transplant centers world-wide reveals that antifungal prophylactic practice has changed significantly in recent years with voriconazole monotherapy as the most commonly prescribed agent.

  7. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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      Feasibility, Reproducibility, Risks and Benefits of Face Transplantation: A Prospective Study of Outcomes (pages 367–378)

      L. Lantieri, M. Hivelin, V. Audard, M. D. Benjoar, J. P. Meningaud, F. Bellivier, N. Ortonne, J.- P. Lefaucheur, A. Gilton, C. Suberbielle, J. Marty, P. Lang and P. Grimbert

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03406.x

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      The authors report that face transplantation under conventional immunosuppression results in improvement in function and quality of life in three of four patients, but remains associated with serious adverse events.

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      Cost Analysis of Conventional Facial Reconstruction Procedures Followed by Face Transplantation (pages 379–385)

      M. Siemionow, J. Gatherwright, R. Djohan and F. Papay

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03373.x

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      The authors analyze the costs of the first US face transplant patient's conventional reconstructive procedures and face transplantation.

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      Restoration of Facial Form and Function After Severe Disfigurement from Burn Injury by a Composite Facial Allograft (pages 386–393)

      B. Pomahac, J. Pribaz, E. Eriksson, D. Annino, S. Caterson, C. Sampson, Y. Chun, D. Orgill, D. Nowinski and S. G. Tullius

      Version of Record online: 7 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03368.x

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      The authors report a successful functional and aesthetic restoration after face transplantation, provide a detailed analysis of the immunosuppressive regimen used, and report on the transfer of rosacea from donor to recipient.

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      Living-Related Liver Transplantation for Siblings with Progressive Familial Intrahepatic Cholestasis 2, with Novel Genetic Findings (pages 394–398)

      H. Shimizu, O. Migita, R. Kosaki, M. Kasahara, A. Fukuda, S. Sakamoto, T. Shigeta, S. Uemoto, A. Nakazawa, T. Kakiuchi and K. Arai

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03397.x

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      The authors report two siblings with progressive familial intrahepatic cholestasis type 2 who have a novel mutation in the ABCB11 gene and have been successfully treated with living related liver transplantation.

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      Open Sphincteroplasty for Benign Ampullary Stricture After Pancreas Transplantation (pages 399–402)

      K. L. Mekeel, A. A. Moss, D. C. Mulligan and K. S. Reddy

      Version of Record online: 7 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03369.x

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      The authors report a pancreas that was transplanted with a benign ampullary stricture and resulted in recurrent graft pancreatitis; it was treated successfully with open sphincteroplasty.

  8. Reports from the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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      HIV Transmission Through Transfusion—Missouri and Colorado, 2008 (pages 403–406)

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03428.x

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      This report details transmission of HIV via blood donation to a kidney transplant recipient and highlights the complexity of donor screening.

  9. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
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    2. You have free access to this content
      Regarding: Humar et al. The Efficacy and Safety of 200 Days Valganciclovir Cytomegalovirus Prophylaxis in High-Risk Kidney Transplant Recipients. Am J Transplant 2010;10:1228–1237 (page 408)

      C. da Cunha-Bang, M. Iversen, S. A. Mortensen, A. Rasmussen, H. Sengeløv, S. S. Sørensen and J. Lundgren

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03349.x

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      To Perfuse or Not to Perfuse Kidneys Donated after Cardiac Death (pages 409–410)

      I. Jochmans, C. Moers, R. Ploeg and J. Pirenne

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03350.x

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      Sometimes Zero Is the Correct Answer (page 411)

      A. J. Matas

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03356.x

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      Negative Pressure Therapy May Delay Resolution of Urinary Leaks (page 412)

      J. Ortiz, M. Siddeswarappa, S. Stewart, K. Khanmoradi, S. Campos and R. Zaki

      Version of Record online: 10 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03362.x

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      More on the Increased Risks of Young Kidney Donors (page 413)

      R. W. Steiner

      Version of Record online: 7 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03371.x

  10. Erratum

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Original Articles
    7. Brief Communications
    8. Case Reports
    9. Reports from the CDC: MMWR
    10. Letters to the Editor
    11. Erratum
    1. You have free access to this content
      Erratum (page 414)

      Version of Record online: 27 JAN 2011 | DOI: 10.1111/j.1600-6143.2010.03435.x

      This article corrects:

      Impaired Proinsulin Processing is a Characteristic of Transplanted Islets

      Vol. 9, Issue 9, 2119–2125, Version of Record online: 20 AUG 2009

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