Edited by: Hans-Uwe Simon
Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains
Article first published online: 21 SEP 2013
© 2013 The Authors. Allergy published by John Wiley & Sons Ltd
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Volume 68, Issue 10, pages 1333–1337, October 2013
How to Cite
Committed mast cell progenitors in mouse blood differ in maturity between Th1 and Th2 strains. Allergy 2013; 68: 1333–1337., , .
- Issue published online: 18 OCT 2013
- Article first published online: 21 SEP 2013
- Manuscript Accepted: 14 JUN 2013
- Swedish Research Council
- Malin and Lennart Philipson Foundation
- mast cell progenitors;
- mast cells
Mast cell progenitors (MCp) leave the bone marrow and migrate to peripheral tissues where they mature. Although the existence of committed MCp in adult mouse and human blood has been postulated, they have never been found. We have isolated a rare population of cells in adult mouse blood, committed to the mast cell lineage. These were identified as lineage− c-kithi ST2+ integrin β7hi CD16/32hi cells. Moreover, a major difference in maturity of these cells based on FcεRI expression was observed between the Th2-prone BALB/c strain and the Th1-prone C57BL/6 strain (66% vs 25% FcεRI+, respectively). Therefore, the choice of mouse strain is critical when studying disease models such as experimental asthma where mast cells and their progenitors are involved.