Edited by: Stephan Weidinger
Triclosan exposure and allergic sensitization in Norwegian children
Version of Record online: 12 NOV 2012
© 2012 John Wiley & Sons A/S
Volume 68, Issue 1, pages 84–91, January 2013
How to Cite
Triclosan exposure and allergic sensitization in Norwegian children. Allergy 2012; DOI: 10.1111/all.12058., , , , , , .
- Issue online: 4 DEC 2012
- Version of Record online: 12 NOV 2012
- Manuscript Accepted: 24 SEP 2012
- Norwegian Institute of Public Health
- Research Council of Norway
- Oslo University Hospital
- National Institutes of Health
- National Institute of Environmental Health Sciences
Exposure to the synthetic antimicrobial chemical, triclosan, used in personal care products, has been hypothesized to lead to allergic disease. We investigated whether triclosan exposure was associated with allergic sensitization and symptoms in 10-year-old Norwegian children.
Urinary concentrations of triclosan were measured in one first morning void from 623 children, collected during 2001–2004. Logistic regression models, controlling for urine specific gravity, parental allergic disease, maternal education, and household income, were fitted for allergic sensitization (either skin prick test positivity or serum-specific IgE ≥ 0.35 kU/l to at least one of 15 evaluated inhalant and food allergens), current rhinitis, and current asthma (questionnaire and exercise challenge test).
The adjusted odds ratio (aOR) for allergic sensitization among those in the fourth quartile of triclosan concentration was 2.0 [95% confidence interval (CI): 1.1, 3.4] compared with the reference group (<the limit of detection), and the aOR per log10 unit increase in triclosan was 1.2 (95% CI: 1.0, 1.4). The aOR for current rhinitis was 1.9 (95% CI: 1.1, 3.4) for the fourth quartile and 1.2 (95% CI: 0.97, 1.4) per log10 unit increase in triclosan.
Triclosan concentrations were associated with allergic sensitization, especially inhalant and seasonal allergens, rather than food allergens. Current rhinitis was associated with the highest levels of triclosan, whereas no association was seen for current asthma. These results are consistent with recent findings in other studies and provide additional evidence for an association between triclosan and allergy.