Edited by: Hans-Uwe Simon
Simultaneous intradermal testing with hymenoptera venoms is safe and more efficient than sequential testing
Article first published online: 14 FEB 2013
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Volume 68, Issue 4, pages 542–544, April 2013
How to Cite
Simultaneous intradermal testing with hymenoptera venoms is safe and more efficient than sequential testing. Allergy 2013; 68: 542–544., , , , .
- Issue published online: 19 MAR 2013
- Article first published online: 14 FEB 2013
- Manuscript Accepted: 24 DEC 2012
- hymenoptera venom allergy;
- intradermal test;
- skin test
According to current guidelines, skin testing for hymenoptera venom allergy should be performed in a stepwise manner, maintaining 15- to 20-min intervals between the injections of venom. Given the long-winded procedure of sequential skin testing, we retrospectively explored the safety of simultaneous intradermal testing.
Four hundred and seventy-eight consecutive patients with a convincing history of an anaphylactic reaction after a hymenoptera sting were tested. All venom concentrations (0.02 ml of 0.001, 0.01, 0.1, and 1.0 μg/ml of honey bee and wasp venom) were administered simultaneously to the skin.
Four hundred and seventy-two (98.7%) patients tolerated the simultaneous intradermal test without any side-effects. Only three subjects (0.6%) had a presumed allergic reaction during the test; another three reactions were considered vasovagal.
Our skin test protocol with four simultaneously injected concentrations of two hymenoptera venoms is safe and permits the investigator to draw rapid conclusions about the individual's sensitization pattern.