Both authors equally contributed to this manuscript.
Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA2LEN study
Article first published online: 5 OCT 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 68, Issue 10, pages 1289–1297, October 2013
How to Cite
Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA²LEN study. Allergy 2013; 68: 1289–1297., , , , , , , , , , , , , , , , , .
Edited by: Michael Wechsler
- Issue published online: 18 OCT 2013
- Article first published online: 5 OCT 2013
- Manuscript Accepted: 30 JUN 2013
- Sixth European Union Framework Program for Research. Grant Number: FOOD-CT-2004-506378
- Fonds Wetenschappelijk Onderzoek Vlaanderen (Flemish Government, Belgium). Grant Number: G.0854.09
- Staphylococcus aureus ;
Specific IgE to Staphylococcus aureus enterotoxins (SE-IgE) has been associated with asthma. In the general population, we aimed to determine the prevalence of and risk factors for serum SE-IgE and to examine the association with asthma.
A postal questionnaire was sent to a random sample of adults in 19 centers across Europe. A random sample of respondents was invited for clinical examination upon which they answered a questionnaire, underwent skin prick tests (SPTs) for common aeroallergens, and provided blood for measurement of total IgE and SE-IgE. Risks were analyzed within centers using weighted logistic regression, and overall estimates calculated using fixed-effects meta-analysis.
2908 subjects were included in this analysis. Prevalence of positive SE-IgE was 29.3%; no significant geographic variation was observed. In contrast to positive skin prick tests, SE-IgE was more common in smokers (<15 pack-year: OR 1.11, P = 0.079, ≥15 pack-year: OR 1.70, P < 0.001), and prevalence did not decrease in older age-groups or in those with many siblings. Total IgE concentrations were higher in those with positive SE-IgE than in those with positive SPT. SE-IgE was associated with asthma (OR 2.10, 95% confidence interval [1.60–2.76], P = 0.001) in a concentration-dependent manner. This effect was independent of SPT result and homogeneous across all centers.
We report for the first time that SE-IgE is common in the general population throughout Europe and that its risk factors differ from those of IgE against aeroallergens. This is the first study to show that SE-IgE is significantly and independently associated with asthma in the general population.