Triclosan exposure and allergic sensitization in Norwegian children

Authors

  • R. J. Bertelsen,

    Corresponding author
    1. Department of Health and Human Services, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institute of Health, RTP, NC, USA
    • Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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  • M. P. Longnecker,

    1. Department of Health and Human Services, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institute of Health, RTP, NC, USA
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  • M. Løvik,

    1. Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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  • A. M. Calafat,

    1. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
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  • K-H. Carlsen,

    1. Department of Pediatrics, Oslo University Hospital, Oslo, Norway
    2. Faculty of Medicine, University of Oslo, Oslo, Norway
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  • S. J. London,

    1. Department of Health and Human Services, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institute of Health, RTP, NC, USA
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  • K. C. Lødrup Carlsen

    1. Department of Pediatrics, Oslo University Hospital, Oslo, Norway
    2. Faculty of Medicine, University of Oslo, Oslo, Norway
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  • Edited by: Stephan Weidinger

Correspondence

Randi J. Bertelsen, Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.

Tel.: +47 21076327

Fax: +47 21076686

E-mail: randi.jacobsen.bertelsen@fhi.no

Abstract

Background

Exposure to the synthetic antimicrobial chemical, triclosan, used in personal care products, has been hypothesized to lead to allergic disease. We investigated whether triclosan exposure was associated with allergic sensitization and symptoms in 10-year-old Norwegian children.

Methods

Urinary concentrations of triclosan were measured in one first morning void from 623 children, collected during 2001–2004. Logistic regression models, controlling for urine specific gravity, parental allergic disease, maternal education, and household income, were fitted for allergic sensitization (either skin prick test positivity or serum-specific IgE ≥ 0.35 kU/l to at least one of 15 evaluated inhalant and food allergens), current rhinitis, and current asthma (questionnaire and exercise challenge test).

Results

The adjusted odds ratio (aOR) for allergic sensitization among those in the fourth quartile of triclosan concentration was 2.0 [95% confidence interval (CI): 1.1, 3.4] compared with the reference group (<the limit of detection), and the aOR per log10 unit increase in triclosan was 1.2 (95% CI: 1.0, 1.4). The aOR for current rhinitis was 1.9 (95% CI: 1.1, 3.4) for the fourth quartile and 1.2 (95% CI: 0.97, 1.4) per log10 unit increase in triclosan.

Conclusion

Triclosan concentrations were associated with allergic sensitization, especially inhalant and seasonal allergens, rather than food allergens. Current rhinitis was associated with the highest levels of triclosan, whereas no association was seen for current asthma. These results are consistent with recent findings in other studies and provide additional evidence for an association between triclosan and allergy.

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