American Journal of Transplantation

Cover image for Vol. 14 Issue 2

February 2014

Volume 14, Issue 2

Pages 245–497

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
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      The AJT Report (pages 245–246)

      Sue Pondrom

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12657

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      A new study points to an overall decline in living donor volume in the United States. “The AJT Report” takes a look at possible reasons for the downturn. Also in this issue, we discuss two back-to-work programs for transplant recipients.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. You have free access to this content
      Literature Watch Implications for transplantation (page 247)

      Daniel J. Campbell and Jonathan S. Bromberg

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12658

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      Several studies highlight the crucial role of Foxo transcription factors in regulatory T cell function, aiding in the development of therapeutic strategies using these cells to modulate alloimmune responses.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. You have free access to this content
      Sirolimus and mTOR Inhibitors in Liver Transplantation: The Wheel Has Come Full Circle (pages 249–250)

      J. Levitsky and S. Feng

      Article first published online: 25 NOV 2013 | DOI: 10.1111/ajt.12545

      This editorial puts into perspective the significance of a decade-old sirolimus trial in relation to the current status of mTOR inhibitors in liver transplantation. See article by Asrani et al on page 356.

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      Left Versus Right Lobe Liver Donation (pages 251–252)

      G. R. Roll and J. P. Roberts

      Article first published online: 4 DEC 2013 | DOI: 10.1111/ajt.12556

      The authors opine on why the complication rates reported in Uchiyama et al (page 367) are not congruent with the existing literature.

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      To Transplant a Kidney With the Heart or Not—That Is the Real Question (pages 253–254)

      V. Kumar and J. A. Tallaj

      Article first published online: 25 NOV 2013 | DOI: 10.1111/ajt.12523

      This editorial addresses the indication for combined heart–kidney transplantation, challenging Schaffer et al's (page 384) recommendations of giving higher priority status exemptions to patients listed for multiple organs.

  4. Comprehensive Review

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. You have full text access to this OnlineOpen article
      Diagnosis and Management of Antibody-Mediated Rejection: Current Status and Novel Approaches (pages 255–271)

      A. Djamali, D. B. Kaufman, T. M. Ellis, W. Zhong, A. Matas and M. Samaniego

      Article first published online: 8 JAN 2014 | DOI: 10.1111/ajt.12589

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      This review addresses the spectrum of antibody-mediated rejection after kidney transplantation, including its pathogenesis, risk factors, phenotypes, the revised Banff 2013 classification, treatment options, and outcomes. Also see meeting report by Haas et al on page 272.

  5. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. Banff 2013 Meeting Report: Inclusion of C4d-Negative Antibody-Mediated Rejection and Antibody-Associated Arterial Lesions (pages 272–283)

      M. Haas, B. Sis, L. C. Racusen, K. Solez, D. Glotz, R. B. Colvin, M. C. R. Castro, D. S. R. David, E. David-Neto, S. M. Bagnasco, L. C. Cendales, L. D. Cornell, A. J. Demetris, C. B. Drachenberg, C. F. Farver, A. B. Farris III, I. W. Gibson, E. Kraus, H. Liapis, A. Loupy, V. Nickeleit, P. Randhawa, E. R. Rodriguez, D. Rush, R. N. Smith, C. D. Tan, W. D. Wallace, M. Mengel and as the Banff meeting report writing committee

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12590

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      The 2013 Banff Transplant Conference defines revised, consensus criteria for acute/active and chronic, active antibody-mediated rejection in renal allograft biopsies, criteria that include C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Also see comprehensive review by Djamali et al on page 255.

  6. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. Basic Science

      Key Role for CD4 T Cells During Mixed Antibody-Mediated Rejection of Renal Allografts (pages 284–294)

      A. Gaughan, J. Wang, R. P. Pelletier, T. Nadasdy, S. Brodsky, S. Roy, M. Lodder, D. Bobek, S. Mofatt-Bruce, R. L. Fairchild, M. L. Henry and G. A. Hadley

      Article first published online: 10 JAN 2014 | DOI: 10.1111/ajt.12596

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      The authors use murine models to explore the immune mechanisms of functional graft injury during antibodymediated rejection of renal allografts, and report a complete domination by CD4 T cells with little to no role for antibody or CD8 T cells in the process.

    2. Alloprimed CD8+ T Cells Regulate Alloantibody and Eliminate Alloprimed B Cells Through Perforin- and FasL-Dependent Mechanisms (pages 295–304)

      J. M. Zimmerer, T. A. Pham, C. L. Wright, K. J. Tobin, P. B. Sanghavi, S. M. Elzein, V. M. Sanders and G. L. Bumgardner

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12565

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      Using a murine transplant model, the authors report that alloprimed CD8+ T cells use perforin and FasL to downregulate alloantibody production by eliminating alloprimed IgG1+ B cells. See online supporting information for 3-dimensional figures of colocalized CD8+ T cells and B cells.

    3. Alloanergization of Human T Cells Results in Expansion of Alloantigen-Specific CD8+CD28 Suppressor Cells (pages 305–318)

      C. M. Barbon, J. K. Davies, A. Voskertchian, R. H. Kelner, L. L. Brennan, L. M. Nadler and E. C. Guinan

      Article first published online: 10 JAN 2014 | DOI: 10.1111/ajt.12575

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      The investigators use in vitro costimulatory blockade–mediated alloanergization to expand CD8+CD28–FOXP3+ suppressor cells with allosuppressive function, and provide in vivo evidence suggesting the feasibility of their use as a tolerance-inducing cell therapy.

    4. The Allo- and Viral-Specific Immunosuppressive Effect of Belatacept, but Not Tacrolimus, Attenuates With Progressive T Cell Maturation (pages 319–332)

      H. Xu, S. D. Perez, J. Cheeseman, A. K. Mehta and A. D. Kirk

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12574

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      The authors characterize CMV- and allo-specific memory T cells and show that belatacept has decreasing inhibitory effect on increasingly matured memory cells, and minimal effect on the most highly differentiated CMV- and allo-specific cells.

    5. Bcl-2 Inhibition to Overcome Memory Cell Barriers in Transplantation (pages 333–342)

      P. E. Cippà, S. S. Gabriel, A. K. Kraus, J. Chen, T. Wekerle, A. Guimezanes, R. P. Wüthrich and T. Fehr

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12554

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      The pro-apoptotic Bcl-2/Bcl-XL inhibitor ABT-737 suppresses allogeneic memory responses and restores sensitivity to costimulation blockade in experimental models of solid organ transplantation and tolerance across memory T cell barriers.

    6. Vascularized Composite Allograft Tolerance Across MHC Barriers in a Large Animal Model (pages 343–355)

      D. A. Leonard, J. M. Kurtz, C. Mallard, A. Albritton, R. Duran-Struuck, E. A. Farkash, R. Crepeau, A. Matar, B. M. Horner, M. A. Randolph, D. H. Sachs, C. A. Huang and C. L. Cetrulo Jr.

      Article first published online: 9 JAN 2014 | DOI: 10.1111/ajt.12560

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      Establishment of stable mixed chimerism across MHC barriers in a clinically relevant miniature swine model induces tolerance of all components of vascularized composite allografts including the critical and challenging skin component.

    7. Clinical Science

      De Novo Sirolimus and Reduced-Dose Tacrolimus Versus Standard-Dose Tacrolimus After Liver Transplantation: The 2000–2003 Phase II Prospective Randomized Trial (pages 356–366)

      S. K. Asrani, R. H. Wiesner, J. F. Trotter, G. Klintmalm, E. Katz, E. Maller, J. Roberts, N. Kneteman, L. Teperman, J. J. Fung and J. M. Millis

      Article first published online: 23 JAN 2014 | DOI: 10.1111/ajt.12543

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      This study reports the results of the international, multicenter, controlled randomized trial of adult primary liver transplant recipients receiving de novo sirolimus and reduced dose tacrolimus or conventional dose tacrolimus, which formed the basis of a black box warning for use of sirolimus immediately after liver transplantation. See editorial by Levitsky and Feng on page 249.

    8. Revisiting the Safety of Living Liver Donors by Reassessing 441 Donor Hepatectomies: Is a Larger Hepatectomy Complication-Prone? (pages 367–374)

      H. Uchiyama, K. Shirabe, H. Nakagawara, T. Ikegami, T. Toshima, Y. Soejima, T. Yoshizumi, Y.-I. Yamashita, N. Harimoto, T. Ikeda and Y. Maehara

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12559

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      The authors reassess 441 donor hepatectomies and find that with cumulative experiences, right hepatectomies are no longer complication-prone compared to left hepatectomies or left lateral segmentectomies. See editorial by Roll and Roberts on page 251.

    9. Liver Stiffness 1 Year After Transplantation Predicts Clinical Outcomes in Patients With Recurrent Hepatitis C (pages 375–383)

      G. Crespo, S. Lens, M. Gambato, J. A. Carrión, Z. Mariño, M.-C. Londoño, R. Miquel, J. Bosch, M. Navasa and X. Forns

      Article first published online: 10 JAN 2014 | DOI: 10.1111/ajt.12594

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      The authors report the excellent accuracy of transient elastography one year after liver transplantation to predict long-term hepatitis C–related clinical outcomes, which are significantly improved in patients with high liver stiffness who respond to antiviral therapy.

    10. Heart and Combined Heart–Kidney Transplantation in Patients With Concomitant Renal Insufficiency and End-Stage Heart Failure (pages 384–396)

      J. M. Schaffer, P. Chiu, S. K. Singh, P. E. Oyer, B. A. Reitz and H. R. Mallidi

      Article first published online: 26 NOV 2013 | DOI: 10.1111/ajt.12522

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      Patients requiring combined heart–kidney transplantation have poor waitlist survival, and although early transplant may help improve outcomes, the optimal therapy for these patients remains uncertain. See editorial by Kumar and Tallaj on page 253.

    11. Sequelae of Early Hospital Readmission After Kidney Transplantation (pages 397–403)

      M. A. McAdams-DeMarco, M. E. Grams, E. King, N. M. Desai and D. L. Segev

      Article first published online: 21 JAN 2014 | DOI: 10.1111/ajt.12563

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      In this national study of kidney transplant recipients using longitudinal Medicare claims data, the authors find that recipients who experienced early hospital readmission are at significantly higher risk of late hospital readmission, graft loss, and death.

    12. Kidneys at Higher Risk of Discard: Expanding the Role of Dual Kidney Transplantation (pages 404–415)

      B. Tanriover, S. Mohan, D. J. Cohen, J. Radhakrishnan, T. L. Nickolas, P. W. Stone, D. S. Tsapepas, R. J. Crew, G. K. Dube, P. R. Sandoval, B. Samstein, E. Dogan, R. S. Gaston, J. N. Tanriover, L. E. Ratner and M. A. Hardy

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12553

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      Dual kidney transplantation based on the Kidney Donor Profile Index is a potential option to streamline allocation of kidneys that otherwise would be discarded.

    13. Human Microbiota Characterization in the Course of Renal Transplantation (pages 416–427)

      W. F. Fricke, C. Maddox, Y. Song and J. S. Bromberg

      Article first published online: 26 DEC 2013 | DOI: 10.1111/ajt.12588

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      Sequencing and classification of oral, rectal, and urinary microbiota of renal allograft recipients reveal significant changes in the structure and diversity of the microbiota resulting from the transplant, with large inter-individual variations with changes that persist over time.

    14. Evidence for Instant Blood-Mediated Inflammatory Reaction in Clinical Autologous Islet Transplantation (pages 428–437)

      B. Naziruddin, S. Iwahashi, M. A. Kanak, M. Takita, T. Itoh and M. F. Levy

      Article first published online: 21 JAN 2014 | DOI: 10.1111/ajt.12558

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      Analysis of peritransplant blood samples from patients undergoing total pancreatectomy followed by autologous islet transplantation reveals the occurrence of instant blood-mediated inflammatory reaction causing damage to transplanted islets by activation of coagulation and inflammation but with little involvement of complement.

    15. Diabetes Is a Major Risk Factor for Mortality After Lung Transplantation (pages 438–445)

      K. L. Hackman, M. J. Bailey, G. I. Snell and L. A. Bach

      Article first published online: 8 JAN 2014 | DOI: 10.1111/ajt.12561

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      A multivariate analysis of all patients undergoing lung transplantation in one center over a 10-year period shows that diabetes status is a major risk factor for mortality.

  7. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. Preoperative Plasma Club (Clara) Cell Secretory Protein Levels Are Associated With Primary Graft Dysfunction After Lung Transplantation (pages 446–452)

      R. J. Shah, N. Wickersham, D. J. Lederer, S. M. Palmer, E. Cantu, J. M. Diamond, S. M. Kawut, V. N. Lama, S. Bhorade, M. Crespo, E. Demissie, J. Sonett, K. Wille, J. Orens, A. Weinacker, P. Shah, S. Arcasoy, D. S. Wilkes, J. D. Christie, L. B. Ware and for the Lung Transplant Outcomes Group

      Article first published online: 8 JAN 2014 | DOI: 10.1111/ajt.12541

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      The authors demonstrate a relationship between perioperative CC-16 blood levels and an increased risk of primary lung allograft dysfunction, particularly in those without idiopathic pulmonary fibrosis as a pretransplant diagnosis.

    2. The Use of Oral Sildenafil for Management of Right Ventricular Dysfunction After Pediatric Heart Transplantation (pages 453–458)

      R. K. Singh, M. E. Richmond, W. A. Zuckerman, T. M. Lee, T. B. Giblin, R. Rodriguez, J. M. Chen and L. J. Addonizio

      Article first published online: 19 DEC 2013 | DOI: 10.1111/ajt.12552

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      In this retrospective cohort study of pediatric heart transplant recipients, the authors demonstrate that oral sildenafil is associated with an improvement in right ventricular dysfunction, pulmonary vascular resistance, and other invasive hemodynamic measurements early after transplant.

    3. Eculizumab Prevents Recurrent Antiphospholipid Antibody Syndrome and Enables Successful Renal Transplantation (pages 459–465)

      B. E. Lonze, A. A. Zachary, C. M. Magro, N. M. Desai, B. J. Orandi, N. N. Dagher, A. L. Singer, N. Carter-Monroe, S. M. Nazarian, D. L. Segev, M. B. Streiff and R. A. Montgomery

      Article first published online: 8 JAN 2014 | DOI: 10.1111/ajt.12540

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      Pre-emptive complement inhibition with eculizumab prevents recurrence of antiphospholipid antibody syndrome in three patients undergoing renal transplantation, two with catastrophic antiphospholipid antibody syndrome.

    4. Photodynamic Therapy Provides Local Control of Cholangiocarcinoma in Patients Awaiting Liver Transplantation (pages 466–471)

      N. D. Cosgrove, A. M. Al-Osaimi, H. K. Sanoff, M. M. Morris, P. W. Read, D. G. Cox, J. A. Mann, C. K. Argo, C. L. Berg, S. J. Pelletier, D. G. Maluf and A. Y. Wang

      Article first published online: 26 DEC 2013 | DOI: 10.1111/ajt.12597

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      Photodynamic therapy is a reasonably well tolerated and safe endoscopic ablation technique that may maintain locoregional tumor control in patients with cholangiocarcinoma who are awaiting liver transplantation.

  8. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. Isolated Peritoneal Donor-Related Plasmacytoma 3 Years After Liver Transplantation: A Case Report (pages 472–476)

      M. Sosin, S. R. Nassif, R. Girlanda, C. S. Desai, R. Satoskar, B. Kallakury, T. Cermak and T. Fishbein

      Article first published online: 26 DEC 2013 | DOI: 10.1111/ajt.12555

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      The authors report a case of donor-related plasmacytoma in a 76-year-old man, three years after a liver transplant for hepatocellular carcinoma, that changes an institutional protocol for handling future donor liver biopsies prior to transplantation.

    2. Fecal Microbiota Transplantation for Refractory Clostridium difficile Colitis in Solid Organ Transplant Recipients (pages 477–480)

      R. J. Friedman-Moraco, A. K. Mehta, G. M. Lyon and C. S. Kraft

      Article first published online: 16 JAN 2014 | DOI: 10.1111/ajt.12577

      The authors describe two solid organ transplant recipients who underwent fecal microbiota transplantation for multiply recurrent C. difficile infection.

  9. Reports From the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
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  10. Images in Transplantation

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. CME

      You have free access to this content
      Persistent Bile Leak After Deceased Donor Split Liver Transplantation (pages 485–487)

      M. P. Senthil Kumar, M. T. P. R. Perera, J. Isaac and D. F. Mirza

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12453

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  11. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. You have free access to this content
      One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model (pages 488–489)

      M. M. Mohiuddin, A. K. Singh, P. C. Corcoran, R. F. Hoyt, M. L. Thomas III, B. G. T. Lewis, M. Eckhaus, K. A. Reimann, N. Klymiuk, E. Wolf, D. Ayares and K. A. Horvath

      Article first published online: 11 DEC 2013 | DOI: 10.1111/ajt.12562

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  12. Errata

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Meeting Report
    7. Original Articles
    8. Brief Communications
    9. Case Reports
    10. Reports From the CDC: MMWR
    11. Images in Transplantation
    12. Letters to the Editor
    13. Errata
    1. You have free access to this content
      Erratum (page 496)

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12665

      This article corrects:
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      Erratum (page 497)

      Article first published online: 28 JAN 2014 | DOI: 10.1111/ajt.12664

      This article corrects:

      Patient Survival After Kidney Transplantation: Relationship to Pretransplant Cardiac Troponin T Levels

      Vol. 9, Issue 6, 1354–1361, Article first published online: 13 MAY 2009

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