These two authors contributed equally to this manuscript.
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils – implications for asthma
Article first published online: 18 JAN 2013
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Volume 68, Issue 3, pages 304–311, March 2013
How to Cite
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils – implications for asthma. Allergy 2013; 68: 304–311., , , .
Edited by: Hans-Uwe Simon
- Issue published online: 8 FEB 2013
- Article first published online: 18 JAN 2013
- Manuscript Accepted: 28 OCT 2012
- Swedish Research Council. Grant Numbers: 20854, 10350
- Swedish Strategic Foundation (SSF)
- Swedish Cancer Society
- Thorsten & Ragnar Söderberg's Foundation
- Swedish Heart Lung Foundation
- Stockholm County Council. Grant Number: 20090136
- Karolinska Institutet
Figure S1. LL-37 mediates LTB4 release from eosinophils (n = 4).
Figure S2. A FPR-2 receptor agonist peptide WKYMVm (Wp), similarly as LL-37, induced cys-LT release from eosinophils (n = 3).
Figure S3. Densitometry analysis of LL-37-induced p-cPLA2 (A) and cPLA2 (B) expression normalized to GAPDH (n = 3).
Figure S4. Densitometry analysis of LL-37-stimulated p-ERK1 and p-ERK2 expression normalized to ERK1 and ERK2 (n = 4).
Figure S5. Densitometry analysis of the effect of PD-98059 on p-cPLA2 expression normalized to cPLA2 (n = 4).
Figure S6. LL-37 induces ECP release from eosinophils (n = 4).
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