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Figure S1. The effect of histamine on epidermal differentiation is dose dependent.

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Figure S2. Histamine perturbs differentiation in organotypic skin cultured with keratinocytes derived from adult skin.

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Figure S3. Histamine induces the change in differentiation by acting directly on keratinocytes.

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Figure S4. The histamine-induced changes in epidermal differentiation are still observed in organotypic skin models that were cultured for longer time period.

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Figure S5. Biotin does not enter the epidermis when added to the surface of skin models and histamine does not modulate epidermal lipid composition.

all12051-sup-0006-Figureslegend.docxWord document15K 

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