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Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms

Authors

  • A. C. Bursztejn,

    Corresponding author
    1. Dermatology Department, Dermato-allergy Unit, ADERME, Batiment des spécialités médicales, Hôpitaux Brabois, Universite de Lorraine, Vandoeuvre les Nancy, France
    • Inserm U954 N-GERE (Nutrition-Génétique-Exposition aux risques environnementaux), Faculté de Médecine et Centre Hospitalier Universitaire, Université de Lorraine, Nancy
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  • A. Romano,

    1. Allergy Unit, Complesso Integrato Columbus, Rome
    2. IRCCS Oasi Maria S.S., Troina, Italy
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    • These authors contributed equally to this work.
  • R. M. Guéant-Rodriguez,

    1. Inserm U954 N-GERE (Nutrition-Génétique-Exposition aux risques environnementaux), Faculté de Médecine et Centre Hospitalier Universitaire, Université de Lorraine, Nancy
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    • These authors contributed equally to this work.
  • J. A. Cornejo,

    1. Research Laboratory for Allergic Diseases and Allergy Service, Carlos Haya Hospital, Malaga, Spain
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  • A. Oussalah,

    1. Inserm U954 N-GERE (Nutrition-Génétique-Exposition aux risques environnementaux), Faculté de Médecine et Centre Hospitalier Universitaire, Université de Lorraine, Nancy
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  • C. Chery,

    1. Inserm U954 N-GERE (Nutrition-Génétique-Exposition aux risques environnementaux), Faculté de Médecine et Centre Hospitalier Universitaire, Université de Lorraine, Nancy
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  • I. Gastin,

    1. Inserm U954 N-GERE (Nutrition-Génétique-Exposition aux risques environnementaux), Faculté de Médecine et Centre Hospitalier Universitaire, Université de Lorraine, Nancy
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  • F. Gaeta,

    1. Allergy Unit, Complesso Integrato Columbus, Rome
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  • A. Barbaud,

    1. Inserm U954 N-GERE (Nutrition-Génétique-Exposition aux risques environnementaux), Faculté de Médecine et Centre Hospitalier Universitaire, Université de Lorraine, Nancy
    2. Dermatology Department, Dermato-allergy Unit, ADERME, Batiment des spécialités médicales, Hôpitaux Brabois, Universite de Lorraine, Vandoeuvre les Nancy, France
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  • M. Blanca,

    1. Research Laboratory for Allergic Diseases and Allergy Service, Carlos Haya Hospital, Malaga, Spain
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    • These authors contributed equally to this work.
  • J. L. Guéant

    Corresponding author
    • Inserm U954 N-GERE (Nutrition-Génétique-Exposition aux risques environnementaux), Faculté de Médecine et Centre Hospitalier Universitaire, Université de Lorraine, Nancy
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  • Edited by: Pascal Demoly

Correspondence

Prof. Jean-Louis Guéant and Dr Anne-Claire Bursztejn, Inserm U954, University of Lorraine and University Hospital of Nancy, 9 Rue de la Forêt de Haye, 54505

Nancy-Vandoeuvre, France.

Tel.: +33 383683292

Fax: +33 383683279

E-mail: jean-louis.gueant@medecine.uhp-nancy.fr and ac.bursztejn@chu-nancy.fr

Abstract

Background

Polymorphisms of interleukin genes related to IgE production and inflammation are predictors of hypersensitivity to betalactam, but nothing is known on the influence of NOD genes, despite their association with inflammation and atopy.

Objective

To evaluate the association of NOD2 and NOD1 polymorphisms with betalactam allergy.

Method

We genotyped 3 polymorphisms of NOD2 and 1 of NOD1 in 368 Italian and 387 Spanish patients, compared with 368 and 326 controls, respectively.

Results

CT/TT genotypes of rs2066845 of NOD2 predicted a lower risk in Italy (P = 0.003), while WT/insC genotype of rs5743293 (also in leucine-rich repeat domain) predicted a higher risk in Spain (P = 0.007). G allele of rs2066845 was associated with a higher level of IgE in the Italian population.

Conclusion

The mirrored influence of these NOD2 polymorphisms on betalactam allergy in two populations suggests a link with pathways of inflammation and/or atopy through mechanisms, which need to be clarified.

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