Both authors contributed equally to this article
Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population
Article first published online: 12 NOV 2012
© 2012 John Wiley & Sons A/S
Volume 68, Issue 1, pages 92–100, January 2013
How to Cite
Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. Allergy 2012; DOI: 10.1111/all.12066., , , , , , , , , , , .
Edited by: Stephan Weidinger
- Issue published online: 4 DEC 2012
- Article first published online: 12 NOV 2012
- Manuscript Accepted: 4 OCT 2012
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare of Japan
- allergic rhinitis;
- single-nucleotide polymorphism
Allergic rhinitis (AR) is a very common disorder peaking in the teenage years that is mediated by hypersensitivity responses to environmental allergens. Although it is well established that the ORMDL3 locus at chromosome 17q21 is associated with susceptibility to bronchial asthma, the genetic influences of the polymorphisms of the locus in allergic rhinitis are unclear.
To examine whether the polymorphisms in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population.
We performed linkage disequilibrium (LD) mapping of the locus using the HapMap database and conducted an association study of the locus with a total of 15 tag SNPs in two independent populations. We further evaluated correlations of genotypes with changes in expression of genes at the region in lymphoblastoid cell lines in the Japanese population and assessed the expression levels of the genes in nasal epithelium and various human tissues.
We found a significant association between a total of five polymorphisms in the 17q21 asthma susceptibility locus, rs9303277, rs7216389, rs7224129, rs3744246, and rs4794820, and AR (minimum Pcombined = 0.00074, rs4794820). The expression level of the ORMDL3 transcript was significantly correlated with the genotype of rs12150079, rs7216389, rs3744246, and rs4794820 with P < 0.01 (minimum P = 0.0058, rs7216389), and ORMDL3 mRNA was highly expressed in nasal epithelium.
Genetic variants in the 17q21 asthma susceptibility locus are significantly associated with AR in the Japanese population.