• 1
    Ebo DG, Hagendorens MM, Bridts CH, De Clerck LS, Stevens WJ. Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy. Clin Exp Allergy 2004;34:137144.
  • 2
    Aalberse RC, Koshte V, Clemens JG. Immunoglobulin E antibodies that crossreact with vegetable foods, pollen, and Hymenoptera venom. J Allergy Clin Immunol 1981;68:356364.
  • 3
    Commins SP, Platts-Mills TA. Allergenicity of carbohydrates and their role in anaphylactic events. Curr Allergy Asthma Rep 2010;10:2933.
  • 4
    Altmann F. The role of protein glycosylation in allergy. Int Arch Allergy Immunol 2007;142:99115.
  • 5
    Bencurova M, Hemmer W, Focke-Tejkl M, Wilson IB, Altmann F. Specificity of IgG and IgE antibodies against plant and insect glycoprotein glycans determined with artificial glycoforms of human transferrin. Glycobiology 2004;14:457466.
  • 6
    Kubelka V, Altmann F, Staudacher E, Tretter V, Marz L, Hard K et al. Primary structures of the N-linked carbohydrate chains from honeybee venom phospholipase A2. Eur J Biochem 1993;213:11931204.
  • 7
    Kurosaka A, Yano A, Itoh N, Kuroda Y, Nakagawa T, Kawasaki T. The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum. J Biol Chem 1991;266:41684172.
  • 8
    Tretter V, Altmann F, Kubelka V, Marz L, Becker WM. Fucose alpha 1,3-linked to the core region of glycoprotein N-glycans creates an important epitope for IgE from honeybee venom allergic individuals. Int Arch Allergy Immunol 1993;102:259266.
  • 9
    Wilson IB, Zeleny R, Kolarich D, Staudacher E, Stroop CJ, Kamerling JP et al. Analysis of Asn-linked glycans from vegetable foodstuffs: widespread occurrence of Lewis a, core alpha1,3-linked fucose and xylose substitutions. Glycobiology 2001;11:261274.
  • 10
    Muller UR, Johansen N, Petersen AB, Fromberg-Nielsen J, Haeberli G. Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species-specific major allergens Api m1 and Ves v5. Allergy 2009;64:543548.
  • 11
    Mari A. IgE to cross-reactive carbohydrate determinants: analysis of the distribution and appraisal of the in vivo and in vitro reactivity. Int Arch Allergy Immunol 2002;129:286295.
  • 12
    Westphal S, Kolarich D, Foetisch K, Lauer I, Altmann F, Conti A et al. Molecular characterization and allergenic activity of Lyc e 2 (beta-fructofuranosidase), a glycosylated allergen of tomato. Eur J Biochem 2003;270:13271337.
  • 13
    Gonzalez-Quintela A, Valcarcel C, Campos J, Alonso M, Sanz ML, Vidal C. Biologic activity of cross-reactive carbohydrate determinants in heavy drinkers. Clin Exp Allergy 2011;41:759761.
  • 14
    Jappe U, Raulf-Heimsoth M. The significance of cross-reactive carbohydrate determinants (CCD) for allergy diagnosis. Allergologie 2008;31:8290.
  • 15
    Malandain H, Giroux F, Cano Y. The influence of carbohydrate structures present in common allergen sources on specific IgE results. Eur Ann Allergy Clin Immunol 2007;39:216220.
  • 16
    Mari A, Ooievaar-de HP, Scala E, Giani M, Pirrotta L, Zuidmeer L et al. Evaluation by double-blind placebo-controlled oral challenge of the clinical relevance of IgE antibodies against plant glycans. Allergy 2008;63:891896.
  • 17
    Mertens M, Amler S, Moerschbacher BM, Brehler R. Cross-reactive carbohydrate determinants strongly affect the results of the basophil activation test in hymenoptera-venom allergy. Clin Exp Allergy 2010;40:13331345.
  • 18
    van der Veen MJ, van Ree R, Aalberse RC, Akkerdaas J, Koppelman SJ, Jansen HM et al. Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J Allergy Clin Immunol 1997;100:327334.
  • 19
    Iacovacci P, Afferni C, Butteroni C, Pironi L, Puggioni EM, Orlandi A et al. Comparison between the native glycosylated and the recombinant Cup a1 allergen: role of carbohydrates in the histamine release from basophils. Clin Exp Allergy 2002;32:16201627.
  • 20
    Foetisch K, Westphal S, Lauer I, Retzek M, Altmann F, Kolarich D et al. Biological activity of IgE specific for cross-reactive carbohydrate determinants. J Allergy Clin Immunol 2003;111:889896.
  • 21
    Jin C, Nitsch S, Hemmer W, Altmann F. Improving allergy diagnosis by removal of CCD-specific IgE from patients′ sera. Allergy 2009;64(Suppl. 90):30.
  • 22
    Jappe U, Petersen A, Raulf-Heimsoth M. Immediate-type allergic reactions and cross-reactive carbohydrate determinants (CCD). Allergo J. 2013;22:2532.
  • 23
    Wilson IB, Harthill JE, Mullin NP, Ashford DA, Altmann F. Core alpha1,3-fucose is a key part of the epitope recognized by antibodies reacting against plant N-linked oligosaccharides and is present in a wide variety of plant extracts. Glycobiology 1998;8:651661.
  • 24
    Jin C, Focke M, Leonard R, Jarisch R, Altmann F, Hemmer W. Reassessing the role of hyaluronidase in yellow jacket venom allergy. J Allergy Clin Immunol 2010;125:184190. e181.
  • 25
    Cecioni S, Faure S, Darbost U, Bonnamour I, Parrot-Lopez H, Roy O et al. Selectivity among two lectins: probing the effect of topology, multivalency and flexibility of “clicked” multivalent glycoclusters. Chemistry 2011;17:21462159.
  • 26
    Dam TK, Brewer CF. Effects of clustered epitopes in multivalent ligand-receptor interactions. Biochemistry 2008;47:84708476.
  • 27
    Hemmer W, Focke M, Kolarich D, Dalik I, Gotz M, Jarisch R. Identification by immunoblot of venom glycoproteins displaying immunoglobulin E-binding N-glycans as cross-reactive allergens in honeybee and yellow jacket venom. Clin Exp Allergy 2004;34:460469.
  • 28
    Vidal C, Sanmartin C, Armisen M, Rodriguez V, Linneberg A, Gonzalez-Quintela A. Minor interference of cross-reactive carbohydrates with the diagnosis of respiratory allergy in standard clinical conditions. Int Arch Allergy Immunol 2012;157:176185.
  • 29
    Sturm GJ, Jin C, Kranzelbinder B, Hemmer W, Sturm EM, Griesbacher A et al. Inconsistent results of diagnostic tools hamper the differentiation between bee and vespid venom allergy. PLoS ONE 2011;6:e20842.
  • 30
    Focke M, Marth K, Flicker S, Valenta R. Heterogeneity of commercial timothy grass pollen extracts. Clin Exp Allergy 2008;38:14001408.
  • 31
    Linneberg A, Fenger RV, Husemoen LL, Vidal C, Vizcaino L, Gonzalez-Quintela A. Immunoglobulin E sensitization to cross-reactive carbohydrate determinants: epidemiological study of clinical relevance and role of alcohol consumption. Int Arch Allergy Immunol 2010;153:8694.