Edited by: Stephan Weidinger
GSTP1 is a hub gene for gene–air pollution interactions on childhood asthma
Version of Record online: 14 OCT 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 68, Issue 12, pages 1614–1617, December 2013
How to Cite
GSTP1 is a hub gene for gene–air pollution interactions on childhood asthma. Allergy 2013; 68: 1614–1617., , , , , , , .
- Issue online: 5 DEC 2013
- Version of Record online: 14 OCT 2013
- Manuscript Accepted: 5 SEP 2013
- Taiwan National Science Council. Grant Numbers: 98-2314-B-002-138-MY3, 96-2314-B-006-053, 95-2314-B-006-103
- gene–air pollution interactions;
- multifactor dimensionality reduction;
- ordered subset information gain analysis
There is growing evidence that multiple genes and air pollutants are associated with asthma. By identifying the effect of air pollution on the general population, the effects of air pollution on childhood asthma can be better understood. We conducted the Taiwan Children Health Study (TCHS) to investigate the influence of gene–air pollution interactions on childhood asthma. Complete monitoring data for the ambient air pollutants were collected from Taiwan Environmental Protection Agency air monitoring stations. Our results show a significant two-way gene–air pollution interaction between glutathione S-transferase P (GSTP1) and PM10 on the risk of childhood asthma. Interactions between GSTP1 and different types of air pollutants have a higher information gain than other gene–air pollutant combinations. Our study suggests that interaction between GSTP1 and PM10 is the most influential gene–air pollution interaction model on childhood asthma. The different types of air pollution combined with the GSTP1 gene may alter the susceptibility to childhood asthma. It implies that GSTP1 is an important hub gene in the anti-oxidative pathway that buffers the harmful effects of air pollution.