Edited by: Thomas Bieber
Mechanisms and potential therapeutic targets in allergic inflammation: recent insights
Version of Record online: 12 NOV 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 68, Issue 12, pages 1487–1498, December 2013
How to Cite
Mechanisms and potential therapeutic targets in allergic inflammation: recent insights. Allergy 2013; 68: 1487–1498., , , , .
- Issue online: 5 DEC 2013
- Version of Record online: 12 NOV 2013
- Manuscript Accepted: 30 SEP 2013
- Swiss National Science Foundation. Grant Number: 310030_135734
- Bulgarian-Swiss Research Programme. Grant Numbers: IZEBZ0_142967, 2012/33-UKMA-10, VEGA 1/0037/11
- inflammatory mechanisms
Deeper insight into pathogenetic pathways and into the biological effects of immunomodulatory agents will help to optimize or adopt therapeutic strategies for atopic disorders. In this article, we highlight selected findings of potential therapeutic relevance that emerged from recent mechanistic studies with focus on molecular and cellular aspects of allergic inflammation. Furthermore, the often complex mechanisms of action of pleiotropic immunomodulatory agents, such as glucocorticoids, vitamin D, or intravenous immunoglobulin (IVIG), are discussed, as their dissection might reveal targets for novel therapeutics or lead to a more rational use of these compounds. Besides reporting novel evidence, this article points to areas of current debate or uncertainty and aims at stimulating scientific discussion and experimental work.