• 1
    Egger M, Mutschlechner S, Wopfner N, Gadermaier G, Briza P, Ferreira F. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. Allergy 2006;61:461476.
  • 2
    Mari A, Ballmer-Weber BK, Vieths S. The oral allergy syndrome: improved diagnostic and treatment methods. Curr Opin Allergy Clin Immunol 2005;5:267273.
  • 3
    Ma S, Sicherer SH, Nowak-Wegrzyn A. A survey on the management of pollen-food allergy syndrome in allergy practices. J Allergy Clin Immunol 2003;112:784788.
  • 4
    Geroldinger-Simic M, Zelniker T, Aberer W, Ebner C, Egger C, Greiderer A et al. Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol 2011;127:616622.
  • 5
    Vanekkrebitz M, Hoffmannsommergruber K, Machado MLD, Susani M, Ebner C, Kraft D et al. Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen. Biochem Biophys Res Commun 1995;214:538551.
  • 6
    Luttkopf D, Muller U, Skov PS, Ballmer-Weber BK, Wuthrich B, Skamstrup Hansen K et al. Comparison of four variants of a major allergen in hazelnut (Corylus avellana) Cor a 1.04 with the major hazel pollen allergen Cor a 1.01. Mol Immunol 2002;38:515525.
  • 7
    Schirmer T, Hoffimann-Sommergrube K, Susani M, Breiteneder H, Markovic-Housley Z. Crystal structure of the major celery allergen Api g 1: molecular analysis of cross-reactivity. J Mol Biol 2005;351:11011109.
  • 8
    Bolhaar ST, Tiemessen MM, Zuidmeer L, van Leeuwen A, Hoffmann-Sommergruber K, Bruijnzeel-Koomen CA et al. Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges. Clin Exp Allergy 2004;34:761769.
  • 9
    Bucher X, Pichler WJ, Dahinden CA, Helbling A. Effect of tree pollen specific, subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut. Allergy 2004;59:12721276.
  • 10
    Hansen KS, Khinchi MS, Skov PS, Bindslev-Jensen C, Poulsen LK, Malling HJ. Food allergy to apple and specific immunotherapy with birch pollen. Mol Nutr Food Res 2004;48:441448.
  • 11
    Kinaciyan T, Jahn-Schmid B, Radakovics A, Zwolfer B, Schreiber C, Francis JN et al. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. J Allergy Clin Immunol 2007;119:937943.
  • 12
    Hecker J, Diethers A, Schulz D, Sabri A, Plum M, Michel Y et al. An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE. Allergy 2012;67:15301537.
  • 13
    Kopac P, Rudin M, Gentinetta T, Gerber R, Pichler C, Hausmann O et al. Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. Allergy 2012;67:280285.
  • 14
    Rashid RS, Smith KA, Nambiar KZ, Frew AJ, Tarzi MD. Pollen-food syndrome is related to Bet v 1/PR-10 protein sensitisation, but not all patients have spring rhinitis. Allergy 2011;66:13911392.
  • 15
    Wallner M, Hauser M, Himly M, Zaborsky N, Mutschlechner S, Harrer A et al. Reshaping the Bet v 1 fold modulates T(H) polarization. J Allergy Clin Immunol 2011;127:15711578.
  • 16
    Kitzmuller C, Wallner M, Deifl S, Mutschlechner S, Walterskirchen C, Zlabinger GJ et al. A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T-cell activation. Allergy 2012;67:13751382.
  • 17
    Thalhamer T, Dobias H, Stepanoska T, Proll M, Stutz H, Dissertori O et al. Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening. J Allergy Clin Immunol 2010;125:926934.
  • 18
    Sheffield P, Garrard S, Derewenda Z. Overcoming expression and purification problems of RhoGDI using a family of “parallel” expression vectors. Protein Expr Purif 1999;15:3439.
  • 19
    Ma Y, Gadermaier G, Bohle B, Bolhaar S, Knulst A, Markovic-Housley Z et al. Mutational analysis of amino acid positions crucial for IgE-binding epitopes of the major apple (Malus domestica) allergen, Mal d 1. Int Arch Allergy Immunol 2006;139:5362.
  • 20
    Lauer I, Alessandri S, Pokoj S, Reuter A, Conti A, Vieths S et al. Expression and characterization of three important panallergens from hazelnut. Mol Nutr Food Res 2008;52(S2):S262S271.
  • 21
    Jensen LB, Torp AM, Andersen SB, Skov PS, Poulsen LK, Knol EF et al. The biological activity of a recombinantly expressed (His)6-tagged peanut allergen (rAra h 1) is unaffected by endotoxin removal. J Immunol Methods 2008;335:116120.
  • 22
    Himly M, Nony E, Chabre H, Van Overtvelt L, Neubauer A, Van Ree R et al. Standardization of allergen products: 1. Detailed characterization of GMP-produced recombinant Bet v 1.0101 as biological reference preparation. Allergy 2009;64:10381045.
  • 23
    Egger M, Jurets A, Wallner M, Briza P, Ruzek S, Hainzl S et al. Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome. PLoS One 2011;6:e17278.
  • 24
    Zaborsky N, Brunner M, Wallner M, Himly M, Karl T, Schwarzenbacher R et al. Antigen aggregation decides the fate of the allergic immune response. J Immunol 2010;184:725735.
  • 25
    Bauer R, Scheiblhofer S, Kern K, Gruber C, Stepanoska T, Thalhamer T et al. Generation of hypoallergenic DNA vaccines by forced ubiquitination: preventive and therapeutic effects in a mouse model of allergy. J Allergy Clin Immunol 2006;118:269276.
  • 26
    Hoffmann-Sommergruber K, Mills EN. Food allergen protein families and their structural characteristics and application in component-resolved diagnosis: new data from the EuroPrevall project. Anal Bioanal Chem 2009;395:2535.
  • 27
    Mogensen JE, Wimmer R, Larsen JN, Spangfort MD, Otzen DE. The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands. J Biol Chem 2002;277:2368423692.
  • 28
    Kofler S, Asam C, Eckhard U, Wallner M, Ferreira F, Brandstetter H. Crystallographically mapped ligand binding differs in high and low IgE binding isoforms of birch pollen allergen Bet v 1. J Mol Biol 2012;422:109123.