Edited by: Michael Wechsler
Increased circulating platelet microparticles as a potential biomarker in asthma
Article first published online: 29 JUL 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 68, Issue 8, pages 1073–1075, August 2013
How to Cite
Increased circulating platelet microparticles as a potential biomarker in asthma. Allergy 2013; 68: 1073–1075., , , , , , , , , .
- Issue published online: 23 AUG 2013
- Article first published online: 29 JUL 2013
- Manuscript Accepted: 24 APR 2013
- Fundação Professor Ernesto Morais
- endothelial and platelet microparticles;
Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication.
In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects.
Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b−−/AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117).
We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.