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American Journal of Transplantation

Cover image for Vol. 13 Issue 5

May 2013

Volume 13, Issue 5

Pages 1115–1374

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Trust is Everything (pages 1115–1116)

      Sue Pondrom

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12277

      This month “The AJT Report” examines a recent case in which waitlist records were falsified, altering the waitlist priority for patients, and explores its impact on public trust and organ donation. Also, we take a look at the case of a donor-transmitted rabies infection that killed a transplant recipient earlier this year.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      LITERATURE Watch Implications for transplantation (page 1117)

      Anna Valujskikh and Jonathan S. Bromberg

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12278

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      New insights into phenotypic and functional heterogeneity of memory B cells have several implications for transplantation.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Advancing Immunosuppression in Heart Transplantation: “One Step Forward, Two Steps Back (pages 1119–1120)

      M. R. Mehra

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12177

      Immunosuppression for cardiac allografts using proliferation signal inhibitors appears to have a narrow therapeutic index, an increased adverse event profile, and no convincing generalizable impact on the incidence of allograft vasculopathy. See article by Eisen et al on page 1203.

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      Risky Business: Models of Risk in Transplant (pages 1121–1122)

      N. Turgeon, K. Schnier and B. Kaplan

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12207

      Despite the behavioral limitations of the mathematical modeling described in Chow et al (page 1227), the authors identify the importance of developing a strategy to increase the utilization of donors at increased risk of infectious transmission, and advise caution when designing models to assess risk for rare events.

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      “Just Because You Can, Does Not Mean That You Should” (pages 1123–1124)

      D. Vicente, B. K. Potter and E. Elster

      Article first published online: 8 MAR 2013 | DOI: 10.1111/ajt.12176

      As enthusiasm for vascularized composite transplantation extends into new potential indications, including lower extremity transplantation, careful consideration of the risks, and cognizance of the benefits of existing treatment modalities, is required to prevent irrational exuberance. See case report by Cavadas et al on page 1343.

  4. Minireview

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Plasmacytoid Dendritic Cells: No Longer an Enigma and Now Key to Transplant Tolerance? (pages 1125–1133)

      N.M. Rogers, J.S. Isenberg and A.W. Thomson

      Article first published online: 25 APR 2013 | DOI: 10.1111/ajt.12229

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      The authors review recent advances in understanding the role of plasmacytoid dendritic cells in regulation of immunity, promotion of transplant tolerance, and potential therapeutic effect in clinical transplantation.

  5. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Summary of FDA Workshop on Ischemia Reperfusion Injury in Kidney Transplantation (pages 1134–1148)

      M. Cavaillé-Coll, S. Bala, E. Velidedeoglu, A. Hernandez, P. Archdeacon, G. Gonzalez, C. Neuland, J. Meyer and R. Albrecht

      Article first published online: 8 APR 2013 | DOI: 10.1111/ajt.12210

      The authors report on a public workshop sponsored by the FDA to discuss various topics related to the effects of ischemia reperfusion injury in kidney transplantation, and seek to guide the design of future clinical trials for the development of medical products to prevent or treat this condition.

  6. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Opportunities for Shared Decision Making in Kidney Transplantation (pages 1149–1158)

      E. J. Gordon, Z. Butt, S. E. Jensen, A. Lok-Ming Lehr, J. Franklin, Y. Becker, L. Sherman, W. J. Chon, N. Beauvais, J. Hanneman, D. Penrod, M. G. Ison and M. M. Abecassis

      Article first published online: 14 MAR 2013 | DOI: 10.1111/ajt.12195

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      This viewpoint discusses the application of shared decision making to kidney transplantation to promote patientcentered care, and highlights the opportunities for and challenges of implementation.

  7. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    1. Basic Science

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      Immunosuppressive Effects of the Traditional Chinese Herb Qu Mai on Human Alloreactive T Cells (pages 1159–1167)

      J. Reid-Adam, N. Yang, Y. Song, P. Cravedi, X-M. Li and P. Heeger

      Article first published online: 22 FEB 2013 | DOI: 10.1111/ajt.12180

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      Screening a panel of traditional Chinese herbs for immunosuppressive properties reveals that a soluble fraction of Qu Mai inhibits human naïve and effector T cell proliferation and cytokine production while simultaneously inducing regulatory T cells.

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      Inhibition of Innate Co-Receptor TREM-1 Signaling Reduces CD4+ T Cell Activation and Prolongs Cardiac Allograft Survival (pages 1168–1180)

      G. Schiechl, S. M. Brunner, R. Kesselring, M. Martin, P. Ruemmele, M. Mack, S. W. Hirt, H. J. Schlitt, E. K. Geissler and S. Fichtner-Feigl

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12186

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      The authors demonstrate that inhibition of the cell surface receptor ‘triggering-receptor-expressed-on-myeloidcells-1’ on antigen-presenting cells reduces the infiltration and differentiation of CD4+ lymphocytes and thereby prevents chronic allograft vasculopathy and fibrotic organ remodeling in murine models of allogeneic heart transplantation.

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      Allergic Conjunctivitis Renders CD4+ T Cells Resistant to T Regulatory Cells and Exacerbates Corneal Allograft Rejection (pages 1181–1192)

      N. J. Reyes, P. W. Chen and J. Y. Niederkorn

      Article first published online: 13 MAR 2013 | DOI: 10.1111/ajt.12198

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      The exacerbation of immune rejection of corneal transplants that occurs in mice with allergic conjunctivitis is due to allergen-induced IL-4, which renders immune effector T cells resistant to the inhibitory effects of T regulatory cells.

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      The Induction of Tolerance of Renal Allografts by Adoptive Transfer in Miniature Swine (pages 1193–1202)

      M. Okumi, J. R. Scalea, B. C. Gillon, M. Tasaki, V. Villani, T. Cormack, A. Hirakata, A. Shimizu, D. H. Sachs and K. Yamada

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12194

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      Utilizing MHC inbred miniature swine, the authors report that tolerance can be adoptively transferred across a class I mismatched (class II matched) barrier by transplanting tolerated kidneys as well as peripheral blood mononuclear cells into naïve animals.

    5. Clinical Science

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      Everolimus Versus Mycophenolate Mofetil in Heart Transplantation: A Randomized, Multicenter Trial (pages 1203–1216)

      H. J. Eisen, J. Kobashigawa, R. C. Starling, D. F. Pauly, A. Kfoury, H. Ross, S.-S. Wang, B. Cantin, A. Van Bakel, G. Ewald, S. Hirt, H. Lehmkuhl, A. Keogh, M. Rinaldi, L. Potena, A. Zuckermann, G. Dong, C. Cornu-Artis and P. Lopez

      Article first published online: 22 FEB 2013 | DOI: 10.1111/ajt.12181

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      In this study comparing cardiac transplant recipients receiving one of two doses of everolimus with reduced dose cyclosporine to patients receiving mycophenolate mofetil with standard dose cyclosporine, the authors find no effect on acute cellular rejection, modestly reduced renal function, and a reduction in the incidence and severity of lesions defined by intravascular ultrasound. See editorial by Mehra on page 1119.

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      Differential Effect of Everolimus on Progression of Early and Late Cardiac Allograft Vasculopathy in Current Clinical Practice (pages 1217–1226)

      M. Masetti, L. Potena, M. Nardozza, P. Prestinenzi, N. Taglieri, F. Saia, V. Pece, G. Magnani, F. Fallani, F. Coccolo, A. Russo, C. Rapezzi, F. Grigioni and A. Branzi

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12208

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      Analysis of early and late changes of graft coronary morphology by intravascular ultrasound suggests that while mTOR inhibition by everolimus protects only from early but not from late vascular disease progression, high-dose statin intake is associated with slower vasculopathy progression early and up to years 5 after transplant.

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      Identifying Appropriate Recipients for CDC Infectious Risk Donor Kidneys (pages 1227–1234)

      E. K. H. Chow, A. B. Massie, A. D. Muzaale, A. L. Singer, L. M. Kucirka, R. A. Montgomery, H. P. Lehmann and D. L. Segev

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12206

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      Using a novel patient-perspective Markov model, this study informs the clinical decision of accepting kidneys from infectious risk donors. See editorial by Turgeon et al on page 1121.

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      Banff Initiative for Quality Assurance in Transplantation (BIFQUIT): Reproducibility of C4d Immunohistochemistry in Kidney Allografts (pages 1235–1245)

      M. Mengel, S. Chan, J. Climenhaga, Y. B Kushner, H. Regele, R. B Colvin and P. Randhawa

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12193

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      This international multicenter study finds that C4d staining on paraffin sections is of limited reproducibility between institutions, and its authors provide recommendations for improving and standardizing C4d staining.

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      Renal Transplantation After Ex Vivo Normothermic Perfusion: The First Clinical Study (pages 1246–1252)

      M. L. Nicholson and S. A. Hosgood

      Article first published online: 22 FEB 2013 | DOI: 10.1111/ajt.12179

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      This study reports early promising results from a pilot experience with ex vivo normothermic kidney perfusion using extended criteria donor kidneys.

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      Tacrolimus Predose Concentrations Do Not Predict the Risk of Acute Rejection After Renal Transplantation: A Pooled Analysis From Three Randomized-Controlled Clinical Trials (pages 1253–1261)

      R. Bouamar, N. Shuker, D. A. Hesselink, W. Weimar, H. Ekberg, B. Kaplan, C. Bernasconi and T. van Gelder

      Article first published online: 8 MAR 2013 | DOI: 10.1111/ajt.12191

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      The authors find no relationship between biopsy-proven acute rejection and tacrolimus predose concentrations, and posit that it is not possible to define the optimal target concentrations for tacrolimus.

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      Transvenous Renal Transplant Biopsy via a Transfemoral Approach (pages 1262–1271)

      A. Schmid, J. Jacobi, M. A. Kuefner, M. Lell, W. Wuest, I. Mayer-Kadner, K. Benz, M. Schmid, K. Amann and M. Uder

      Article first published online: 13 MAR 2013 | DOI: 10.1111/ajt.12199

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      The authors report on an experience using transvenous renal transplant biopsy to enable histological evaluation in patients unsuitable for percutaneous transplant biopsy.

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      Microvascular Damage in Type 1 Diabetic Patients Is Reversed in the First Year After Simultaneous Pancreas–Kidney Transplantation (pages 1272–1281)

      M. Khairoun, E. J. P. de Koning, B. M. van den Berg, E. Lievers, H.C. de Boer, A. F. M. Schaapherder, M. J. K. Mallat, J. I. Rotmans, P. J. M. van der Boog, A. J. van Zonneveld, J. W. de Fijter, T. J. Rabelink and M. E. J. Reinders

      Article first published online: 22 FEB 2013 | DOI: 10.1111/ajt.12182

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      Labial microvasular tortuosity, a surgate measure of generalized microvascular disease, is reversed after simultaneous pancreas—kidney transplantation.

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      Human Liver Regeneration Is Characterized by the Coordinated Expression of Distinct MicroRNA Governing Cell Cycle Fate (pages 1282–1295)

      S. Salehi, H. C. Brereton, M. J. Arno, D. Darling, A. Quaglia, J. O'Grady, N. Heaton and V. R. Aluvihare

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12183

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      Studying a rare type of human liver transplantation that allows regeneration of the recipient liver, the authors demonstrate that successful and failed regeneration are accompanied by changes in miRNA expression that govern cell cycle fate.

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      De novo Cancer-Related Death in Australian Liver and Cardiothoracic Transplant Recipients (pages 1296–1304)

      R. Na, A. E. Grulich, N. S. Meagher, G. W. McCaughan, A. M. Keogh and C. M. Vajdic

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12192

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      De novo cancer is the leading cause of late death in Australian liver and cardiothoracic transplant recipients.

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      Gene Expression Profiling Reveals Clear Differences Between EBV-Positive and EBV-Negative Posttransplant Lymphoproliferative Disorders (pages 1305–1316)

      J. Morscio, D. Dierickx, J. F. Ferreiro, A. Herreman, P. Van Loo, E. Bittoun, G. Verhoef, P. Matthys, J. Cools, I. Wlodarska, C. De Wolf-Peeters, X. Sagaert and T. Tousseyn

      Article first published online: 14 MAR 2013 | DOI: 10.1111/ajt.12196

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      Gene expression profiling reveals clear differences between EBV-positive and EBV-negative posttransplant lymphoproliferative disorders.

  8. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Center-Level Utilization of Kidney Paired Donation (pages 1317–1322)

      A. B. Massie, S. E. Gentry, R. A. Montgomery, A. A. Bingaman and D. L. Segev

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12189

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      Utilization of kidney paired donation remains concentrated among a small number of transplant centers, and as such is yet to optimally realize its potential to boost live donor transplant availability.

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      Kidney Transplantation From Donors After Cardiac Death: An Initial Report of 71 Cases From China (pages 1323–1326)

      G.-D. Chen, D. Shiu-Chung Ko, C.-X. Wang, J. Qiu, M. Han, X.-S. He and L.-Z. Chen

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12190

      The authors report on a recent case series of kidney transplants from donors after cardiac death with promising results.

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      Ex vivo Normothermic Machine Perfusion and Viability Testing of Discarded Human Donor Livers (pages 1327–1335)

      S. op den Dries, N. Karimian, M. E. Sutton, A. C. Westerkamp, M. W. N. Nijsten, A. S. H. Gouw, J. Wiersema-Buist, T. Lisman, H. G. D. Leuvenink and R. J. Porte

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12187

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      This study demonstrates the technical feasibility of normothermic machine perfusion of human donor livers.

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      Adaptation Over a Wide Range of Donor Graft Lung Size Discrepancies in Living-Donor Lobar Lung Transplantation (pages 1336–1342)

      F. Chen, T. Kubo, T. Yamada, M. Sato, A. Aoyama, T. Bando and H. Date

      Article first published online: 15 MAR 2013 | DOI: 10.1111/ajt.12188

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      In living-donor lobar lung transplantation, donor grafts overinfl ate or underinfl ate to the extent that they can preserve their native function in the new recipient's environment.

  9. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Bilateral Transfemoral Lower Extremity Transplantation: Result at 1 Year (pages 1343–1349)

      P. C. Cavadas, A. Thione, A. Carballeira and M. Blanes

      Article first published online: 22 FEB 2013 | DOI: 10.1111/ajt.12178

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      The authors present the 12-month results of a bilateral transfemoral transplantation of the lower extremities. See editorial by Vicente et al on page 1123.

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      Lessons and Insights From ABO-Incompatible Lung Transplantation (pages 1350–1353)

      G. I. Snell, M. Holmes, B. J. Levvey, A. Shipp, C. Robertson, G. P. Westall and S. Cohney

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12185

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      A case of an inadvertent ABO-incompatible lung transplant suggests some low-titer ABO antibody recipients can achieve long-term survival.

  10. Reports From the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      Advisory Committee on Immunization Practices (ACIP) Recommended Immunization Schedule for Adults Aged 19 Years and Older—United States, 2013 (pages 1354–1363)

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12279

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      Updated adult immunization guidelines include the use of PCV13 for immunocompromised adults, zoster vaccine for “normal” hosts at age 60 and expanded indications for human papillomavirus vaccination in young adult men.

  11. Images in Transplantation

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    1. CME

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      Chronic Abdominal Pain in a Liver Transplant Recipient (pages 1364–1366)

      W. Bleibel, C. L. Berg and A. Y. Wang

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12156

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  12. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Meeting Report
    7. Personal Viewpoint
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
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      The First Transplant Kidney Biopsy Ever Performed (pages 1367–1368)

      H. Kreis, L.-H. Noël and C. Legendre

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12214

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      Clara Cells and Injury Post Lung Transplantation: An Evolving Story (page 1370)

      A. Bourdin, N. A. Mifsud, B. Chanez, P. Chanez, G. Snell and T. C. Kotsimbos

      Article first published online: 6 MAR 2013 | DOI: 10.1111/ajt.12184

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      Tacrolimus Exposure After Liver Transplantation in Randomized Controlled Trials: Too Much for Too Long (pages 1371–1372)

      M. Rodríguez-Perálvarez, G. Germani, T. Darius, J. Lerut, E. Tsochatzis, M. De la Mata and A. K. Burroughs

      Article first published online: 26 APR 2013 | DOI: 10.1111/ajt.12216

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      Everolimus With Reduced Tacrolimus in Liver Transplantation (pages 1373–1374)

      P. De Simone, S. Beckebaum, B. Koneru, J. Fung and F. Saliba

      Article first published online: 19 APR 2013 | DOI: 10.1111/ajt.12215

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