Edited by: Hans-Uwe Simon
Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
Article first published online: 15 NOV 2012
© 2012 John Wiley & Sons A/S
Volume 68, Issue 1, pages 37–47, January 2013
How to Cite
Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Allergy 2012; DOI: 10.1111/all.12051., , , , , , , , .
Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms.
- Issue published online: 4 DEC 2012
- Article first published online: 15 NOV 2012
- Manuscript Accepted: 17 SEP 2012
- Austrian Science Fund. Grant Number: T545–B19
- Deutsche Forschungsgemeinschaft. Grant Number: Gu434/5–2
- European Community COST Actions. Grant Numbers: BM0903, BM0806
Figure S1. The effect of histamine on epidermal differentiation is dose dependent.
Figure S2. Histamine perturbs differentiation in organotypic skin cultured with keratinocytes derived from adult skin.
Figure S3. Histamine induces the change in differentiation by acting directly on keratinocytes.
Figure S4. The histamine-induced changes in epidermal differentiation are still observed in organotypic skin models that were cultured for longer time period.
Figure S5. Biotin does not enter the epidermis when added to the surface of skin models and histamine does not modulate epidermal lipid composition.
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