American Journal of Transplantation

Cover image for Vol. 14 Issue 3

March 2014

Volume 14, Issue 3

Pages 499–739

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. You have free access to this content
      The AJT Report (pages 499–500)

      Sue Pondrom

      Article first published online: 25 FEB 2014 | DOI: 10.1111/ajt.12686

      Does robotic surgery have a place in transplantation? We ask critics and proponents of this technical approach to weigh in. Also this month, we take a look at a new organ transport and tracking system due out later this year.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. You have free access to this content
      Literature Watch Implications for transplantation (page 501)

      Walker Julliard, Jonathan Bromberg and Joshua Mezrich

      Article first published online: 25 FEB 2014 | DOI: 10.1111/ajt.12687

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      Is it possible that interactions between the environment and immune cells in mucosal surfaces lead to autoimmunity and chronic rejection in organ transplant recipients? The answer may be found in recent data involving the aryl hydrocarbon receptor.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. You have free access to this content
      Autophagy for Tolerance Induction in Transplantation (pages 503–504)

      B. Vokaer and A. Le Moine

      Article first published online: 16 JAN 2014 | DOI: 10.1111/ajt.12613

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      The authors discuss the role of autophagy and Beclin-1 in immunity and transplant tolerance induction. See article by Verghese et al on page 545.

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      Research and Innovation in the Deceased Donor (pages 505–506)

      D. A. Gerber, A. Glazier and S. Feng

      Article first published online: 10 JAN 2014 | DOI: 10.1111/ajt.12566

      The authors use a recently completed multidonor hospital study that involved treating donors with albuterol prior to organ recovery as an example of a recent low-risk trial to demonstrate the ongoing need for and challenges involving donor intervention trials. See article by Ware et al on page 621.

  4. Minireview

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. The Purinergic System in Allotransplantation (pages 507–514)

      A. Vergani, S. Tezza, C. Fotino, G. Visner, A. Pileggi, A. Chandraker and P. Fiorina

      Article first published online: 16 JAN 2014 | DOI: 10.1111/ajt.12567

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      This minireview summarizes the emerging role of the purinergic system in allograft rejection and focuses on the unique opportunities presented by newly developed drugs that target the purinergic system to promote long-term allograft survival.

  5. Special Article

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. New Quality Monitoring Tools Provided by the Scientific Registry of Transplant Recipients: CUSUM (pages 515–523)

      J. J. Snyder, N. Salkowski, D. Zaun, S. N. Leppke, T. Leighton, A. K. Israni and B. L. Kasiske

      Article first published online: 6 FEB 2014 | DOI: 10.1111/ajt.12628

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      This article provides guidance on the use and interpretation of the cumulative sum charts being provided to all kidney, heart, liver, and lung transplant programs in the United States by the Scientific Registry of Transplant Recipients.

  6. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. AST Cutting Edge of Transplantation 2013 Meeting Report: A Comprehensive Look at B Cells and Antibodies in Transplantation (pages 524–530)

      M. Mengel, A. Chong, D. M. Rothstein, E. Zorn and J. S. Maltzman

      Article first published online: 24 JAN 2014 | DOI: 10.1111/ajt.12593

      The major unmet needs related to patients with antibody-mediated rejection include improved understanding of B cell maturation and antibody responses, more precise diagnostics for risk stratification and monitoring of treatment effects, and innovative multicenter trial designs to adjudicate the value of multimodality therapies.

  7. Personal Viewpoints

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. What Are the Harms of Refusing to Allow Living Kidney Donation? An Expanded View of Risks and Benefits (pages 531–537)

      M. B. Allen, P. L. Abt and P. P. Reese

      Article first published online: 24 JAN 2014 | DOI: 10.1111/ajt.12599

      The authors argue that a complete risk/benefit analysis for living kidney donation requires consideration of the potential harms of refusing individuals the opportunity to donate, observe that current UNOS regulations may perpetuate a narrow understanding of risks and benefits, and identify areas for improvement in research and clinical practice related to live donors.

    2. Estimating Risks of De Novo Kidney Diseases After Living Kidney Donation (pages 538–544)

      R. W. Steiner, J. H. Ix, D. E. Rifkin and B. Gert

      Article first published online: 24 FEB 2014 | DOI: 10.1111/ajt.12625

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      The epidemiology of kidney diseases in the general population suggests changes in living kidney donor selection practices.

  8. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. Basic Science

      Costimulatory Blockade-Induced Allograft Survival Requires Beclin1 (pages 545–553)

      D. A. Verghese, A. Yadav, P. Bizargity, B. Murphy, P. S. Heeger and B. Schröppel

      Article first published online: 6 FEB 2014 | DOI: 10.1111/ajt.12610

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      This study demonstrates that the autophagy-related protein Beclin-1 facilitates T cell death and permits Treg cellmediated suppression required for costimulatory blockade–induced heart allograft survival in mice. See editorial by Vokaer and Le Moine on page 503.

    2. A Novel Approach Inducing Transplant Tolerance by Activated Invariant Natural Killer T Cells With Costimulatory Blockade (pages 554–567)

      T. Hirai, Y. Ishii, M. Ikemiyagi, E. Fukuda, K. Omoto, M. Namiki, M. Taniguchi and K. Tanabe

      Article first published online: 6 FEB 2014 | DOI: 10.1111/ajt.12606

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      This study establishes mixed hematopoietic chimerism with in vivo regulatory T cell expansion using combined liposomal alpha-galactosylceramide therapy and low dose CD40/CD154 blockade to control immune direction of invariant natural killer T cells.

    3. Endogenous Memory CD8 T Cells Directly Mediate Cardiac Allograft Rejection (pages 568–579)

      C. A. Su, S. Iida, T. Abe and R. L. Fairchild

      Article first published online: 6 FEB 2014 | DOI: 10.1111/ajt.12605

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      This study shows that endogenous memory CD8 T cells in unprimed mice infiltrate and reject cardiac allografts that have been subjected to prolonged cold ischemia despite costimulatory blockade.

    4. Spi6 Protects Alloreactive CD4+ But Not CD8+ Memory T Cell From Granzyme B Attack by Double-Negative T Regulatory Cell (pages 580–593)

      Y. Su, A. M. Jevnikar, X. Huang, D. Lian and Z.-X. Zhang

      Article first published online: 12 FEB 2014 | DOI: 10.1111/ajt.12614

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      This study reports that CD4+ memory T cells resist T regulatory cell suppression and accelerate allograft rejection by highly expressing granzyme B inhibitor serine protease inhibitor 6.

    5. Novel GMP-Compatible Protocol Employing an Allogeneic B Cell Bank for Clonal Expansion of Allospecific Natural Regulatory T Cells (pages 594–606)

      S. Landwehr-Kenzel, F. Issa, S.-H. Luu, M. Schmück, H. Lei, A. Zobel, A. Thiel, N. Babel, K. Wood, H.-D. Volk and P. Reinke

      Article first published online: 27 JAN 2014 | DOI: 10.1111/ajt.12629

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      An allogeneic B cell bank allows fast and GMP-compatible expansion of even low-abundance allospecific nTreg clones, which are more potent suppressors of specific alloresponses than their polyclonal counterparts, both in vitro and in vivo.

    6. High CTLA-4 Expression on Th17 Cells Results in Increased Sensitivity to CTLA-4 Coinhibition and Resistance to Belatacept (pages 607–614)

      S. M. Krummey, J. A. Cheeseman, J. A. Conger, P. S. Jang, A. K. Mehta, A. D. Kirk, C. P. Larsen and M. L. Ford

      Article first published online: 12 FEB 2014 | DOI: 10.1111/ajt.12600

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      This study demonstrates that human Th17 cells are resistant to the costimulation inhibitor belatacept and that a high frequency of Th17 memory cells is associated with acute rejection episodes in belatacept-treated renal transplant recipients.

    7. Clinical Science

      A Novel Organ Donor Facility: A Decade of Experience With Liver Donors (pages 615–620)

      M. B. M. Doyle, N. Vachharajani, J. R. Wellen, J. A. Lowell, S. Shenoy, G. Ridolfi, M. D. Jendrisak, J. Coleman, M. Maher, D. Brockmeier, D. Kappel and W. C. Chapman

      Article first published online: 25 FEB 2014 | DOI: 10.1111/ajt.12607

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      The authors report on the establishment of the nation's first Organ Procurement Organization–based organ recovery facility with a goal of increasing efficiencies, reducing costs, and reducing procurement surgeon travel.

    8. A Randomized Trial of the Effects of Nebulized Albuterol on Pulmonary Edema in Brain-Dead Organ Donors (pages 621–628)

      L. B. Ware, M. Landeck, T. Koyama, Z. Zhao, J. Singer, R. Kern, N. Neidlinger, J. Nguyen, E. Johnson, D. R. Janz, G. R. Bernard, J. W. Lee, M. A. Matthay and the California Transplant Donor Network

      Article first published online: 24 JAN 2014 | DOI: 10.1111/ajt.12564

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      In a randomized double-blind trial in 506 organ donors, the authors find that treatment with high-dose inhaled albuterol during the donor management period did not improve donor oxygenation or increase donor lung utilization. See editorial by Gerber et al on page 505.

    9. Lamivudine Compared With Newer Antivirals for Prophylaxis of Hepatitis B Core Antibody Positive Livers: A Cost-Effectiveness Analysis (pages 629–634)

      A. J. Wright, J. A. Fishman and R. T. Chung

      Article first published online: 24 JAN 2014 | DOI: 10.1111/ajt.12598

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      Using a Markov model, this study shows that lamivudine remains the most cost-effective option over tenofovir and entecavir for prophylaxis of recipients of hepatitis B core antibody positive liver transplants.

    10. REFINE: A Randomized Trial Comparing Cyclosporine A and Tacrolimus on Fibrosis After Liver Transplantation for Hepatitis C (pages 635–646)

      G. Levy, F. G. Villamil, F. Nevens, H. J. Metselaar, P.-A. Clavien, G. Klintmalm, R. Jones, M. Migliaccio, H. Prestele, R. Orsenigo and on behalf of the REFINE Study Group

      Article first published online: 23 JAN 2014 | DOI: 10.1111/ajt.12620

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      Results of the REFINE study, a multicenter prospective trial designed to examine whether choice of calcineurin inhibitor affects the rate of liver fibrosis due to posttransplant hepatitis C virus recurrence, show that overall fibrosis progression is similar in patients receiving either cyclosporine or tacrolimus, whereas in patients receiving steroid-free regimens, the use of cyclosporine leads to reduced severity of fibrosis progression at one year after liver transplantation.

    11. Combined Heart–Liver Transplantation in the MELD Era: Do Waitlisted Patients Require Exception Status? (pages 647–659)

      J. M. Schaffer, P. Chiu, S. K. Singh, P. E. Oyer, B. A. Reitz and H. R. Mallidi

      Article first published online: 12 FEB 2014 | DOI: 10.1111/ajt.12595

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      A retrospective review of UNOS data shows that patients listed for a combined heart–liver transplant have a lower incidence of transplant and higher waitlist mortality, but equivalent posttransplant outcomes compared to either isolated heart or isolated liver transplant candidates.

    12. Very Early” Intrahepatic Cholangiocarcinoma in Cirrhotic Patients: Should Liver Transplantation Be Reconsidered in These Patients? (pages 660–667)

      G. Sapisochin, C. Rodríguez de Lope, M. Gastaca, J. Ortiz de Urbina, M. A. Suarez, J. Santoyo, J. F. Castroagudín, E. Varo, R. López-Andujar, F. Palacios, G. Sanchez Antolín, B. Perez, A. Guiberteau, G. Blanco, M. L. González-Diéguez, M. Rodriguez, M. A. Varona, M. A. Barrera, Y. Fundora, J. A. Ferron, E. Ramos, J. Fabregat, R. Ciria, S. Rufian, A. Otero, M. A. Vazquez, J. A. Pons, P. Parrilla, G. Zozaya, J. I. Herrero, R. Charco and J. Bruix

      Article first published online: 10 JAN 2014 | DOI: 10.1111/ajt.12591

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      This multicenter study analyzes the outcome of patients transplanted for hepatocellular carcinoma who were found to have an intrahepatic cholangiocarcinoma at pathology examination, and focuses on the excellent posttransplant outcome of patients with single intrahepatic cholangiocarcinomas ≤2 cm.

    13. Pain Identifies Squamous Cell Carcinoma in Organ Transplant Recipients: The SCOPE-ITSCC PAIN Study (pages 668–676)

      J. N. Bouwes Bavinck, C. A. Harwood, R. E. Genders, H. C. Wisgerhof, E. I. Plasmeijer, L. Mitchell, E. B. Olasz, D. D. Mosel, M. S. Pokorney, A. L. Serra, L. Feldmeyer, K. Baumann Conzett, S. Piaserico, A. Belloni Fortina, K. Jahn, A. Geusau, M. J. P. Gerritsen, D. Seçkin, A. T. Güleç, P. Cetkovská, J. Ricar, B. Imko-Walczuk, C. M. Proby and G. F. L. Hofbauer

      Article first published online: 24 JAN 2014 | DOI: 10.1111/ajt.12587

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      Pain is a powerful warning signal for invasive cutaneous squamous cell carcinoma in organ transplant recipients.

    14. Alemtuzumab and Sirolimus in Renal Transplantation: Six-Year Results of a Single-Arm Prospective Pilot Study (pages 677–684)

      A. I. Sutherland, M. Z. Akhtar, M. Zilvetti, J. Brockmann, S. Ruse, S. V. Fuggle, S. Sinha, P. Harden and P. J. Friend

      Article first published online: 7 JAN 2014 | DOI: 10.1111/ajt.12572

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      Kidney transplant patients switched at six months from tacrolimus to sirolimus maintenance therapy, in the context of alemtuzumab induction and low-dose mycophenolate, demonstrate good graft outcomes and compliance with the allocated therapy.

  9. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. Immune Responses to Collagen-IV and Fibronectin in Renal Transplant Recipients With Transplant Glomerulopathy (pages 685–693)

      N. Angaswamy, C. Klein, V. Tiriveedhi, J. Gaut, S. Anwar, A. Rossi, D. Phelan, J. R. Wellen, S. Shenoy, W. C. Chapman and T. Mohanakumar

      Article first published online: 10 JAN 2014 | DOI: 10.1111/ajt.12592

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      In this retrospective study, the authors demonstrate that biopsy-proven transplant glomerulopathy in renal transplant recipients is associated with immune responses to self-antigens Collagen-IV and fibronectin.

    2. You have full text access to this OnlineOpen article
      Endovascular Method for Transplantation of Insulin-Producing Cells to the Pancreas Parenchyma in Swine (pages 694–700)

      J. Lundberg, S. Stone-Elander, X.-M. Zhang, O. Korsgren, S. Jonsson and S. Holmin

      Article first published online: 12 FEB 2014 | DOI: 10.1111/ajt.12601

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      This study presents one-year follow-up safety data on the microendovascular trans-vessel wall technique and shows that the technique can be used to transplant insulin-producing cells to the swine pancreas parenchyma.

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      Everolimus and Early Calcineurin Inhibitor Withdrawal: 3-Year Results From a Randomized Trial in Liver Transplantation (pages 701–710)

      M. Sterneck, G. M. Kaiser, N. Heyne, N. Richter, F. Rauchfuss, A. Pascher, P. Schemmer, L. Fischer, C. G. Klein, S. Nadalin, F. Lehner, U. Settmacher, P. Neuhaus, D. Gotthardt, M. Loss, S. Ladenburger, E. M. Paulus, M. Mertens and H. J. Schlitt

      Article first published online: 6 FEB 2014 | DOI: 10.1111/ajt.12615

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      The beneficial effect on renal function achieved by early CNI withdrawal and treatment with everolimus after liver transplantation is still evident after three years.

    4. Vascular Communications Between Donor and Recipient Tissues After Successful Full Face Transplantation (pages 711–719)

      K. K. Kumamaru, G. C. Sisk, D. Mitsouras, K. Schultz, M. L. Steigner, E. George, D. S. Enterline, E. M. Bueno, B. Pomahac and F. J. Rybicki

      Article first published online: 6 FEB 2014 | DOI: 10.1111/ajt.12608

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      Dynamic 320-detector row computed tomography angiography noninvasively identifies adequate blood flow with extensive vascular reorganization in three patients imaged one year after successful full face transplantation.

  10. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. Partial Esophageal Transplantation Is Possible as Part of a Multivisceral Graft (pages 720–723)

      K. Vakili and H. B. Kim

      Article first published online: 21 JAN 2014 | DOI: 10.1111/ajt.12623

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      Partial esophageal transplant as part of a multivisceral graft is described in a child requiring distal esophagectomy along with multivisceral resection for inflammatory myofibroblastic tumor.

    2. Heterotaxy Syndrome With Malrotation of the Gut and Interrupted Vena Cava Does Not Preclude Safe Procurement of Multivisceral Graft (pages 724–728)

      H. Hartog, D. F. Mirza and M. T. P. R. Perera

      Article first published online: 6 FEB 2014 | DOI: 10.1111/ajt.12627

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      In an era of severe organ shortage of pediatric multivisceral grafts, this report describes successful procurement and transplantation of a multivisceral graft from a pediatric donor with heterotaxy syndrome including malrotation of the gut and interrupted vena cava.

  11. Reports From the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. MMWR: CDC Guidance for Evaluating Healthcare Personnel for Hepatitis B Virus Protection and for Administering Postexposure Management (pages 729–731)

      E. A. Blumberg

      Article first published online: 25 FEB 2014 | DOI: 10.1111/ajt.12688

      This article summarizes recent recommendations of the CDC regarding prevention of hepatitis B in healthcare personnel.

  12. Images in Transplantation

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. CME

      You have free access to this content
  13. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
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      ATG Brands and DSA (page 737)

      D. Focosi and U. Boggi

      Article first published online: 21 JAN 2014 | DOI: 10.1111/ajt.12622

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      HLA Antibodies in ATGs (page 738)

      I. Popow and P. Steinberger

      Article first published online: 21 JAN 2014 | DOI: 10.1111/ajt.12621

  14. Erratum

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Minireview
    6. Special Article
    7. Meeting Report
    8. Personal Viewpoints
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    15. Erratum
    1. You have free access to this content
      Erratum (page 739)

      Article first published online: 25 FEB 2014 | DOI: 10.1111/ajt.12695

      This article corrects:

      Intraplaque Hemorrhage in Cardiac Allograft Vasculopathy

      Vol. 14, Issue 1, 184–192, Article first published online: 4 DEC 2013

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