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American Journal of Transplantation

Cover image for Vol. 12 Issue 9

September 2012

Volume 12, Issue 9

Pages 2263–2563

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. You have free access to this content
      The AJT Report: News and issues that affect organ and tissue transplantation (pages 2263–2264)

      NORRA MACREADY

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04255.x

      Researchers are studying new high-tech solutions to help improve medication adherence, self-management skills and overall health outcomes in transplant patients.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
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      LITERATURE Watch: Implications for transplantation (page 2265)

      Xian C. Li, Jonathan S. Bromberg and Jonathan S. Bromberg

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04256.x

      Recent studies suggest that mast cells function in a broad spectrum of immune and nonimmune responses, which may fundamentally change our perceptions about how peripheral tolerance or homeostasis is induced and maintained.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
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      Reducing Complications in Pediatric Liver Transplantation: Do We Have the Answer? (pages 2267–2268)

      J. Emond

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04208.x

      This editorial accompanies a paper describing a quality initiative in pediatric liver transplant and points out the pitfalls in quality-based guidelines both specific to the Englesbe report (page 2301) and generic in the field of quality.

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      Costimulation Blockade—A Double-Edged Sword? (pages 2269–2270)

      J. S. Maltzman

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04185.x

      The author describes the findings of Riella et al (see April issue) and Charbonnier et al (see page 2313) that CTLA4Ig worsens outcomes in regulatory T cell–dependent models of transplantation and discusses how these findings may impact future research and clinical use of related drugs.

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      Perspectives on Lung Transplantation and Donation-After-Determination-of-Cardiac-Death Donors (pages 2271–2272)

      R. B. Love

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04199.x

      An Australian collaborative report confirms that the regular use of donation-after-determination-of-cardiac-death lungs is both feasible and underutilized. See article by Levvey et al on page 2406.

  4. Minireviews

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
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      Informed Consent for Living Donation: A Review of Key Empirical Studies, Ethical Challenges and Future Research (pages 2273–2280)

      E. J. Gordon

      Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04102.x

      This review highlights challenges to informed consent for both live kidney donors and live liver donors, and situates trends within broader policy contexts, ethical debates and avenues for future innovative research.

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      Hepatitis E Virus: What Transplant Physicians Should Know (pages 2281–2287)

      N. Kamar, F. Legrand-Abravanel, J. Izopet and L. Rostaing

      Article first published online: 30 APR 2012 | DOI: 10.1111/j.1600-6143.2012.04078.x

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      In organ transplant recipients, hepatitis E virus may be responsible for chronic hepatitis and extra-hepatic manifestations that can require specific antiviral therapy.

  5. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
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      Diagnosis and Management of Tuberculosis in Transplant Donors: A Donor-Derived Infections Consensus Conference Report (pages 2288–2300)

      M. I. Morris, J. S. Daly, E. Blumberg, D. Kumar, M. Sester, N. Schluger, S.-H. Kim, B. S. Schwartz, M. G. Ison, A. Humar, N. Singh, M. Michaels, J. P. Orlowski, F. Delmonico, T. Pruett, G. T. John and C. N. Kotton

      Article first published online: 6 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04205.x

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      This consensus report reviews current epidemiology and diagnostic testing for the identification of latent and active tuberculosis infection in deceased and living organ transplant donors and provides recommendations for the management of transplant donors and recipients, as well as suggested areas for future research.

  6. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. You have free access to this content
      Reducing Pediatric Liver Transplant Complications: A Potential Roadmap for Transplant Quality Improvement Initiatives Within North America (pages 2301–2306)

      M. J. Englesbe, B. Kelly, J. Goss, A. Fecteau, J. Mitchell, W. Andrews, G. Krapohl, J. C. Magee, G. Mazariegos, S. Horslen and J. Bucuvalas

      Article first published online: 6 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04204.x

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      This viewpoint describes a multi-institutional quality collaborative approach within the Studies in Pediatric Liver Transplantation group and may represent a useful framework for physician-driven, broad-based quality improvement within transplantation. See editorial by Emond on page 2267.

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      Preventable Errors in Organ Transplantation: An Emerging Patient Safety Issue? (pages 2307–2312)

      M. G. Ison, J. L. Holl and D. Ladner

      Article first published online: 15 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04139.x

      The authors provide examples of several recent high-profile patient safety events linked to system and process weaknesses and suggest that the transplant community needs to embrace the implementation of evidence-based system and process improvements to effectively mitigate existing safety vulnerabilities.

  7. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. Basic Science

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      CTLA4-Ig Restores Rejection of MHC Class-II Mismatched Allografts by Disabling IL-2-Expanded Regulatory T Cells (pages 2313–2321)

      L.-M. Charbonnier, B. Vokaer, P. H. Lemaître, K. A. Field, O. Leo and A. Le Moine

      Article first published online: 3 JUL 2012 | DOI: 10.1111/j.1600-6143.2012.04184.x

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      CTLA4-Ig promotes CD4-mediated allograft rejection by counteracting a regulatory T cell–based protocol for tolerance induction. See editorial by Maltzman on page 2269.

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      Lymphotoxin-Beta Receptor Blockade Induces Inflammation and Fibrosis in Tolerized Cardiac Allografts (pages 2322–2334)

      Y. Nakayama and J. S. Bromberg

      Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04090.x

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      Lymphotoxin-beta receptor blockade induces inflammation with neutrophils and CD8 T cells, and fibrosis in tolerized cardiac allografts.

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      Donor-Specific CD8+Foxp3+ T Cells Protect Skin Allografts and Facilitate Induction of Conventional CD4+Foxp3+ Regulatory T Cells (pages 2335–2347)

      N. M Lerret, J. L Houlihan, T. Kheradmand, K. L Pothoven, Z. J Zhang and X. Luo

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04120.x

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      Alloantigen-specific CD8+Foxp3+ regulatory T cells exert their suppressive function by inducing the down-regulation of costimulatory molecules on CD11c+CD8α+ dendritic cells and facilitating the conversion of naïve CD4+ T cells into CD4+CD25+Foxp3+ cells.

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      Cyclophilin A and Nuclear Factor of Activated T Cells Are Essential in Cyclosporine-Mediated Suppression of Polyomavirus BK Replication (pages 2348–2362)

      Y. J. Li, H. H. Wu, C. H. Weng, Y. C. Chen, C. C. Hung, C. W. Yang, R. Y. L. Wang, N. Sakamoto and Y. C. Tian

      Article first published online: 29 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04116.x

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      Cyclophilin A and the nuclear factor of activated T cells are shown to be essential in cyclosporine-mediated suppression of polyomavirus BK replication.

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      Protective Effects of Transgenic Human Endothelial Protein C Receptor Expression in Murine Models of Transplantation (pages 2363–2372)

      K. F. E. Lee, B. Lu, J. C. Roussel, L. J. Murray-Segal, E. J. Salvaris, S. J. Hodgkinson, B. M. Hall, A. J. F. d'Apice, P. J. Cowan and H. Gock

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04122.x

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      Transgenic human endothelial protein C receptor expression protects against thrombosis and inflammation in mouse models of transplantation.

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      Localization of Mesenchymal Stromal Cells Dictates Their Immune or Proinflammatory Effects in Kidney Transplantation (pages 2373–2383)

      F. Casiraghi, N. Azzollini, M. Todeschini, R. A. Cavinato, P. Cassis, S. Solini, C. Rota, M. Morigi, M. Introna, R. Maranta, N. Perico, G. Remuzzi and M. Noris

      Article first published online: 29 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04115.x

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      In a murine kidney transplant model, posttransplant MSC infusion causes premature graft dysfunction and fails to prolong graft survival, while pretransplant MSC infusion induces a significant prolongation of kidney graft survival by a regulatory T cell–dependent mechanism.

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      Permanent CNI Treatment for Prevention of Renal Allograft Rejection in Sensitized Hosts Can Be Replaced by Regulatory T Cells (pages 2384–2394)

      A. Siepert, S. Ahrlich, K. Vogt, C. Appelt, K. Stanko, A. Kühl, J. van den Brandt, H. M. Reichardt, H. Nizze, M. Lehmann, M. Tiedge, H.-D. Volk, B. Sawitzki and P. Reinke

      Article first published online: 15 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04143.x

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      Adoptive transfer of green fluorescent protein expressing alloreactive memory CD4+ and CD8+ T cells 7 or even 100 days prior to kidney transplantation elicits an acute rejection refractory to T cell depletion, which can only be prevented by permanent cyclosporine A therapy or a combined treatment of cyclosporine A and regulatory T cells.

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      Enhanced De Novo Alloantibody and Antibody-Mediated Injury in Rhesus Macaques (pages 2395–2405)

      E. K. Page, A. J. Page, J. Kwun, A. C. Gibby, F. Leopardi, J. B. Jenkins, E. A. Strobert, M. Song, R. A. Hennigar, N. Iwakoshi and S. J. Knechtle

      Article first published online: 9 JUL 2012 | DOI: 10.1111/j.1600-6143.2012.04074.x

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      Homeostatic repopulation of CD4+ memory T cells enhances early alloantibody production and antibody-mediated renal allograft injury in CD3-specific immunotoxin-treated rhesus macaques.

    9. Clinical Science

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      Excellent Clinical Outcomes From a National Donation-After-Determination-of-Cardiac-Death Lung Transplant Collaborative (pages 2406–2413)

      B. J. Levvey, M. Harkess, P. Hopkins, D. Chambers, C. Merry, A. R. Glanville and G. I. Snell

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1600-6143.2012.04193.x

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      This article describes excellent clinical outcomes following a large multicenter Australian Collaborative series of Maastricht category III donation-after-determination-of-cardiac-death donor lung transplants. See editorial by Love on page 2271.

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      Donor-Derived Fungal Infections in Organ Transplant Recipients: Guidelines of the American Society of Transplantation, Infectious Diseases Community of Practice (pages 2414–2428)

      N. Singh, S. Huprikar, S. D. Burdette, M. I. Morris, J. E. Blair, L. J. Wheat and the American Society of Transplantation, Infectious Diseases Community of Practice, Donor-Derived Fungal Infection Working Group

      Article first published online: 13 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04100.x

      This document presents the guidelines endorsed by the American Society of Transplantation regarding the characteristics, diagnostic evaluation and approach to the management of donor-derived fungal infections in organ transplant recipients.

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      Chain Transplantation: Initial Experience of a Large Multicenter Program (pages 2429–2436)

      M. L. Melcher, D. B. Leeser, H. A. Gritsch, J. Milner, S. Kapur, S. Busque, J. P. Roberts, S. Katznelson, W. Bry, H. Yang, A. Lu, S. Mulgaonkar, G. M. Danovitch, G. Hil and J. L. Veale

      Article first published online: 19 JUL 2012 | DOI: 10.1111/j.1600-6143.2012.04156.x

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      The authors report on the largest series of kidney chain transplants, which includes 54 nondirected donors and 272 recipients of whom 46% are ethnic minorities and 63% received shipped grafts from other centers.

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      Kidney Function and Risk of Cardiovascular Disease and Mortality in Kidney Transplant Recipients: The FAVORIT Trial (pages 2437–2445)

      D. E. Weiner, M. A. Carpenter, A. S. Levey, A. Ivanova, E. H. Cole, L. Hunsicker, B. L. Kasiske, S. J. Kim, J. W. Kusek and A. G. Bostom

      Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04101.x

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      In stable kidney transplant recipients participating in the FAVORIT Trial, lower estimated glomerular filtration rate, beginning at a level of 45 ml/min per 1.73 m2, is independently associated with cardiovascular disease events and all-cause mortality, suggesting that reduced kidney function itself may directly lead to cardiovascular disease independent of preexisting comorbidities.

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      Randomized Phase 2b Trial of Tofacitinib (CP-690,550) in De Novo Kidney Transplant Patients: Efficacy, Renal Function and Safety at 1 Year (pages 2446–2456)

      F. Vincenti, H. Tedesco Silva, S. Busque, P. O’Connell, J. Friedewald, D. Cibrik, K. Budde, A. Yoshida, S. Cohney, W. Weimar, Y. S. Kim, N. Lawendy, S.-P. Lan, E. Kudlacz, S. Krishnaswami and G. Chan

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04127.x

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      The authors present the results of a phase 2b trial of tofacitinib in renal transplantation.

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      Cytomegalovirus Replication Kinetics in Solid Organ Transplant Recipients Managed by Preemptive Therapy (pages 2457–2464)

      S. F. Atabani, C. Smith, C. Atkinson, R. W. Aldridge, M. Rodriguez-Perálvarez, N. Rolando, M. Harber, G. Jones, A. O’Riordan, A. K. Burroughs, D. Thorburn, J. O’Beirne, R. S. B. Milne, V. C. Emery and P. D. Griffiths

      Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04087.x

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      The authors show that preemptive antiviral therapy is an effective approach for control and prevention of cytomegalovirus replication after renal and liver transplantation, even in high-risk patients.

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      Liver Retransplantation in HIV-Infected Patients: A Prospective Cohort Study (pages 2465–2476)

      M. Gastaca, F. Aguero, A. Rimola, M. Montejo, P. Miralles, R. Lozano, L. Castells, M. Abradelo, M. de la Mata, F. San Juan Rodríguez, E. Cordero, S. del Campo, C. Manzardo, J.O. de Urbina, I. Pérez, G. de la Rosa, J. M. Miro and the FIPSE OLT-HIV investigators

      Article first published online: 15 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04142.x

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      HIV-infected liver transplant patients have lower survival after liver retransplantation than matched HIV-negative liver retransplanted recipients; however, HIV-infected patients with undetectable HCV RNA at retransplantation or undergoing late retransplantation have a more favorable outcome, similar to that in their HIV-negative counterparts.

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      Hypothermic Machine Preservation Reduces Molecular Markers of Ischemia/Reperfusion Injury in Human Liver Transplantation (pages 2477–2486)

      S. D. Henry, E. Nachber, J. Tulipan, J. Stone, C. Bae, L. Reznik, T. Kato, B. Samstein, J. C. Emond and J. V. Guarrera

      Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04086.x

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      The authors report that hypothermic machine preservation of 20 transplanted human livers resulted in down-regulation of a variety of molecular markers of ischemia/reperfusion injury compared to standard cold storage control cases.

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      Randomized Controlled Trial of Sirolimus Conversion in Cardiac Transplant Recipients With Renal Insufficiency (pages 2487–2497)

      A. Zuckermann, Anne Keogh, M. G. Crespo-Leiro, D. Mancini, F. González Vilchez, L. Almenar, S. Brozena, H. Eisen, S. See Tai and S. Kushwaha

      Article first published online: 9 JUL 2012 | DOI: 10.1111/j.1600-6143.2012.04131.x

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      This randomized, comparative, multinational study of cardiac transplant recipients with mild to moderate renal insufficiency shows that conversion to sirolimus from calcineurin inhibitor therapy significantly improves renal function but with an attendant risk of acute rejection.

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      Benchmarking in the Process of Donation After Brain Death: A Methodology to Identify Best Performer Hospitals (pages 2498–2506)

      R. Matesanz, E. Coll, B. Domínguez-Gil, G. de la Rosa, R. Marazuela, V. Arráez, P. Elorrieta, A. Fernández-García, C. Fernández-Renedo, J. Galán, P. Gómez-Marinero, C. Martín-Delagebasala, S. Martín-Jiménez, N. Masnou, P. Salamero, J. Sánchez-Ibáñez, E. Serna, F. Martínez-Soba, A. Pastor-Rodríguez, E. Bouzas and P. Castro

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04128.x

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      The authors provide a detailed description of a benchmarking methodology that allows the identification of best performer hospitals in the process of donation after brain death.

  8. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. You have free access to this content
      Continuously Evaluating Performance in Deceased Donation: The Spanish Quality Assurance Program (pages 2507–2513)

      G. de la Rosa, B. Domínguez-Gil, R. Matesanz, S. Ramón, J. Alonso-Álvarez, J. Araiz, G. Choperena, J. L. Cortés, D. Daga, J. Elizalde, D. Escudero, E. Escudero, C. Fernández-Renedo, M. A. Frutos, J. Galán, M. A. Getino, F. Guerrero, M. Lara, L. López-Sánchez, S. Macías, J. Martínez-Guillén, N. Masnou, S. Pedraza, T. Pont and A. Sánchez-Rodríguez

      Article first published online: 15 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04138.x

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      The Spanish Quality Assurance Program applied to the process of donation after brain death represents a systematic, continuous and sustainable approach for a comprehensive assessment of this process, allowing for the estimation of the potential of donation, the analysis of performance and the identification of areas for improvement.

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      Brain Death Determination in Israel: The First Two Years Experience Following Changes to the Brain Death Law—Opportunities and Challenges (pages 2514–2518)

      J. Cohen, T. Ashkenazi, E. Katvan and P. Singer

      Article first published online: 17 MAY 2012 | DOI: 10.1111/j.1600-6143.2012.04089.x

      An analysis of changes made to the Brain Death Act in Israel accommodating requirements of the religious authorities reveals many obstacles to brain death determination.

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      Changes in Neurocognitive Functioning Following Lung Transplantation (pages 2519–2525)

      B. M. Hoffman, J. A. Blumenthal, R. C. Carney, C. V. F. O’Hayer, K. Freedland, P. J. Smith, M. A. Babyak, R. D. Davis, J. P. Mathew, T. Martinu and S. Palmer

      Article first published online: 30 APR 2012 | DOI: 10.1111/j.1600-6143.2012.04072.x

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      Data provided by 49 patients who completed neuropsychological tests before and 6 months following lung transplantation suggest that verbal memory may improve after lung transplantation, whereas executive function may improve for younger patients but decline for older patients.

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      Bortezomib for Acute Antibody-Mediated Rejection in Liver Transplantation (pages 2526–2531)

      F. Paterno, M. Shiller, G. Tillery, J. G. O’Leary, B. Susskind, J. Trotter and G. B. Klintmalm

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04126.x

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      This study reviews three cases of acute antibody-mediated rejection in ABO-compatible liver transplant recipients treated with proteasome-inhibitor therapy (bortezomib) with remarkable clinical, immunologic and histologic outcomes.

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      Low-Dose IL-2 for In Vivo Expansion of CD4+ and CD8+ Regulatory T Cells in Nonhuman Primates (pages 2532–2537)

      A. Aoyama, D. Klarin, Y. Yamada, S. Boskovic, O. Nadazdin, K. Kawai, D. Schoenfeld, J. C. Madsen, A. B. Cosimi, G. Benichou and T. Kawai

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04133.x

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      Low-dose IL-2 therapy significantly expands functional CD4+ and CD8+ regulatory T cells in the peripheral blood with limited expansion of non-Treg cells in nonhuman primates.

  9. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. You have free access to this content
      Learning Curve in Tracheal Allotransplantation (pages 2538–2545)

      P. R. Delaere, J. J. Vranckx, J. Meulemans, V. Vander Poorten, K. Segers, D. Van Raemdonck, P. De Leyn, H. Decaluwé, C. Dooms and G. Verleden

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04125.x

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      The authors describe optimal approaches to tracheal revascularization, transplantation and withdrawal of immunosuppression in four tracheal allotransplantation cases.

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      Antibody Mediated Rejection Associated With Complement Factor H–Related Protein 3/1 Deficiency Successfully Treated With Eculizumab (pages 2546–2553)

      D. Noone, J. Al-Matrafi, K. Tinckam, P. F. Zipfel, A. M. Herzenberg, P. S. Thorner, F. G. Pluthero, W. H. A. Kahr, G. Filler, D. Hebert, E. Harvey and C. Licht

      Article first published online: 8 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04124.x

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      Eculizumab is successful in treating severe antibody-mediated rejection in a kidney transplant recipient with CFHR1 deletion, highlighting a promising new treatment strategy for this condition and raising the possibility that CFHR1 deficiency may predispose or aggravate posttransplant antibody-mediated rejection.

  10. Reports From the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
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      FDA Approval of an Extended Period for Administering VariZIG for Postexposure Prophylaxis of Varicella (page 2554)

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04257.x

      The recommendation for timing of administration of varicella immune globulin to nonimmune immunosuppressed hosts who have a significant exposure has been extended from 4 to 10 days following exposure.

  11. Book Review

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. You have free access to this content
  12. Images in Transplantation

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. CME

      You have free access to this content
  13. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Meeting Report
    7. Personal Viewpoints
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Book Review
    13. Images in Transplantation
    14. Letters to the Editor
    1. You have free access to this content
      Primary Intrarenal Posttransplant Lymphoproliferative Disorder Detected by Surveillance Protocol Biopsy (pages 2559–2560)

      E. Benetti, G. Ghirardo, M. Della Vella, M. L. Valente and L. Murer

      Article first published online: 15 JUN 2012 | DOI: 10.1111/j.1600-6143.2012.04136.x

      • image
    2. You have free access to this content
    3. You have free access to this content
      Immunosuppressive Potential and Side Effects of Everolimus (page 2563)

      L. Liefeldt, P. Glander, S. Brakemeier and K. Budde

      Article first published online: 27 AUG 2012 | DOI: 10.1111/j.1600-6143.2012.04158.x

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