• 1
    Asher MI, Montefort S, Bjorkston B, Lai C, Strachan D, Weiland S et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006;368:733743.
  • 2
    The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet 1998;351:12251232.
  • 3
    Silva CHM, Silva T, Morales N, Fernandes K, Pinto R. Quality of life in children and adolescents with allergic rhinitis. Braz J Otorhinolaryngol 2009;75:642649.
  • 4
    Roberts G, Hurley C, Lack G. Development of a quality-of-life assessment for the allergic child or teenager with multisystem allergic disease. Journal of Allergy & Clinical Immunology 2003;111:491497.
  • 5
    Vuurman EF, van Veggel LM, Uiterwijk MM, Leutner D, O'Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children's learning. Ann Allergy Asthma Immunol 1993;71:121126.
  • 6
    Walker S, Khan W, Fletcher M, Cullinan P, Harris J, Sheikh A. Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study. J Allergy Clin Immunol 2007;120:381387.
  • 7
    Emin O, Mustafa S, Nedim S. Psychological stress and family functioning in mothers of children with allergic rhinitis. Int J Pediatr Otorhinolaryngol 2009;73:17951798.
  • 8
    Harbour R, Miller J. A new system for grading recommendations in evidence based guidelines. BMJ 2001;323:334336.
  • 9
    Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al. Allergic rhinitis and its impact on asthma ARIA 2008 update in collaboration with the World Health Organization, GA2LEN and Aller Gen. Allergy 2008;63:8160.
  • 10
    Burbach GJ, Heinzerling LM, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini S et al. GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe. Allergy 2009;64:15071515.
  • 11
    Durham SR, Smurthwaite L, Gould HJ. Local IgE production. Am J Rhinol 2000;14:305307.
  • 12
    Shin S, Choi S, Hur G, Lee K, Kim S, Cho J et al. Local production of total IgE and specific antibodies to the house dust mite in adenoid tissue. Pediatr Allergy Immunol 2009;20:134141.
  • 13
    Montoro J, Del Cuvillo A, Mullol J, Molina X, Bartra J, Davila I et al. Validation of the modified allergic rhinitis and its impact on asthma (ARIA) severity classification in allergic rhinitis children: the PEDRIAL study. Allergy 2012;67:14371442.
  • 14
    Corne JM, Lau L, Scott SJ, Davies R, Johnston SL, Howarth PH. The relationship between atopic status and IL-10 nasal lavage levels in the acute and persistent inflammatory response to upper respiratory tract infection. Am J Respir Crit Care Med 2001;163:11011107.
  • 15
    Ant K, Pearce N, Anderson HR, Ellwood P, Montefort S, Shah J. Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood ISAAC Phase Three. Allergy 2009;64:123148.
  • 16
    Bjorksten B, Clayton T, Ellwood P, Stewart A, Strachan D. Worldwide time trends for symptoms of rhinitis and conjunctivitis: Phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol 2008;19:110124.
  • 17
    Online Manual. International Study of Asthma and Allergies in Childhood., accessed on 16th February 2013.
  • 18
    Herr M, Clarisse B, Nikasinovic L, Foucault C, Le Marec AM, Giordanella JP et al. Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort. Allergy 2011;66:214221.
  • 19
    Kurukulaaratchy RJ, Karmaus W, Raza A, Matthews S, Roberts G, Arshad SH. The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life. Clin Exp Allergy 2011;41:851859.
  • 20
    Keil T, Bockelbrink A, Reich A, Hoffmann U, Kamin W, Forster J et al. The natural history of allergic rhinitis in childhood. Pediatr Allergy Immunol 2010;21:962969.
  • 21
    Rochat MK, Illi S, Ege MJ, Lau S, Keil T, Wahn U et al. Allergic rhinitis as a predictor for wheezing onset in school-aged children. J Allergy Clin Immunol 2010;126:11701175.
  • 22
    Burgess J, Walters EH, Byrnes G, Matheson M, Jenkins M, Wharton C et al. Childhood allergic rhinitis predicts asthma incidence and persistence to middle age: a longitudinal study. J Allergy Clin Immunol 2007;120:863869.
  • 23
    Scadding GK, Durham SR, Mirakian R, Jones NS, Leech SC, Farooque S et al. BSACI guidelines for the management of allergic and non-allergic rhinitis. Clin Exp Allergy 2008;38:1942.
  • 24
    Juniper E, Ståhl E, Doty R, Simons F, Allen D, Howarth P. Clinical outcomes and adverse effect monitoring in allergic rhinitis. J Allergy Clin Immunol 2005;115:S390S413.
  • 25
    Chen C, Lin Y, Wen C, Wang L, Lin K, Chiu S et al. Quantitative assessment of allergic shiners in children with allergic rhinitis. J Allergy Clin Immunol 2009;123:665671.
  • 26
    Greber C, Keil T, Kulig M, Roll S, Wahn U, Wahn V et al. History of respiratory infections in the first 12 yr among children from a birth cohort. Pediatr Allergy Immunol 2008;19:505512.
  • 27
    Fokkens W, Lund V, Mullol J. European position paper on rhinosinusitis and nasal polyps. Rhinol Suppl 2007;2007:1136.
  • 28
    Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:112.
  • 29
    Bertelsen R, Lodrup C, Carlsen K. Rhinitis in children: co-morbidities and phenotypes. Pediatr Allergy Immunol 2010;21:612622.
  • 30
    Modrzynski M, Zawisza E. An analysis of the incidence of adenoid hypertrophy in allergic children. Int J Pediatr Otorhinolaryngol 2007;71:713719.
  • 31
    Modrzynski M, Zawisza E. The influence of birch pollination on the adenoid size in children with intermittent allergic rhinitis. Int J Pediatr Otorhinolaryngol 2007;71:10171023.
  • 32
    Ramos RTT, Daltro CHC, Gregorio PB. OSAS in children: clinical and polysomnographic respiratory profile. Braz J Otorhinolaryngol 2006;72:355361.
  • 33
    Alles R, Parikh A, Hawk L, Darby Y, Romero JN, Scadding G. The prevalence of atopic disorders in children with chronic otitis media with effusion. Pediatr Allergy Immunol 2001;12:102106.
  • 34
    Umapathy D, Alles R, Scadding G. A community based questionnaire study on the association between symptoms suggestive of otitis media with effusion, rhinitis and asthma in primary school children. Int J Pediatr Otorhinolaryngol 2007;71:705712.
  • 35
    Chantzi FM, Kafetzis DA, Bairamis T, Avramidou C, Paleologou N, Grimani I et al. IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion. Allergy 2006;61:332336.
  • 36
    Shin S, Choi G, Lee K, Kim S, Cho J, Park H. IgE response to staphylococcal enterotoxins in adenoid tissues from atopic children. Laryngoscope 2009;119:171175.
  • 37
    Kurukulaaratchy RJ, Raza A, Scott M, Williams P, Ewart S, Matthews S et al. Characterisation of asthma that develops during adolescence; findings from the Isle of Wight Birth Cohort. Respir Med 2012;106:329337.
  • 38
    Hamouda S, Karila C, Connault T, Scheinmann P, De Blic J. Allergic rhinitis in children with asthma: a questionnaire-based study. Clin Exp Allergy 2008;38:761766.
  • 39
    Kurukulaaratchy RJ, Fenn M, Matthews S, Arshad SH. Characterisation of atopic and non-atopic wheeze in 10 year old children. Thorax 2004;59:563568.
  • 40
    Ballardini N, Kull I, Lind T, Hallner E, Almqvist C, Ostblom E et al. Development and comorbidity of eczema, asthma and rhinitis to age 12 years data from the BAMSE birth cohort. Allergy 2012;67:537544.
  • 41
    Chawes BL, Bonnelykke K, Kreiner-Moller E, Bisgaard H. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol 2010;126:567573.
  • 42
    Valovirta E, Pawankar R. Survey on the impact of comorbid allergic rhinitis in patients with asthma. BMC Pulm Med 2006;6:S3.
  • 43
    Lasmar L, Camargos P, Ordones A, Gaspar G, Campos E, Ribeiro G. Prevalence of allergic rhinitis and its impact on the use of emergency care services in a group of children and adolescents with moderate to severe persistent asthma. J Pediatr 2007;83:555561.
  • 44
    Murray CS, Poletti G, Kebadze T, Morris J, Woodcock A, Johnston SL et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 2006;61:376382.
  • 45
    Plevkova J, Varechova S, Brozmanova M, Tatar M. Testing of cough reflex sensitivity in children suffering from allergic rhinitis and common cold. J Physiol Pharmacol 2006;57:289296.
  • 46
    Asher MI, Stewart AW, Wong G, Strachan DP, Garcia-Marcos L, Anderson HR. Changes over time in the relationship between symptoms of asthma, rhinoconjunctivitis and eczema: a global perspective from the International Study of Asthma and Allergies in Childhood (ISAAC). Allergol Immunopathol 2012;40:267274.
  • 47
    Webber CM, England RW. Oral allergy syndrome: a clinical, diagnostic, and therapeutic challenge. Ann Allergy Asthma Immunol 2010;104:101108.
  • 48
    Westman M, Stjarne P, Asarnoj A, Kull I, van Hage M, Wickman M et al. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol 2012;129:403408.
  • 49
    Scadding G, Hellings P, Alobid I, Bachert C, Fokkens W, van Wijk R et al. Diagnostic tools in Rhinology, EAACI position paper. Clin Transl Allergy 2011;1:2.
  • 50
    Bousquet J, Heinzerling L, Bachert C, Papadopoulos NG, Bousquet PJ, Burney PG et al. Practical guide to skin prick tests in allergy to aeroallergens. Allergy 2012;67:1824.
  • 51
    Melillo G, Bonini S, Cocco G, Davies RJ, de Monchy JG, Frolund L et al. EAACI provocation tests with allergens. Allergy 1997;52(35 Suppl):135.
  • 52
    Marinho S, Simpson A, Lowe L, Kissen P, Murray C, Custovic A. Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study. Allergy 2007;62:385393.
  • 53
    Simpson A, Tan VY, Winn J, Svensen M, Bishop CM, Heckerman DE et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med 2010;181:12001206.
  • 54
    Marinho S, Simpson A, Soderstrom L, Woodcock A, Ahlstedt S, Custovic A. Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study. Allergy 2007;62:13791386.
  • 55
    Simpson A, Soderstrom L, Ahlstedt S, Murray CS, Woodcock A, Custovic A. IgE antibody quantification and the probability of wheeze in preschool children. J Allergy Clin Immunol 2005;116:744749.
  • 56
    Wickman M, Lilja G, Soderstrom L, Van H, Ahlstedt S. Quantitative analysis of IgE antibodies to food and inhalant allergens in 4-year-old children reflects their likelihood of allergic disease. Allergy 2005;60:650657.
  • 57
    Valenta R, Twaroch T, Swoboda I. Component-resolved diagnosis to optimize allergen-specific immunotherapy in the Mediterranean area. J Investig Allergol Clin Immunol 2007;17(Suppl 40):8892.
  • 58
    Nicolaou N, Murray C, Belgrave D, Poorafshar M, Simpson A, Custovic A. Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. J Allergy Clin Immunol 2011;127:684685.
  • 59
    Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol 2010;125:191197.
  • 60
    Strippoli MP, Frischer T, Barbato A, Snijders D, Maurer E, Lucas JSA et al. Management of primary ciliary dyskinesia in European children: recommendations and clinical practice. Eur Respir J 2012;39:14821491.
  • 61
    Hellings PW, Fokkens WJ, Akdis C, Bachert C, Cingi C, Dietz de Loos D et al. Uncontrolled allergic rhinitis and chronic rhinosinusitis: where do we stand today? Allergy 2013;68:17.
  • 62
    Vogl TJ, Stemmler J, Heye B, Schopohl J, Danek A, Bergman C et al. Kallman syndrome versus idiopathic hypogonadotropic hypogonadism at MR imaging. Radiology 1994;191:5357.
  • 63
    Sandoval C, Dong S, Visintainer P, Ozkaynak MF, Jayabose S. Clinical and laboratory features of 178 children with recurrent epistaxis. J Pediatr Hematol Oncol 2002;24:4749.
  • 64
    Shields MD, Bush A, Everard ML, McKenzie S, Primhak R. Recommendations for the assessment and management of cough in children. Thorax 2008;63(Suppl 3):iii1iii15.
  • 65
    Nurmatov U, van Schayck CP, Hurwitz B, Sheikh A. House dust mite avoidance measures for perennial allergic rhinitis: an updated Cochrane systematic review. Allergy 2012;67:158165.
  • 66
    Custovic A, Wijk RG. The effectiveness of measures to change the indoor environment in the treatment of allergic rhinitis and asthma: ARIA update in collaboration with GA2LEN. Allergy 2005;60:11121115.
  • 67
    Shah S, Nayak A, Ratner P, Roland P, Michael W. Effects of olopatadine hydrochloride nasal spray 06% in the treatment of seasonal allergic rhinitis: a phase III, multicenter, randomized, double-blind, active- and placebo-controlled study in adolescents and adults. Clin Ther 2009;31:99107.
  • 68
    Bachert C, Kuna P, Sanquer F, Ivan P, Dimitrov V, Gorina MM et al. Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients. Allergy 2009;64:158165.
  • 69
    Meltzer EO, Scheinmann P, Rosado Pinto JE, Bachert C, Hedlin G, Wahn U et al. Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis – a pooled analysis of three studies. Pediatr Allergy Immunol 2004;15:253260.
  • 70
    de Blic J, Wahn U, Billard E, Alt R, Pujazon M. Levocetirizine in children: evidenced efficacy and safety in a 6-week randomized seasonal allergic rhinitis trial. Pediatr Allergy Immunol 2005;16:267275.
  • 71
    Wahn U, Meltzer EO, Finn AF, Kowalski ML, Decosta P, Hedlin G et al. Fexofenadine is efficacious and safe in children (aged 6–11 years) with seasonal allergic rhinitis. J Allergy Clin Immunol 2003;111:763769.
  • 72
    Yang YH, Lin YT, Lu MY, Tsai MJ, Chiang BL. A double-blind, placebo-controlled, and randomized study of loratadine (Clarityne) syrup for the treatment of allergic rhinitis in children aged 3 to 12 years. Asian Pac J Allergy Immunol 2001;19:171175.
  • 73
    Benninger M, Farrar J, Blaiss M, Chipps B, Ferguson B, Krouse J et al. Evaluating approved medications to treat allergic rhinitis in the United States: an evidence-based review of efficacy for nasal symptoms by class. Ann Allergy Asthma Immunol 2010;104:1329.
  • 74
    Simons FE, Simons KJ. Histamine and H1-antihistamines: celebrating a century of progress. J Allergy Clin Immunol 2011;128:11391150.
  • 75
    Church MK, Maurer M, Simons FER, Bindslev-Jensen C, Van Cauwenberge P, Bousquet J et al. Risk of first-generation H1-antihistamines: a GA2LEN position paper. Allergy 2010;65:459466.
  • 76
    Ng KH, Chong D, Wong CK, Ong HT, Lee CY, Lee BW et al. Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study. Pediatrics 2004;113:e116e121.
  • 77
    Anolik R, Pearlman D, Teper A, Gates D. Mometasone furoate improves nasal and ocular symptoms of seasonal allergic rhinitis in adolescents. Allergy Asthma Proc 2009;30:406412.
  • 78
    Ratner P, Meltzer E, Teper A. Mometasone furoate nasal spray is safe and effective for 1-year treatment of children with perennial allergic rhinitis. Int J Pediatr Otorhinolaryngol 2009;73:651657.
  • 79
    Wandalsen G, Mendes AI, Solé D. Objective improvement in nasal congestion and nasal hyperreactivity with use of nasal steroids in persistent allergic rhinitis. Am J Rhinol Allergy 2010;24:e32e36.
  • 80
    Nathan R, Berger W, Yang W, Cheema A, Silvey M, Wu W et al. Effect of once-daily fluticasone furoate nasal spray on nasal symptoms in adults and adolescents with perennial allergic rhinitis. Ann Allergy Asthma Immunol 2008;100:497505.
  • 81
    Jacobs R, Martin B, Hampel F, Toler W, Ellsworth A, Philpot E. Effectiveness of fluticasone furoate 110 mug once daily in the treatment of nasal and ocular symptoms of seasonal allergic rhinitis in adults and adolescents sensitized to mountain cedar pollen. Curr Med Res Opin 2009;25:13931401.
  • 82
    Vasar M, Houle P, Douglass J, Meltzer E, Silvey M, Wu W et al. Fluticasone furoate nasal spray: effective monotherapy for symptoms of perennial allergic rhinitis in adults/adolescents. Allergy Asthma Proc 2008;29:313321.
  • 83
    Fokkens WJ, Jogi R, Reinartz S, Sidorenko I, Sitkauskiene B, Faris MA et al. Once daily fluticasone furoate nasal spray is effective in seasonal allergic rhinitis caused by grass pollen. Allergy 2007;62:10781084.
  • 84
    Martin B, Ratner P, Hampel F, Andrews C, Toler T, Wu W et al. Optimal dose selection of fluticasone furoate nasal spray for the treatment of seasonal allergic rhinitis in adults and adolescents. Allergy Asthma Proc 2007;28:216225.
  • 85
    Ratner P, Wingertzahn M, Van B, Hampel F, Darken P, Shah T. Efficacy and safety of ciclesonide nasal spray for the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 2006;118:11421148.
  • 86
    Meltzer E, Kunjibettu S, Hall N, Wingertzahn M, Murcia C, Berger W et al. Efficacy and safety of ciclesonide, 200 microg once daily, for the treatment of perennial allergic rhinitis. Ann Allergy Asthma Immunol 2007;98:175181.
  • 87
    Berger W, Nayak A, Lanier B, Kaiser H, LaForce C, Darken P et al. Efficacy and safety of once-daily ciclesonide nasal spray in children with allergic rhinitis. Pediatr Asthma Allergy Immunol 2008;21:7382.
  • 88
    Chervinsky P, Kunjibettu S, Miller D, Prenner B, Raphael G, Hall N et al. Long-term safety and efficacy of intranasal ciclesonide in adult and adolescent patients with perennial allergic rhinitis. Ann Allergy Asthma Immunol 2007;99:6976.
  • 89
    Baena C, Patel P. Efficacy and long-term safety of mometasone furoate nasal spray in children with perennial allergic rhinitis. Curr Med Res Opin 2010;26:20472055.
  • 90
    McCormack P, Scott L. Fluticasone furoate: intranasal use in allergic rhinitis. Drugs 2007;67:19051915.
  • 91
    Mspero J, Rosenblut A, Finn A, Lim J, Wu W, Philpot E. Safety and efficacy of fluticasone furoate in pediatric patients with perennial allergic rhinitis. Otolaryngology – Head and Neck Surgery 2008;138:3037.
  • 92
    Al S, Fedorowicz Z, Alhashimi D, Jamal A. Topical nasal steroids for intermittent and persistent allergic rhinitis in children. Cochrane Database Syst Rev 2007 (1):CD003163.
  • 93
    Meltzer E, Tripathy I, Máspero J, Wu W, Philpot E. Safety and tolerability of fluticasone furoate nasal spray once daily in paediatric patients aged 6–11 years with allergic rhinitis: subanalysis of three randomized, double-blind, placebo-controlled, multicentre studies. Clin Drug Invest 2009;29:7986.
  • 94
    Camargos P, Ibiapina C, Lasmar L, Cruz AA. Obtaining concomitant control of allergic rhinitis and asthma with a nasally inhaled corticosteroid. Allergy 2007;62:310316.
  • 95
    Pedersen W, Hjuler I, Bisgaard H, Mygind N. Nasal inhalation of budesonide from a spacer in children with perennial rhinitis and asthma. Allergy 1998;53:383387.
  • 96
    Lohia S, Schlosser RJ, Soler ZM. Impact of intranasal corticosteroids on asthma outcomes in allergic rhinitis: a meta-analysis. Allergy 2013;68:569579.
  • 97
    Bielory L. Ocular symptom reduction in patients with seasonal allergic rhinitis treated with the intranasal corticosteroid mometasone furoate. Ann Allergy Asthma Immunol 2008;100:272279.
  • 98
    Allen DB, Meltzer EO, Lemanske RF, Philpot EE, Faris MA, Kral KM et al. No growth suppression in children treated with the maximum recommended dose of fluticasone propionate aqueous nasal spray for one year. Allergy Asthma Proc 2002;23:407413.
  • 99
    Daley-Yates PT, Kunka RL, Yin Y, Andrews SM, Callejas S, Ng C. Bioavailability of fluticasone propionate and mometasone furoate aqueous nasal sprays. Eur J Clin Pharmacol 2004;60:265268.
  • 100
    Fink RS, Pierre LN, Daley-Yates PT, Richards DH, Gibson A, Honour JW. Hypothalamic-pituitary-adrenal axis function after inhaled corticosteroids: unreliability of urinary free cortisol estimation. J Clin Endocrinol Metab 2002;87:45414546.
  • 101
    Schenkel EJ, Skoner DP, Bronsky EA, Miller SD, Pearlman DS, Rooklin A et al. Absence of growth retardation in children with perennial allergic rhinitis after one year of treatment with mometasone furoate aqueous nasal spray. Pediatrics 2000;105:E22.
  • 102
    Rachelefsky GS. Pharmacologic management of allergic rhinitis. J Allergy Clin Immunol 1998;101:S367S369.
  • 103
    Skoner DP, Rachelefsky GS, Meltzer EO, Chervinsky P, Morris RM, Seltzer JM et al. Detection of growth suppression in children during treatment with intranasal beclomethasone dipropionate. Pediatrics 2000;105:E23.
  • 104
    Mygind N, Laursen LC, Dahl M. Systemic corticosteroid treatment for seasonal allergic rhinitis: a common but poorly documented therapy. Allergy 2000;55:1115.
  • 105
    Wolthers OD, Pedersen S. Short-term growth in children with allergic rhinitis treated with oral antihistamine, depot and intranasal glucocorticosteroids. Acta Paediatr 1993;82:635640.
  • 106
    LiAlbert M, Abdullah V, Tsen C, Au C, Lam H, So H et al. Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis – a randomized placebo-controlled study. Pediatr Pulmonol 2009;44:10851092.
  • 107
    Razi C, Bakirtas A, Harmanci K, Turktas I, Erbas D. Effect of montelukast on symptoms and exhaled nitric oxide levels in 7- to 14-year-old children with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2006;97:767774.
  • 108
    Wilson AM, O'Byrne PM, Parameswaran K. Leukotriene receptor antagonists for allergic rhinitis: a systematic review and meta-analysis. Am J Med 2004;116:338344.
  • 109
    Grainger J, Drake-Lee A. Montelukast in allergic rhinitis: a systematic review and meta-analysis. Clin Otolaryngol 2006;31:360367.
  • 110
    Pattanaik D, Lieberman P. Vasomotor rhinitis. Curr Allergy Asthma Rep 2010;10:8491.
  • 111
    Meltzer EO, Caballero F, Fromer LM, Krouse JH, Scadding G. Treatment of congestion in upper respiratory diseases. Int J Gen Med 2010;3:6991.
  • 112
    Schuller DE, Selcow JE, Joos TH, Hannaway PJ, Hirsch SR, Schwartz HJ et al. A multicenter trial of nedocromil sodium, 1% nasal solution, compared with cromolyn sodium and placebo in ragweed seasonal allergic rhinitis. J Allergy Clin Immunol 1990;86:554561.
  • 113
    Garavello W, Di B, Romagnoli M, Sambataro G, Gaini R. Nasal rinsing with hypertonic solution: an adjunctive treatment for pediatric seasonal allergic rhinoconjunctivitis. Int Arch Allergy Immunol 2005;137:310314.
  • 114
    Li H, Sha Q, Zuo K, Jiang H, Cheng L, Shi J et al. Nasal saline irrigation facilitates control of allergic rhinitis by topical steroid in children. ORL J Otorhinolaryngol Relat Spec 2009;71:5055.
  • 115
    Jeffe JS, Bhushan B, Schroeder J. Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol 2012;76:409413.
  • 116
    Vignola AM, Humbert M, Bousquet J, Boulet LP, Hedgecock S, Blogg M et al. Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with concomitant allergic asthma and persistent allergic rhinitis: SOLAR. Allergy 2004;59:709717.
  • 117
    Man LX. Complementary and alternative medicine for allergic rhinitis. Current Opinion in Otolaryngology & Head & Neck Surgery 2009;17:226231.
  • 118
    Anolik R, Mometasone Furoate Nasal Spray With Loratadine Study Group. Clinical benefits of combination treatment with mometasone furoate nasal spray and loratadine vs monotherapy with mometasone furoate in the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2008;100:264271.
  • 119
    Martin BG, Andrews CP, van Bavel JH, Hampel FC, Klein KC, Prillaman BA et al. Comparison of fluticasone propionate aqueous nasal spray and oral montelukast for the treatment of seasonal allergic rhinitis symptoms. Ann Allergy Asthma Immunol 2006;96:851857.
  • 120
    Di LG, Pacor ML, Pellitteri ME, Morici G, Di GA, Lo BC et al. Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in mono-therapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis. Clin Exp Allergy 2004;34:259267.
  • 121
    Watanasomsiri A, Poachanukoon O, Vichyanond P. Efficacy of montelukast and loratadine as treatment for allergic rhinitis in children. Asian Pac J Allergy Immunol 2008;26:8995.
  • 122
    Chen S, Lu K, Sun H, Chang W, Lue K, Chou M. Randomized placebo-controlled trial comparing montelukast and cetirizine for treating perennial allergic rhinitis in children aged 2–6 yr. Pediatr Allergy Immunol 2006;17:4954.
  • 123
    Blom HM, Van Rijswijk JB, Garrelds IM, Mulder PG, Timmermans T, Gerth van Wijk R. Intranasal capsaicin is efficacious in non-allergic, non-infectious perennial rhinitis. A placebo-controlled study. Clin Exp Allergy 1997;27:796801.
  • 124
    Calderon MA, Gerth van Wijk R, Eichler I, Matricardi PM, Varga EM, Kopp MV et al. Perspectives on allergen-specific immunotherapy in childhood: an EAACI position statement. Pediatr Allergy Immunol 2012;23:300306.
  • 125
    Bufe A, Roberts G. Specific immunotherapy in children. Clin Exp Allergy 2011;41:12561262.
  • 126
    Walker SM, Durham SR, Till SJ, Roberts G, Corrigan CJ, Leech SC et al. Immunotherapy for allergic rhinitis. Clin Exp Allergy 2011;41:11771200.
  • 127
    Halken S, Lau S, Valovirta E. New visions in specific immunotherapy in children: an iPAC summary and future trends. Pediatr Allergy Immunol 2008;19(Suppl 70):6070.
  • 128
    Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev 2007 (1):CD001936.
  • 129
    Vance GHS, Goldring S, Warner JO, Cox H, Sihra B, Hughes S et al. A national audit of pollen immunotherapy for children in the United Kingdom: patient selection and programme safety. Clin Exp Allergy 2011;41:13131323.
  • 130
    Niggemann B, Jacobsen L, Dreborg S, Ferdousi HA, Halken S, Koivikko A et al. Five-year follow-up on the PAT study: specific immunotherapy and long- term prevention of asthma in children. Allergy 2006;61:855859.
  • 131
    Portnoy J, Bagstad K, Kanarek H, Pacheco F, Hall B, Barnes C. Premedication reduces the incidence of systemic reactions during inhalant rush immunotherapy with mixtures of allergenic extracts. Ann Allergy Asthma Immunol 1994;73:409418.
  • 132
    Kopp MV. Role of immunmodulators in allergen-specific immunotherapy. Allergy 2011;66:792797.
  • 133
    Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, Noble W et al. Long-term clinical efficacy of grass pollen immunotherapy. N Engl J Med 1999;341:468475.
  • 134
    Radulovic S, Wilson D, Calderon M, Durham S. Systematic reviews of sublingual immunotherapy (SLIT). Allergy 2011;66:740752.
  • 135
    Pajno GB, Caminiti L, Crisafulli G, Vita D, Valenzise M, De Luca R et al. Direct comparison between continuous and coseasonal regimen for sublingual immunotherapy in children with grass allergy: a randomized controlled studyPediatr Allergy Immunol 2011;22:803807.
  • 136
    Novembre E, Galli E, Landi F, Caffarelli C, Pifferi M, De Marco E et al. Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 2004;114:851857.
  • 137
    Valovirta E, Berstad AKH, de Blic J, Bufe A, Eng P, Halken S et al. Design and recruitment for the GAP trial, investigating the preventive effect on asthma development of an SQ-standardized grass allergy immunotherapy tablet in children with grass Pollen–Induced allergic rhinoconjunctivitis. Clin Ther 2011;33:15371546.
  • 138
    Wahn U, Tabar A, Kuna P, Halken S, Montagut A, de Beaumont O et al. Efficacy and safety of 5-grass-pollen sublingual immunotherapy tablets in pediatric allergic rhinoconjunctivitis. J Allergy Clin Immunol 2009;123:160166.
  • 139
    Bufe A, Eberle P, Franke B, Funck J, Kimmig M, Klimek L et al. Safety and efficacy in children of an SQ-standardized grass allergen tablet for sublingual immunotherapy. J Allergy Clin Immunol 2009;123:167173.
  • 140
    Penagos M, Compalati E, Tarantini F, Baena C, Huerta J, Passalacqua G et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol 2006;97:141148.
  • 141
    Fiocchi A, Pajno G, La G, Pezzuto F, Incorvaia C, Sensi L et al. Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years. Ann Allergy Asthma Immunol 2005;95:254258.
  • 142
    Calderon MA, Simons FER, Malling HJ, Lockey RF, Moingeon P, Demoly P. Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile. Allergy 2012;67:302311.
  • 143
    Senna G, Lombardi C, Canonica GW, Passalacqua G. How adherent to sublingual immunotherapy prescriptions are patients? The manufacturers' viewpoint J Allergy Clin Immunol 2010;126:668669.
  • 144
    Vita D, Caminiti L, Ruggeri P, Pajno GB. Sublingual immunotherapy: adherence based on timing and monitoring control visits. Allergy 2010;65:668669.
  • 145
    Durham SR, Emminger W, Kapp A, Colombo G, de Monchy JG, Rak S et al. Long-term clinical efficacy in grass pollen–induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet. J Allergy Clin Immunol 2010;125:e7.
  • 146
    Schadlich PK, Brecht JG. Economic evaluation of specific immunotherapy versus symptomatic treatment of allergic rhinitis in Germany. Pharmacoeconomics 2000;17:3752.
  • 147
    Hankin C, Cox L, Lang D, Levin A, Gross G, Eavy G et al. Allergy immunotherapy among Medicaid-enrolled children with allergic rhinitis: patterns of care, resource use, and costs. J Allergy Clin Immunol 2008;121:227232.
  • 148
    Hankin C, Cox L, Lang D, Bronstone A, Fass P, Leatherman B et al. Allergen immunotherapy and health care cost benefits for children with allergic rhinitis: a large-scale, retrospective, matched cohort study. Ann Allergy Asthma Immunol 2010;104:7985.
  • 149
    Wong IY, Soh SE, Chng SY, Shek LP, Goh DY, Van Bever HP et al. Compliance with topical nasal medication – an evaluation in children with rhinitis. Pediatr Allergy Immunol 2010;21:11461150.
  • 150
    Van Cauwenberge P, Bachert C, Passalacqua G, Bousquet J, Canonica GW, Durham SR et al. Consensus statement on the treatment of allergic rhinitis. European Academy of Allergology and Clinical Immunology. Allergy 2000;55:116134.