Edited by: Douglas Robinson
Myeloid dendritic cells type 2 in allergic asthma
Version of Record online: 3 AUG 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 68, Issue 10, pages 1322–1326, October 2013
How to Cite
Myeloid dendritic cells type 2 in allergic asthma. Allergy 2013; 68: 1322–1326., , , , , .
- Issue online: 18 OCT 2013
- Version of Record online: 3 AUG 2013
- Manuscript Accepted: 22 MAY 2013
- dendritic cells;
- moderate/severe asthma;
- myeloid dendritic cells type 2 (mDC2s)
Myeloid dendritic cells type 2 (mDC2s) are a new subtype of DCs identified in both the circulation and the lung and suggested to have a role in allergic asthma.
Circulating mDC2s were enumerated in 19 healthy, 18 atopic nonasthmatic, 18 mild atopic asthmatic, and 16 moderate/severe atopic asthmatic subjects using flow cytometry.
The number of circulating mDC2s was significantly lower in atopic subjects compared with healthy controls and in asthmatic subjects compared with nonasthmatic subjects. There was a trend toward lower levels of circulating mDC2s with increasing allergy and asthma severity. The largest differences were seen in moderate/severe atopic asthmatics being 430.78 ± 48.91/ml compared with healthy controls being 767.05 ± 101.64/ml (P < 0.05).
Circulating mDC2s are lower in atopic and asthmatic subjects, which suggests that these cells efflux from the blood into the airways in patients with allergic disease.