The Ethics Committee of South Karelia Central Hospital approved the study protocol, and all patients gave their written consent prior to the commencement of the study
Salt chamber treatment is ineffective in treating eosinophilic inflammation in asthma
Article first published online: 12 NOV 2012
© 2012 John Wiley & Sons A/S
Volume 68, Issue 1, pages 125–127, January 2013
How to Cite
Salt chamber treatment is ineffective in treating eosinophilic inflammation in asthma. Allergy 2012; DOI: 10.1111/all.12061., , , .
Edited by: Michael Wechsier
- Issue published online: 4 DEC 2012
- Article first published online: 12 NOV 2012
- Manuscript Accepted: 27 SEP 2012
- Finland's Slot Machine Association
- The Social Insurance Institution of Finland
We have shown that salt chamber treatment reduces airway hyper-responsiveness as an add-on therapy in adult asthmatics on inhaled corticosteroids.
We assessed whether this effect is due to the suppression of eosinophilic airway inflammation. Thirty-nine adult asthmatics on inhaled corticosteroids were randomized to receive active salt chamber treatment with low-salt treatment 6.6 mg/m3 (n = 14), high-salt treatment 10.8 mg/m3 (n = 15) or placebo 0.3 mg/m3 (n = 10) 10 times in a 2 weeks' period in a double-blind manner.
The level of induced sputum eosinophilic cationic protein μg/l, was 3070 before and 4651 after the low-salt treatment period, on average. In the high-salt treatment group, it was 12 192 μg/l vs 11 803 and in the placebo group 3942 vs 4144, respectively. Salt chamber treatment had no effect on sputum eosinophil or neutrophil cell numbers.
The reduction in hyper-responsiveness observed in the previous study is probably not due to the effect on eosinophilic inflammation.