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Increased circulating platelet microparticles as a potential biomarker in asthma

Authors


  • Edited by: Michael Wechsler

Correspondence

Delfim Duarte, Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, Centre for Medical Research, 2nd floor, Rua Dr. Plácido Costa, 91, 4200-450 Porto, Portugal.

Tel.: +351 220426680

Fax: +351 225513624

E-mail: delfimd@med.up.pt

Abstract

Background

Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication.

Methods

In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects.

Results

Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (= 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b−−/AnV+) were significantly increased before (P = 0.005) but not after adjustments (= 0.117).

Conclusions

We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

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