• 1
    Jansen DF, Timens W, Kraan J, Rijcken B, Postma DS. (A)symptomatic bronchial hyper-responsiveness and asthma. Respir Med 1997;91:121134.
  • 2
    Laprise C, Boulet LP. Asymptomatic airway hyperresponsiveness: a three-year follow-up. Am J Respir Crit Care Med 1997;156(2 Pt 1):403409.
  • 3
    Brutsche MH, Downs SH, Schindler C, Gerbase MW, Schwartz J, Frey M et al. Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study. Thorax 2006;61:671677.
  • 4
    Rasmussen F, Taylor DR, Flannery EM, Cowan JO, Greene JM, Herbison GP et al. Outcome in adulthood of asymptomatic airway hyperresponsiveness in childhood: a longitudinal population study. Pediatr Pulmonol 2002;34:164171.
  • 5
    Porsbjerg C, von Linstow ML, Ulrik CS, Nepper-Christensen SC, Backer V. Outcome in adulthood of asymptomatic airway hyperresponsiveness to histamine and exercise-induced bronchospasm in childhood. Ann Allergy Asthma Immunol 2005;95:137142.
  • 6
    Betz R, Kohlhaufl M, Kassner G, Mullinger B, Maier K, Brand P et al. Increased sputum IL-8 and IL-5 in asymptomatic nonspecific airway hyperresponsiveness. Lung 2001;179:119133.
  • 7
    Laprise C, Laviolette M, Boutet M, Boulet LP. Asymptomatic airway hyperresponsiveness: relationships with airway inflammation and remodelling. Eur Respir J 1999;14:6373.
  • 8
    Sohn SW, Chang YS, Lee HS, Chung DH, Lee CT, Kim YH et al. Atopy may be an important determinant of subepithelial fibrosis in subjects with asymptomatic airway hyperresponsiveness. J Korean Med Sci 2008;23:390396.
  • 9
    Boulet LP, Turcotte H. Lung hyperinflation, perception of bronchoconstriction and airway hyperresponsiveness. Clin Invest Med 2007;30:211.
  • 10
    van den Berge M, ten Hacken NH, Cohen J, Douma WR, Postma DS. Small airway disease in asthma and COPD: clinical implications. Chest 2011;139:412423.
  • 11
    Currie GP, Jackson CM, Lee DK, Lipworth BJ. Determinants of airway hyperresponsiveness in mild asthma. Ann Allergy Asthma Immunol 2003;90:560563.
  • 12
    Aronsson D, Tufvesson E, Bjermer L. Comparison of central and peripheral airway involvement before and during methacholine, mannitol and eucapnic hyperventilation challenges in mild asthmatics. Clin Respir J 2011;5:1018.
  • 13
    Segal LN, Goldring RM, Oppenheimer BW, Stabile A, Reibman J, Rom WN et al. Disparity between proximal and distal airway reactivity during methacholine challenge. COPD 2011;8:145152.
  • 14
    Farah CS, King GG, Brown NJ, Downie SR, Kermode JA, Hardaker KM et al. The role of the small airways in the clinical expression of asthma in adults. J Allergy Clin Immunol 2012;129:381387.
  • 15
    Shi Y, Aledia AS, Tatavoosian AV, Vijayalakshmi S, Galant SP, George SC. Relating small airways to asthma control by using impulse oscillometry in children. J Allergy Clin Immunol 2012;129:671678.
  • 16
    Mansur AH, Manney S, Ayres JG. Methacholine-induced asthma symptoms correlate with impulse oscillometry but not spirometry. Respir Med 2008;102:4249.
  • 17
    Jansen DF, Rijcken B, Schouten JP, Kraan J, Weiss ST, Timens W et al. The relationship of skin test positivity, high serum total IgE levels, and peripheral blood eosinophilia to symptomatic and asymptomatic airway hyperresponsiveness. Am J Respir Crit Care Med 1999;159:924931.
  • 18
    Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A et al. Standardisation of spirometry. Eur Respir J 2005;26:319338.
  • 19
    Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG et al. Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 2000;161:309329.
  • 20
    Borg G. Borg's perceived exertion and pain scales. Champaign, IL: Human Kinetics Publishers; 1998.
  • 21
    Riemersma R, Postma D, Kerstjens H, Buijssen K, Boezen M, Aalbers R et al. Development of a questionnaire for the assessment of bronchial hyperresponsiveness. Prim Care Respir J 2009;18:287293.
  • 22
    Juniper EF, O'Byrne PM, Guyatt GH, Ferrie PJ, King DR. Development and validation of a questionnaire to measure asthma control. Eur Respir J 1999;14:902907.
  • 23
    Aronsson D, Tufvesson E, Ankerst J, Bjermer L. Allergic rhinitis with hyper-responsiveness differ from asthma in degree of peripheral obstruction during metacholine challenge test. Clin Physiol Funct Imaging 2008;28:8185.
  • 24
    Tufvesson E, Aronsson D, Ankerst J, George SC, Bjermer L. Peripheral nitric oxide is increased in rhinitic patients with asthma compared to bronchial hyperresponsiveness. Respir Med 2007;101:23212326.
  • 25
    Boulet LP, Prince P, Turcotte H, Lemiere C, Olivenstein R, Laprise C et al. Clinical features and airway inflammation in mild asthma versus asymptomatic airway hyperresponsiveness. Respir Med 2006;100:292299.
  • 26
    Yoshikawa T, Kanazawa H. Phenotypic differences between asymptomatic airway hyperresponsiveness and remission of asthma. Respir Med 2011;105:2430.
  • 27
    Brand PL, Rijcken B, Schouten JP, Koeter GH, Weiss ST, Postma DS. Perception of airway obstruction in a random population sample. Relationship to airway hyperresponsiveness in the absence of respiratory symptoms. Am Rev Respir Dis 1992;146:396401.
  • 28
    Collins RA, Parsons F, Deverell M, Hollams EM, Holt PG, Sly PD. Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status. J Allergy Clin Immunol 2011;128:301307.
  • 29
    Tantisira KG, Colvin R, Tonascia J, Strunk RC, Weiss ST, Fuhlbrigge AL et al. Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med 2008;178:325331.
  • 30
    Farah CS, Kermode JA, Downie SR, Brown NJ, Hardaker KM, Berend N et al. Obesity is a determinant of asthma control independent of inflammation and lung mechanics. Chest 2011;140:659666.
  • 31
    Cohen J, Postma DS, Douma WR, Vonk JM, De Boer AH, ten Hacken NH. Particle size matters: diagnostics and treatment of small airways involvement in asthma. Eur Respir J 2011;37:532540.