• 1
    Nagata K, Tanaka K, Ogawa K, Kemmotsu K, Imai T, Yoshie O et al. Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol 1999;162:12781286.
  • 2
    Nagata K, Hirai H, Tanaka K, Ogawa K, Aso T, Sugamura K et al. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett 1999;459:195199.
  • 3
    Hirai H, Tanaka K, Yoshie O, Ogawa K, Kenmotsu K, Takamori Y et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med 2001;193:255261.
  • 4
    Cosmi L, Annunziato F, Galli MIG, Maggi RME, Nagata K, Romagnani S. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol 2000;30:29722979.
  • 5
    Shirasaki H, Kikuchi M, Kanaizumi E, Himi T. Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosa. Ann Allergy Asthma Immunol 2009;102: 110115.
  • 6
    Monneret G, Gravel S, Diamond M, Rokach J, Powell WS. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 2001;98:19421948.
  • 7
    Xue L, Gyles SL, Wettey FR, Gazi L, Townsend E, Hunter MG et al. Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. J Immunol 2005;175:65316536.
  • 8
    Xue L, Barrow A, Pettipher R. Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway. J Immunol 2009;182:75807586.
  • 9
    Kagawa S, Fukunaga K, Oguma T, Suzuki Y, Shiomi T, Sayama K et al. Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma. Int Arch Allergy Immunol 2011;155(Suppl 1):611.
  • 10
    Nomiya R, Okano M, Fujiwara T, Maeda M, Kimura Y, Kino K et al. CRTH2 Plays an Essential Role in the Pathophysiology of Cry j 1-Induced Pollinosis in Mice. J Immunol 2008;180:56805688.
  • 11
    Spik I, Brenuchon C, Angeli V, Staumont D, Fleury S, Capron M et al. Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. J Immunol 2005;174:37033708.
  • 12
    Nantel F, Fong C, Lamontagne S, Wright DH, Giaid A, Desrosiers M et al. Expression of prostaglandin D synthase and the prostaglandin D2 receptors DP and CRTH2 in human nasal mucosa. Prostaglandins Other Lipid Mediat 2004;73:87101.
  • 13
    Wang YH, Ito T, Homey B, Watanabe N, Martin R, Barnes CJ et al. Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells. Immunity 2006;24:827838.
  • 14
    Yahara H, Satoh T, Miyagishi C, Yokozeki H. Increased expression of CRTH2 on eosinophils in allergic skin diseases. J Eur Acad Dermatol Venereol 2010;24:7576.
  • 15
    Mutalithas K, Guillen C, Day C, Brightling CE, Pavord ID, Wardlaw AJ. CRTH2 expression on T cells in asthma. Clin Exp Immunol 2010;161:3440.
  • 16
    Wenzel SE, Westcott JY, Larsen GL. Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. J Allergy Clin Immunol 1991;87:540548.
  • 17
    Balzar S, Fajt ML, Comhair SA, Erzurum SC, Bleecker E, Busse WW et al. Mast cell phenotype, location, and activation in severe asthma: data from the severe asthma research program. Am J Respir Crit Care Med 2011;183:299309.
  • 18
    Barnes N, Pavord I, Chuchalin A, Bell J, Hunter M, Lewis T et al. A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma. Clin Exp Allergy 2012;42:3848.
  • 19
    Huang JL, Gao PS, Mathias RA, Yao TC, Chen LC, Kuo ML et al. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. Hum Mol Genet 2004;13:26912697.
  • 20
    Wang J, Xu Y, Zhao H, Sui H, Liang H, Jiang X. Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children. Mol Biol Rep 2009;36:15491553.
  • 21
    Cameron L, Depner M, Kormann M, Klopp N, Illig T, von Mutius E et al. Genetic variation in CRTh2 influences development of allergic phenotypes. Allergy 2009;64:14781485.
  • 22
    Palikhe NS, Kim SH, Cho BY, Ye YM, Choi GS, Park HS. Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease. Allergy 2010;65:338346.
  • 23
    Brenner DR, Tepylo K, Eny KM, Cahill LE, El-Sohemy A. Comparison of body mass index and waist circumference as predictors of cardiometabolic health in a population of young Canadian adults. Diabetol Metab Syndr 2010;2:28.
  • 24
    Schratl P, Sturm EM, Royer JF, Sturm GJ, Lippe IT, Peskar BA et al. Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase. Eur J Immunol 2006;36:24012409.
  • 25
    Schratl P, Royer JF, Kostenis E, Ulven T, Sturm EM, Waldhoer M et al. The role of the prostaglandin D2 receptor, DP, in eosinophil trafficking. J Immunol 2007;179:47924799.
  • 26
    Wambre E, DeLong JH, James EA, LaFond RE, Robinson D, Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. J Allergy Clin Immunol 2012;129:544551, 551 e541–547.
  • 27
    De Fanis U, Mori F, Kurnat RJ, Lee WK, Bova M, Adkinson NF et al. GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. Blood 2007;109:43434350.
  • 28
    Quapp R, Madsen N, Cameron L. Characterization of the promoter of human CRTh2, a prostaglandin D2 receptor. Biochem Biophys Res Commun 2007;363:948953.
  • 29
    Nair P, Pizzichini MM, Kjarsgaard M, Inman MD, Efthimiadis A, Pizzichini E et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360:985993.
  • 30
    Ekerfelt C, Ernerudh J, Jenmalm MC. Detection of spontaneous and antigen-induced human interleukin-4 responses in vitro: comparison of ELISPOT, a novel ELISA and real-time RT-PCR. J Immunol Methods 2002;260:5567.
  • 31
    Cameron L, Webster RB, Strempel JM, Kiesler P, Kabesch M, Ramachandran H et al. Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation. J Immunol 2006;177:86338642.
  • 32
    Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973984.
  • 33
    Bradding P, Green RH. Subclinical phenotypes of asthma. Curr Opin Allergy Clin Immunol 2010;10:5459.
  • 34
    Szczeklik W, Sanak M, Szczeklik A. Functional effects and gender association of COX-2 gene polymorphism G-765C in bronchial asthma. J Allergy Clin Immunol 2004;114:248253.