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American Journal of Transplantation

Cover image for Vol. 14 Issue 4

April 2014

Volume 14, Issue 4

Pages 741–984

  1. The AJT Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      The AJT Report (pages 741–742)

      Sue Pondrom

      Version of Record online: 25 MAR 2014 | DOI: 10.1111/ajt.12728

      Kidney transplant surgeons will take a 10% pay cut in relative value units in 2014. This issue of “The AJT Report” investigates what this cut might mean for transplantation. Also in this issue, we take a look at two new independent studies showing an increased risk of end-stage renal disease in kidney donors.

  2. Literature Watch

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Literature Watch Implications for transplantation (page 743)

      Xian C. Li and Jonathan Bromberg

      Version of Record online: 25 MAR 2014 | DOI: 10.1111/ajt.12729

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      Considerable focus has been directed toward the identification of immunosuppressive approaches that both inhibit allospecific effectors while simultaneously stimulating and expanding Foxp3+ Tregs, and recent literature supports a paradigm in which mTOR inhibition favors Foxp3+ Tregs over T effector cells.

  3. Editorials

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Is Donor Glycosylation the Gatekeeper for Xenotransplantation? (pages 745–747)

      B. A. Cobb

      Version of Record online: 16 JAN 2014 | DOI: 10.1111/ajt.12637

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      Skin transplantation using mice with and without the human fucosyltransferase 1 enzyme reveals that isolated differences in glycosylation of donor grafts impacts both T cell‒ and NK cell‒mediated responses within the recipient. See article by Gock et al on page 797.

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      Assessing the Cells in the Lung Lavage: An Untapped Resource in Lung Transplant Monitoring (pages 748–749)

      D. C. Neujahr

      Version of Record online: 21 JAN 2014 | DOI: 10.1111/ajt.12632

      This editorial places phenotypic assessment of cells from lung lavage into the growing field of immune monitoring in solid organ transplantation. See article by Greenland et al on page 831.

  4. Comprehensive Review

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Harnessing Regulatory T Cells for Clinical Use in Transplantation: The End of the Beginning (pages 750–763)

      S. C. Juvet, A. G. Whatcott, A. R. Bushell and K. J. Wood

      Version of Record online: 4 MAR 2014 | DOI: 10.1111/ajt.12647

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      With the ONE study of regulatory T cell therapy in kidney transplantation beginning shortly, this review covers the historical background, preclinical science, and preliminary human data that have led to this point.

  5. Minireview

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Transplantation Genetics: Current Status and Prospects (pages 764–778)

      B. Almoguera, A. Shaked and B. J. Keating

      Version of Record online: 11 MAR 2014 | DOI: 10.1111/ajt.12653

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      This article reviews the recent advances in genomic technologies and genetic studies in transplantation and outlines the translational potential that such genomic knowledge may bring to this field.

  6. Meeting Report

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      The Role of Donor-Specific HLA Alloantibodies in Liver Transplantation (pages 779–787)

      J. G. O'Leary, A. J. Demetris, L. S. Friedman, H. M. Gebel, P. F. Halloran, A. D. Kirk, S. J. Knechtle, S. V. McDiarmid, A. Shaked, P. I. Terasaki, K. J. Tinckam, S. J. Tomlanovich, K. J. Wood, E. S. Woodle, A. A. Zachary and G. B. Klintmalm

      Version of Record online: 1 MAR 2014 | DOI: 10.1111/ajt.12667

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      Assembled experts provide insights, explore controversies, and develop recommendations for future research on the consequences of donor-specific alloantibodies in liver transplantation.

  7. Personal Viewpoint

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Hepatitis B Reactivation and Rituximab: A New Boxed Warning and Considerations for Solid Organ Transplantation (pages 788–796)

      S. T. Martin, S. M. Cardwell, M. D. Nailor and S. Gabardi

      Version of Record online: 4 MAR 2014 | DOI: 10.1111/ajt.12649

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      This report describes the basis behind the FDA's recent Boxed Warning issued to rituximab regarding hepatitis B reactivation; the potential impact on the solid organ transplant community; and recommendations for screening, prophylaxis, and treatment.

  8. Original Articles

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    1. Basic Science

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      Altered Glycosylation in Donor Mice Causes Rejection of Strain-Matched Skin and Heart Grafts (pages 797–805)

      H. Gock, L. J. Murray-Segal, A. C. Winterhalter, A. Aminian, G. T. C. Moore, S. J. Brown, A. J. F. d'Apice and P. J. Cowan

      Version of Record online: 6 FEB 2014 | DOI: 10.1111/ajt.12634

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      Skin and heart grafts from transgenic mice expressing a human fucosyltransferase are rapidly rejected by otherwise completely matched recipients, suggesting that differences in glycosylation between donor and recipient can provoke a powerful rejection response. See editorial by Cobb on page 745.

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      Everolimus Inhibits Anti-HLA I Antibody-Mediated Endothelial Cell Signaling, Migration and Proliferation More Potently Than Sirolimus (pages 806–819)

      Y.-P. Jin, N. M. Valenzuela, M. E. Ziegler, E. Rozengurt and E. F. Reed

      Version of Record online: 1 MAR 2014 | DOI: 10.1111/ajt.12669

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      The authors investigate the effects of the mTOR inhibitor everolimus on HLA-I antibody-induced endothelial cell signaling, and find that everolimus inhibits HLA-I antibody-mediated formation of mTOR complexes, activation of mTORC1- and mTORC2-related signaling networks, and functional changes more potently than sirolimus.

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      Perivascular Stromal Cells as a Potential Reservoir of Human Cytomegalovirus (pages 820–830)

      M. A. Soland, L. R. Keyes, R. Bayne, J. Moon, C. D. Porada, S. St. Jeor and G. Almeida-Porada

      Version of Record online: 4 MAR 2014 | DOI: 10.1111/ajt.12642

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      This study demonstrates that human CMV infects and propagates within bone marrow, liver, brain, and lung perivascular stromal cells, with the highest infection rate seen in lung cells, and suggests that perivascular bone marrow stromal cells may constitute an unrecognized natural CMV reservoir.

    4. Clinical Science

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      Bronchoalveolar Lavage Cell Immunophenotyping Facilitates Diagnosis of Lung Allograft Rejection (pages 831–840)

      J. R. Greenland, N. P. Jewell, M. Gottschall, N. N. Trivedi, J. Kukreja, S. R. Hays, J. P. Singer, J. A. Golden and G. H. Caughey

      Version of Record online: 11 FEB 2014 | DOI: 10.1111/ajt.12630

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      Quantification of bronchoalveolar lavage cell types, including CD25+ and natural killer cells, can help discriminate between infection and acute rejection, predict future acute rejection, and predict bronchiolitis obliterans syndrome in lung transplant recipients. See editorial by Neujahr on page 748.

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      Bile Acid Aspiration Associated With Lung Chemical Profile Linked to Other Biomarkers of Injury After Lung Transplantation (pages 841–848)

      D. C. Neujahr, K. Uppal, S. D. Force, F. Fernandez, C. Lawrence, A. Pickens, R. Bag, C. Lockard, A. D. Kirk, V. Tran, K. Lee, D. P. Jones and Y. Park

      Version of Record online: 19 FEB 2014 | DOI: 10.1111/ajt.12631

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      This study shows that distinct biochemical patterns are found in the lung lavages of transplant patients depending on the presence or absence of bile acids, and links these biochemical patterns to other biomarkers of lung injury.

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      Antibody Desensitization Therapy in Highly Sensitized Lung Transplant Candidates (pages 849–856)

      L. D. Snyder, A. L. Gray, J. M. Reynolds, G. M. Arepally, A. Bedoya, M. G. Hartwig, R. D. Davis, K. E. Lopes, W. E. Wegner, D. F. Chen and S. M. Palmer

      Version of Record online: 19 FEB 2014 | DOI: 10.1111/ajt.12636

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      An aggressive multimodal desensitization protocol does not significantly reduce pretransplant HLA antibodies in a broadly sensitized lung transplant candidate cohort.

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      Adapted Treatment of Epstein–Barr Virus Infection to Prevent Posttransplant Lymphoproliferative Disorder After Heart Transplantation (pages 857–866)

      S. Choquet, S. Varnous, C. Deback, J. L. Golmard and V. Leblond

      Version of Record online: 19 FEB 2014 | DOI: 10.1111/ajt.12640

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      The authors show that an algorithm assessing Epstein‒Barr virus viral load, and responding with decreasing immunosuppression and rituximab, is highly effective in controlling posttransplant lymphoproliferative disorder in heart transplant patients.

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      Prevalence, Incidence and Risk Factors for Donor-Specific Anti-HLA Antibodies in Maintenance Liver Transplant Patients (pages 867–875)

      A. Del Bello, N. Congy-Jolivet, F. Muscari, L. Lavayssière, L. Esposito, I. Cardeau-Desangles, J. Guitard, G. Dörr, B. Suc, J. P. Duffas, L. Alric, C. Bureau, M. Danjoux, C. Guilbeau-Frugier, A. Blancher, L. Rostaing and N. Kamar

      Version of Record online: 1 MAR 2014 | DOI: 10.1111/ajt.12651

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      The authors describe the incidence, prevalence, and consequences of donor-specific anti-HLA antibodies in maintenance liver transplant patients.

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      Impact of HLA Mismatch at First Kidney Transplant on Lifetime With Graft Function in Young Recipients (pages 876–885)

      B. J. Foster, M. Dahhou, X. Zhang, R. W. Platt, J. M. Smith and J. A. Hanley

      Version of Record online: 19 FEB 2014 | DOI: 10.1111/ajt.12643

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      Pediatric and young adult kidney transplant recipients with better ABDR HLA matching at first transplant have significantly greater subsequent lifetime graft function and significantly shorter wait times for a second transplant after first graft failure.

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      Glutathione S-Transferase Iso-Enzymes in Perfusate From Pumped Kidneys Are Associated With Delayed Graft Function (pages 886–896)

      I. E. Hall, R. S. Bhangoo, P. P. Reese, M. D. Doshi, F. L. Weng, K. Hong, H. Lin, G. Han, R. D. Hasz, M. J. Goldstein, B. Schröppel and C. R. Parikh

      Version of Record online: 24 FEB 2014 | DOI: 10.1111/ajt.12635

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      The authors show that kidney machine pump perfusate levels of the pi iso-enzyme of glutathione S-transferase are associated with delayed graft function but are no different between discarded and transplanted kidneys, whereas renal resistive indices are different and may be driving discard decisions.

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      Banff Fibrosis Study: Multicenter Visual Assessment and Computerized Analysis of Interstitial Fibrosis in Kidney Biopsies (pages 897–907)

      A. B. Farris, S. Chan, J. Climenhaga, B. Adam, C. O. C. Bellamy, D. Serón, R. B. Colvin, J. Reeve and M. Mengel

      Version of Record online: 20 FEB 2014 | DOI: 10.1111/ajt.12641

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      Renal fibrosis assessment on histopathology varies between observers, as demonstrated by multicenter Banff Working Group studies, which also show that computerized image analysis could provide standardized measurements that correlate with organ function.

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      Sterile Leukocyturia Is Associated With Interstitial Fibrosis and Tubular Atrophy in Kidney Allograft Protocol Biopsies (pages 908–915)

      S. Coelho, F. Ortíz, R. Gelpi, P. Koskinen, N. Porta, O. Bestard, E. Melilli, O. Taco, J. Torras, E. Honkanen, J. M. Grinyó and J. M. Cruzado

      Version of Record online: 12 FEB 2014 | DOI: 10.1111/ajt.12639

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      This collaborative study suggests that sterile leukocyturia might be a low-cost marker of interstitial fibrosis and tubular atrophy in kidney allograft biopsies.

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      Economic Consequences Incurred by Living Kidney Donors: A Canadian Multi-Center Prospective Study (pages 916–922)

      S. Klarenbach, J. S. Gill, G. Knoll, T. Caulfield, N. Boudville, G. V. R. Prasad, M. Karpinski, L. Storsley, D. Treleaven, J. Arnold, M. Cuerden, P. Jacobs, A. X. Garg and for the Donor Nephrectomy Outcomes Research (DONOR) Network

      Version of Record online: 5 MAR 2014 | DOI: 10.1111/ajt.12662

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      In a prospective costing study, the authors find that economic consequences incurred by living kidney donors are frequent and nontrivial, and a notable proportion of donors experience significant costs.

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      Family Perspectives on Deceased Organ Donation: Thematic Synthesis of Qualitative Studies (pages 923–935)

      A. Ralph, J. R. Chapman, J. Gillis, J. C. Craig, P. Butow, K. Howard, M. Irving, B. Sutanto and A. Tong

      Version of Record online: 10 MAR 2014 | DOI: 10.1111/ajt.12660

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      This thematic synthesis of qualitative research provides a conceptual understanding of how bereaved families can derive emotional benefit from the act of donation, while some may experience uncertainty about death and the donation process, emotional and cognitive burden, and decisional dissonance.

  9. Brief Communications

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Diagnosis of Early Pancreas Graft Failure via Antibody-Mediated Rejection: Single-Center Experience With 256 Pancreas Transplantations (pages 936–942)

      H. de Kort, M. J. K. Mallat, C. van Kooten, E. de Heer, S. H. Brand-Schaaf, A. M. van der Wal, C. Roufosse, D. L. Roelen, J. A. Bruijn, F. H. Claas, J. W. de Fijter and I. M. Bajema

      Version of Record online: 12 FEB 2014 | DOI: 10.1111/ajt.12624

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      This study evaluating simultaneous pancreas‒kidney transplant outcomes shows that antibody-mediated rejection is an important contributor to pancreas graft loss within 1 year posttransplantation, but this condition can be obscured by thrombosis.

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      Temporal Trends in the Incidence, Treatment and Outcomes of Hip Fracture After First Kidney Transplantation in the United States (pages 943–951)

      S. Sukumaran Nair, C. R. Lenihan, M. E. Montez-Rath, D. W. Lowenberg, G. M. Chertow and W. C. Winkelmayer

      Version of Record online: 20 FEB 2014 | DOI: 10.1111/ajt.12652

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      In first-time kidney transplant recipients in the United States, the authors find that case-mix adjusted hip fracture rates declined between 1997 and 2010, partly explained by changes in immunosuppressive regimens.

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      Evidence for a Gene Controlling the Induction of Transplantation Tolerance (pages 952–959)

      P. W. Lee, J. S. Hanekamp, V. Villani, P. A. Vagefi, R. A. Cina, C. Kamano, P. E. O'Malley, S. Arn, K. Yamada and D. H. Sachs

      Version of Record online: 4 MAR 2014 | DOI: 10.1111/ajt.12646

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      The unexpected rejection of kidney transplants across a class I MHC mismatch in a subline of miniature swine with a high coefficient of inbreeding provides evidence for mutation in a gene required for the induction of tolerance.

  10. Case Reports

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Liver Transplantation in Defects of Cholesterol Biosynthesis: The Case of Lathosterolosis (pages 960–965)

      P. L. Calvo, A. Brunati, M. Spada, R. Romagnoli, G. Corso, G. Parenti, M. Rossi, M. Baldi, G. Carbonaro, E. David, A. Pucci, A. Amoroso and M. Salizzoni

      Version of Record online: 12 MAR 2014 | DOI: 10.1111/ajt.12645

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      Liver transplantation corrects the metabolic unbalance in a child with lathosterolosis (OMIM #607330) and favors amelioration of her neurodevelopmental delay.

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      Should We Reconsider Lung Transplantation Through Uncontrolled Donation After Circulatory Death? (pages 966–971)

      Y. Suzuki, J. L. Tiwari, J. Lee, J. M. Diamond, N. P. Blumenthal, K. Carney, C. Borders, J. Strain, G. W. Alburger, D. Jackson Jr., J. Timar, J. Berg, R. D. Hasz and E. Cantu

      Version of Record online: 6 FEB 2014 | DOI: 10.1111/ajt.12633

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      The authors discuss their experience and consideration of logistical, legal, and ethical factors in uncontrolled DCD lung transplantation in the United States.

  11. Reports From the CDC: MMWR

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Advisory Committee on Immunization Practices Recommended Immunization Schedules for Persons Aged 0 Through 18 Years—United States, 2014 (pages 972–973)

      Version of Record online: 25 MAR 2014 | DOI: 10.1111/ajt.12730

      The 2014 pediatric immunization guideline changes are highlighted in these recommendations.

  12. Images in Transplantation

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
    1. CME

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      Persistent Shortness of Breath in a Kidney Transplant Recipient (pages 974–976)

      F. Ahmed, J. H. Helderman, A. Langone and H. Schaefer

      Version of Record online: 25 MAR 2014 | DOI: 10.1111/ajt.12537

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  13. Letters to the Editor

    1. Top of page
    2. The AJT Report
    3. Literature Watch
    4. Editorials
    5. Comprehensive Review
    6. Minireview
    7. Meeting Report
    8. Personal Viewpoint
    9. Original Articles
    10. Brief Communications
    11. Case Reports
    12. Reports From the CDC: MMWR
    13. Images in Transplantation
    14. Letters to the Editor
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      Kidney Transplantation From a Donor With Acute Kidney Injury: An Unexpected Outcome (pages 977–978)

      F. Mescia, R. Piras, M. Noris, G. Marchetti, G. Rossini, G. Remuzzi and P. Ruggenenti

      Version of Record online: 6 FEB 2014 | DOI: 10.1111/ajt.12648

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      Adjunctive Glucocorticoid Therapy for Non-HIV-Related Pneumocystis carinii Pneumonia (NH-PCP) (pages 982–983)

      J. A. McKinnell, A. P. Cannella, P. Injean and A. Gregson

      Version of Record online: 19 FEB 2014 | DOI: 10.1111/ajt.12655

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      Muted, But Not Mute (page 984)

      S. I. Martin

      Version of Record online: 1 MAR 2014 | DOI: 10.1111/ajt.12654

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