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American Journal of Transplantation

Cover image for Vol. 11 Issue 7

July 2011

Volume 11, Issue 7

Pages 1345–1546

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1345–1346)

      SUE PONDROM

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03658.x

      This month, “The AJT Report” reviews a recent organ allocation error and the use of standardized surgical checklists to reduce the incidence of such preventable operative errors. Also this month, a look at an increase in registered organ donors in the United States.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      LITERATURE Watch: Implications for transplantation (page 1347)

      JONATHAN S. BROMBERG

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03662.x

      This month's Literature Watch highlights new pathways falling outside of the typical acquired immune spectrum that hold promise to remedy immune maladies that are resistant to current therapeutics.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      The Risk and Opportunity of Homeostatic Repopulation (pages 1349–1350)

      P. Stock and A. D. Kirk

      Article first published online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03543.x

      The immune system's propensity to promote lymphocyte proliferation and activation in response to lymphopenia has predictable characteristics that should be considered when immunosuppressive protocols are deployed. See article by Cherkassky et al on page 1388.

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      Uncontrolled Donation after Circulatory Determination of Death (UDCDD) and the Definition of Death (pages 1351–1352)

      D. W. Hanto and R. M. Veatch

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03583.x

      The New York City protocol for a trial of uncontrolled donation after circulatory determination of death, which includes measures to reestablish circulation to maintain organ perfusion, may create confusion and controversy around the declaration of death and pose a setback for organ donation and uncontrolled donation protocols. See article by Wall et al on page 1417.

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      After Nine Years of MELD, Fundamental Questions of Fairness Remain (pages 1353–1354)

      J. C. Lai and S. Feng

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03502.x

      Do we care about gender differences in liver transplantation rates if there are no differences in wait-list mortality? See article by Mathur et al on page 1435.

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      The Search for CNI-Free Immunosuppression: No Free Lunch (pages 1355–1356)

      H.-U. Meier-Kriesche and B. Kaplan

      Article first published online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03541.x

      Calcineurin inhibitor-free immunosuppression continues to be challenged by efficacy and safety problems. See article by Friman et al on page 1444.

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      The Long and Winding Road to Kidney Transplantation (pages 1357–1358)

      P. P. Reese and R. D. Bloom

      Article first published online: 12 APR 2011 | DOI: 10.1111/j.1600-6143.2011.03523.x

      Listing status awareness is a potentially modifiable mechanism that may lead to disparities in kidney transplant access. See brief communication by Gillespie et al on page 1522.

  4. Minireviews

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      Targeting B Cells and Antibody in Transplantation (pages 1359–1367)

      M. R. Clatworthy

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03554.x

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      This article reviews recent advances in the field of B cell biology, including data suggesting a regulatory role for B cells, and discusses the potential implications for therapeutic strategies in transplantation.

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      The Emerging Role of Brazil in Clinical Trial Conduct for Transplantation (pages 1368–1375)

      H. Tedesco Silva Jr., C. R. Felipe, M. Abbud-Filho, V. Garcia and J. O. Medina-Pestana

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03564.x

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      The authors describe the development of an integrated national transplant program and clinical research regulation in Brazil as prime factors increasing the number of transplants performed in Brazil and driving the country's increased participation in clinical transplantation trials.

  5. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      Should Metformin Be Our Antiglycemic Agent of Choice Post-transplantation? (pages 1376–1381)

      A. Sharif

      Article first published online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03550.x

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      The author puts forward an argument for metformin, the oldest and most well known antiglycemic agent, to be considered as the first-line agent post-transplantation due to its unique and potentially advantageous benefits to organ recipients.

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      Improving Long-Term Renal Allograft Survival via a Road Less Traveled By (pages 1382–1387)

      M. D. Stegall, W. D. Park, P. G. Dean and F. G. Cosio

      Article first published online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03557.x

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      The authors opine that improvements in long-term outcomes will not involve wholesale changes in current immunosuppression, but rather will entail in-depth follow-up aimed at the identification of the major causes of late graft loss and the development of therapy for each specific cause.

  6. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
    1. Basic Science

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      Evaluation of Alloreactivity in Kidney Transplant Recipients Treated with Antithymocyte Globulin Versus IL-2 Receptor Blocker (pages 1388–1396)

      L. Cherkassky, M. Lanning, P. N. Lalli, J. Czerr, H. Siegel, L. Danziger-Isakov, T. Srinivas, A. Valujskikh, D. A. Shoskes, W. Baldwin, R. L. Fairchild and E. D. Poggio

      Article first published online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03540.x

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      Assessment of cellular alloreactivity in kidney transplant recipients receiving either a T cell depleting or a non-T cell depleting antibody for induction therapy shows a differential effect on donor and nondonor alloimmune cellular responses. See editorial by Stock and Kirk on page 1349.

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      Anti-Complement Component C5 mAb Synergizes with CTLA4Ig to Inhibit Alloreactive T cells and Prolong Cardiac Allograft Survival in Mice (pages 1397–1406)

      H. Raedler, M. B. Vieyra, S. Leisman, P. Lakhani, W. Kwan, M. Yang, K. Johnson, S. J. Faas, P. Tamburini and P. S. Heeger

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03561.x

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      The authors show that a C5-specific monoclonal antibody synergizes with CTLA4Ig to prolong heterotopic heart transplant survival in naïve mice through inhibiting T cell activation and limiting T cell trafficking into the allograft.

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      Vascularized Bone Marrow-Based Immunosuppression Inhibits Rejection of Vascularized Composite Allografts in Nonhuman Primates (pages 1407–1416)

      R. N. Barth, E. D. Rodriguez, G. S. Mundinger, A. J. Nam, J. S. Ha, H. Hui-Chou, L. S. Jones, A. Panda, S. T. Shipley, C. B. Drachenberg, D. Kukuruga and S. T. Bartlett

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03551.x

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      The authors describe immunomodulatory effects of vascularized bone marrow allografts, including inhibition of rejection responses, transient chimerism and suppressed B cell responses, in a nonhuman primate model of vascularized facial composite allografts.

    4. Clinical Science

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      Derivation of the Uncontrolled Donation after Circulatory Determination of Death Protocol for New York City (pages 1417–1426)

      S. P. Wall, B. J. Kaufman, A. J. Gilbert, Y. Yushkov, M. Goldstein, J. E. Rivera, D. O’Hara, H. Lerner, M. Sabeta, M. Torres, C. L. Smith, Z. Hedrington, F. Selck, K. G. Munjal, M. Machado, S. Montella, M. Pressman, L. W. Teperman, N. N. Dubler, L. R. Goldfrank and for the NYC UDCDD Study Group

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03582.x

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      This article reports on development of New York City's Uncontrolled Donation after Circulatory Determination of Death protocol. See editorial by Hanto and Veatch on page 1351.

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      Kidney Transplantation from Donors after Cardiac Death: Uncontrolled versus Controlled Donation (pages 1427–1434)

      E. R. P. Hoogland, M.G.J. Snoeijs, B. Winkens, M. H. L. Christaans and L. W. E. van Heurn

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03562.x

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      This study shows that the short-term and long-term outcomes of kidney transplantation from uncontrolled and controlled donors after cardiac death are equivalent.

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      Sex-Based Disparities in Liver Transplant Rates in the United States (pages 1435–1443)

      A. K. Mathur, D. E. Schaubel, Qi Gong, M. K. Guidinger and R. M. Merion

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03498.x

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      Geographically distinct, sex-based disparities in access to liver transplantation from the waiting list are evident in the United States that persist despite accounting for numerous gender-relevant clinical factors, and suggest gender-based inequity in care for patients with liver disease. See editorial by Lai and Feng on page 1353.

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      Sotrastaurin, a Novel Small Molecule Inhibiting Protein-Kinase C: Randomized Phase II Study in Renal Transplant Recipients (pages 1444–1455)

      S. Friman, W. Arns, B. Nashan, F. Vincenti, B. Banas, K. Budde, D. Cibrik, L. Chan, J. Klempnauer, S. Mulgaonkar, M. Nicholson, J. Wahlberg, K.-M. Wissing, K. Abrams, S. Witte and E. S. Woodle

      Article first published online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03538.x

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      A calcineurin inhibitor-free regimen including sotrastaurin, a novel small molecule inhibiting protein-kinase C, is shown to be associated with insufficient efficacy, but better renal function, in patients on study drug compared with the control regimen. See editorial by Meier-Kriesche and Kaplan on page 1355.

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      Interstitial Fibrosis Evolution on Early Sequential Screening Renal Allograft Biopsies Using Quantitative Image Analysis (pages 1456–1463)

      A. Servais, V. Meas-Yedid, L. H. Noël, F. Martinez, C. Panterne, H. Kreis, J. Zuber, M. O. Timsit, Ch. Legendre, J. C. Olivo-Marin and E. Thervet

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03594.x

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      Interstitial fibrosis evolution on early sequential renal biopsies assessed by automatic color image analysis is more important during the first 3 months and has some predictive implications for change in renal function.

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      Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts (pages 1464–1477)

      A.B. Farris, D. Taheri, T. Kawai, L. Fazlollahi, W. Wong, N. Tolkoff-Rubin, T. R. Spitzer, A. J. Iafrate, F. I. Preffer, S. A. LoCascio, B. Sprangers, S. Saidman, R. N. Smith, A. B. Cosimi, M. Sykes, D. H. Sachs and R. B. Colvin

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03572.x

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      Engraftment syndrome, characterized by transient azotemia, inflammation with sparse recipient T cells in peritubular capillaries, and endothelial injury, is observed around 10–15 days in recipients of combined bone marrow/kidney allografts, followed by recovery in most patients.

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      Very Late Heart Transplant Rejection Is Associated with Microvascular Injury, Complement Deposition and Progression to Cardiac Allograft Vasculopathy (pages 1478–1487)

      A. Loupy, A. Cazes, R. Guillemain, C. Amrein, A. Hedjoudje, M. Tible, V. Pezzella, J. N. Fabiani, C. Suberbielle, D. Nochy, G. S. Hill, J. P. Empana, X. Jouven, P. Bruneval and J. P. Duong Van Huyen

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03563.x

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      This study of protocol cardiac allograft biopsies suggests that very late rejection can be observed in clinically stable patients and likely involves antibody-mediated processes that contribute to subsequent progression to severe cardiac allograft vasculopathy.

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      Increased Incidence and Mortality Associated With Skin Cancers After Cardiac Transplant (pages 1488–1497)

      M. Alam, R. N. Brown, D. H. Silber, G. M. Mullen, D. S. Feldman, R. M. Oren, C. W. Yancy and the Cardiac Transplant Research Database Group

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03598.x

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      Analysis of incidence data from a transplant database accounting for approximately one-quarter of heart transplants in the United States during the period 1993–2004 finds an elevated risk of skin cancer, particularly cutaneous squamous cell carcinoma.

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      A Case–Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients (pages 1498–1508)

      C. M. Proby, C. A. Harwood, R. E. Neale, A. C. Green, S. Euvrard, L. Naldi, G. Tessari, M. C. W. Feltkamp, M. N. C. de Koning, W. G. V. Quint, T. Waterboer, M. Pawlita, S. Weissenborn, U. Wieland, H. Pfister, E. Stockfleth, I. Nindl, D. Abeni, J. ter Schegget, J. N. Bouwes Bavinck and the EPI-HPV-UV-CA group

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03589.x

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      In a case-control study from Europe, DNA testing on eyebrow hairs and analysis of serum antibodies to L1 proteins taken as a combined measure of beta-papillomavirus (betaPV) infection show an association between betaPV infection and cutaneous squamous cell carcinoma in organ transplant recipients.

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      Less Maintenance Immunosuppression in Lung Transplantation Following Hematopoietic Stem Cell Transplantation From the Same Living Donor (pages 1509–1516)

      F. Chen, M. Yamane, M. Inoue, T. Shiraishi, T. Oto, M. Minami, J. Yanagisawa, T. Fujinaga, T. Shoji, S. Toyooka, M. Okumura, S. Miyoshi, T. Bando and H. Date

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03591.x

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      Living-donor lobar lung transplantation involving the same donor as for hematopoietic stem cell transplantation appears to have advantages related to lower immunosuppression compared to living-donor lobar lung transplantation from relatives who are not the hematopoietic stem cell transplantation donors.

  7. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      Intensivist-Led Management of Brain-Dead Donors Is Associated with an Increase in Organ Recovery for Transplantation (pages 1517–1521)

      K. Singbartl, R. Murugan, A. M. Kaynar, D. W. Crippen, S. A. Tisherman, K. Shutterly, S. A. Stuart, R. Simmons and J. M. Darby

      Article first published online: 30 MAR 2011 | DOI: 10.1111/j.1600-6143.2011.03485.x

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      This study shows that the routine involvement of intensivists in donor management is associated with a significant increase in transplanted organs and should be considered as a new strategy to alleviate the shortage of transplantable organs.

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      Lack of Listing Status Awareness: Results of a Single-Center Survey of Hemodialysis Patients (pages 1522–1526)

      A. Gillespie, H. Hammer, J. Lee, C. Nnewihe, J. Gordon and P. Silva

      Article first published online: 12 APR 2011 | DOI: 10.1111/j.1600-6143.2011.03524.x

      A survey of an urban hemodialysis center finds that a significant number of patients who want a deceased donor kidney transplant mistakenly believe they are on the transplant waiting list when they are actually not listed. See editorial by Reese and Bloom on page 1357.

  8. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
    1. You have full text access to this OnlineOpen article
      Blood Group A Isoagglutinins in A2[RIGHTWARDS ARROW] O Simultaneous Liver/Kidney Transplantation May Not Influence Kidney Function (pages 1527–1530)

      C. F. Bryan, B. Abdulkarim, A. Nawabi, D. Stewart and S. G. Yarlagadda

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03575.x

      One-year graft outcome in A2 to O simultaneous liver/kidney transplantation (SLK) is comparable to that of ABO-compatible SLK transplants and represents a strategy to increase O candidates' access to donor organs.

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      Passive Transient Transfer of Peanut Allergy by Liver Transplantation (pages 1531–1534)

      P. Dewachter, C. Vézinet, P. Nicaise-Roland, S. Chollet-Martin, D. Eyraud, H. Creusvaux, J. C. Vaillant and C. Mouton-Faivre

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03576.x

      The authors report a case of transferred symptomatic IgE-mediated peanut allergy following elective and blood-group-compatible liver transplantation, and demonstrate that, in this patient, the allergy was transient and therefore passive.

  9. Reports from the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      Hepatitis C Virus Infection Among Adolescents and Young Adults—Massachusetts, 2002–2009 (pages 1535–1538)

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03659.x

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      This report highlights the changing demographics for hepatitis C infection in Massachusetts, an observation which may have repercussions for the donor pool, specifically the assessment of donors at increased risk for HCV infection.

  10. Book Review

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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  11. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Personal Viewpoints
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports from the CDC: MMWR
    11. Book Review
    12. Letters to the Editor
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      Anti-Cw Donor-specific Alloantibodies Can Lead to Positive Flow Cytometry Crossmatch and Irreversible Acute Antibody-Mediated Rejection (pages 1543–1544)

      T. Bachelet, L. Couzi, G. Guidicelli, K. Moreau, D. Morel, P. Merville and J.-L. Taupin

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03584.x

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