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American Journal of Transplantation

Cover image for Vol. 11 Issue 8

August 2011

Volume 11, Issue 8

Pages 1547–1760

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 1547–1548)

      SUE PONDROM

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03707.x

      UNOS has given its Kidney Transplantation Committee the green light to develop a new kidney allocation policy based on a concept intended to improve age-matching and survival rates. This month, “The AJT Report” takes a closer look at this concept and speaks with some of its supporters and opponents.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have free access to this content
      LITERATURE Watch: Implications for transplantation (page 1549)

      JONATHAN S. BROMBERG

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03708.x

      This month's “Literature Watch” highlights newly identified and potentially transformative genes for renal diseases with particular commentary on the limitations of genome wide association studies.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have free access to this content
      How to Use mTOR Inhibitors? The Search Goes On (pages 1551–1552)

      K. Budde

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03574.x

      The results of the ORION trial, where two sirolimus-based therapeutic strategies were investigated, provide an opportunity to learn important lessons for the design of future studies and to critically review the role of mTOR inhibitors after transplantation. See article by Flechner et al on page 1633.

    2. You have free access to this content
      Steroid Withdrawal in Patients Transplanted for IgA Nephropathy—A Disease-Specific Consideration? (pages 1553–1555)

      S. J. Cohney

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03668.x

      The author provides critical and contextual assessment of Clayton et al's study suggesting an increase in graft loss from recurrent IgA following steroid elimination. See page 1645.

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      Defining Living Kidney Donor ESRD Risk—Looking Beyond Race and Gender (pages 1556–1558)

      T. R. Srinivas

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03610.x

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      This editorial highlights the complex relationship between race, gender and biology in understanding the risk of developing end stage renal disease after living kidney donation. See article by Cherikh et al on page 1650.

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      Cyclosporine A or Tacrolimus for Hepatitis C Recurrence? An Old Debate (pages 1559–1560)

      X. Forns and M. Navasa

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03511.x

      Prospective studies analyzing the potential influence of cyclosporine A versus tacrolimus following liver transplant for hepatitis C virus on the new anti-viral protease and polymerase inhibitors might help address the perennial debate of the best calcineurin inhibitor for this indication. See article by Irish et al on page 1676.

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      Immunization Against Influenza: A Balancing Act (pages 1561–1562)

      D. Kumar and L. Danziger-Isakov

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03605.x

      Given that influenza vaccination is an important preventive measure, studies showing association between vaccination and formation of HLA alloantibodies need to be interpreted with caution. See brief communication by Katarinis et al on page 1727.

  4. Minireviews

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have full text access to this OnlineOpen article
      Liver Ischemia and Reperfusion Injury: New Insights into Mechanisms of Innate—Adaptive Immune-Mediated Tissue Inflammation (pages 1563–1569)

      Y. Zhai, R. W. Busuttil and J. W. Kupiec-Weglinski

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03579.x

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      Liver inflammation triggered by the insults of peri-transplant ischemia and reperfusion is an innate immune-dominated local response regulated by CD4+ T cells.

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      Surveillance Protocol Kidney Transplant Biopsies: Their Evolving Role in Clinical Practice (pages 1570–1575)

      L. K. Henderson, B. J. Nankivell and J. R. Chapman*

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03677.x

      This paper reviews the role of surveillance kidney biopsies in routine clinical practice and clinical research studies.

  5. Special Article

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have full text access to this OnlineOpen article
      Evolution of the Role of the Transplant Pharmacist on the Multidisciplinary Transplant Team (pages 1576–1583)

      R. R. Alloway, R. Dupuis, S. Gabardi, T. E. Kaiser, D. J. Taber, E. M. Tichy, N. A. Weimert-Pilch and on behalf of the American Society of Transplantation Transplant Pharmacy Community of Practice and the American College of Clinical Pharmacy Immunology/Transplantation Practice and Research Network

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03601.x

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      This article reviews the role and training of the transplant pharmacist and provides guidance for implementation of novel pharmacy services.

  6. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have full text access to this OnlineOpen article
      Skin Cancer in Transplant Recipients, Out of the Woods. Scientific Retreat of the ITSCC and SCOPE (pages 1584–1591)

      O. R. Colegio and E. M. Billingsley

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03645.x

      Transplant dermatologists and skin cancer researchers present a snapshot of the current state of research on transplant-associated skin cancers discussed at the Biennial Scientific Retreat of the International Transplant Skin Cancer Collaborative and Skin Care in Organ Transplant Patients Europe held in October 2010.

  7. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have full text access to this OnlineOpen article
      Mastering the Risk of HLA Antibodies in Kidney Transplantation: An Algorithm Based on Pretransplant Single-Antigen Flow Bead Techniques (pages 1592–1598)

      C. Lefaucheur, C. Antoine, C. Suberbielle and D. Glotz

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03560.x

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      The authors present an algorithm that manages sensitized patients on the waiting list based on a predicted probability of transplantation at the lowest risk of HLA antibodies.

  8. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. Basic Science

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      Selective CD28 Blockade Attenuates Acute and Chronic Rejection of Murine Cardiac Allografts in a CTLA-4-Dependent Manner (pages 1599–1609)

      T. Zhang, S. Fresnay, E. Welty, N. Sangrampurkar, E. Rybak, H. Zhou, X.-F. Cheng, Q. Feng, C. Avon, A. Laaris, M. Whitters, A. M. Nagelin, R. M. O’Hara Jr and A. M. Azimzadeh

      Article first published online: 12 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03624.x

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      Selectively blocking CD28 using a monovalent non-activating antibody fragment in conjunction with a short course of CD154 or calcineurin inhibition synergistically promotes long-term graft acceptance and intra-graft Tregs, and this effect is prevented by CTLA-4 blockade.

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      The Potency of Allospecific Tregs Cells Appears to Correlate With T Cell Receptor Functional Avidity (pages 1610–1620)

      J. Y. S. Tsang, K. Ratnasothy, D. Li, Y. Chen, R. P. Bucy, K. F. Lau, L. Smyth, G. Lombardi, R. Lechler and P. K. H. Tam

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03650.x

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      Allospecific regulatory T cells with different T cell receptor functional avidity appear to have differential regulatory capacities in graft survival.

    3. You have full text access to this OnlineOpen article
      Hearts From DCD Donors Display Acceptable Biventricular Function After Heart Transplantation in Pigs (pages 1621–1632)

      A. A. Ali, P. White, B. Xiang, H-Y. Lin, S. S. Tsui, E. Ashley, T.W. Lee, J. R. H. Klein, K. Kumar, R. C. Arora, S. R. Large, G. Tian and D. H. Freed

      Article first published online: 12 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03622.x

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      Using a large animal model of heart transplantation, the authors show that hearts from donation after cardiac death donors recover sufficient metabolic and contractile function to support the circulation of a recipient animal.

    4. Clinical Science

      You have full text access to this OnlineOpen article
      The ORION Study: Comparison of Two Sirolimus-Based Regimens versus Tacrolimus and Mycophenolate Mofetil in Renal Allograft Recipients (pages 1633–1644)

      S. M. Flechner, M. Glyda, S. Cockfield, J. Grinyó, Ch. Legendre, G. Russ, S. Steinberg, K. M. Wissing and S. S. Tai

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03573.x

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      Two sirolimus-based regimens are compared to tacrolimus in de novo kidney transplant recipients, and the intention to treat outcomes at two years are not improved for the sirolimus treated groups. See editorial by Budde on page 1551.

      Corrected by:

      Erratum

      Vol. 12, Issue 1, 268, Article first published online: 13 JAN 2012

    5. You have full text access to this OnlineOpen article
      Steroids and Recurrent IgA Nephropathy After Kidney Transplantation (pages 1645–1649)

      P. Clayton, S. McDonald and S. Chadban

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03667.x

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      A large registry study finds that steroid use is associated with a significantly lower risk of graft loss from recurrent IgA nephropathy. See editorial by Cohney on page 1553.

    6. You have full text access to this OnlineOpen article
      Ethnic and Gender Related Differences in the Risk of End-Stage Renal Disease After Living Kidney Donation (pages 1650–1655)

      W. S. Cherikh, C. J. Young, B. F. Kramer, S. E. Taranto, H. B. Randall and P.-Y. Fan

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03609.x

      This study utilizes the OPTN and CMS databases to demonstrate that although the ESRD rates after living kidney donation are higher for Black compared to White donors and for male compared to female donors, these ethnic- and gender-related differences compare favorably to those reported in the general population. See editorial by Srinivas on page 1656.

    7. You have full text access to this OnlineOpen article
      Rapamycin-Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression (pages 1656–1664)

      T. Tataranni, G. Biondi, M. Cariello, M. Mangino, G. Colucci, M. Rutigliano, P. Ditonno, F. P. Schena, L. Gesualdo and G. Grandaliano

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03590.x

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      Rapamycin influences phosphate homeostasis and insulin resistance modulating klotho expression in epithelial tubular cells and this event is mediated by mTORC2 through AKT phosphorylation.

    8. You have full text access to this OnlineOpen article
      Efficacy and Safety of Early Cyclosporine Conversion to Sirolimus with Continued MMF—Four-Year Results of the Postconcept Study (pages 1665–1675)

      Y. Lebranchu, A. Thierry, E. Thervet, M. Büchler, I. Etienne, P. F. Westeel, B. Hurault de Ligny, B. Moulin, J. P. Rérolle, T. Frouget, S. Girardot-Seguin and O. Toupance

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03637.x

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      A randomized study of an early cyclosporine to sirolimus conversion at 3 months after transplantation (the CONCEPT study) shows that the renal benefit observed at 1 year is maintained and even more pronounced at 4 years.

    9. You have full text access to this OnlineOpen article
      Cyclosporine versus Tacrolimus Treated Liver Transplant Recipients with Chronic Hepatitis C: Outcomes Analysis of the UNOS/OPTN Database (pages 1676–1685)

      W. D. Irish, S. Arcona, D. Bowers and J. F. Trotter

      Article first published online: 12 MAY 2011 | DOI: 10.1111/j.1600-6143.2011.03508.x

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      Administration of cyclosporine maintenance immunosuppression to HCV-infected liver transplant recipients at time of hospital discharge is associated with an increased risk of graft failure compared to administration of tacrolimus. See editorial by Forns and Navasa on page 1559.

    10. You have full text access to this OnlineOpen article
      Fibrosing Cholestatic Hepatitis in HIV/HCV Co-Infected Transplant Patients—Usefulness of Early Markers After Liver Transplantation (pages 1686–1695)

      T. M. Antonini, M. Sebagh, A. M. Roque-Afonso, E. Teicher, B. Roche, R. Sobesky, A. Coilly, P. Vaghefi, R. Adam, D. Vittecoq, D. Castaing, D. Samuel and J.-C. Duclos-Vallée

      Article first published online: 12 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03608.x

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      An early diagnosis of fibrosing cholestatic hepatitis, which develops after liver transplantation in 19% of a cohort of HIV/HCV coinfected patients, is feasible.

    11. You have full text access to this OnlineOpen article
      Can the Dropout Risk of Candidates with Hepatocellular Carcinoma Predict Survival after Liver Transplantation? (pages 1696–1704)

      A. Cucchetti, M. Cescon, V. Bertuzzo, E. Bigonzi, G. Ercolani, M. C. Morelli, M. Ravaioli and A. D. Pinna

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03570.x

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      Data from recipients with hepatocellular carcinoma are reviewed and show that the higher the dropout probability while on waiting list, the lower the predicted survival after transplantation, a relationship that is worsened by hepatitis C positivity.

    12. You have full text access to this OnlineOpen article
      Patients’ Willingness to Accept Expanded Criteria Donor Liver Transplantation (pages 1705–1711)

      J. R. Rodrigue, D. W. Hanto and M. P. Curry

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03592.x

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      Findings from this study show that not all patients are willing to accept liver transplantation using an expanded criteria donor, although most patients were willing to accept moderately or substantially higher one-year mortality risk for expanded criteria donor transplantation relative to standard criteria donor transplantation.

    13. You have full text access to this OnlineOpen article
      Transplanting Kidneys Without Points for HLA-B Matching: Consequences of the Policy Change (pages 1712–1718)

      V. B. Ashby, F. K. Port, R. A. Wolfe, J. J. Wynn, W. W. Williams, J. P. Roberts and A. B. Leichtman

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03606.x

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      This article examines graft survival and transplant distributions by race and ethnicity, both before and after the 2003 change in the US kidney allocation system that eliminated priority for HLA-B similarity.

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      The Impact of Variation in Donation After Cardiac Death Policies Among Donor Hospitals: A Regional Analysis (pages 1719–1726)

      J. Y. Rhee, R. Ruthazer, K. O’Connor, F. L. Delmonico, R. S. Luskin and R. B. Freeman

      Article first published online: 12 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03634.x

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      A regional analysis of donation after cardiac death policies reveals a great deal of variability, which may impact donation rates, transplantation rates and clinical outcomes.

  9. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have full text access to this OnlineOpen article
      De Novo Anti-HLA Antibody After Pandemic H1N1 and Seasonal Influenza Immunization in Kidney Transplant Recipients (pages 1727–1733)

      I. Katerinis, K. Hadaya, R. Duquesnoy, S. Ferrari-Lacraz, S. Meier, C. van Delden, P.-Y. Martin, C.-A. Siegrist and J. Villard

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03604.x

      This study demonstrates an unexpectedly high rate of transient de novo anti-HLA antibody after pandemic H1N1 and seasonal influenza immunization in kidney transplant recipients. See editorial by Kumar and Danziger-Izakov on page 1561.

    2. You have full text access to this OnlineOpen article
      Relative Resistance of Human CD4+ Memory T Cells to Suppression by CD4+CD25+ Regulatory T Cells (pages 1734–1742)

      B. Afzali, P. J. Mitchell, C. Scottà, J. Canavan, F. C. Edozie, H. Fazekasova, G. M. Lord, S. John, L. D. Barber, M. P. Hernandez-Fuentes, R. I. Lechler and G. Lombardi

      Article first published online: 12 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03635.x

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      This study describes lower suppressive capability of human regulatory T cells on autologous responder cells, which is of relevance to the design of clinical trials of cell therapy for the induction of tolerance to transplanted tissues.

  10. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have full text access to this OnlineOpen article
      Left Renal Vein Ligation: A Technique to Mitigate Low Portal Flow from Splenic Vein Siphon during Liver Transplantation (pages 1743–1747)

      R. R. Slater, N. Jabbour, A. Abou Abbass, V. Patil, J. Hundley, M. Kazimi, D. Kim, A. Yoshida and M. Abouljoud

      Article first published online: 10 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03578.x

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      Inadequate portal flows during liver transplant can be successfully ameliorated by ligating the left renal vein when a surgical or spontaneous shunt is present.

    2. You have full text access to this OnlineOpen article
      Do NK Cells Contribute to the Pathophysiology of Transplant-Associated Thrombotic Microangiopathy? (pages 1748–1752)

      M. Ansari, M. Vukicevic, A. L. Rougemont, S. Moll, P. Parvex, F. Gumy-Pause, Y. Chalandon, J. Passweg, H. Ozsahin and E. Roosnek

      Article first published online: 30 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03617.x

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      NK cells may contribute to transplant-associated thrombotic microangiopathy and its progression.

  11. Reports from the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have free access to this content
      Investigation Update: Outbreak of Shiga Toxin-Producing E. coli O104 (STEC O104:H4) Infections Associated With Travel to Germany (pages 1753–1754)

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03706.x

      Updated information is provided by the CDC regarding the European E. coli O104 outbreak, which may have relevance for transplant recipients and donors.

  12. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have free access to this content
      Liver Transplantation in an Adult With Sclerosing Cholangitis due to Multisystem Langerhans Cell Histiocytosis (pages 1755–1756)

      R. J. Lee, C. Leung, E. J. Lim, P. W. Angus, P. S. Bhathal, P. Crowley, M. Gonzales, D. Stella, J. F. Seymour and A. G. Speer

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03661.x

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      Delineating the Picture of Renal Graft Injury in 2011 (page 1757)

      A. Loupy, D. Vernerey, G.S. Hill, Ch. Legendre and D. Anglicheau

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03603.x

    3. You have free access to this content
      An Important Debate (page 1758)

      Mark D. Stegall, Walter Park and Fernando Cosio

      Article first published online: 14 JUN 2011 | DOI: 10.1111/j.1600-6143.2011.03602.x

  13. Errata

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports from the CDC: MMWR
    13. Letters to the Editor
    14. Errata
    1. You have free access to this content
      Erratum (page 1759)

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03710.x

      This article corrects:
    2. You have free access to this content
      Erratum (page 1760)

      Article first published online: 28 JUL 2011 | DOI: 10.1111/j.1600-6143.2011.03711.x

      This article corrects:

      Poster Abstracts

      Vol. 11, Issue Supplement s2, 213–527, Article first published online: 4 APR 2011

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