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American Journal of Transplantation

Cover image for Vol. 13 Issue 6

June 2013

Volume 13, Issue 6

Pages 1375–1621

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      The AJT Report (pages 1375–1376)

      Norra Macready

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12321

      The Supreme Court s ruling on the Affordable Care Act allowed states to opt out of the law's Medicaid expansion. In this issue of “The AJT Report,” we look at how the expansion—and nonparticipation in the expansion—might impact the field of transplantation.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      LITERATURE Watch Implications for transplantation (page 1377)

      Yannick D. Muller, Raphael P. H. Meier, Jonathan S. Bromberg and Leo H. Bühler

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12322

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      Experiments injecting pluripotent cells into blastocyst embryos open exciting possibilities for the generation of self-specific organs in xenogeneic animals.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Incorporation of Pathology and Laboratory Findings Into Management Algorithms for Polyomavirus Nephropathy (pages 1379–1381)

      P. Randhawa

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12226

      This editorial summarizes the problems associated with biopsy interpretation and its role in planning appropriate therapy for patients with resolving polyomavirus nephropathy. See article by Menter et al on page 1474.

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      More Donors Are Available—Why Don't We Use Them? (page 1382)

      R. E. Chinnock

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12245

      The authors ask the question—why are so many potential donors refused when potential pediatric heart transplant recipients have the highest pretransplant mortality rate of any solid organ transplant group? See article by Easterwood et al on page 1484.

  4. Minireviews

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Mycophenolate Fetal Toxicity and Risk Evaluation and Mitigation Strategies (pages 1383–1389)

      M. Kim, S. Rostas and S. Gabardi

      Version of Record online: 25 APR 2013 | DOI: 10.1111/ajt.12238

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      This is a review of the fetal risks associated with mycophenolic acid preparations, and an evaluation of the required Risk Evaluation and Mitigation Strategy elements associated with these drugs.

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      Qualitative Research in Organ Transplantation: Recent Contributions to Clinical Care and Policy (pages 1390–1399)

      A. Tong, J. R. Chapman, A. Israni, E. J. Gordon and J. C. Craig

      Version of Record online: 6 MAY 2013 | DOI: 10.1111/ajt.12239

      Qualitative research provides insights into some of the important but elusive questions in transplantation, and this review highlights recent contributions of qualitative research to transplantation practice and policy, identifying key principles to guide qualitative research appraisal.

  5. Special Article

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Challenges to Research and Innovation to Optimize Deceased Donor Organ Quality and Quantity (pages 1400–1404)

      P. L. Abt, C. L. Marsh, T. B. Dunn, W. R. Hewitt, J. R. Rodrigue, J. M. Ham and S. Feng

      Version of Record online: 25 APR 2013 | DOI: 10.1111/ajt.12243

      This report is a collaborative effort to identify and highlight some of the ethical, logistical, and regulatory ambiguities that impede the development, design, and implementation of innovative trials relevant to deceased donor organ donation.

  6. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Optimal Testing of the Live Organ Donor for Blood-Borne Viral Pathogens: The Report of a Consensus Conference (pages 1405–1415)

      E. A. Blumberg, M. G. Ison, T. L. Pruett, D. L. Segev and on behalf of the Optimal Testing of the Live Organ Donor Consensus Conference Participants

      Version of Record online: 19 APR 2013 | DOI: 10.1111/ajt.12205

      The authors summarize the results of a consensus conference on testing live organ donors for HIV, hepatitis B and hepatitis C viruses.

  7. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
    1. Basic Science

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      Amnion-Derived Multipotent Progenitor Cells Support Allograft Tolerance Induction (pages 1416–1428)

      K. Anam, Y. Lazdun, P. M. Davis, R. A. Banas, E. A. Elster and T. A. Davis

      Version of Record online: 7 MAY 2013 | DOI: 10.1111/ajt.12252

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      The authors demonstrate that a subset of human amnion epithelial cells can promote engraftment of limiting numbers of donor bone marrow leading to stable multilineage mixed-chimerism and skin allograft tolerance.

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      Co-Transplantation of Bone Marrow-Derived Endothelial Progenitor Cells Improves Revascularization and Organization in Islet Grafts (pages 1429–1440)

      B. J. Oh, S. H. Oh, S. M. Jin, S. Suh, J. C. Bae, C. -G. Park, M. -S. Lee, M. -K. Lee, J. H. Kim and K. -W. Kim

      Version of Record online: 18 APR 2013 | DOI: 10.1111/ajt.12222

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      Co-transplantation of bone marrow-derived early endothelial progenitor cells improves islet graft organization and promotes graft revascularization by both a paracrine effect and direct incorporation into vascular endothelial cells.

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      Normothermic Acellular Ex Vivo Liver Perfusion Reduces Liver and Bile Duct Injury of Pig Livers Retrieved After Cardiac Death (pages 1441–1449)

      M. U. Boehnert, J. C. Yeung, F. Bazerbachi, J. M. Knaak, N. Selzner, I. D. McGilvray, O. D. Rotstein, O. A. Adeyi, S. M. Kandel, P. Rogalla, P. M. Yip, G. A. Levy, S. Keshavjee, D. R. Grant and M. Selzner

      Version of Record online: 13 MAY 2013 | DOI: 10.1111/ajt.12224

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      Normothermic ex vivo liver perfusion decreases hepatocyte death and bile duct injury of grafts obtained after cardiac death.

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      Controlled Oxygenated Rewarming of Cold Stored Liver Grafts by Thermally Graduated Machine Perfusion Prior to Reperfusion (pages 1450–1460)

      T. Minor, P. Efferz, M. Fox, J. Wohlschlaeger and B. Lüer

      Version of Record online: 25 APR 2013 | DOI: 10.1111/ajt.12235

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      This report provides evidence in an ex vivo pig liver model that recovery of cold stored grafts can be improved by graduated rewarming upon short-term machine perfusion prior to implantation, mitigating ‘rewarming injury’ upon blood reperfusion, oxygen-free radical release and energetic dys-homeostasis.

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      Role of T Cell Recruitment and Chemokine-Regulated Intra-Graft T Cell Motility Patterns in Corneal Allograft Rejection (pages 1461–1473)

      Y. Tan, M. H. Abdulreda, F. Cruz-Guilloty, N. Cutrufello, A. Shishido, R. E. Martinez, S. Duffort, X. Xia, J. Echegaray-Mendez, R. B. Levy, P.-O. Berggren and V. L. Perez

      Version of Record online: 22 APR 2013 | DOI: 10.1111/ajt.12228

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      The authors show that chemokines produced locally within corneal allografts play an important role in the in situ activation and dynamic behavior of infiltrating effector T cells that may guide antichemokine localized interventions to promote corneal allograft survival after transplantation.

    6. Clinical Science

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      Pathology of Resolving Polyomavirus-Associated Nephropathy (pages 1474–1483)

      T. Menter, M. Mayr, S. Schaub, M. J. Mihatsch, H. H. Hirsch and H. Hopfer

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12218

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      This study analyzes the histological features associated with the resolution of polyomavirus nephropathy, and shows that resolution is regularly associated with a significant increase in intraepithelial lymphocytes and interstitial infl ammation, morphologically indistinguishable from interstitial rejection. See editorial by Randhawa on page 1379.

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      Pediatric Cardiac Transplantation Using Hearts Previously Refused for Quality: A Single Center Experience (pages 1484–1490)

      R. Easterwood, R. K. Singh, E. D. McFeely, W. A. Zuckerman, L. J. Addonizio, L. Gilmore, K. Beddows, J. M. Chen and M. E. Richmond

      Version of Record online: 6 MAY 2013 | DOI: 10.1111/ajt.12237

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      In this study at a large single center, the authors show that survival after pediatric heart transplantation is identical in recipients who received hearts refused by other centers on the basis of quality as compared with those who received primarily-offered organs, suggesting that these organs are not necessarily of lesser quality. See editorial by Chinnock on page 1382.

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      Long-Term Outcome After Heart Transplantation Predicted by Quantitative Myocardial Blush Grade in Coronary Angiography (pages 1491–1502)

      N. P. Hofmann, A. Voss, H. Dickhaus, M. Erbacher, A. Doesch, P. Ehlermann, G. Gitsioudis, S. J. Buss, E. Giannitsis, H. A. Katus and G. Korosoglou

      Version of Record online: 25 APR 2013 | DOI: 10.1111/ajt.12223

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      Quantification of myocardial blush grade during surveillance coronary angiography aids the risk stratification of patients after heart transplantation by predicting all-cause mortality, cardiac death, and coronary revascularisation procedures.

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      A Single Dose of Rituximab Does Not Deplete B Cells in Secondary Lymphoid Organs but Alters Phenotype and Function (pages 1503–1511)

      E. G. Kamburova, H. J. P. M. Koenen, K. J. E. Borgman, I. J. ten Berge, I. Joosten and L. B. Hilbrands

      Version of Record online: 9 APR 2013 | DOI: 10.1111/ajt.12220

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      The authors report that although a single dose of rituximab results in a nearly complete B cell depletion in the peripheral blood of renal transplant recipients, there is a relative increase of B cells with a switched memory phenotype in lymph nodes of these patients that may result in an altered immune response.

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      Primary CNS Posttransplant Lymphoproliferative Disease (PTLD): An International Report of 84 Cases in the Modern Era (pages 1512–1522)

      A. M. Evens, S. Choquet, A. R. Kroll-Desrosiers, D. Jagadeesh, S. M. Smith, F. Morschhauser, V. Leblond, R. Roy, B. Barton, L. I. Gordon, M. K. Gandhi, D. Dierickx, D. Schiff, T. M. Habermann and R. Trappe

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12211

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      In an international analysis of solid organ transplant recipients with primary central nervous system posttransplant lymphoproliferative disease, the authors find that the disease is associated with renal transplantation, typically occurs late and retains EBV positivity, and the dominant prognostic factor for survival is response to first-line therapy.

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      Plasma Cell Neoplasms in US Solid Organ Transplant Recipients (pages 1523–1532)

      E. A. Engels, C. A. Clarke, R. M. Pfeiffer, C. F. Lynch, D. D. Weisenburger, T. M. Gibson, O. Landgren and L. M. Morton

      Version of Record online: 1 MAY 2013 | DOI: 10.1111/ajt.12234

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      In this large US population-based study, the authors demonstrate that transplant recipients have an elevated risk for plasma cell neoplasms and document several risk factors for this type of malignancy, including Epstein Barr virus infection, recipient age, and the presence of primary biliary cirrhosis.

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      What Liver Transplant Outcomes Can Be Expected in the Uninsured Who Become Insured via the Affordable Care Act? (pages 1533–1540)

      L. N. Glueckert, D. Redden, M. A. Thompson, A. Haque, S. H. Gray, J. Locke, D. E. Eckhoff, M. Fouad and D. A. DuBay

      Version of Record online: 9 MAY 2013 | DOI: 10.1111/ajt.12244

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      This retrospective study measures outcomes in a cohort of charity-care liver transplant recipients and demonstrates significantly higher mortality, episodes of acute rejection and missed clinic appointments compared to privately- and publicly-insured patients.

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      De Novo Donor-Specific HLA Antibodies Decrease Patient and Graft Survival in Liver Transplant Recipients (pages 1541–1548)

      H. Kaneku, J. G. O'Leary, N. Banuelos, L. W. Jennings, B. M. Susskind, G. B. Klintmalm and P. I. Terasaki

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12212

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      This single-center retrospective cohort study assesses the development of de novo donor-specific HLA antibodies at one year after liver transplantation and finds that the presence of these antibodies is an independent risk factor for patient death and graft loss.

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      Impact of Sarcopenia on Survival in Patients Undergoing Living Donor Liver Transplantation (pages 1549–1556)

      T. Kaido, K. Ogawa, Y. Fujimoto, Y. Ogura, K. Hata, T. Ito, K. Tomiyama, S. Yagi, A. Mori and S. Uemoto

      Version of Record online: 19 APR 2013 | DOI: 10.1111/ajt.12221

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      Sarcopenia is closely involved with posttransplant mortality in patients undergoing living donor liver transplantation and perioperative nutritional therapy significantly improves overall survival, even in patients with sarcopenia.

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      Racial Differences in Determinants of Live Donor Kidney Transplantation in the United States (pages 1557–1565)

      T. S. Purnell, P. Xu, N. Leca and Y. N. Hall

      Version of Record online: 13 MAY 2013 | DOI: 10.1111/ajt.12258

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      The authors estimate racial and ethnic differences in live donor kidney transplantation attributable to individual and contextual factors and find that the relative contribution of these determinants to delayed transplantation varies widely by race and ethnicity.

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      Outcomes After Kidney Transplantation of Patients Previously Diagnosed With Atrial Fibrillation (pages 1566–1575)

      C. R. Lenihan, M. E. Montez-Rath, J. D. Scandling, M. P. Turakhia and W. C. Winkelmayer

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12197

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      New kidney transplant recipients who have previously been diagnosed with atrial fibrillation experience excess mortality, graft loss, and ischemic stroke rates compared with otherwise similar recipients without diagnosed atrial fibrillation.

  8. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Oral Paricalcitol Reduces the Prevalence of Posttransplant Hyperparathyroidism: Results of an Open Label Randomized Trial (pages 1576–1585)

      H. Amer, M. D. Griffin, M. D. Stegall, F. G. Cosio, W. D. Park, W. K. Kremers, R. L. Heilman, M. J. Mazur, K. Hamawi, T. S. Larson and R. Kumar

      Version of Record online: 19 APR 2013 | DOI: 10.1111/ajt.12227

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      Paricalcitol decreases the prevalence of post-kidney transplant hyperparathyroidism and may have beneficial effects on renal allograft histology.

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      Lentivirus IL-10 Gene Therapy Down-Regulates IL-17 and Attenuates Mouse Orthotopic Lung Allograft Rejection (pages 1586–1593)

      S. Hirayama, M. Sato, S. Loisel-Meyer, Y. Matsuda, H. Oishi, Z. Guan, T. Saito, J. Yeung, M. Cypel, D. M. Hwang, J. A. Medin, M. Liu and S. Keshavjee

      Version of Record online: 19 APR 2013 | DOI: 10.1111/ajt.12230

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      Lentivirus-mediated trans-airway IL-10 gene therapy attenuates the Th17 response and histological acute rejection in an orthotopic mouse lung transplantation.

  9. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Literature Review of Passenger Lymphocyte Syndrome Following Renal Transplantation and Two Case Reports (pages 1594–1600)

      L. Nadarajah, N. Ashman, R. Thuraisingham, C. Barber, S. Allard and L. Green

      Version of Record online: 25 APR 2013 | DOI: 10.1111/ajt.12219

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      The authors review the literature and discuss two case reports in passenger lymphocyte syndrome in renal transplantation.

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      Sofosbuvir and Daclatasvir Combination Therapy in a Liver Transplant Recipient With Severe Recurrent Cholestatic Hepatitis C (pages 1601–1605)

      R. J. Fontana, E. A. Hughes, M. Bifano, H. Appelman, D. Dimitrova, R. Hindes and W. T. Symonds

      Version of Record online: 17 APR 2013 | DOI: 10.1111/ajt.12209

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      A patient with severe cholestatic hepatitis C virus genotype 1b infection at nine months after liver transplantation was successfully treated with a six-month course of oral sofosbuvir in combination with daclatasvir and remains HCV RNA negative during posttreatment follow-up with improved liver biochemistries and health.

  10. Reports From the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Update: Severe Respiratory Illness Associated With a Novel Coronavirus—Worldwide, 2012–2013 (pages 1606–1607)

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12320

      A novel coronavirus associated with severe respiratory tract illness and person-to-person spread has been described in patients with travel to the Arabian peninsula and neighboring countries as well as their close contacts. Although not yet described in transplant recipients or donors, providers should be aware of this association.

  11. Images in Transplantation

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
    1. CME

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  12. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      Flow is Critical for Maintaining a Protective Phenotype in Renal Proximal Tubular Cells (pages 1617–1618)

      M.-O. Timsit, W. J. Adams, A. Laguna-Fernandez, T. Ichimura, J. V. Bonventre, G. García-Cardeña and S. G. Tullius

      Version of Record online: 25 APR 2013 | DOI: 10.1111/ajt.12242

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      Human Herpesvirus 8 (HHV8) Infection and Related Diseases in Italian Transplant Cohorts (pages 1619–1620)

      G. Riva, P. Barozzi, C. Quadrelli, D. Vallerini, E. Zanetti, F. Forghieri, A. Chiereghin, I. Libri, U. Maggiore, C. Buzio, T. Lazzarotto, F. Narni, M. Luppi and L. Potenza

      Version of Record online: 22 APR 2013 | DOI: 10.1111/ajt.12225

  13. Erratum

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireviews
    6. Special Article
    7. Meeting Report
    8. Original Articles
    9. Brief Communications
    10. Case Reports
    11. Reports From the CDC: MMWR
    12. Images in Transplantation
    13. Letters to the Editor
    14. Erratum
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      ERRATUM (page 1621)

      Version of Record online: 30 MAY 2013 | DOI: 10.1111/ajt.12270

      This article corrects:

      Aspergillosis in Solid Organ Transplantation

      Vol. 13, Issue s4, 228–241, Version of Record online: 6 MAR 2013

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