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American Journal of Transplantation

Cover image for Vol. 11 Issue 6

June 2011

Volume 11, Issue 6

Pages 1109–1343

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1109–1110)

      SUE PONDROM

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03629.x

      Has transplantation, once the innovative darling of medicine, lost its novelty for young surgeons and physicians?“The AJT Report” takes a look at the shortage of trainees in transplant medicine and surgery and possible ways to solve the problem. Also this month, new OPTN/UNOS officers and board members take their posts.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      LITERATURE Watch (page 1111)

      JONATHAN S. BROMBERG

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03630.x

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      Recent studies in microbial pathogenesis show that innate immunity is the major, primary response to certain pathogens, and give insight into opportunistic infections and their treatment.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      Evaluating the Risk of Cancer Transmission to Optimize Organ Usage (pages 1113–1114)

      C. J. E. Watson and J. A. Bradley

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03569.x

      The authors emphasize that the risks of donor cancer transmission should be balanced against the risks faced by potential recipients remaining on the waiting list if organs are discarded. See viewpoint by Nalesnik et al on page 1140.

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      Feces in Our Food, Viruses in Our Organs: Donor Surveillance, Organ Transplantation and the Risk for Disease Transmission (pages 1115–1116)

      T. Pruett

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03600.x

      The author opines that organ transplantation differs in fundamental ways from transfusion and tissue donation, and that these differences warrant a different threshold of acceptable risk when considering donor-derived disease transmission. See articles by Kucirka et al (page 1176 and page 1188) and Ellingson et al (page 1201).

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      Creating a Safer Donor: A Quarter Century of Progress? (pages 1117–1118)

      E. A. Blumberg

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03599.x

      The author discusses issues related to safety and donor-derived transmission events. See article by Ison et al on page 1218.

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      Miles to Go… (pages 1119–1120)

      A. D. Kirk, S. J. Knechtle, C. P. Larsen, K. A. Newell and T. C. Pearson

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03542.x

      The authors outline ways in which transplant research will need to reinvent itself to address the root causes of late allograft loss. See article by Lodhi et al on page 1226.

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      Laparoscopic Kidney Transplantation—Novel or Novelty? (pages 1121–1122)

      E. Benedetti and R. Shapiro

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03510.x

      The authors discuss the rationale for considering laparoscopic kidney transplantation. See case report by Modi et al on page 1320.

  4. Minireview

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      An Update on Donor-Derived Disease Transmission in Organ Transplantation (pages 1123–1130)

      M. G. Ison and M. A. Nalesnik

      Version of Record online: 28 MAR 2011 | DOI: 10.1111/j.1600-6143.2011.03493.x

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      The authors review the current epidemiology of donor-derived diseases and outline key next steps.

  5. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      Antibody-Mediated Rejection—An Ounce of Prevention Is Worth a Pound of Cure (pages 1131–1139)

      J. A. Bradley, W. M. Baldwin, A. Bingaman, C. Ellenrieder, H. M. Gebel, D. Glotz and A. D. Kirk

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03581.x

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      This meeting report summarizes the presentations of the ROTRF Sunrise Symposium at the XXIII Congress of The Transplantation Society, which addressed key areas relevant to the treatment and prevention of antibody-mediated rejection.

  6. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      Donor-Transmitted Malignancies in Organ Transplantation: Assessment of Clinical Risk (pages 1140–1147)

      M. A. Nalesnik, E. S. Woodle, J. M. DiMaio, B. Vasudev, L. W. Teperman, S. Covington, S. Taranto, J. P. Gockerman, R. Shapiro, V. Sharma, L. J. Swinnen, A. Yoshida and M. G. Ison

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03565.x

      The ad hoc Malignancy Subcommittee of the ad hoc Disease Transmission Advisory Committee of OPTN/UNOS puts forth a framework within which to evaluate organ donor malignancy transmission risk. See editorial by Watson and Bradley on page 1113.

  7. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
    1. Basic Science

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      Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease (pages 1148–1157)

      K. L. Hippen, S. C. Merkel, D. K. Schirm, C. Nelson, N. C. Tennis, J. L. Riley, C. H. June, J. S. Miller, J. E. Wagner and B. R. Blazar

      Version of Record online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03558.x

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      This study demonstrates that potent suppressive function is induced when human CD4+25− T cells are expanded in the presence of rapamycin and TGFβ, and that adoptive transfer of these induced regulatory T cells ameliorates disease in a xenogeneic model of graft versus host disease.

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      A Novel Method for Quantitative Monitoring of Transplanted Islets of Langerhans by Positive Contrast Magnetic Resonance Imaging (pages 1158–1168)

      L. A. Crowe, F. Ris, S. Nielles-Vallespin, P. Speier, S. Masson, M. Armanet, P. Morel, C. Toso, D. Bosco, T. Berney and J.-P. Vallee

      Version of Record online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03559.x

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      This study describes a novel quantitative MRI method for follow-up of the success and survival of islets of Langerhans labeled with iron oxide after transplantation into rat livers.

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      Characterization of the Withdrawal Phase in a Porcine Donation after the Cardiac Death Model (pages 1169–1175)

      J. Y. Rhee, J. Alroy and R. B. Freeman

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03567.x

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      Development of a porcine donation after cardiac death model may allow a deeper understanding of the withdrawal phase of donation after cardiac death.

    4. Clinical Science

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      Risk of Window Period HIV Infection in High Infectious Risk Donors: Systematic Review and Meta-Analysis (pages 1176–1187)

      L. M. Kucirka, H. Sarathy, P. Govindan, J. H. Wolf, T. A. Ellison, L. J. Hart, R. A. Montgomery, R. L. Ros and D. L. Segev

      Version of Record online: 2 MAR 2011 | DOI: 10.1111/j.1600-6143.2010.03329.x

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      To better understand the risk of undetected HIV infection in deceased donors in high-risk behavior categories, the authors perform a meta-analysis, pooling incidence rates from studies of high-risk populations and converting them into estimates of window period infections. See editorial by Pruett on page 1115.

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      Risk of Window Period Hepatitis-C Infection in High Infectious Risk Donors: Systematic Review and Meta-Analysis (pages 1188–1200)

      L. M. Kucirka, H. Sarathy, P. Govindan, J. H. Wolf, T. A. Ellison, L. J. Hart, R. A. Montgomery, R. L. Ros and D. L. Segev

      Version of Record online: 14 MAR 2011 | DOI: 10.1111/j.1600-6143.2011.03460.x

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      This meta-analysis of HCV incidence among persons in CDC high-risk behavior categories (originally designed to screen for HIV risk) provides estimates of the risk of window period HCV infection among potential donors in each behavior category. See editorial by Pruett on page 1115.

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      Estimated Risk of Human Immunodeficiency Virus and Hepatitis C Virus Infection among Potential Organ Donors from 17 Organ Procurement Organizations in the United States (pages 1201–1208)

      K. Ellingson, D. Seem, M. Nowicki, D. M. Strong, M. J. Kuehnert and for the Organ Procurement Organization Nucleic Acid Testing Yield Project Team

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03518.x

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      Results from this study suggest that the risk of undetected HCV infection among potential organ donors can be significantly reduced by screening with Nucleic Acid Testing as opposed to serology testing for both normal- and high-risk donors. See editorial by Pruett on page 1115.

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      Estimating the Potential Pool of HIV-Infected Deceased Organ Donors in the United States (pages 1209–1217)

      B. J. Boyarsky, E. C. Hall, A. L. Singer, R. A. Montgomery, K. A. Gebo and D. L. Segev

      Version of Record online: 28 MAR 2011 | DOI: 10.1111/j.1600-6143.2011.03506.x

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      This study of three national registries estimates that organs from several hundred HIV-infected potential deceased donors would be available to HIV-infected patients if the federal ban on transplantation of HIV-infected organs were lifted.

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      Transmission of Human Immunodeficiency Virus and Hepatitis C Virus From an Organ Donor to Four Transplant Recipients (pages 1218–1225)

      M. G. Ison, E. Llata, C. S. Conover, J. J. Friedewald, S. I. Gerber, A. Grigoryan, W. Heneine, J. M. Millis, D. M. Simon, C.-G. Teo, M. J. Kuehnert and and the HIV-HCV Transplantation Transmission Investigation Team

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03597.x

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      The authors present details regarding a case in which HCV and HIV infections were transmitted from a single donor to multiple recipients. See editorial by Blumberg on page 1117.

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      Solid Organ Allograft Survival Improvement in the United States: The Long-Term Does Not Mirror the Dramatic Short-Term Success (pages 1226–1235)

      S. A. Lodhi, K. E. Lamb and H. U. Meier-Kriesche

      Version of Record online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03539.x

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      Outcomes in solid organ allograft survival in the US have improved because of significant reductions in first year graft loss rates, while subsequent yearly graft loss rates have not significantly improved since 1989. See editorial by Kirk et al on page 1119.

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      Mechanisms of Donor-Specific Tolerance in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation (pages 1236–1247)

      G. Andreola, M. Chittenden, J. Shaffer, A. B. Cosimi, T. Kawai, P. Cotter, S. A. LoCascio, T. Morokata, B. R. Dey, N. T. Tolkoff-Rubin, F. Preffer, T. Bonnefoix, K. Kattleman, T. R. Spitzer, D. H. Sachs and M. Sykes

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03566.x

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      Patients rendered tolerant to renal allografts by combined kidney and bone marrow transplantation demonstrate long-term, specific and complete T cell unresponsiveness to their donors by mechanisms that may include clonal deletion.

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      IL-17 Expression by Tubular Epithelial Cells in Renal Transplant Recipients with Acute Antibody-Mediated Rejection (pages 1248–1259)

      A. Loverre, T. Tataranni, G. Castellano, C. Divella, M. Battaglia, P. Ditonno, M. Corcelli, M. Mangino, L. Gesualdo, F. P. Schena and G. Grandaliano

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03529.x

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      The authors demonstrate that tubular epithelial cells represent a significant source for IL-17 in acute antibody-mediated rejection through the activation of the complement cascade and JAK2 phosphorylation that, in the clinical area, may represent a suitable therapeutic target.

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      Post-transplant Lymphoproliferative Disorders: Determination of Donor/Recipient Origin in a Large Cohort of Kidney Recipients (pages 1260–1269)

      J. Olagne, S. Caillard, M. P. Gaub, M. P. Chenard and B. Moulin

      Version of Record online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03544.x

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      Analyzing the origin of the tumor cells in post-transplant lymphomas occurring in 43 kidney recipients, the authors show that 16 tumors were of donor and 27 were of recipient origin.

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      Disclosing Recipient Information to Potential Living Donors: Preferences of Donors and Recipients, Before and After Surgery (pages 1270–1278)

      J. R. Rodrigue, K. Ladin, M. Pavlakis and D. A. Mandelbrot

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03580.x

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      This study shows that most living kidney donors and kidney transplant patients favor the sharing of certain transplant candidate information, highlighting the need for transplant programs to consider how to best balance the potential donor's right to receive information with the recipient's right to privacy and confidentiality.

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      Living Donor Age and Kidney Transplant Outcomes (pages 1279–1286)

      K. Noppakun, F. G. Cosio, P. G. Dean, S. J. Taler, R. Wauters and J. P. Grande

      Version of Record online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03552.x

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      This study shows, in a cohort of 1063 adult living kidney transplant recipients, that increasing living donor age is associated with higher incidence of post-transplant proteinuria and reduced death-censored graft survival, two interrelated variables.

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      Early Trajectories of Depressive Symptoms after Liver Transplantation for Alcoholic Liver Disease Predicts Long-Term Survival (pages 1287–1295)

      A. DiMartini, M. A. Dew, D. Chaiffetz, M. G. Fitzgerald, M. E. deVera and P. Fontes

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03496.x

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      After controlling for medical factors associated with poorer survival, liver transplant recipients with increasing or persisting depression within the first post-operative year were more than twice as likely to die within the subsequent years.

  8. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      Pretransplant Immune-Regulation Predicts Allograft Tolerance (pages 1296–1301)

      P. Dutta, M. Dart, D. A. Roenneburg, J. R. Torrealba and W. J. Burlingham

      Version of Record online: 30 MAR 2011 | DOI: 10.1111/j.1600-6143.2011.03484.x

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      The authors show that tolerance or rejection of a heart allograft in F1 backcross mice can be predicted by pre-transplant, trans-vivo DTH analysis of T regulatory cells specific for noninherited maternal antigens.

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      Telomeric Rather than Centromeric Activating KIR Genes Protect from Cytomegalovirus Infection after Kidney Transplantation (pages 1302–1307)

      M. Stern, K. Hadaya, G. Hönger, P.-Y. Martin, J. Steiger, C. Hess and J. Villard

      Version of Record online: 12 APR 2011 | DOI: 10.1111/j.1600-6143.2011.03516.x

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      This study analyzes the impact of killer-cell immunoglobulin-like receptor (KIR) genotype on cytomegalovirus infection after kidney transplantation and demonstrates that the protective effect previously attributed to possession of activating KIR genes can be mapped to the telomeric part of the KIR locus.

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      Adenovirus Disease after Kidney Transplantation: Course of Infection and Outcome in Relation to Blood Viral Load and Immune Recovery (pages 1308–1314)

      S. P. Watcharananan, R. Avery, A. Ingsathit, K. Malathum, W. Chantratita, V. Mavichak, P. Chalermsanyakorn, S. Jirasiritham and V. Sumethkul

      Version of Record online: 30 MAR 2011 | DOI: 10.1111/j.1600-6143.2011.03479.x

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      This study reports on the characteristics and outcome of adenovirus disease among kidney recipients and shows that prompt reduction of immunosuppression and close monitoring of blood viral load are useful, particularly in high-risk patients with infection early post-transplantation.

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      Quality of Life in Kidney Donors (pages 1315–1319)

      G. Mjøen, K. Stavem, L. Westlie, K. Midtvedt, P. Fauchald, G. Norby and H. Holdaas

      Version of Record online: 12 APR 2011 | DOI: 10.1111/j.1600-6143.2011.03517.x

      A retrospective study on Norwegian kidney donors shows little regret and overall good quality of life compared to the background population.

  9. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      Laparoscopic Kidney Transplantation: An Initial Experience (pages 1320–1324)

      P. Modi, J. Rizvi, B. Pal, R. Bharadwaj, P. Trivedi, A. Trivedi, K. Patel, K. Shah, J. Vyas, S. Sharma, K. Shah, R. Chauhan and H. Trivedi

      Version of Record online: 12 APR 2011 | DOI: 10.1111/j.1600-6143.2011.03512.x

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      This paper presents technical details related to the operative procedure of laparoscopic kidney transplantation. See editorial by Benedetti and Shapiro on page 1121.

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      The Impact of IL28B Genetic Variants on Recurrent Hepatitis C in Liver Transplantation: Significant Lessons from a Dual Graft Case (pages 1325–1329)

      T. Motomura, A. Taketomi, T. Fukuhara, Y. Mano, K. Takeishi, T. Toshima, N. Harada, H. Uchiyama, T. Yoshizumi, Y. Soejima, K. Shirabe, Y. Matsuura and Y. Maehara

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03537.x

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      In this dual graft liver transplantation case, each graft with different IL28B genotype showed significantly different pathological findings and viral kinetics after interferon therapy for recurrent hepatitis C.

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      Cytomegalovirus Prostatitis in a Heart Transplant Recipient (pages 1330–1333)

      N. G. Rouphael, S. R. Laskar, A. Smith and G. M. Lyon

      Version of Record online: 12 APR 2011 | DOI: 10.1111/j.1600-6143.2011.03519.x

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      This article describes the case of a heart transplant recipient with cytomegalovirus prostatitis and prostate cancer in the absence of cytomegalovirus viremia at the time of diagnosis.

  10. Reports from the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      HIV Transmitted from a Living Organ Donor—New York City, 2009 (pages 1334–1337)

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03631.x

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      Live kidney donation resulted in transmission of HIV from a high-risk donor tested 79 days prior to donation to recipient.

  11. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
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      Transmission of Donor-Specific Skin Condition From Donor to Recipient of Facial Allograft (page 1340)

      A.P. Saavedra, E.M. Bueno, S.R. Granter and B. Pomahac

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03596.x

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      The Use of Executed Prisoners as a Source of Organ Transplants in China Must Stop (page 1342)

      G.M. Danovitch, M.E. Shapiro and J. Lavee

      Version of Record online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03555.x

  12. Retraction

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports from the CDC: MMWR
    12. Letters to the Editor
    13. Retraction
    1. You have free access to this content
      Retraction (page 1343)

      Version of Record online: 6 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03632.x

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