Edited by: Thomas Bieber
CD8+ T cells producing IL-3 and IL-5 in non-IgE-mediated eosinophilic diseases
Article first published online: 11 NOV 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 68, Issue 12, pages 1622–1625, December 2013
How to Cite
CD8+ T cells producing IL-3 and IL-5 in non-IgE-mediated eosinophilic diseases. Allergy 2013; 68: 1622–1625., .
- Issue published online: 5 DEC 2013
- Article first published online: 11 NOV 2013
- Manuscript Accepted: 30 SEP 2013
- Deutsche Forschungsgemeinschaft
- Swiss National Foundation
- T cells
The cytokines IL-5, IL-3, and GM-CSF are crucial for eosinophil development, survival, and function. To better understand their role in non-IgE-mediated eosinophilic diseases, we investigated plasma levels of these cytokines as well as cytokine expression in peripheral blood T cells. While we did not find any evidence for an involvement of T-cell-derived GM-CSF, some of these patients did show an increased proportion of IL-5- or IL-3-producing CD4+ T cells. However, in a significant proportion of patients, IL-5-producing CD8+ T cells, so-called Tc2 cells, which in healthy donors can only be detected at very low levels, were prominent. Furthermore, increased IL-3 production by CD8+ T cells was also observed, strongly supporting the notion that CD8+ T cells, not just CD4+ T cells, must also be considered as a potential source of the cytokines promoting eosinophilia.