Edited by: Pascal Demoly
Diagnosis of immediate hypersensitivity reactions to radiocontrast media
Article first published online: 31 AUG 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 68, Issue 9, pages 1203–1206, September 2013
How to Cite
Diagnosis of immediate hypersensitivity reactions to radiocontrast media. Allergy 2013; 68: 1203–1206., , , , , , , , , .
- Issue published online: 18 SEP 2013
- Article first published online: 31 AUG 2013
- Manuscript Accepted: 28 MAY 2013
- FIS-Thematic Networks
- Co-operative Research Centres. Grant Number: RIRAAF/RD07/0064
- basophil activation test;
- drug provocation test;
- immediate hypersensitivity reactions;
- radiocontrast media;
- skin tests
No consensus exists on the diagnostic approach for immediate hypersensitivity reactions (IHR) to radiocontrast media (RCM). We analyzed the diagnostic value of a skin test (ST), drug provocation test (DPT) and basophil activation test (BAT) in patients with symptoms compatible with IHR to RCM.
Ninety patients with symptoms suggestive of IHR to RCM were evaluated. ST with a panel of RCM was performed, and if negative, DPT was carried out with the culprit RCM. If ST or DPT were positive, tolerance was assessed with an alternative RCM and BAT was carried out with the same panel used for ST.
Eight (8.9%) cases were confirmed as having IHR, 5 (62.5%) by ST and 3 (37.5%) by DPT. Five from those confirmed as IHR (62.5%) had a positive BAT.
Hypersensitivity to RCM was confirmed in 9%, by ST or DPT. BAT proved a valuable method for diagnosis.